GB8708886D0 - 2beta-morpholino-androstane derivatives - Google Patents

2beta-morpholino-androstane derivatives

Info

Publication number
GB8708886D0
GB8708886D0 GB878708886A GB8708886A GB8708886D0 GB 8708886 D0 GB8708886 D0 GB 8708886D0 GB 878708886 A GB878708886 A GB 878708886A GB 8708886 A GB8708886 A GB 8708886A GB 8708886 D0 GB8708886 D0 GB 8708886D0
Authority
GB
United Kingdom
Prior art keywords
2beta
morpholino
cpds
acyl
androstane derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB878708886A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Priority to GB878708886A priority Critical patent/GB8708886D0/en
Publication of GB8708886D0 publication Critical patent/GB8708886D0/en
Priority to DE1995175040 priority patent/DE19575040I2/en
Priority to EP88200621A priority patent/EP0287150B1/en
Priority to AT88200621T priority patent/ATE79631T1/en
Priority to ES88200621T priority patent/ES2043781T3/en
Priority to DE8888200621T priority patent/DE3873803T2/en
Priority to IE101788A priority patent/IE63672B1/en
Priority to ZA882481A priority patent/ZA882481B/en
Priority to CA000563772A priority patent/CA1291117C/en
Priority to NZ224228A priority patent/NZ224228A/en
Priority to HU881903A priority patent/HU198738B/en
Priority to KR1019880004157A priority patent/KR0130208B1/en
Priority to DK198802028A priority patent/DK174743B1/en
Priority to US07/181,139 priority patent/US4894369A/en
Priority to FI881707A priority patent/FI89057C/en
Priority to AU14570/88A priority patent/AU608313B2/en
Priority to JP63091231A priority patent/JPH0753751B2/en
Priority to PT87250A priority patent/PT87250B/en
Priority to GR920402633T priority patent/GR3006275T3/el
Priority to NL940010C priority patent/NL940010I2/en
Priority to KR1019970016531A priority patent/KR100221116B1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Underground Structures, Protecting, Testing And Restoring Foundations (AREA)
  • Measurement Of Velocity Or Position Using Acoustic Or Ultrasonic Waves (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

2-Morpholinyl-androstane derivs. of fomrula (I), their mono- and bis-quat. ammonium cpds. and the acid addn. salts of (I) or its mono-quat. ammonium cpds. are new. In the formula, R1 = H or 1-12C opt. substd. acyl; R2 = H or 1-12C acyl; R3 = CH2, N(Me) or a bond. - Pref. R1 = H; R2 = 1-6C satd. acyl; R3 = CH2 or bond; and cpds. are 16 beta-monoquat. ammonium cpds..
GB878708886A 1987-04-14 1987-04-14 2beta-morpholino-androstane derivatives Pending GB8708886D0 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
GB878708886A GB8708886D0 (en) 1987-04-14 1987-04-14 2beta-morpholino-androstane derivatives
DE1995175040 DE19575040I2 (en) 1987-04-14 1988-04-05 2-Beta-morpholino androstanderivate and process for their preparation
EP88200621A EP0287150B1 (en) 1987-04-14 1988-04-05 Novel 2 beta-morpholino-androstane derivatives and processes for their preparation
AT88200621T ATE79631T1 (en) 1987-04-14 1988-04-05 2-BETA MORPHOLINO ANDRODE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION.
ES88200621T ES2043781T3 (en) 1987-04-14 1988-04-05 A PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 2BETA-MORFOLINO-ANDROSTANO.
DE8888200621T DE3873803T2 (en) 1987-04-14 1988-04-05 2-BETA MORPHOLINO ANDROSTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
IE101788A IE63672B1 (en) 1987-04-14 1988-04-06 Novel 2beta-morpholino-androstane derivatives and processes for their preparation
ZA882481A ZA882481B (en) 1987-04-14 1988-04-08 2beta-morpholino-androstane derivatives and processes for their preparation
CA000563772A CA1291117C (en) 1987-04-14 1988-04-11 2.beta.-MORPHOLINO-ANDROSTANE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION
NZ224228A NZ224228A (en) 1987-04-14 1988-04-12 16-substituted 2b-morpholino-androstane derivatives and pharmaceutical compositions
JP63091231A JPH0753751B2 (en) 1987-04-14 1988-04-13 Novel 2β-morpholino-androstane derivative and process for producing the same
HU881903A HU198738B (en) 1987-04-14 1988-04-13 Process for producing new 2beta-morpholino-androstane derivatives
KR1019880004157A KR0130208B1 (en) 1987-04-14 1988-04-13 Novel 2ñô-morpholino-androstane derivatives and process for their preparation
DK198802028A DK174743B1 (en) 1987-04-14 1988-04-13 2-Beta-morpholino androstane derivatives and process for their preparation and agent containing the compound
US07/181,139 US4894369A (en) 1987-04-14 1988-04-13 Novel 2β-morpholino-androstane derivatives
FI881707A FI89057C (en) 1987-04-14 1988-04-13 Process for Preparation of New 2-Morpholinoandrost Derivatives
AU14570/88A AU608313B2 (en) 1987-04-14 1988-04-13 Novel 2 beta-morpholino-androstane derivatives and processes for their preparation
PT87250A PT87250B (en) 1987-04-14 1988-04-14 METHOD OF PREPARING 2BETA-MORPHOLINE-ANDROSTAN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GR920402633T GR3006275T3 (en) 1987-04-14 1992-11-19
NL940010C NL940010I2 (en) 1987-04-14 1994-06-07 Novel 2-beta-morpholino androstane derivatives and process for their preparation.
KR1019970016531A KR100221116B1 (en) 1987-04-14 1997-04-30 2 beta-morpholino-androstane derivatives and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878708886A GB8708886D0 (en) 1987-04-14 1987-04-14 2beta-morpholino-androstane derivatives

