GB939516A - Sulphonyl ureas - Google Patents
Sulphonyl ureasInfo
- Publication number
- GB939516A GB939516A GB19349/61A GB1934961A GB939516A GB 939516 A GB939516 A GB 939516A GB 19349/61 A GB19349/61 A GB 19349/61A GB 1934961 A GB1934961 A GB 1934961A GB 939516 A GB939516 A GB 939516A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hexahydrophenethyl
- cycloheptyl
- cyclopentyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0939516/IV(a)/1> wherein R is an alkyl, alkenyl, aralkyl, alkoxyalkyl, aryloxyalkyl, cycloalkyl, cycloalkyl-alkyl, cycloalkoxyalkyl or alkylthioalkyl group or an aryl group which may optionally bear alkyl, alkoxy or halogen substituents; e.g. R may be n-propyl, n-butyl, cyclohexyl, cyclopentyl, benzyl, cycloheptyl or hexahydrophenethyl. The compounds are prepared by reacting p-vinylbenzenesulphonamide with the appropriate isocyanate in an organic solvent in the presence of an equivalent of alkali. p-Vinylbenzene sulphonamide used as a starting material is made by chlorosulphonating phenethyl bromide, treating the resulting p-2-bromoethyl-benzenesulphonyl chloride with ammonia to give p-2-bromoethylbenzene sulphonamide and treating with alcoholic potassium hydroxide. Isocyanates used as starting materials such as n-heptyl-, n-octyl, t-pentyl-, cyclopentyl, cycloheptyl, cyclooctyl, hexahydrobenzyl-, hexahydrophenethyl, b -phenoxyethyl- and ethylthioethyl-isocyanate are made by the action of phosgene on the appropriate amine.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB19349/61A GB939516A (en) | 1961-05-29 | 1961-05-29 | Sulphonyl ureas |
SE5972/62A SE308715B (en) | 1961-05-29 | 1962-05-28 | |
BE618257A BE618257A (en) | 1961-05-29 | 1962-05-29 | 3- (p-vinylbenzenesulfonyl) ureas substituted in position 1 and process for their preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB19349/61A GB939516A (en) | 1961-05-29 | 1961-05-29 | Sulphonyl ureas |
Publications (1)
Publication Number | Publication Date |
---|---|
GB939516A true GB939516A (en) | 1963-10-16 |
Family
ID=10127867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB19349/61A Expired GB939516A (en) | 1961-05-29 | 1961-05-29 | Sulphonyl ureas |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE618257A (en) |
GB (1) | GB939516A (en) |
SE (1) | SE308715B (en) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0949916A1 (en) * | 1996-10-04 | 1999-10-20 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
WO2014143659A1 (en) * | 2013-03-15 | 2014-09-18 | Araxes Pharma Llc | Irreversible covalent inhibitors of the gtpase k-ras g12c |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
US9810690B2 (en) | 2015-10-19 | 2017-11-07 | Araxes Pharma Llc | Method for screening inhibitors of Ras |
US9840516B2 (en) | 2013-10-10 | 2017-12-12 | Araxes Pharma Llc | Substituted quinazolines as inhibitors of KRAS G12C |
US9862701B2 (en) | 2014-09-25 | 2018-01-09 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US9988357B2 (en) | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
US10111874B2 (en) | 2014-09-18 | 2018-10-30 | Araxes Pharma Llc | Combination therapies for treatment of cancer |
US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US10246424B2 (en) | 2015-04-10 | 2019-04-02 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US10280172B2 (en) | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10377743B2 (en) | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
US10414757B2 (en) | 2015-11-16 | 2019-09-17 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
US10428064B2 (en) | 2015-04-15 | 2019-10-01 | Araxes Pharma Llc | Fused-tricyclic inhibitors of KRAS and methods of use thereof |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10736897B2 (en) | 2017-05-25 | 2020-08-11 | Araxes Pharma Llc | Compounds and methods of use thereof for treatment of cancer |
US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
