GB9215733D0 - Method of and apparatus for determining a property of a sample - Google Patents
Method of and apparatus for determining a property of a sampleInfo
- Publication number
- GB9215733D0 GB9215733D0 GB929215733A GB9215733A GB9215733D0 GB 9215733 D0 GB9215733 D0 GB 9215733D0 GB 929215733 A GB929215733 A GB 929215733A GB 9215733 A GB9215733 A GB 9215733A GB 9215733 D0 GB9215733 D0 GB 9215733D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- pct
- pulse
- response
- sample
- sec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000601 blood cell Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/13—Details pertaining to apertures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
- G01N15/132—Circuits
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)
Abstract
PCT No. PCT/GB93/01544 Sec. 371 Date Apr. 7, 1995 Sec. 102(e) Date Apr. 7, 1995 PCT Filed Jul. 22, 1993 PCT Pub. No. WO94/02846 PCT Pub. Date Feb. 3, 1994An apparatus and method for determining a property of a sample, derived from a response obtained from the sample after an electrical pulse has been applied to it. Blood cells are subjected to an electrical pulse, a response is obtained using data retrieval means and a Fourier Transform is applied to the response. As the pulse applied is of very short duration (ideally a Dirac pulse) the Fourier transform yields information across a very broad bandwidth, typically several MHz, and accordingly a wide range of frequency response data is obtained. Certain cellular defects can be deduced from the transformed data. A detector is provided to detect precisely the presence of a cell as it passes through a particular region of an oriface. This is then used to trigger the pulse at a precisely controlled instant. This reduces the effect of random dispersion and can be adapted to ignore noise peaks which inevitably occur. The invention may be operated continuously and provides information across a bandwidth which is wider than was previously possible.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929215733A GB9215733D0 (en) | 1992-07-24 | 1992-07-24 | Method of and apparatus for determining a property of a sample |
DE69321592T DE69321592T2 (en) | 1992-07-24 | 1993-07-22 | METHOD AND DEVICE FOR DETERMINING A PROPERTY OF A SAMPLE |
EP93917888A EP0651882B1 (en) | 1992-07-24 | 1993-07-22 | Method of and apparatus for determining a property of a sample |
JP6504296A JPH07509560A (en) | 1992-07-24 | 1993-07-22 | Method and apparatus for determining sample properties |
US08/374,659 US5691633A (en) | 1992-07-24 | 1993-07-22 | Method of and apparatus for determining a property of a sample |
PCT/GB1993/001544 WO1994002846A1 (en) | 1992-07-24 | 1993-07-22 | Method of and apparatus for determining a property of a sample |
AT93917888T ATE172302T1 (en) | 1992-07-24 | 1993-07-22 | METHOD AND DEVICE FOR DETERMINING A PROPERTY OF A SAMPLE |
KR1019950700203A KR950702707A (en) | 1992-07-24 | 1993-07-22 | METHOD OF AND APPARATUS FOR DETERMINING A PROPERTY OF A SAMPLE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929215733A GB9215733D0 (en) | 1992-07-24 | 1992-07-24 | Method of and apparatus for determining a property of a sample |
Publications (1)
Publication Number | Publication Date |
---|---|
GB9215733D0 true GB9215733D0 (en) | 1992-09-09 |
Family
ID=10719223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB929215733A Pending GB9215733D0 (en) | 1992-07-24 | 1992-07-24 | Method of and apparatus for determining a property of a sample |
Country Status (8)
Country | Link |
---|---|
US (1) | US5691633A (en) |
EP (1) | EP0651882B1 (en) |
JP (1) | JPH07509560A (en) |
KR (1) | KR950702707A (en) |
AT (1) | ATE172302T1 (en) |
DE (1) | DE69321592T2 (en) |
GB (1) | GB9215733D0 (en) |
WO (1) | WO1994002846A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9604292D0 (en) * | 1996-02-29 | 1996-05-01 | Hybaid Ltd | Estimation of a nucleic acid |
GB9717932D0 (en) * | 1997-08-22 | 1997-10-29 | Hybaid Ltd | Estimation of nucleic acid |
US8071384B2 (en) | 1997-12-22 | 2011-12-06 | Roche Diagnostics Operations, Inc. | Control and calibration solutions and methods for their use |
WO2000049386A2 (en) * | 1999-02-18 | 2000-08-24 | Coulter International Corp. | Solid state rf oscillator-detector for flow cytometer |
