IL90359A0 - Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production - Google Patents
Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their productionInfo
- Publication number
- IL90359A0 IL90359A0 IL90359A IL9035989A IL90359A0 IL 90359 A0 IL90359 A0 IL 90359A0 IL 90359 A IL90359 A IL 90359A IL 9035989 A IL9035989 A IL 9035989A IL 90359 A0 IL90359 A0 IL 90359A0
- Authority
- IL
- Israel
- Prior art keywords
- thiophosphoramidite
- nucleoside
- polynucleotide
- production
- phosphorodithioate compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11060089A IL110600A (en) | 1988-05-26 | 1989-05-19 | Nucleoside and polynucleotide phosphorodithioate compounds and their production |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19888688A | 1988-05-26 | 1988-05-26 | |
US31401189A | 1989-02-22 | 1989-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL90359A0 true IL90359A0 (en) | 1989-12-15 |
Family
ID=26894243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL90359A IL90359A0 (en) | 1988-05-26 | 1989-05-19 | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and their production |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0378615A4 (en) |
JP (1) | JPH03501128A (en) |
KR (1) | KR900701813A (en) |
AU (1) | AU626305B2 (en) |
ES (1) | ES2015665A6 (en) |
IL (1) | IL90359A0 (en) |
WO (1) | WO1989011486A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194599A (en) * | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
US6756496B1 (en) | 1988-09-23 | 2004-06-29 | Isis Pharmaceuticals, Inc. | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues |
US5470967A (en) * | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
US5151510A (en) * | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
EP0463712A3 (en) | 1990-06-27 | 1992-04-08 | University Patents, Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
US5602240A (en) * | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5378825A (en) * | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5623070A (en) * | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
CA2092002A1 (en) * | 1990-09-20 | 1992-03-21 | Mark Matteucci | Modified internucleoside linkages |
US5965722A (en) | 1991-05-21 | 1999-10-12 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ras gene with chimeric and alternating oligonucleotides |
DK0549107T3 (en) | 1991-10-11 | 1998-08-31 | Dade Behring Marburg Gmbh | Process for Preparing a Polynucleotide for Use in Single Primer Amplification and Phosphorothioate-Containing Oils |
WO1994021243A1 (en) * | 1993-03-16 | 1994-09-29 | Board Of Regents Of The University Of Nebraska | Novel metal binding agents, and methods and compositions for their use to treat metal toxicity |
US6001982A (en) | 1993-07-29 | 1999-12-14 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
US5571902A (en) * | 1993-07-29 | 1996-11-05 | Isis Pharmaceuticals, Inc. | Synthesis of oligonucleotides |
EP0932698A1 (en) * | 1996-03-26 | 1999-08-04 | Lynx Therapeutics, Inc. | Oligonucleotide treatments and compositions for human melanoma |
US7255874B1 (en) | 2001-12-21 | 2007-08-14 | Closure Medical Corporation | Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto |
JP6358955B2 (en) | 2012-10-31 | 2018-07-18 | 武田薬品工業株式会社 | Novel modified nucleic acid |
JOP20170192A1 (en) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | Cyclic dinucleotide |
CN110678447B (en) | 2017-06-16 | 2023-12-12 | 卫材R&D管理有限公司 | Modified nucleic acid monomer compounds and oligonucleotide analogues |
CA3085406A1 (en) * | 2017-12-22 | 2019-06-27 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorodithioate internucleoside linkage |
EP3728591A1 (en) * | 2017-12-22 | 2020-10-28 | Roche Innovation Center Copenhagen A/S | Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage |
CN111039977B (en) * | 2019-12-31 | 2022-11-08 | 广州同隽医药科技有限公司 | Phosphorylylation reagent and application thereof in oligonucleotide synthesis |
JP2023553069A (en) * | 2020-12-08 | 2023-12-20 | エフ. ホフマン-ラ ロシュ アーゲー | Novel synthesis of phosphorodithioate oligonucleotides |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US808708A (en) * | 1905-09-20 | 1906-01-02 | Earnest R Wingate | Clamp. |
US3451997A (en) * | 1965-11-30 | 1969-06-24 | Kyowa Hakko Kogyo Kk | Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives |
DE2122529A1 (en) * | 1971-05-06 | 1972-12-14 | Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen | Thiophosphate analogs of the nucleoside di and tnphosphate and processes for their preparation |
US3853844A (en) * | 1972-08-04 | 1974-12-10 | R Robins | Nucleoside 3{40 ,5{40 ,-cyclic phosphorothioates |
US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
US4373071A (en) * | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
US4728730A (en) * | 1984-09-12 | 1988-03-01 | Wisconsin Alumini Research Foundation | Synthesis of nucleoside thiophosphoanhydrides |
JPS6251695A (en) * | 1985-08-29 | 1987-03-06 | Yuki Gosei Yakuhin Kogyo Kk | Synthesis of phosphoroamidite |
AU5418290A (en) * | 1989-03-31 | 1990-11-05 | University Patents Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
WO1991004983A1 (en) * | 1989-10-05 | 1991-04-18 | University Patents, Inc. | Nucleoside and polynucleotide thiophosphoramidite and phosphorodithioate compounds and processes |
-
1989
- 1989-05-19 IL IL90359A patent/IL90359A0/en unknown
- 1989-05-25 EP EP19890906571 patent/EP0378615A4/en not_active Withdrawn
- 1989-05-25 AU AU37392/89A patent/AU626305B2/en not_active Ceased
- 1989-05-25 JP JP1506397A patent/JPH03501128A/en active Pending
- 1989-05-25 WO PCT/US1989/002293 patent/WO1989011486A1/en not_active Application Discontinuation
- 1989-05-25 KR KR1019900700156A patent/KR900701813A/en not_active Application Discontinuation
- 1989-05-26 ES ES8901786A patent/ES2015665A6/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR900701813A (en) | 1990-12-04 |
AU3739289A (en) | 1989-12-12 |
EP0378615A4 (en) | 1992-04-08 |
ES2015665A6 (en) | 1990-09-01 |
WO1989011486A1 (en) | 1989-11-30 |
JPH03501128A (en) | 1991-03-14 |
EP0378615A1 (en) | 1990-07-25 |
AU626305B2 (en) | 1992-07-30 |
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