HUP0102803A2 - Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents - Google Patents

Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents

Info

Publication number
HUP0102803A2
HUP0102803A2 HU0102803A HUP0102803A HUP0102803A2 HU P0102803 A2 HUP0102803 A2 HU P0102803A2 HU 0102803 A HU0102803 A HU 0102803A HU P0102803 A HUP0102803 A HU P0102803A HU P0102803 A2 HUP0102803 A2 HU P0102803A2
Authority
HU
Hungary
Prior art keywords
biologically active
active agents
sustained delivery
biodegradable hydrogels
hydrogels
Prior art date
Application number
HU0102803A
Other languages
Hungarian (hu)
Inventor
Subodh Shah
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of HUP0102803A2 publication Critical patent/HUP0102803A2/en
Publication of HUP0102803A3 publication Critical patent/HUP0102803A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

A jelen találmány tárgyát általánosságban olyan gyógyszerészetikészítmények kifejlesztése képezi, amelyek biztosítják a biológiailagaktív polipeptidek elnyújtott idejű felszabadulását. Közelebbről, ajelen találmány tárgyát hőérzékeny és biológiailag lebonthatóhidrogélek felhasználása képezi, biológiailag aktív anyagok elnyújtottidejű felszabadulásának biztosítására, amely hidrogélek a poli(D-, L-vagy L-tejsav) (PLA) vagy a poli-(laktid-ko-glikolid) (PLGA) és apolietilénglikol (PEG) blokk-kopolimerjei. ÓThe subject of the present invention is generally the development of pharmaceutical compositions that ensure the prolonged release of biologically active polypeptides. More specifically, the subject of the present invention is the use of thermosensitive and biodegradable hydrogels for the sustained release of biologically active substances, which hydrogels are poly(D-, L- or L-lactic acid) (PLA) or poly(lactide-co-glycolide) (PLGA ) and block copolymers of polyethylene glycol (PEG). HE

HU0102803A 1998-06-30 1999-06-25 Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents HUP0102803A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10733498A 1998-06-30 1998-06-30
PCT/US1999/014206 WO2000000222A1 (en) 1998-06-30 1999-06-25 Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents

Publications (2)

Publication Number Publication Date
HUP0102803A2 true HUP0102803A2 (en) 2001-11-28
HUP0102803A3 HUP0102803A3 (en) 2004-06-28

Family

ID=22316103

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102803A HUP0102803A3 (en) 1998-06-30 1999-06-25 Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents

Country Status (9)

Country Link
EP (1) EP1091761A1 (en)
JP (1) JP2002519333A (en)
KR (1) KR20010053259A (en)
CN (1) CN1321092A (en)
AU (1) AU754003B2 (en)
CA (1) CA2335852A1 (en)
HU (1) HUP0102803A3 (en)
IL (1) IL140268A0 (en)
WO (1) WO2000000222A1 (en)

Families Citing this family (45)