US6204668B1 (en) * | 1999-02-22 | 2001-03-20 | Coulter International Corp. | DC/RF blood cell detector using isolated bridge circuit having automatic amplitude and phase balance components |
WO2001018246A1 (en) * | 1999-08-26 | 2001-03-15 | The Trustees Of Princeton University | Microfluidic and nanofluidic electronic devices for detecting changes in capacitance of fluids and methods of using |
US6437551B1 (en) | 1999-11-02 | 2002-08-20 | The Regents Of The University Of California | Microfabricated AC impedance sensor |
US7279883B2 (en) | 2001-01-23 | 2007-10-09 | Lydia L. Sohn | Particle analyzer and methods for use thereof |
DE10145249B4 (en) * | 2001-09-06 | 2009-01-15 | Klaus-Dieter Holzrichter | Device for generating a test signal |
CA2502580C (en) * | 2002-10-31 | 2013-09-10 | University Of Massachusetts | Rapid cell block embedding method and apparatus |
US7541161B2 (en) * | 2002-10-31 | 2009-06-02 | University Of Massachusetts | Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins |
US8148164B2 (en) | 2003-06-20 | 2012-04-03 | Roche Diagnostics Operations, Inc. | System and method for determining the concentration of an analyte in a sample fluid |
US7645373B2 (en) | 2003-06-20 | 2010-01-12 | Roche Diagnostic Operations, Inc. | System and method for coding information on a biosensor test strip |
US7718439B2 (en) | 2003-06-20 | 2010-05-18 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
US8206565B2 (en) | 2003-06-20 | 2012-06-26 | Roche Diagnostics Operation, Inc. | System and method for coding information on a biosensor test strip |
US7452457B2 (en) | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
US8058077B2 (en) | 2003-06-20 | 2011-11-15 | Roche Diagnostics Operations, Inc. | Method for coding information on a biosensor test strip |
US7645421B2 (en) | 2003-06-20 | 2010-01-12 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
WO2005078118A1 (en) | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
JP4643921B2 (en) * | 2004-03-26 | 2011-03-02 | 独立行政法人科学技術振興機構 | Method for detecting passage of fluid in a flow path and method for controlling fluid flow |
US7569126B2 (en) | 2004-06-18 | 2009-08-04 | Roche Diagnostics Operations, Inc. | System and method for quality assurance of a biosensor test strip |
CA2890945C (en) | 2005-07-20 | 2016-11-29 | Bayer Healthcare Llc | Gated amperometry |
US8000783B2 (en) * | 2005-08-10 | 2011-08-16 | Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Processor controlled voltage-current analysis for nerve and muscle tissues |
EP1934591B1 (en) | 2005-09-30 | 2019-01-02 | Ascensia Diabetes Care Holdings AG | Gated voltammetry |
US7769962B2 (en) * | 2005-12-12 | 2010-08-03 | Jeda Technologies, Inc. | System and method for thread creation and memory management in an object-oriented programming environment |
US8202733B1 (en) * | 2006-12-18 | 2012-06-19 | Shervin Javadi | System and method for obtaining a differential flow rate |
US7906076B2 (en) * | 2007-07-02 | 2011-03-15 | University Of Massachusetts | Method and apparatus for biopsy sample processing |
WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
US9915599B2 (en) | 2013-02-08 | 2018-03-13 | Sony Corporation | Microparticle analysis apparatus and microparticle analysis system |
WO2019127563A1 (en) * | 2017-12-30 | 2019-07-04 | 深圳迈瑞生物医疗电子股份有限公司 | Particle analyzer using sheath flow impedance and measurement method therefor |
WO2020152501A1 (en) * | 2019-01-23 | 2020-07-30 | Twtg R&D B.V. | Electrical impedance spectrography using a capacitive voltage divider |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2656508A (en) * | 1949-08-27 | 1953-10-20 | Wallace H Coulter | Means for counting particles suspended in a fluid |
US3502974A (en) * | 1966-05-23 | 1970-03-24 | Coulter Electronics | Signal modulated apparatus for generating and detecting resistive and reactive changes in a modulated current path for particle classification and analysis |
US3793587A (en) * | 1971-03-10 | 1974-02-19 | Licentia Gmbh | Particle volume and cross-section measurement |
US3801904A (en) * | 1972-09-11 | 1974-04-02 | Coulter Electronics | Particle study apparatus including an axial trajectory sensor |
CH549210A (en) * | 1972-09-14 | 1974-05-15 | Contraves Ag | METHOD AND METER FOR DETERMINING THE TRUE AVERAGE VOLUME OF PARTICLES SUSPENDED IN AN ELECTROLYTICALLY CONDUCTIVE LIQUID. |
US3815022A (en) * | 1972-10-04 | 1974-06-04 | Gen Electric | Method and apparatus for measuring small aspherical particles |
