GB873239A - Chloroquine derivatives - Google Patents

Chloroquine derivatives

Info

Publication number
GB873239A
GB873239A GB19934/59A GB1993459A GB873239A GB 873239 A GB873239 A GB 873239A GB 19934/59 A GB19934/59 A GB 19934/59A GB 1993459 A GB1993459 A GB 1993459A GB 873239 A GB873239 A GB 873239A
Authority
GB
United Kingdom
Prior art keywords
base
acid
chloroquinoline
butylamino
diethylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19934/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert And Carriere SA Des Lab
Original Assignee
Robert And Carriere SA Des Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert And Carriere SA Des Lab filed Critical Robert And Carriere SA Des Lab
Publication of GB873239A publication Critical patent/GB873239A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises the digentisate, di-(p-hydroxybenzoate), di-(2,3-dihydroxybenzoate) and digallate of 4-(4-diethylamino-1-methyl-n-butylamino)-7-chloroquinoline, and pharmaceutical compositions (see Group VI) containing at least one salt of the above base with a hydroxybenzoic acid having not more than three phenolic hydroxy groups. The compounds, which combat rheumatic diseases, are prepared by interacting the base with the desired acid.ALSO:Pharmaceutical compositions in the form of compressed tablets comprise at least one salt of 4 - (4 - diethylamino - 1 - methyl - n - butylamino) - 7 - chloroquinoline with a hydroxybenzoic acid containing not more than three phenolic hydroxy groups, in the proportion of one molecule of the base to two molecules of the said acid, and a pharmaceutical carrier.
GB19934/59A 1958-06-16 1959-06-10 Chloroquine derivatives Expired GB873239A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR873239X 1958-06-16

Publications (1)

Publication Number Publication Date
GB873239A true GB873239A (en) 1961-07-19

Family

ID=9359211

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19934/59A Expired GB873239A (en) 1958-06-16 1959-06-10 Chloroquine derivatives

Country Status (1)

Country Link
GB (1) GB873239A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1009440A1 (en) * 1997-07-03 2000-06-21 University Of Iowa Research Foundation Method for inhibiting immunostimulatory dna associated responses

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1009440A1 (en) * 1997-07-03 2000-06-21 University Of Iowa Research Foundation Method for inhibiting immunostimulatory dna associated responses
EP1009440A4 (en) * 1997-07-03 2004-03-17 Donald E Macfarlane Method for inhibiting immunostimulatory dna associated responses

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