IL101715A - Recombinant dna-derived cholera toxin subunit analogs - Google Patents

Recombinant dna-derived cholera toxin subunit analogs

Info

Publication number
IL101715A
IL101715A IL10171592A IL10171592A IL101715A IL 101715 A IL101715 A IL 101715A IL 10171592 A IL10171592 A IL 10171592A IL 10171592 A IL10171592 A IL 10171592A IL 101715 A IL101715 A IL 101715A
Authority
IL
Israel
Prior art keywords
recombinant dna
cholera toxin
toxin subunit
subunit analogs
derived
Prior art date
Application number
IL10171592A
Other versions
IL101715A0 (en
Original Assignee
Amgen Inc
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, Univ Southern California filed Critical Amgen Inc
Publication of IL101715A0 publication Critical patent/IL101715A0/en
Publication of IL101715A publication Critical patent/IL101715A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/832—Drug, bio-affecting and body treating compositions involving bacterial toxin that has modified amino acid sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/909—Vibrio
IL10171592A 1991-05-02 1992-04-28 Recombinant dna-derived cholera toxin subunit analogs IL101715A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69473391A 1991-05-02 1991-05-02

Publications (2)

Publication Number Publication Date
IL101715A0 IL101715A0 (en) 1992-12-30
IL101715A true IL101715A (en) 2005-06-19

Family

ID=24790064

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10171592A IL101715A (en) 1991-05-02 1992-04-28 Recombinant dna-derived cholera toxin subunit analogs

Country Status (18)

