HUP9903770A2 - Method and composition for reconforming multi-epitopic antigens to initiate an immune response - Google Patents

Method and composition for reconforming multi-epitopic antigens to initiate an immune response

Info

Publication number
HUP9903770A2
HUP9903770A2 HU9903770A HUP9903770A HUP9903770A2 HU P9903770 A2 HUP9903770 A2 HU P9903770A2 HU 9903770 A HU9903770 A HU 9903770A HU P9903770 A HUP9903770 A HU P9903770A HU P9903770 A2 HUP9903770 A2 HU P9903770A2
Authority
HU
Hungary
Prior art keywords
immune response
reconforming
initiate
composition
antigens
Prior art date
Application number
HU9903770A
Other languages
Hungarian (hu)
Inventor
Richard P. Baum
Ragupathy Madiyalakan
Antoine A. Noujaim
Birgit Schultes
Original Assignee
Altarex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altarex Corporation filed Critical Altarex Corporation
Publication of HUP9903770A2 publication Critical patent/HUP9903770A2/en
Publication of HUP9903770A3 publication Critical patent/HUP9903770A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát imműnválasz kiváltására és/vagy főkőzásáraalkalmas eljárásők és készítmények képezik. Közelebbről, a találmányszerinti eljárásők és készítmények alkalmazásával többepitópősantigének imműnőgenitása válatőztatható meg őly módőn, hőgy azantigénhez őlyan - kizárólag egy epitóphőz kötődő - specifikűskötőreagenst adnak, melynek kötődése az antigén imműnőgén sajátságaitmegváltőztatja. ŕThe subject of the invention are procedures and preparations suitable for inducing and/or priming an immune response. More specifically, by using the methods and preparations according to the invention, the immunogenicity of multiple epitope antigens can be changed in such a way that a specific binding reagent is added to the antigen in such a way that only one epitope binds, the binding of which changes the characteristics of the antigen immunogen. ŕ

HU9903770A 1996-05-15 1996-05-15 Method and composition for reconforming multi-epitopic antigens to initiate an immune response HUP9903770A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB1996/000461 WO1997042973A1 (en) 1996-05-15 1996-05-15 Method and composition for reconforming multi-epitopic antigens to initiate an immune response

Publications (2)

Publication Number Publication Date
HUP9903770A2 true HUP9903770A2 (en) 2000-03-28
HUP9903770A3 HUP9903770A3 (en) 2001-07-30

Family

ID=46171074

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903770A HUP9903770A3 (en) 1996-05-15 1996-05-15 Method and composition for reconforming multi-epitopic antigens to initiate an immune response

Country Status (17)

Country Link
US (7) US6241985B1 (en)
EP (2) EP0910407B1 (en)
JP (1) JP3565351B2 (en)
KR (1) KR20020011137A (en)
AT (1) ATE233102T1 (en)
BR (1) BR9612619A (en)
CA (1) CA2253602A1 (en)
DE (1) DE69626423T2 (en)
DK (1) DK0910407T3 (en)
ES (1) ES2193240T3 (en)
HU (1) HUP9903770A3 (en)
IL (1) IL126803A (en)
NO (2) NO321511B1 (en)
NZ (3) NZ332588A (en)
PT (1) PT910407E (en)
SI (1) SI0910407T1 (en)
WO (1) WO1997042973A1 (en)

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KR20130118998A (en) * 2005-07-29 2013-10-30 프로비던스 헬스 앤드 서비시즈, 오레곤 Defective ribosomal products in blebs(dribbles) and methods of use to stimulate an immune response
EP1948802A4 (en) * 2005-10-13 2009-01-14 Virexx Medical Corp Chimeric antigen containing hepatitis c virus polypeptide and fc fragment for eliciting an immune response
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Also Published As

Publication number Publication date
NZ332588A (en) 2000-11-24
US20010036457A1 (en) 2001-11-01
US20080131443A1 (en) 2008-06-05
NZ505174A (en) 2002-03-01
JPH11509558A (en) 1999-08-24
AU5658096A (en) 1997-12-05
EP0910407B1 (en) 2003-02-26
NO321511B1 (en) 2006-05-15
US6241985B1 (en) 2001-06-05
US20080311127A1 (en) 2008-12-18
NO985304D0 (en) 1998-11-13
US6086873A (en) 2000-07-11
NZ516264A (en) 2002-04-26
DE69626423T2 (en) 2004-03-18
KR20020011137A (en) 2002-02-07
BR9612619A (en) 1999-07-20
WO1997042973A1 (en) 1997-11-20
US20070036798A1 (en) 2007-02-15
EP1297846A1 (en) 2003-04-02
DK0910407T3 (en) 2003-06-16
HUP9903770A3 (en) 2001-07-30
AU711270B2 (en) 1999-10-07
ATE233102T1 (en) 2003-03-15
JP3565351B2 (en) 2004-09-15
IL126803A (en) 2003-11-23
NO985304L (en) 1998-11-13
IL126803A0 (en) 1999-08-17
US20080206318A1 (en) 2008-08-28
SI0910407T1 (en) 2003-10-31
PT910407E (en) 2003-07-31
NO20061203L (en) 1998-11-13
EP0910407A1 (en) 1999-04-28
ES2193240T3 (en) 2003-11-01
DE69626423D1 (en) 2003-04-03
CA2253602A1 (en) 1997-11-20

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Owner name: ALTAREX MEDICAL CORP., CA

Free format text: FORMER OWNER(S): ALTAREX CORPORATION, US; ALTAREX MEDICAL CORP., CA

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished