IN2013MU00665A - - Google Patents

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Publication number
IN2013MU00665A
IN2013MU00665A IN665MU2013A IN2013MU00665A IN 2013MU00665 A IN2013MU00665 A IN 2013MU00665A IN 665MU2013 A IN665MU2013 A IN 665MU2013A IN 2013MU00665 A IN2013MU00665 A IN 2013MU00665A
Authority
IN
India
Prior art keywords
present
novel compounds
provides
oxalate
raloxifene
Prior art date
Application number
Inventor
Srinivas Laxminarayan Pathi
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Chandrasekaran Ramasubbu
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Priority to IN665MU2013 priority Critical patent/IN2013MU00665A/en
Priority to ZA2014/01636A priority patent/ZA201401636B/en
Priority to PCT/GB2014/000081 priority patent/WO2014135834A1/en
Publication of IN2013MU00665A publication Critical patent/IN2013MU00665A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides raloxifene oxalate, including derivatives thereof. In particular, the present invention provides solvates and/or hydrates of raloxifene oxalate, and polymorphs thereof. The present invention also provides processes for preparing the novel compounds, pharmaceutical compositions including the novel compounds and medical uses of the novel compounds.
IN665MU2013 2013-03-05 2014-03-05 IN2013MU00665A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IN665MU2013 IN2013MU00665A (en) 2013-03-05 2014-03-05
ZA2014/01636A ZA201401636B (en) 2013-03-05 2014-03-05 Oxalic acid addition salts and/or solvates of a selective estrogen receptor modulator
PCT/GB2014/000081 WO2014135834A1 (en) 2013-03-05 2014-03-05 Oxalic acid addition salts and/or solvates of a selective estrogen receptor modulator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN665MU2013 IN2013MU00665A (en) 2013-03-05 2014-03-05

Publications (1)

Publication Number Publication Date
IN2013MU00665A true IN2013MU00665A (en) 2015-07-03

Family

ID=50382470

Family Applications (1)

Application Number Title Priority Date Filing Date
IN665MU2013 IN2013MU00665A (en) 2013-03-05 2014-03-05

Country Status (3)

Country Link
IN (1) IN2013MU00665A (en)
WO (1) WO2014135834A1 (en)
ZA (1) ZA201401636B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016279330B2 (en) 2015-06-16 2020-05-14 Jiangsu Hengrui Medicine Co., Ltd. Piperidine derivative and preparation method and pharmaceutical use thereof
MX2018007844A (en) 2015-12-22 2019-01-21 Jiangsu Hengrui Medicine Co Benzopiperidine derivative, preparation method thereof and medical use thereof.
KR20220125272A (en) 2020-01-10 2022-09-14 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Tricyclic tetrahydroisoquinoline derivatives, methods for their preparation and use thereof in the medical field
TW202317582A (en) 2021-07-09 2023-05-01 大陸商江蘇恒瑞醫藥股份有限公司 Salt forms of tricyclic tetrahydroisoquinoline derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4358593A (en) 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
CO4410190A1 (en) 1994-09-19 1997-01-09 Lilly Co Eli 3- [4- (2-AMINOETOXI) -BENZOIL] -2-ARIL-6-HYDROXYBENZO [b] CRYSTALLINE THIOPHEN
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
AU7165398A (en) 1997-04-30 1998-11-24 Eli Lilly And Company A regioselective alkylation process for preparing substituted benzo{b}thiophenes
EP1832583A1 (en) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene sulphuric acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
JP2009541385A (en) * 2006-06-27 2009-11-26 サンド・アクチエンゲゼルシヤフト Novel process for the production of salt
WO2008047105A1 (en) * 2006-10-17 2008-04-24 Cipla Limited Crystalline form of benzothiophene compound and process for preparation thereof
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy

Also Published As

Publication number Publication date
ZA201401636B (en) 2014-11-26
WO2014135834A1 (en) 2014-09-12
WO2014135834A8 (en) 2014-11-27

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