DE2502621C3 (en) * | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Measurement of elastic and dielectric properties of the membrane of living cells |
DE2656654C3 (en) * | 1976-12-14 | 1981-02-12 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaftense.V., 3400 Goettingen | Device for measuring the volume and certain optical properties of particles |
US4434398A (en) * | 1978-05-18 | 1984-02-28 | Particle Data, Inc. | Porous passage means and method for particle analyzing systems |
US4296373A (en) * | 1979-07-12 | 1981-10-20 | Hycel, Inc. | Hematology cell counting apparatus incorporating multiple transducers for sequential operation |
US4438390A (en) * | 1981-03-23 | 1984-03-20 | Coulter Electronics, Inc. | Tandem sensing zones for improved signal-to-noise ratio in particle analyzer |
US4420720A (en) * | 1981-06-29 | 1983-12-13 | Coulter Electronics, Inc. | Field focused particle sensing zone |
US4791355A (en) * | 1986-10-21 | 1988-12-13 | Coulter Electronics Inc. | Particle analyzer for measuring the resistance and reactance of a particle |
JP2815435B2 (en) * | 1989-12-22 | 1998-10-27 | 株式会社日立製作所 | Particle analyzer and blood cell counter |
WO1992004630A1 (en) * | 1990-08-30 | 1992-03-19 | University College Of Wales Aberystwyth | Analytical method |
-
1992
- 1992-07-24 GB GB929215733A patent/GB9215733D0/en active Pending
-
1993
- 1993-07-22 JP JP6504296A patent/JPH07509560A/en active Pending
- 1993-07-22 AT AT93917888T patent/ATE172302T1/en not_active IP Right Cessation
- 1993-07-22 WO PCT/GB1993/001544 patent/WO1994002846A1/en active IP Right Grant
- 1993-07-22 DE DE69321592T patent/DE69321592T2/en not_active Expired - Fee Related
- 1993-07-22 EP EP93917888A patent/EP0651882B1/en not_active Expired - Lifetime
- 1993-07-22 US US08/374,659 patent/US5691633A/en not_active Expired - Fee Related
- 1993-07-22 KR KR1019950700203A patent/KR950702707A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US5691633A (en) | 1997-11-25 |
EP0651882B1 (en) | 1998-10-14 |
KR950702707A (en) | 1995-07-29 |
JPH07509560A (en) | 1995-10-19 |
EP0651882A1 (en) | 1995-05-10 |
DE69321592T2 (en) | 1999-03-04 |
WO1994002846A1 (en) | 1994-02-03 |
ATE172302T1 (en) | 1998-10-15 |
DE69321592D1 (en) | 1998-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB9215733D0 (en) | Method of and apparatus for determining a property of a sample | |
Green | Auditory detection of a noise signal | |
US20070202829A1 (en) | Receiver for Narrowband Interference Cancellation | |
US5579335A (en) | Split band processing for spread spectrum communications | |
KR950704696A (en) | Removing the Effects of Acoustic Ringing and Reducing Temperature Effects in the Detection of Explosives by NQR | |
TW200723919A (en) | Synchronization channel scheme for super 3G | |
ES8205464A1 (en) | Actuation device for an acoustic emission measuring system using the detection of the background noise. | |
AU4253296A (en) | A method of obtaining information | |
ATE170346T1 (en) | APPARATUS AND METHOD FOR TUNING A MIXER FILTER | |
EP0278669A3 (en) | Methods and apparatus for frequency response analysis | |
MY118297A (en) | Unsteady signal analyzer and medium for recording unsteady signal analyzer program | |
Zwicker et al. | Binaural masking-level difference as a function of masker and test-signal duration | |
Beck et al. | Theory and application of time‐resolved optoacoustics in gases | |
DE69119729D1 (en) | Monitoring of partial discharges | |
CA2118322A1 (en) | Apparatus for non-destructive testing of dielectric/magnetic materials | |
Hill et al. | Techniques for detecting and characterising covert communication signals | |
HK55496A (en) | Process for transmitting an audio signal | |
Leshowitz et al. | Masking with continuous and gated sinusoids | |
AU6494596A (en) | Method and apparatus for broadband decoupling in nuclear magnetic resonance with chirp pulses | |
IE831146L (en) | Method for analysing complex signals | |
AU1314997A (en) | Analytical apparatus | |
Hall et al. | Detection threshold for a two‐tone complex | |
Fujino et al. | A study of performance of frequency hopping-spread spectrum communication using rapidly synchronous acquisition system | |
Litvinenko et al. | Complex Analysis of the Jovian S-burst Internal Structure | |
Boye | A method of rapid and automatic search for radio signals within the HF band |