Country Link
US (2) US5874287A (en)
EP (1) EP0584284B9 (en)
JP (1) JP3242106B2 (en)
KR (1) KR100249888B1 (en)
CN (1) CN1067679A (en)
AR (1) AR248167A1 (en)
AT (1) ATE199393T1 (en)
AU (1) AU665013B2 (en)
CA (1) CA2102105A1 (en)
DE (1) DE69231708T2 (en)
DK (1) DK0584284T3 (en)
ES (1) ES2156110T3 (en)
GR (1) GR3035724T3 (en)
IL (1) IL101715A (en)
MX (1) MX9202030A (en)
NZ (1) NZ242539A (en)
WO (1) WO1992019265A1 (en)
ZA (1) ZA923162B (en)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
IT1253009B (en) * 1991-12-31 1995-07-10 Sclavo Ricerca S R L DETOXIFIED IMMUNOGENIC MUTANTS OF COLERIC TOXIN AND TOXIN LT, THEIR PREPARATION AND USE FOR THE PREPARATION OF VACCINES
GB9513371D0 (en) 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
US6436407B1 (en) 1994-08-26 2002-08-20 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic adjuvant
US6019982A (en) * 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant
GB9603314D0 (en) * 1996-02-16 1996-04-17 Biocine Spa Immunogenic detoxified mutant toxins
GB9622660D0 (en) 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
WO1999010372A1 (en) 1997-08-27 1999-03-04 Chiron Corporation Molecular mimetics of meningococcal b epitopes
AU3089599A (en) * 1998-03-18 1999-10-11 Smithkline Beecham Corporation Production of purified mutant enterotoxin for use as an adjuvant
US6033673A (en) * 1998-03-18 2000-03-07 The Administrators Of Tulane Educational Fund Double mutant enterotoxin for use as an adjuvant
NZ508366A (en) 1998-05-01 2004-03-26 Chiron Corp Neisseria meningitidis antigens and compositions
US6576244B1 (en) 1998-06-19 2003-06-10 Acambis, Inc. LT and CT in parenteral immunization methods against helicobacter infection
DE69937571T2 (en) * 1998-09-30 2008-09-04 The Government Of The United States Of America As Represented By The Uniformed Services University Of The Health Sciences MUTATEN CHOLERA HOLOTOXIN AS AID
EP1175144A4 (en) * 1998-12-22 2002-10-30 Thompson Boyce Plant Res Orally immunogenic bacterial enterotoxins expressed in transgenic plants
WO2000039302A2 (en) 1998-12-31 2000-07-06 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
JP2002537355A (en) 1999-02-26 2002-11-05 カイロン コーポレイション Use of bioadhesives and adjuvants for mucosal delivery of antigen
CA2689696C (en) 1999-02-26 2013-08-06 Novartis Vaccines And Diagnostics, Inc. Microemulsions with adsorbed macromolecules and microparticles
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
US7384640B1 (en) 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
WO2001070257A1 (en) * 2000-03-17 2001-09-27 Uab Research Foundation Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediated or humoral immunity
WO2001089456A2 (en) 2000-05-19 2001-11-29 The Administrators Of The Tulane Educational Fund Hybrid lt-a/ct-b holotoxin for use as an adjuvant
WO2002019968A2 (en) * 2000-09-08 2002-03-14 University Of Maryland Biotechnology Institute Genetically engineered co-expression dna vaccines, construction methods and uses thereof
US20030162733A1 (en) * 2000-11-27 2003-08-28 Haynes Joel R. Nucleic acid adjuvants
EP1363663B1 (en) 2001-01-12 2011-03-02 Novartis Vaccines and Diagnostics, Inc. Nucleic acid mucosal immunization
WO2002083855A2 (en) 2001-04-16 2002-10-24 Wyeth Holdings Corporation Novel streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
AU2002346249B2 (en) 2001-06-07 2007-03-15 The Regents Of The University Of Colorado Mutant Forms of Cholera Holotoxin as an Adjuvant
IL159209A0 (en) * 2001-06-07 2004-06-01 Wyeth Corp Mutant forms of cholera holotoxin as an adjuvant
US8481043B2 (en) 2001-06-22 2013-07-09 Cpex Pharmaceuticals, Inc. Nasal immunization
WO2003004657A1 (en) 2001-07-05 2003-01-16 Chiron Corporation Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof
EP2412242A3 (en) 2001-07-05 2012-06-13 Novartis Vaccines and Diagnostics, Inc. Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
AR045702A1 (en) 2001-10-03 2005-11-09 Chiron Corp COMPOSITIONS OF ASSISTANTS.
MX339524B (en) 2001-10-11 2016-05-30 Wyeth Corp Novel immunogenic compositions for the prevention and treatment of meningococcal disease.
EP2572707A3 (en) 2002-02-20 2013-11-06 Novartis Vaccines and Diagnostics, Inc. Microparticles with adsorbed polypeptide-containing molecules
JP2005532789A (en) 2002-03-15 2005-11-04 ワイス・ホールデイングス・コーポレーシヨン P4 protein variant of non-typeable Haemophilus influenzae with reduced enzymatic activity
US7785608B2 (en) 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
US20080159957A1 (en) 2002-10-01 2008-07-03 W Michael Kavanaugh Anti-Cancer and Anti-Infectious Disease Compositions and Methods for Using Same
WO2004060396A2 (en) 2002-12-27 2004-07-22 Chiron Corporation Immunogenic compositions containing phospholpid
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
WO2005020964A1 (en) 2003-06-02 2005-03-10 Chiron Corporation Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
US8071652B2 (en) 2003-08-21 2011-12-06 The Board Of Regents Of The University Of Texas System Method of treating irritable bowel syndrome