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US6245740B1 (en) * 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
WO2001041735A2 (en) * 1999-12-07 2001-06-14 Amgen Inc. Thermosensitive biodegradable hydrogels based on low molecular weight pluronics
AU2001242144A1 (en) * 2000-03-15 2001-09-24 Yu-Ling Cheng Environment responsive gelling copolymer
US7160931B2 (en) 2000-03-15 2007-01-09 Yu-Ling Cheng Thermally reversible implant and filler
US7193007B2 (en) 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
KR100434439B1 (en) * 2000-04-11 2004-06-04 이재민 A Method on Preparation of W/O/W Multple Emulsions Stabilized by Poly/Poly Block Copolymer
WO2002049501A2 (en) 2000-12-18 2002-06-27 Board Of Regents, University Of Texas System Local regional chemotherapy and radiotherapy using in situ hydrogel
US20030003074A1 (en) * 2001-06-14 2003-01-02 Macromed, Inc. Formulations of lymphokines and method of use thereof for local or both local and systemic control of proliferative cell disorders
KR100488002B1 (en) * 2001-06-20 2005-05-09 주식회사 삼양사 Amphiphilic block copolymer consisting of hydrophilic polyalkylene glycol block and hydrophobic block, copolymer of aromatic side chain - containing α-hydroxyl acid derivatives and lactides
JP4202656B2 (en) * 2002-02-19 2008-12-24 サンスター株式会社 Topical sustained-release ointment
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
KR100560069B1 (en) * 2002-11-29 2006-03-13 주식회사 태평양 Biodegradable amphiphilic block copolymers and a method for preparing thereof
US7223826B2 (en) 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US20040151691A1 (en) 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
CN1296097C (en) * 2003-02-25 2007-01-24 吴建梅 Polymer micelle medicine-carrying system
EP1642921B1 (en) 2003-07-07 2008-08-27 Nof Corporation Triblock copolymer, method for producing the same and biocompatible material
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AU2005299748B2 (en) * 2004-10-21 2009-04-09 Tgel Bio Co., Ltd In situ controlled release drug delivery system
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GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
ES2396502T3 (en) * 2006-09-19 2013-02-22 Genzyme Corporation Formulations for the therapeutic administration of thyroid stimulating hormone (TSH)
CN101333295B (en) * 2007-06-27 2011-01-05 中国科学院化学研究所 Biodegradable high molecular nanometer particles, special polymer thereof and preparation method thereof
JP2012501965A (en) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド Drug-loaded polymer nanoparticles and methods for producing and using the same
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US8563041B2 (en) 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
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EP2509634B1 (en) 2009-12-11 2019-03-06 Pfizer Inc Stable formulations for lyophilizing therapeutic particles
JP5965844B2 (en) 2009-12-15 2016-08-10 バインド セラピューティックス インコーポレイテッド Therapeutic polymer nanoparticle compositions having high glass transition temperature or high molecular weight copolymers
EP2629760A4 (en) * 2010-10-22 2014-04-02 Bind Therapeutics Inc Therapeutic nanoparticles with high molecular weight copolymers
CA2852386C (en) * 2011-10-17 2019-05-21 Poly-Med, Inc. Absorbable in situ gel-forming system, method of making and use thereof
ES2732377T3 (en) 2012-09-17 2019-11-22 Pfizer Therapeutic nanoparticle preparation procedure
WO2014053542A1 (en) 2012-10-02 2014-04-10 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
US10980860B2 (en) * 2012-10-11 2021-04-20 Ascendis Pharma A/S Diagnosis, prevention and treatment of diseases of the joint
US10413496B2 (en) 2012-10-15 2019-09-17 L'oreal Aqueous wax dispersions
US10626294B2 (en) 2012-10-15 2020-04-21 L'oreal Aqueous wax dispersions containing volatile solvents
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WO2014088321A1 (en) 2012-12-06 2014-06-12 주식회사 엘지화학 Lactide copolymer, method for producing same, and resin composition comprising same
JP6176998B2 (en) * 2013-05-13 2017-08-09 学校法人 関西大学 Temperature-responsive biodegradable polymer composition and method for producing the same
BR112016021130A2 (en) 2014-03-14 2017-08-15 Pfizer THERAPEUTIC NANOPARTICLES, PHARMACEUTICAL COMPOSITION INCLUDING THE SAID NANOPARTICLES, PROCESS FOR THE PREPARATION AND USE THEREOF
US10561596B2 (en) 2014-04-11 2020-02-18 L'oreal Compositions and dispersions containing particles comprising a polymer
KR101620090B1 (en) * 2015-04-20 2016-05-12 주식회사 티젤바이오 Kit for drug delivery, Apparatus for preparing drug delivery system, and A preparation method of drug delivery system
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US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
CN1195788C (en) * 1997-10-03 2005-04-06 麦克罗梅德公司 Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties

Also Published As

Publication number Publication date
IL140268A0 (en) 2002-02-10
KR20010053259A (en) 2001-06-25
JP2002519333A (en) 2002-07-02
AU754003B2 (en) 2002-10-31
WO2000000222A1 (en) 2000-01-06
CA2335852A1 (en) 2000-01-06
AU4959999A (en) 2000-01-17
HUP0102803A3 (en) 2004-06-28
EP1091761A1 (en) 2001-04-18
CN1321092A (en) 2001-11-07
WO2000000222A9 (en) 2000-07-20

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