IL140283A0 - An assay for predictive markers indicating the presence of non-fertilisable ova - Google Patents

An assay for predictive markers indicating the presence of non-fertilisable ova

Info

Publication number
IL140283A0
IL140283A0 IL14028399A IL14028399A IL140283A0 IL 140283 A0 IL140283 A0 IL 140283A0 IL 14028399 A IL14028399 A IL 14028399A IL 14028399 A IL14028399 A IL 14028399A IL 140283 A0 IL140283 A0 IL 140283A0
Authority
IL
Israel
Prior art keywords
medium
maturation
assay
heading
human gamete
Prior art date
Application number
IL14028399A
Original Assignee
Medi Cult As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK199900885A external-priority patent/DK199900885A/en
Application filed by Medi Cult As filed Critical Medi Cult As
Publication of IL140283A0 publication Critical patent/IL140283A0/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0609—Oocytes, oogonia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/367—Infertility, e.g. sperm disorder, ovulatory dysfunction

Abstract

<heading lvl="0">Abstract of Disclosure</heading> The present invention relates to a method for in vitro maturation of a human gamete by culturing an immature human gamete in a chemically defined cell culture medium. The human gamete can be a spermatocyte or an oocyte. The maturation end point is metaII. The advantage of the described medium is a synchronised cumulus-, cytoand nuclear maturation completed within a period of 20 to 30 hours. The medium should preferably contain ATA (Aurin Tri Carboxylicacid) as an anti-apototic agent. The medium should preferably not contain BSA, HSA or other directly serum derived products or substances.
IL14028399A 1998-06-22 1999-06-22 An assay for predictive markers indicating the presence of non-fertilisable ova IL140283A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9011598P 1998-06-22 1998-06-22
DK199900885A DK199900885A (en) 1998-06-22 Procedure for assigning any amount to a given credit card account
PCT/DK1999/000344 WO1999067644A1 (en) 1998-06-22 1999-06-22 Assay to indicate the presence of non-fertilisable ova

Publications (1)

Publication Number Publication Date
IL140283A0 true IL140283A0 (en) 2002-02-10

Family

ID=26064838

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14039499A IL140394A0 (en) 1998-06-22 1999-06-22 A method for in vitro maturation of human gametes
IL14028399A IL140283A0 (en) 1998-06-22 1999-06-22 An assay for predictive markers indicating the presence of non-fertilisable ova

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL14039499A IL140394A0 (en) 1998-06-22 1999-06-22 A method for in vitro maturation of human gametes

Country Status (23)

Country Link
US (2) US20010028878A1 (en)
EP (2) EP1090300B1 (en)
JP (1) JP2002519640A (en)
CN (2) CN1161615C (en)
AT (1) ATE407363T1 (en)
AU (2) AU4360599A (en)
BR (1) BR9911470A (en)
CA (2) CA2335793A1 (en)
DE (1) DE69939468D1 (en)
EE (1) EE200000763A (en)
ES (1) ES2313785T3 (en)
HR (1) HRP20000888A2 (en)
HU (1) HUP0103392A2 (en)
ID (1) ID27197A (en)
IL (2) IL140394A0 (en)
IS (1) IS5768A (en)
NO (2) NO20006519L (en)
NZ (1) NZ509451A (en)
PL (1) PL345318A1 (en)
RU (1) RU2227916C2 (en)
SK (1) SK19152000A3 (en)
TR (1) TR200003830T2 (en)
WO (2) WO1999067644A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005518823A (en) 2002-03-08 2005-06-30 マクギル・ユニバーシテイ In vitro maturation of immature human oocytes
EP1539932A1 (en) * 2002-06-17 2005-06-15 Kobenhavns Amts Sygehus, Herlev In vitro fertilisation
DK1697504T3 (en) * 2003-11-26 2011-11-14 Merck Serono Sa Use of IL-6 type cytokines to mature oocytes
WO2007008521A1 (en) * 2005-07-07 2007-01-18 Lonnie Shea Stage specific follicle maturation systems
CN103275930B (en) * 2013-06-20 2014-07-09 江苏皓康生物医药科技有限公司 Oocyte in-vitro maturity nutrient solution and preparation method thereof
EP3155092B1 (en) * 2014-06-10 2024-02-28 polybiocept GmbH Culture medium for cellular immunotherapy
BR112018068474B1 (en) * 2016-02-24 2024-01-30 Universitá Degli Studi Di Milano, Unimi FOLLICULAR SYSTEM FOR IN VITRO OOCYTE MATURATION AND KIT
CN110628705A (en) * 2019-10-22 2019-12-31 山东畜牧兽医职业学院 Donkey embryo flushing fluid and application method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614715A (en) * 1982-05-14 1986-09-30 The Board Of Trustees Of The University Of Illinois Predictive test for impending ovulation in mammals
RU2013989C1 (en) * 1991-08-13 1994-06-15 Борис Васильевич Леонов Method for determining ovulation
GB9217866D0 (en) * 1992-08-21 1992-10-07 Unilever Plc Monitoring method
CA2176248A1 (en) * 1993-12-16 1995-06-22 Steven C. March Methods and means for determining the female fertile period
GB9410345D0 (en) * 1994-05-24 1994-07-13 Univ Oxford Brookes Method of genetic testing
GB9603326D0 (en) * 1996-02-16 1996-04-17 Royal Free Hosp School Med Predictive assay
DE69619236D1 (en) * 1996-09-27 2002-03-21 Unilever Plc monitoring procedures
GB9625175D0 (en) * 1996-12-04 1997-01-22 Medi Cult As Serum-free cell culture media

Also Published As

Publication number Publication date
TR200003830T2 (en) 2002-01-21
NO20006519D0 (en) 2000-12-20
WO1999067365A1 (en) 1999-12-29
RU2227916C2 (en) 2004-04-27
SK19152000A3 (en) 2001-12-03
JP2002519640A (en) 2002-07-02
AU760165B2 (en) 2003-05-08
NO20006545D0 (en) 2000-12-21
ES2313785T3 (en) 2009-03-01
HUP0103392A2 (en) 2002-01-28
CN1607391A (en) 2005-04-20
DE69939468D1 (en) 2008-10-16
EP1090300B1 (en) 2008-09-03
EP1088056A1 (en) 2001-04-04
ATE407363T1 (en) 2008-09-15
CA2335793A1 (en) 1999-12-29
CN1313951A (en) 2001-09-19
WO1999067644A1 (en) 1999-12-29
AU4360499A (en) 2000-01-10
NO20006519L (en) 2001-02-21
EP1090300A1 (en) 2001-04-11
EE200000763A (en) 2002-06-17
IS5768A (en) 2000-12-12
ID27197A (en) 2001-03-08
HRP20000888A2 (en) 2001-12-31
BR9911470A (en) 2001-03-20
PL345318A1 (en) 2001-12-03
NO20006545L (en) 2001-02-21
CN1161615C (en) 2004-08-11
US20020115211A1 (en) 2002-08-22
NZ509451A (en) 2003-03-28
CA2335632A1 (en) 1999-12-29
IL140394A0 (en) 2002-02-10
AU4360599A (en) 2000-01-10
US20010028878A1 (en) 2001-10-11

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