GB0325494D0 (en) * 2003-10-31 2003-12-03 Sbl Vaccin Ab Expression system
PL2336147T3 (en) 2003-12-17 2015-01-30 Janssen Alzheimer Immunotherap A beta immunogenic peptide carrier conjugates and methods of producing same
HUE026000T2 (en) 2003-12-17 2016-04-28 Wyeth Llc Immunogenic peptide carrier conjugates and methods of producing same
GB0410220D0 (en) 2004-05-07 2004-06-09 Kirkham Lea Ann Mutant pneumolysin proteins
CA2562037A1 (en) 2004-05-21 2005-12-08 Wyeth Altered fibronectin-binding protein of staphylococcus aureus
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
WO2007001423A2 (en) 2004-10-21 2007-01-04 Wyeth Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens
US20100015211A1 (en) 2004-11-01 2010-01-21 Barnett Susan W Combination Approaches For Generating Immune Responses
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
KR20150061019A (en) 2005-04-08 2015-06-03 와이어쓰 엘엘씨 Multivalent pneumococcal polysaccharide-protein conjugate composition
TW200806315A (en) 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
WO2008094188A2 (en) 2006-07-17 2008-08-07 Anza Therapeutics, Inc. Methods and compositions using listeria for enhancing immunogenicity by prime boost
AR064642A1 (en) 2006-12-22 2009-04-15 Wyeth Corp POLINUCLEOTIDE VECTOR THAT INCLUDES IT RECOMBINATING CELL THAT UNDERSTANDS THE VECTOR POLYPEPTIDE, ANTIBODY, COMPOSITION THAT UNDERSTANDS THE POLINUCLEOTIDE, VECTOR, RECOMBINATING CELL POLYPEPTIDE OR ANTIBODY, USE OF THE COMPOSITION AND A COMPOSITION AND A METHOD
EP2244695A1 (en) 2007-12-07 2010-11-03 Novartis AG Compositions for inducing immune responses
US9415006B2 (en) 2008-05-23 2016-08-16 The Regents Of The University Of Michigan Immunogenic compositions comprising nanoemulsion and hepatitis B virus immunogen and methods of using the same
EP2328928A2 (en) 2008-08-25 2011-06-08 Dana-Farber Cancer Institute, Inc. Conserved influenza hemagglutinin epitope and antibodies thereto
US20100092526A1 (en) 2008-09-26 2010-04-15 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same
EP2356135B1 (en) 2008-11-05 2017-10-25 Wyeth LLC Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (bhs) disease
EP2346529B1 (en) 2008-11-12 2016-02-10 Theraclone Sciences, Inc. Human m2e peptide immunogens
BRPI1005670A8 (en) 2009-01-05 2017-12-26 Epitogenesis Inc adjuvant compositions and processes of use.
EP2405758B1 (en) 2009-03-09 2016-04-27 Molecular Express, Inc. Methods and compositions for liposomal formulation of antigens and uses thereof
ITMI20090946A1 (en) 2009-05-28 2010-11-29 Novartis Ag EXPRESSION OF RECOMBINANT PROTEINS
ES2566646T3 (en) 2009-06-16 2016-04-14 The Regents Of The University Of Michigan Nanoemulsion vaccines
ES2613630T3 (en) 2010-05-23 2017-05-25 Aduro Biotech, Inc. Methods and compositions that use Listeria for an auxiliary cancer treatment
HUE048398T2 (en) 2010-06-04 2020-07-28 Wyeth Llc Vaccine formulations
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
HUE052850T2 (en) 2010-08-23 2021-05-28 Wyeth Llc Stable formulations of neisseria meningitidis rlp2086 antigens
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
SE535625C2 (en) * 2010-10-28 2012-10-16 Toleranzia Ab New compositions and procedures for the treatment of autoimmune and allergic diseases
US20140287022A1 (en) 2011-04-26 2014-09-25 Molecular Express, Inc. Liposomal formulations
CN103717235A (en) 2011-06-24 2014-04-09 埃皮托吉尼西斯有限公司 Pharmaceutical compositions, comprising a combination of select carriers, vitamins, tannins and flavonoids as antigen-specific immuno-modulators
ITMI20111182A1 (en) 2011-06-28 2012-12-29 Canio Buonavoglia VACCINE FOR CORONAVIRUS CANINO
MX2014005548A (en) 2011-11-14 2014-08-21 Novartis Ag Immunogenic complexes of polyanionic carbomers and env polypeptides and methods of manufacture and use thereof.
SA115360586B1 (en) 2012-03-09 2017-04-12 فايزر انك Neisseria meningitidis compositions and methods thereof
KR101763625B1 (en) 2012-03-09 2017-08-01 화이자 인코포레이티드 Neisseria meningitidis compositions and methods thereof
KR102057217B1 (en) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
EP3608401A1 (en) 2012-07-05 2020-02-12 Ohio State Innovation Foundation Compositions and methods related to viral vaccines
MX2015000789A (en) 2012-07-19 2015-05-07 Zoetis Llc Bovine influenza c virus compositions.
WO2014018724A1 (en) 2012-07-27 2014-01-30 Zoetis Llc Tick toxin compositions
MY167579A (en) 2012-08-16 2018-09-20 Pfizer Glycoconjugation processes and compositions
DK2912186T3 (en) 2012-10-24 2021-02-22 Platelet Targeted Therapeutics Llc TREATMENT TARGETED TO BLOOD PLATES
KR20140075196A (en) 2012-12-11 2014-06-19 에스케이케미칼주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
KR20140075201A (en) 2012-12-11 2014-06-19 에스케이케미칼주식회사 Multivalent pneumococcal polysaccharide-protein conjugate composition
ES2685894T3 (en) 2013-03-08 2018-10-15 Pfizer Inc. Immunogenic fusion polypeptides
