HUP0202551A2 - Chemical biochemical and biological process with chip for minimise and thereof use - Google Patents

Chemical biochemical and biological process with chip for minimise and thereof use

Info

Publication number
HUP0202551A2
HUP0202551A2 HU0202551A HUP0202551A HUP0202551A2 HU P0202551 A2 HUP0202551 A2 HU P0202551A2 HU 0202551 A HU0202551 A HU 0202551A HU P0202551 A HUP0202551 A HU P0202551A HU P0202551 A2 HUP0202551 A2 HU P0202551A2
Authority
HU
Hungary
Prior art keywords
compounds
biological
chip
output
unit
Prior art date
Application number
HU0202551A
Other languages
Hungarian (hu)
Inventor
Ferenc Darvas
László Ürge
Lajos Gödörházy
Tamás Karancsi
Dániel Szalay
György Dormán
Original Assignee
Comgenex, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Comgenex, Inc. filed Critical Comgenex, Inc.
Priority to HU0202551A priority Critical patent/HUP0202551A2/en
Publication of HU0202551D0 publication Critical patent/HU0202551D0/hu
Priority to PCT/HU2003/000063 priority patent/WO2004012856A1/en
Priority to AU2003249102A priority patent/AU2003249102A1/en
Publication of HUP0202551A2 publication Critical patent/HUP0202551A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/10—Methods of screening libraries by measuring physical properties, e.g. mass
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/007—Simulation or vitual synthesis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00822—Metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00986—Microprocessor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Structural Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A találmány tárgya kémiai, biokémiai és biológiai folyamatokminiatürizálására szolgáló hibrid lapka (chip), amely egy- vagytöbbrétegű lapkából (chipből) áll, továbbá egymással szorosösszeköttetésben az alábbi egységeket tartalmazza: a) vegyületekfizikai mozgatását is megvalósító, a vegyületek kémiai szintézisére éstisztítására szolgáló egységet, b) vegyületek fizikai mozgatását ismegvalósító, a vegyületek kémiai analízisére szolgáló egységet, c)vegyületek fizikai mozgatását is megvalósító, a vegyületek biológiaihatásvizsgálatára szolgáló egységet, d) adott esetben egy olyanelektronikus egységet, adott esetben félvezető lapkát, amely beégetvetartalmaz (i) legalább egy - a biológiai hatás és a kémiai szerkezetközött összefüggést felállító algoritmust realizáló - számítógépesprogramkódját, amely inputként egy vagy több vegyület kémiaiszerkezetét és biológiai hatását fogadja el, outputként pedig további,várhatóan kívánt biológiai hatással rendelkező egy vagy több vegyületszerkezetét adja, (ii) egy olyan szintézisprogram kódját, amelyinputként az (i) pontban outputként kapott egy vagy több vegyületképletét, outputként e vegyületek előállításának laboratóriumielőiratát szolgáltatja, (iii) egy olyan vezérlőprogram kódját, amelyinputként az (ii) pontban outputként egy vagy több laboratóriumielőiratot, outputként az a) pontban szereplő egység vezérlésiprogramját szolgáltatja, (iv) továbbá adott esetben az a)-d) pontokbanszereplő egységek és programok vezérlését, így többek között ezekindítását, leállítását, optimálását adott esetben a biológiaihatásvizsgálat során elérendő küszöbérték révén vezérlő programkódját. A találmány szerinti hibrid lapka (chip) vegyületek, ezenbelül előnyösen biológiailag aktív vegyületek előállításában,analízisében, hatásvizsgálatában, metabolizmus, toxicitás és másbármilyen adaptálható biológiai kölcsönhatás mérésében alkalmazható. ÓThe subject of the invention is a hybrid chip (chip) for the miniaturization of chemical, biochemical and biological processes, which consists of a chip (chip) with one or more layers, and also contains the following units in close connection with each other: a) a unit for the chemical synthesis and purification of compounds, which also realizes the physical movement of compounds, b ) a unit that also implements the physical movement of compounds and serves for the chemical analysis of the compounds, c) a unit that also implements the physical movement of compounds and is used for testing the biological effects of the compounds, d) where appropriate, an electronic unit, where appropriate a semiconductor chip, which contains (i) at least one - the biological - the computer program code that implements the algorithm establishing the relationship between the effect and the chemical structure, which accepts as input the chemical structure and biological effect of one or more compounds, and gives as output the structure of one or more compounds with the expected biological effect, (ii) the code of a synthesis program that, as input, the formula of one or more compounds received as output in point (i), and the laboratory protocol for the production of these compounds as output, (iii) the code of a control program that provides as input one or more laboratory protocols as output in point (ii), and as output the control program of the unit listed in point a), (iv) ) and, where appropriate, the program code that controls the control of the units and programs included in points a)-d), such as, among other things, their start, stop, and optimization through the threshold value to be reached during the biological impact test. The hybrid chip according to the invention can be used in the production, analysis, impact assessment, metabolism, toxicity and any other adaptable biological interaction of compounds, preferably biologically active compounds. HE

HU0202551A 2002-08-01 2002-08-01 Chemical biochemical and biological process with chip for minimise and thereof use HUP0202551A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HU0202551A HUP0202551A2 (en) 2002-08-01 2002-08-01 Chemical biochemical and biological process with chip for minimise and thereof use
PCT/HU2003/000063 WO2004012856A1 (en) 2002-08-01 2003-07-30 Hybrid chip for the miniaturization of chemical, biomedical, and biological processes and method of application
AU2003249102A AU2003249102A1 (en) 2002-08-01 2003-07-30 Hybrid chip for the miniaturization of chemical, biomedical, and biological processes and method of application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0202551A HUP0202551A2 (en) 2002-08-01 2002-08-01 Chemical biochemical and biological process with chip for minimise and thereof use

Publications (2)

Publication Number Publication Date
HU0202551D0 HU0202551D0 (en) 2002-10-28
HUP0202551A2 true HUP0202551A2 (en) 2004-03-29

Family

ID=89980671

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202551A HUP0202551A2 (en) 2002-08-01 2002-08-01 Chemical biochemical and biological process with chip for minimise and thereof use

Country Status (3)

Country Link
AU (1) AU2003249102A1 (en)
HU (1) HUP0202551A2 (en)
WO (1) WO2004012856A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
DE19917398C2 (en) * 1999-04-16 2002-06-20 Accoris Gmbh Modular chemical microsystem
DE10028875A1 (en) * 2000-06-10 2001-12-20 Hte Gmbh Automatic formation and iterative optimization of substance library, employs integrated process embracing manufacture, performance testing, and test result analysis

Also Published As

Publication number Publication date
AU2003249102A1 (en) 2004-02-23
WO2004012856A1 (en) 2004-02-12
HU0202551D0 (en) 2002-10-28

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