Publications (1)

Publication Number Publication Date
GB8708886D0 true GB8708886D0 (en) 1987-05-20

Family

ID=10615781

Family Applications (1)

Application Number Title Priority Date Filing Date
GB878708886A Pending GB8708886D0 (en) 1987-04-14 1987-04-14 2beta-morpholino-androstane derivatives

Country Status (19)

Country Link
US (1) US4894369A (en)
EP (1) EP0287150B1 (en)
JP (1) JPH0753751B2 (en)
KR (2) KR0130208B1 (en)
AT (1) ATE79631T1 (en)
AU (1) AU608313B2 (en)
CA (1) CA1291117C (en)
DE (2) DE19575040I2 (en)
DK (1) DK174743B1 (en)
ES (1) ES2043781T3 (en)
FI (1) FI89057C (en)
GB (1) GB8708886D0 (en)
GR (1) GR3006275T3 (en)
HU (1) HU198738B (en)
IE (1) IE63672B1 (en)
NL (1) NL940010I2 (en)
NZ (1) NZ224228A (en)
PT (1) PT87250B (en)
ZA (1) ZA882481B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes
HU210076B (en) * 1992-11-02 1995-01-30 Tuba Process for producing androstane derivatives substituted with quaternisaeted amino group in 16-position and for producing pharmaceutical compositions containing them
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
IT1277700B1 (en) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa PROCESS OF PREPARATION OF 2-BETA, 16-BETA-DIAMINO 3-ALPHA, 17-BETA-DIACYLOSS 5-ALPHAANDROSTANS, STRUCTURED NEUROMUSCULAR BLOCKERS
KR20040088519A (en) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. Active Agent Delivery Systems and Methods for Protecting and Administering Active Agents
US7579461B2 (en) * 2004-01-15 2009-08-25 Chemagis Ltd. Processes for the preparation of rocuronium bromide and intermediates thereof
US20060058275A1 (en) * 2004-07-15 2006-03-16 Oded Friedman Processes for preparing stabilized, highly pure rocuronium bromide
US20060058276A1 (en) * 2004-07-15 2006-03-16 Oded Friedman Processes for the preparation and purification of rocuronium bromide
US20060009485A1 (en) * 2005-06-23 2006-01-12 Chemagis Ltd Method of reprocessing quaternary ammonium-containing neuromuscular blocking agents
EP2107066A3 (en) * 2005-09-13 2009-10-21 Sicor, Inc. Processes for the synthesis of rocuronium bromide
GB2445746A (en) * 2007-01-17 2008-07-23 Texcontor Ets Use of carbonated water as a solvent for freeze drying, and method of purification comprising dissolution of material in carbonated water and freeze drying
CN101125878B (en) * 2007-09-30 2011-01-12 浙江仙琚制药股份有限公司 Method for preparing steroid muscle relaxants rocuronium bromide
CN101863948B (en) * 2009-04-17 2013-07-24 重庆医药工业研究院有限责任公司 High-purity (2 beta, 3 alpha, 5 alpha, 16 beta, 17 beta)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)-androstane-3,17-diol or composition thereof and preparation method thereof
