IL134291A0 - Substituted 4-oxo-napthyridine-3- carboxamides as gaba brain receptor ligands - Google Patents

Substituted 4-oxo-napthyridine-3- carboxamides as gaba brain receptor ligands

Info

Publication number
IL134291A0
IL134291A0 IL13429198A IL13429198A IL134291A0 IL 134291 A0 IL134291 A0 IL 134291A0 IL 13429198 A IL13429198 A IL 13429198A IL 13429198 A IL13429198 A IL 13429198A IL 134291 A0 IL134291 A0 IL 134291A0
Authority
IL
Israel
Prior art keywords
napthyridine
carboxamides
oxo
substituted
receptor ligands
Prior art date
Application number
IL13429198A
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of IL134291A0 publication Critical patent/IL134291A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13429198A 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3- carboxamides as gaba brain receptor ligands IL134291A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
IL134291A0 true IL134291A0 (en) 2001-04-30

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13429198A IL134291A0 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3- carboxamides as gaba brain receptor ligands

Country Status (24)

Country Link
EP (1) EP1007526A1 (en)
JP (1) JP2001514181A (en)
KR (1) KR20010023313A (en)
CN (1) CN1268136A (en)
AP (1) AP2000001742A0 (en)
AU (1) AU753800B2 (en)
BG (1) BG104192A (en)
BR (1) BR9811362A (en)
CA (1) CA2301599C (en)
EG (1) EG21717A (en)
HU (1) HUP0003258A3 (en)
IL (1) IL134291A0 (en)
IS (1) IS5382A (en)
LV (1) LV12539B (en)
NO (1) NO20000822L (en)
NZ (1) NZ502548A (en)
OA (1) OA11293A (en)
PE (1) PE130999A1 (en)
PL (1) PL338783A1 (en)
SI (1) SI20270A (en)
SK (1) SK2162000A3 (en)
TW (1) TW574221B (en)
WO (1) WO1999010347A1 (en)
YU (1) YU10500A (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60018274T2 (en) * 1999-05-06 2005-08-04 Neurogen Corp., Branford SUBSTITUTED 4-OXO-CHINOLINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS
US6448246B1 (en) 1999-05-25 2002-09-10 Neurogen Corporation Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
ATE345129T1 (en) 2000-10-12 2006-12-15 Merck & Co Inc AZA- AND POLYAZA-NAPHTHALENYL CARBONIC ACID AMIDES AS HIV INTEGRASE INHIBITORS
WO2002030426A1 (en) 2000-10-12 2002-04-18 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
YU27903A (en) 2000-10-12 2006-05-25 Merck & Co. Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
JP2004527500A (en) * 2001-03-01 2004-09-09 ファイザー・プロダクツ・インク Nicotine receptor partial agonist, estrogen, selective estrogen modulator or combination of vitamin E and GABAA inverse agonist for the treatment of cognitive impairment
AR036256A1 (en) 2001-08-17 2004-08-25 Merck & Co Inc SODIUM SALT OF AN HIV INTEGRAS INHIBITOR, PROCESSES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
ATE370948T1 (en) 2002-01-17 2007-09-15 Merck & Co Inc HYDROXYNAPHTHYRIDINONCARBONIC ACID AMIDES, WHICH ARE SUITABLE AS INHIBITORS OF HIV INTEGRASE
JP4494020B2 (en) 2002-03-15 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション N- (substituted benzyl) -8-hydroxy-1,6-naphthyridine-7-carboxamide useful as an HIV integrase inhibitor
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
JP5373613B2 (en) * 2006-10-16 2013-12-18 バイオノミクス リミテッド Novel anxiolytic compounds
CA2670116C (en) * 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204813A1 (en) * 1972-05-08 1976-03-05 Yamanouchi Pharma Co Ltd PROCESS FOR THE PREPARATION OF AMPYLICIN DERIVATIVES
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279875A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun PROCESS FOR PREPARING ACTIVATED CARBONIC ACID ESTERS
DD279887A1 (en) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun METHOD OF PREPARING D-ALPHA- (4 (1H) -1,5-NAPHTHYRIDONE-3-CARBOXAMIDO) -BENZYLPENICILLIN AND OTHER BETA LACTAMANTIBIOTICS
DD295360A5 (en) * 1987-07-03 1991-10-31 Akad Wissenschaften Process for the preparation of activated carboxylic acid esters
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
LV12539A (en) 2000-10-20
OA11293A (en) 2002-11-19
LV12539B (en) 2001-01-20
AU9117398A (en) 1999-03-16
BG104192A (en) 2001-05-31
NO20000822L (en) 2000-04-13
NZ502548A (en) 2002-06-28
JP2001514181A (en) 2001-09-11
PL338783A1 (en) 2000-11-20
SI20270A (en) 2000-12-31
WO1999010347A1 (en) 1999-03-04
CA2301599C (en) 2003-03-25
SK2162000A3 (en) 2001-03-12
NO20000822D0 (en) 2000-02-18
EP1007526A1 (en) 2000-06-14
HUP0003258A2 (en) 2001-03-28
TW574221B (en) 2004-02-01
CA2301599A1 (en) 1999-03-04
PE130999A1 (en) 1999-12-16
IS5382A (en) 2000-02-22
AP2000001742A0 (en) 2000-02-24
YU10500A (en) 2002-10-18
AU753800B2 (en) 2002-10-31
EG21717A (en) 2002-02-27
BR9811362A (en) 2000-08-22
CN1268136A (en) 2000-09-27
KR20010023313A (en) 2001-03-26
HUP0003258A3 (en) 2001-05-28

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