JP2016512841A (en) 2013-03-15 2016-05-09 ゾエティス・サービシーズ・エルエルシー B. Multivalent vaccine Interference effect of cattle on trehaloci infection
RU2662968C2 (en) 2013-09-08 2018-07-31 Пфайзер Инк. Immunogenic composition for neisseria meningitidis (options)
EP3063171B1 (en) 2013-11-01 2019-07-24 University Of Oslo Albumin variants and uses thereof
US9993541B2 (en) 2013-11-13 2018-06-12 University Of Oslo Outer membrane vesicles and uses thereof
WO2015071763A2 (en) 2013-11-15 2015-05-21 Oslo Universitetssykehus Hf Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
KR102049826B1 (en) 2014-01-21 2019-12-03 화이자 인코포레이티드 Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
EP4286000A3 (en) 2014-01-21 2024-02-14 Pfizer Inc. Streptococcus pneumoniae capsular polysaccharides and conjugates thereof
EP3443983B1 (en) 2014-02-14 2022-07-20 Pfizer Inc. Immunogenic glycoprotein conjugates
US11083788B2 (en) 2014-10-10 2021-08-10 The Regents Of The University Of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
EP3270959A1 (en) 2015-02-19 2018-01-24 Pfizer Inc Neisseria meningitidis compositions and methods thereof
WO2016141320A2 (en) 2015-03-05 2016-09-09 Northwestern University Non-neuroinvasive viruses and uses thereof
WO2016179034A2 (en) 2015-05-01 2016-11-10 The Trustees Of The University Of Pennsylvania Methods and compositions for stimulating immune response using potent immunostimulatory rna motifs
PT3334454T (en) 2015-08-14 2022-12-20 Univ Melbourne Mycoplasma bovis compositions
CN108348593B (en) 2015-08-31 2022-08-16 泰克诺瓦克斯股份有限公司 Human Respiratory Syncytial Virus (HRSV) virus-like particle (VLPS) based vaccines
CA3010977A1 (en) 2016-01-11 2017-07-20 Zoetis Services Llc Novel cross protective vaccine compositions for porcine epidemic diarrhea virus
WO2017158426A1 (en) 2016-03-14 2017-09-21 University Of Oslo Engineered immunoglobulins with altered fcrn binding
WO2017158421A1 (en) 2016-03-14 2017-09-21 University Of Oslo Anti-viral engineered immunoglobulins
WO2017201390A1 (en) 2016-05-19 2017-11-23 The Regents Of The University Of Michigan Novel adjuvant compositions
WO2017210215A1 (en) 2016-05-31 2017-12-07 The Government Of The United States Of America As Represented By The Secretary Of The Army Zika virus vaccine and methods of production
EP3471761A2 (en) 2016-06-21 2019-04-24 University Of Oslo Hla binding vaccine moieties and uses thereof
WO2017220753A1 (en) 2016-06-22 2017-12-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Pneumococcal polysaccharide-protein conjugate composition
EP3269385A1 (en) 2016-07-12 2018-01-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Pneumococcal polysaccharide-protein conjugate composition
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
SG11201906519RA (en) 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof
GB201703529D0 (en) 2017-03-06 2017-04-19 Cambridge Entpr Ltd Vaccine composition
WO2018183666A1 (en) 2017-03-31 2018-10-04 Boston Medical Center Corporation Methods and compositions using highly converved pneumococcal surface proteins
EP3641828B1 (en) 2017-06-23 2023-11-22 Affinivax, Inc. Immunogenic compositions
JP2020533338A (en) 2017-09-07 2020-11-19 ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ Vaccine molecule
WO2019048936A1 (en) 2017-09-07 2019-03-14 University Of Oslo Vaccine molecules
EP3574915A1 (en) 2018-05-29 2019-12-04 Neovacs Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity
AU2020323498A1 (en) 2019-07-31 2022-03-03 Sk Bioscience Co., Ltd. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
CA3164306A1 (en) 2020-01-10 2021-07-15 Lg Chem, Ltd. Composition comprising antigen-presenting cell co-expressing mhc and tumor antigen, and cancer treatment using same
AU2021211012A1 (en) 2020-01-24 2022-08-25 Aim Immunotech Inc. Methods, compositions, and vaccines for treating a virus infection
JP2023522050A (en) 2020-04-16 2023-05-26 パーイミューン エスエーエス 28KDA GST protein from Schistosoma for the treatment of vasculitis
EP3900739A1 (en) 2020-04-21 2021-10-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synthetic streptococcus pneumoniae saccharide conjugates to conserved membrane protein
CA3192500A1 (en) 2020-09-17 2022-03-24 Laurent REBER Immunogenic product comprising an ige fragment for treating ige-mediated inflammatory disorders
EP4313132A1 (en) 2021-03-31 2024-02-07 Vib Vzw Vaccine compositions for trypanosomatids
WO2024069420A2 (en) 2022-09-29 2024-04-04 Pfizer Inc. Immunogenic compositions comprising an rsv f protein trimer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328209A (en) * 1979-04-11 1982-05-04 Board Of Regents, The University Of Texas System Cholera vaccine
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
US4935364A (en) * 1983-03-04 1990-06-19 Swiss Serum And Vaccine Institute Berne Method of isolating restriction fragment deletions in vibrio cholerae and products thereof
US4882278A (en) * 1983-04-29 1989-11-21 President And Fellows Of Harvard College Non-toxinogenic vibrio cholerae mutants

