HUP0200580A3 - Polymorphic crystalline forms of celecoxib, process their preparation and pharmaceutical compositions containing them - Google Patents

Polymorphic crystalline forms of celecoxib, process their preparation and pharmaceutical compositions containing them

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Publication number
HUP0200580A3
HUP0200580A3 HU0200580A HUP0200580A HUP0200580A3 HU P0200580 A3 HUP0200580 A3 HU P0200580A3 HU 0200580 A HU0200580 A HU 0200580A HU P0200580 A HUP0200580 A HU P0200580A HU P0200580 A3 HUP0200580 A3 HU P0200580A3
Authority
HU
Hungary
Prior art keywords
celecoxib
preparation
pharmaceutical compositions
compositions containing
crystalline forms
Prior art date
Application number
HU0200580A
Other languages
Hungarian (hu)
Original Assignee
Pharmacia Corp Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp Chicago filed Critical Pharmacia Corp Chicago
Publication of HUP0200580A2 publication Critical patent/HUP0200580A2/en
Publication of HUP0200580A3 publication Critical patent/HUP0200580A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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HU0200580A 1999-12-08 2000-12-01 Polymorphic crystalline forms of celecoxib, process their preparation and pharmaceutical compositions containing them HUP0200580A3 (en)

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Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
ATE366569T1 (en) 2000-07-20 2007-08-15 Lauras As USE OF COX-2 INHIBITORS AS IMMUNOSTIMULANTS FOR THE TREATMENT OF HIV OR AIDS
JP2004534812A (en) 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク Pharmaceutical composition of dispersion of drug and neutral polymer
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
WO2004061433A1 (en) * 2002-12-30 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
WO2003074474A2 (en) 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
WO2004026235A2 (en) * 2002-09-20 2004-04-01 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
JP2006511499A (en) * 2002-05-13 2006-04-06 ファルマシア コーポレイション Stable amorphous celecoxib composite and its preparation
JP2005535602A (en) 2002-05-31 2005-11-24 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド Novel conazole crystal forms and related methods, pharmaceutical compositions and methods
IL165383A0 (en) * 2002-06-21 2006-01-15 Transform Pharmaceuticals Inc Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
AU2003303591A1 (en) * 2002-12-30 2004-07-29 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
ES2450648T3 (en) * 2004-06-29 2014-03-25 Takeda Pharma A/S Manufacture of pharmaceutical compositions with rapid release of water insoluble drugs and pharmaceutical compositions obtained by the process of the invention
GB0423103D0 (en) * 2004-10-19 2004-11-17 Boots Healthcare Int Ltd Therapeutic agents
CA2600822A1 (en) * 2005-03-14 2006-09-21 Nycomed Gmbh Method for preventing cardiovascular diseases
CN103462920A (en) * 2012-06-06 2013-12-25 南京亿华药业有限公司 Oral cyclo-oxygenase-2 inhibitor Celecoxib composition
CN103524416B (en) * 2013-10-29 2016-08-17 湖北华世通生物医药科技有限公司 A kind of Novel celecoxib crystal form A and preparation method thereof
CN103539739B (en) * 2013-10-30 2016-02-10 中美华世通生物医药科技（武汉）有限公司 A kind of Novel celecoxib crystal form B and preparation method thereof
CN103508958A (en) * 2013-10-30 2014-01-15 中美华世通生物医药科技（武汉）有限公司 Novel celecoxib crystal form C and preparation method thereof
KR101476096B1 (en) * 2014-03-28 2014-12-24 대원제약주식회사 Pharmaceutical composition comprising celecoxib with improved solubility

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
CA2276945C (en) * 1993-11-30 2006-08-01 G.D. Searle & Co. Tricyclic-substituted pyrazolyl benzenesulfonamides and pharmaceutical compositions thereof
WO1996025405A1 (en) * 1995-02-13 1996-08-22 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US5633272A (en) * 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US5756529A (en) * 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
US5981576A (en) * 1995-10-13 1999-11-09 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
EP0863134A1 (en) * 1997-03-07 1998-09-09 Merck Frosst Canada Inc. 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2
US20070004655A9 (en) * 1998-04-27 2007-01-04 Murphy Gerald P Nr-cam gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors

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ZA200107146B (en) 2002-08-29
PT1150959E (en) 2008-04-21
KR20020002386A (en) 2002-01-09
AR027897A1 (en) 2003-04-16
YU57801A (en) 2005-07-19
AU2041201A (en) 2001-06-18
CN1411447A (en) 2003-04-16
TWI276435B (en) 2007-03-21
CN1216869C (en) 2005-08-31
SV2002000235A (en) 2002-06-13
PT1150960E (en) 2005-06-30
BG65239B1 (en) 2007-09-28
HUP0200580A2 (en) 2002-11-28
KR100717570B1 (en) 2007-05-15
WO2001041536A2 (en) 2001-06-14
CZ20012875A3 (en) 2002-02-13
ECSP003807A (en) 2005-07-06
PE20010911A1 (en) 2001-09-10
MY128366A (en) 2007-01-31
EA200401397A1 (en) 2005-08-25
AR030039A1 (en) 2003-08-13
ES2236011T3 (en) 2005-07-16
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OA11831A (en) 2005-08-23
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