US10822312B2 (en) | 2016-03-30 | 2020-11-03 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US11059819B2 (en) | 2017-01-26 | 2021-07-13 | Janssen Biotech, Inc. | Fused hetero-hetero bicyclic compounds and methods of use thereof |
US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
-
1961
- 1961-05-29 GB GB19349/61A patent/GB939516A/en not_active Expired
-
1962
- 1962-05-28 SE SE5972/62A patent/SE308715B/xx unknown
- 1962-05-29 BE BE618257A patent/BE618257A/en unknown
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0949916A4 (en) * | 1996-10-04 | 2001-04-25 | Lilly Co Eli | Antitumor compositions and methods of treatment |
EP0949916A1 (en) * | 1996-10-04 | 1999-10-20 | Eli Lilly And Company | Antitumor compositions and methods of treatment |
US10273207B2 (en) | 2013-03-15 | 2019-04-30 | Araxes Pharma Llc | Covalent inhibitors of kras G12C |
WO2014143659A1 (en) * | 2013-03-15 | 2014-09-18 | Araxes Pharma Llc | Irreversible covalent inhibitors of the gtpase k-ras g12c |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
US9926267B2 (en) | 2013-03-15 | 2018-03-27 | Araxes Pharma Llc | Covalent inhibitors of K-Ras G12C |
US10919850B2 (en) | 2013-03-15 | 2021-02-16 | Araxes Pharma Llc | Covalent inhibitors of KRas G12C |
US11878985B2 (en) | 2013-10-10 | 2024-01-23 | Araxes Pharma Llc | Substituted quinazolines as inhibitors of KRAS G12C |
US9840516B2 (en) | 2013-10-10 | 2017-12-12 | Araxes Pharma Llc | Substituted quinazolines as inhibitors of KRAS G12C |
US10927125B2 (en) | 2013-10-10 | 2021-02-23 | Araxes Pharma Llc | Substituted cinnolines as inhibitors of KRAS G12C |
US10370386B2 (en) | 2013-10-10 | 2019-08-06 | Araxes Pharma Llc | Substituted quinolines as inhibitors of KRAS G12C |
US10111874B2 (en) | 2014-09-18 | 2018-10-30 | Araxes Pharma Llc | Combination therapies for treatment of cancer |
US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
US9862701B2 (en) | 2014-09-25 | 2018-01-09 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10246424B2 (en) | 2015-04-10 | 2019-04-02 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US10829458B2 (en) | 2015-04-10 | 2020-11-10 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US10428064B2 (en) | 2015-04-15 | 2019-10-01 | Araxes Pharma Llc | Fused-tricyclic inhibitors of KRAS and methods of use thereof |
US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US10351550B2 (en) | 2015-07-22 | 2019-07-16 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
US10975071B2 (en) | 2015-09-28 | 2021-04-13 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US9810690B2 (en) | 2015-10-19 | 2017-11-07 | Araxes Pharma Llc | Method for screening inhibitors of Ras |
US10414757B2 (en) | 2015-11-16 | 2019-09-17 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
US11021470B2 (en) | 2015-11-16 | 2021-06-01 | Araxes Pharma Llc | 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof |
US9988357B2 (en) | 2015-12-09 | 2018-06-05 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
US10822312B2 (en) | 2016-03-30 | 2020-11-03 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
US10723738B2 (en) | 2016-09-29 | 2020-07-28 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10280172B2 (en) | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10377743B2 (en) | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
US11059819B2 (en) | 2017-01-26 | 2021-07-13 | Janssen Biotech, Inc. | Fused hetero-hetero bicyclic compounds and methods of use thereof |
US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
US10736897B2 (en) | 2017-05-25 | 2020-08-11 | Araxes Pharma Llc | Compounds and methods of use thereof for treatment of cancer |
US11377441B2 (en) | 2017-05-25 | 2022-07-05 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
Also Published As
Publication number | Publication date |
---|---|
BE618257A (en) | 1962-11-29 |
SE308715B (en) | 1969-02-24 |
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