CN101824066B (en) * 2010-04-08 2012-06-13 浙江仙琚制药股份有限公司 Method for preparing rocuronium bromide midbody compound crystal
CN103119051B (en) * 2011-01-26 2015-09-23 浙江华海药业股份有限公司 The preparation method of Zemuron
US9024013B2 (en) 2011-04-25 2015-05-05 Zhejiang Huahai Pharmaceutical Co., Ltd Method for purifying rocuronium bromide
CA2914154C (en) 2013-07-01 2021-05-25 Maruishi Pharmaceutical Co., Ltd. Rocuronium preparation causing less pain, method for producing the same, and method for reducing and/or alleviating vascular pain to be induced using the same
CN105566433A (en) * 2016-01-15 2016-05-11 安徽悦康凯悦制药有限公司 Rocuronium bromide production technology
CN108570090B (en) * 2018-05-25 2021-02-02 江苏盈科生物制药有限公司 Preparation method of high-purity rocuronium bromide
CN110734468B (en) 2018-07-20 2021-04-16 济南高德医药科技有限公司 Refining method of rocuronium bromide crude product
CN110240624B (en) * 2019-08-01 2020-06-09 天津红日药业股份有限公司 Androstane derivative and preparation method and application thereof
CN111057122B (en) * 2019-12-25 2021-04-30 武汉华龙生物制药有限公司 Preparation method of rocuronium bromide
CN115160397B (en) * 2020-09-29 2023-08-01 天津红日药业股份有限公司 Androstane derivatives, preparation method and application thereof
CN114088842B (en) * 2021-11-19 2023-03-21 江苏正济药业股份有限公司 Rocuronium bromide intermediate and impurity detection method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
GB1454749A (en) * 1972-11-29 1976-11-03 Akzo Nv 2beta, 16beta-diamino-androstanes and their preparation
IE53463B1 (en) * 1981-06-15 1988-11-23 Akzo Nv Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same
GB8709565D0 (en) * 1987-04-23 1987-05-28 Akzo Nv 2beta,16beta-diaminoandrostanes

Also Published As

Publication number Publication date
DE19575040I2 (en) 2003-09-18
FI89057C (en) 1993-08-10
AU608313B2 (en) 1991-03-28
US4894369A (en) 1990-01-16
KR0130208B1 (en) 1998-04-03
GR3006275T3 (en) 1993-06-21
KR19980078895A (en) 1998-11-25
EP0287150B1 (en) 1992-08-19
HUT47595A (en) 1989-03-28
IE63672B1 (en) 1995-05-31
NZ224228A (en) 1990-03-27
ES2043781T3 (en) 1994-01-01
DE3873803T2 (en) 1993-06-24
CA1291117C (en) 1991-10-22
JPH0753751B2 (en) 1995-06-07
NL940010I1 (en) 1994-07-18
FI881707A0 (en) 1988-04-13
FI89057B (en) 1993-04-30
EP0287150A1 (en) 1988-10-19
DK202888A (en) 1988-10-15
PT87250B (en) 1992-08-31
IE881017L (en) 1988-10-14
JPS63277693A (en) 1988-11-15
HU198738B (en) 1989-11-28
DE3873803D1 (en) 1992-09-24
ATE79631T1 (en) 1992-09-15
DK174743B1 (en) 2003-10-13
PT87250A (en) 1988-05-01
KR100221116B1 (en) 1999-10-01
ZA882481B (en) 1988-09-29
AU1457088A (en) 1988-10-20
FI881707A (en) 1988-10-15
NL940010I2 (en) 1997-10-01
DK202888D0 (en) 1988-04-13
KR880012632A (en) 1988-11-28

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