Also Published As

Publication number Publication date
DE69231708D1 (en) 2001-04-05
US5770203A (en) 1998-06-23
DK0584284T3 (en) 2001-06-18
CA2102105A1 (en) 1992-11-03
GR3035724T3 (en) 2001-07-31
EP0584284A1 (en) 1994-03-02
CN1067679A (en) 1993-01-06
EP0584284B9 (en) 2002-11-13
JPH06507551A (en) 1994-09-01
MX9202030A (en) 1993-02-01
ZA923162B (en) 1993-04-28
KR100249888B1 (en) 2000-04-01
WO1992019265A1 (en) 1992-11-12
ATE199393T1 (en) 2001-03-15
US5874287A (en) 1999-02-23
ES2156110T3 (en) 2001-06-16
AU665013B2 (en) 1995-12-14
EP0584284B1 (en) 2001-02-28
DE69231708T2 (en) 2001-07-05
JP3242106B2 (en) 2001-12-25
NZ242539A (en) 1993-11-25
EP0584284A4 (en) 1995-03-15
AR248167A1 (en) 1995-06-30
IL101715A0 (en) 1992-12-30
AU2293092A (en) 1992-12-21

Similar Documents

Publication Publication Date Title
IL101715A (en) Recombinant dna-derived cholera toxin subunit analogs
GB9119703D0 (en) Medico-surgical device
GB9115909D0 (en) Recombinant dna
GB9120416D0 (en) Catheter placement units
AP9200368A0 (en) Vaccine
EP0499744A3 (en) Electrode placement training system
EP0639981A4 (en) Igf-1 analogs.
AU114247S (en) Bottle
AU114767S (en) Bottle
AU114245S (en) Bottle
AU113871S (en) Bottle
EP0505999A3 (en) Outline enhancing device
AU113464S (en) Dummy clip
AU113825S (en) Bottle
GB9106568D0 (en) Recombinant antigen
AU114729S (en) Bottle
CA69205S (en) Bottle
CA68313S (en) Bottle
CA68339S (en) Bottle
CA69078S (en) Bottle
CA69197S (en) Bottle
IL97079A0 (en) Nasal drops
GB9105275D0 (en) Interlining
GB9113163D0 (en) Medicinal
AU113358S (en) Bottle

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired