ID29128A - GEN FOR EPOTILON BIOSINTHESIS - Google Patents

GEN FOR EPOTILON BIOSINTHESIS

Info

Publication number
ID29128A
ID29128A IDW20002594A ID20002594A ID29128A ID 29128 A ID29128 A ID 29128A ID W20002594 A IDW20002594 A ID W20002594A ID 20002594 A ID20002594 A ID 20002594A ID 29128 A ID29128 A ID 29128A
Authority
ID
Indonesia
Prior art keywords
epotilon
biosinthesis
gen
epotilon biosinthesis
Prior art date
Application number
IDW20002594A
Other languages
Indonesian (id)
Inventor
Istvan Molnar
Thomas Schupp
James Madison Ligon
Ross Zirkle
Jorn Gorlach
Devon Cyr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ID29128A publication Critical patent/ID29128A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
IDW20002594A 1998-06-18 1999-06-16 GEN FOR EPOTILON BIOSINTHESIS ID29128A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9950498A 1998-06-18 1998-06-18
US10163198P 1998-09-24 1998-09-24
US11890699P 1999-02-05 1999-02-05

Publications (1)

Publication Number Publication Date
ID29128A true ID29128A (en) 2001-08-02

Family

ID=27378840

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20002594A ID29128A (en) 1998-06-18 1999-06-16 GEN FOR EPOTILON BIOSINTHESIS

Country Status (16)

Country Link
EP (1) EP1088078A2 (en)
JP (3) JP2002518004A (en)
KR (1) KR100511233B1 (en)
CN (1) CN100374565C (en)
AU (1) AU753567B2 (en)
BR (1) BR9911349A (en)
CA (1) CA2329774A1 (en)
HU (1) HUP0102186A3 (en)
ID (1) ID29128A (en)
IL (3) IL139735A0 (en)
NO (2) NO20006195L (en)
NZ (1) NZ508326A (en)
PL (1) PL200157B1 (en)
SK (1) SK19242000A3 (en)
TR (1) TR200003759T2 (en)
WO (1) WO1999066028A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1386922B1 (en) 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereof, analogues and uses thereof
FR2775187B1 (en) 1998-02-25 2003-02-21 Novartis Ag USE OF EPOTHILONE B FOR THE MANUFACTURE OF AN ANTIPROLIFERATIVE PHARMACEUTICAL PREPARATION AND A COMPOSITION COMPRISING EPOTHILONE B AS AN IN VIVO ANTIPROLIFERATIVE AGENT
DE19846493A1 (en) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA sequence coding for products involved in the biosynthesis of polyketide or heteropolyketide compounds, especially epothilone
KR20070087132A (en) * 1998-11-20 2007-08-27 코산 바이오사이언시즈, 인코포레이티드 Recombinant methods and materials for producing epothilone and epothilone derivatives
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
AU2001245263A1 (en) * 2000-01-21 2001-07-31 Kosan Biosciences, Inc. Method for cloning polyketide synthase genes
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
CN100480389C (en) * 2000-04-28 2009-04-22 科塞生物科学有限公司 Production of polyketides
WO2002030356A2 (en) 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs
US7257562B2 (en) 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
US6719540B2 (en) 2002-03-12 2004-04-13 Bristol-Myers Squibb Company C3-cyano epothilone derivatives
AU2006211216B2 (en) * 2005-01-31 2011-02-03 Merck Sharp & Dohme Llc Purification process for plasmid DNA
JP2014508516A (en) 2011-01-28 2014-04-10 アミリス， インコーポレイテッド Screening of microcolonies encapsulated in gel
CN103518136A (en) 2011-05-13 2014-01-15 阿迈瑞斯公司 Methods and compositions for detecting microbial production of water-immiscible compounds
WO2014025941A1 (en) 2012-08-07 2014-02-13 Jiang Hanxiao Methods for stabilizing production of acetyl-coenzyme a derived compounds
ES2721920T3 (en) 2013-03-15 2019-08-06 Amyris Inc Use of phosphoketolase and phosphotransacetylase for the production of compounds derived from acetyl-coenzyme A
PT3030662T (en) 2013-08-07 2020-03-25 Amyris Inc Methods for stabilizing production of acetyl-coenzyme a derived compounds
AU2016284696B2 (en) 2015-06-25 2021-10-28 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (en) * 2015-12-24 2022-08-05 武汉合生科技有限公司 Biosynthetic gene cluster of compounds and application thereof
CN111138444B (en) * 2020-01-08 2022-05-03 山东大学 Epothilone B glucoside compounds and enzymatic preparation and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU753546B2 (en) * 1996-11-18 2002-10-24 Helmholtz-Zentrum Fuer Infektionsforschung Gmbh Epothilone C, D, E and F, production process, and their use as cytostatic as well as phytosanitary agents

Also Published As

Publication number Publication date
IL139735A (en) 2009-06-15
JP2002518004A (en) 2002-06-25
BR9911349A (en) 2001-03-13
HUP0102186A3 (en) 2005-10-28
JP2008092958A (en) 2008-04-24
HUP0102186A2 (en) 2001-10-28
WO1999066028A3 (en) 2000-06-29
CN1305530A (en) 2001-07-25
KR100511233B1 (en) 2005-08-31
PL200157B1 (en) 2008-12-31
WO1999066028A2 (en) 1999-12-23
AU4611699A (en) 2000-01-05
NO20006195D0 (en) 2000-12-06
CA2329774A1 (en) 1999-12-23
NO20091055L (en) 2001-02-16
IL139735A0 (en) 2002-02-10
PL345579A1 (en) 2001-12-17
NZ508326A (en) 2003-10-31
TR200003759T2 (en) 2001-06-21
IL190391A0 (en) 2008-11-03
SK19242000A3 (en) 2001-07-10
KR20010052962A (en) 2001-06-25
JP2006061166A (en) 2006-03-09
CN100374565C (en) 2008-03-12
AU753567B2 (en) 2002-10-24
NO20006195L (en) 2001-02-16
EP1088078A2 (en) 2001-04-04

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