GB708148A - Hemostatic preparations and process for the manufacture thereof - Google Patents

Hemostatic preparations and process for the manufacture thereof

Info

Publication number
GB708148A
GB708148A GB29675/51A GB2967551A GB708148A GB 708148 A GB708148 A GB 708148A GB 29675/51 A GB29675/51 A GB 29675/51A GB 2967551 A GB2967551 A GB 2967551A GB 708148 A GB708148 A GB 708148A
Authority
GB
United Kingdom
Prior art keywords
acridine
ethoxy
manufacture
hydroxypropylamino
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29675/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB708148A publication Critical patent/GB708148A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

In the manufacture of a haemostatic preparation, thrombin is reacted in aqueous solution with an acridine compound containing a basic substituent in the 9-position. Substances known to accelerate the action of thrombin, such as protamines, gelatine, starch, thrombocyte extracts, polyvinyl pyrrolidone, pectin or pectin derivatives, or alginates and their derivatives may also be incorporated in the preparation, which may be freeze-dried. Acridine compounds specified are 2-ethoxy-6 : 9-diamino acridine lactate, 2-ethoxy-9-[para (g -diethylamino - b - hydroxypropylamino-phenylamino] acridine trihydrochloride, 3-nitro-9-(g -diethylamino-b -hydroxypropylamino)-acridine dihydrochloride, 2-ethoxy-9-ethylaminoacridine hydrochloride. 2-ethoxy-9-(parahydroxyphenylethylamino)-acridine glycolate, 2-ethoxy-9-[11phenyl-21 : 31 : dimethyl pyrazolonyl-41]-amino-acridine-hydrochloride.
GB29675/51A 1950-12-18 1951-12-18 Hemostatic preparations and process for the manufacture thereof Expired GB708148A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE708148X 1950-12-18

Publications (1)

Publication Number Publication Date
GB708148A true GB708148A (en) 1954-04-28

Family

ID=6617538

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29675/51A Expired GB708148A (en) 1950-12-18 1951-12-18 Hemostatic preparations and process for the manufacture thereof

Country Status (1)

Country Link
GB (1) GB708148A (en)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008019001A2 (en) * 2006-08-04 2008-02-14 Senorx, Inc. Marker formed of starch or other suitable polysaccharide
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US7792569B2 (en) 1999-02-02 2010-09-07 Senorx, Inc. Cavity-filling biopsy site markers
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8157862B2 (en) 1997-10-10 2012-04-17 Senorx, Inc. Tissue marking implant
US8224424B2 (en) 1999-02-02 2012-07-17 Senorx, Inc. Tissue site markers for in vivo imaging
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US8437834B2 (en) 2006-10-23 2013-05-07 C. R. Bard, Inc. Breast marker
US8447386B2 (en) 2003-05-23 2013-05-21 Senorx, Inc. Marker or filler forming fluid
US8486028B2 (en) 2005-10-07 2013-07-16 Bard Peripheral Vascular, Inc. Tissue marking apparatus having drug-eluting tissue marker
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US8579931B2 (en) 1999-06-17 2013-11-12 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8634899B2 (en) 2003-11-17 2014-01-21 Bard Peripheral Vascular, Inc. Multi mode imaging marker
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US8670818B2 (en) 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US8718745B2 (en) 2000-11-20 2014-05-06 Senorx, Inc. Tissue site markers for in vivo imaging
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
WO2015079433A1 (en) 2013-11-26 2015-06-04 Omrix Biopharmaceuticals Ltd. Dry pad comprising thrombin and pectin
US9149341B2 (en) 1999-02-02 2015-10-06 Senorx, Inc Deployment of polysaccharide markers for treating a site within a patient
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US9579077B2 (en) 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US9848956B2 (en) 2002-11-18 2017-12-26 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US10342635B2 (en) 2005-04-20 2019-07-09 Bard Peripheral Vascular, Inc. Marking device with retractable cannula
CN116212008A (en) * 2023-03-15 2023-06-06 武汉康宁美生物科技有限公司 Wound surface disinfection gel and preparation method thereof

Cited By (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8157862B2 (en) 1997-10-10 2012-04-17 Senorx, Inc. Tissue marking implant
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US9039763B2 (en) 1997-10-10 2015-05-26 Senorx, Inc. Tissue marking implant
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8965486B2 (en) 1999-02-02 2015-02-24 Senorx, Inc. Cavity filling biopsy site markers
US7792569B2 (en) 1999-02-02 2010-09-07 Senorx, Inc. Cavity-filling biopsy site markers
US10172674B2 (en) 1999-02-02 2019-01-08 Senorx, Inc. Intracorporeal marker and marker delivery device
US8219182B2 (en) 1999-02-02 2012-07-10 Senorx, Inc. Cavity-filling biopsy site markers
US8224424B2 (en) 1999-02-02 2012-07-17 Senorx, Inc. Tissue site markers for in vivo imaging
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US9044162B2 (en) 1999-02-02 2015-06-02 Senorx, Inc. Marker delivery device with releasable plug
US9649093B2 (en) 1999-02-02 2017-05-16 Senorx, Inc. Cavity-filling biopsy site markers
US9861294B2 (en) 1999-02-02 2018-01-09 Senorx, Inc. Marker delivery device with releasable plug
US9237937B2 (en) 1999-02-02 2016-01-19 Senorx, Inc. Cavity-filling biopsy site markers
US9149341B2 (en) 1999-02-02 2015-10-06 Senorx, Inc Deployment of polysaccharide markers for treating a site within a patient
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US8626270B2 (en) 1999-02-02 2014-01-07 Senorx, Inc. Cavity-filling biopsy site markers
US9579159B2 (en) 1999-06-17 2017-02-28 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8579931B2 (en) 1999-06-17 2013-11-12 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8718745B2 (en) 2000-11-20 2014-05-06 Senorx, Inc. Tissue site markers for in vivo imaging
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US8177792B2 (en) 2002-06-17 2012-05-15 Senorx, Inc. Plugged tip delivery tube for marker placement
US8784433B2 (en) 2002-06-17 2014-07-22 Senorx, Inc. Plugged tip delivery tube for marker placement
US9848956B2 (en) 2002-11-18 2017-12-26 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US10813716B2 (en) 2002-11-18 2020-10-27 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US10299881B2 (en) 2003-05-23 2019-05-28 Senorx, Inc. Marker or filler forming fluid
US10045832B2 (en) 2003-05-23 2018-08-14 Senorx, Inc. Marker or filler forming fluid
US8626269B2 (en) 2003-05-23 2014-01-07 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US9801688B2 (en) 2003-05-23 2017-10-31 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8880154B2 (en) 2003-05-23 2014-11-04 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8639315B2 (en) 2003-05-23 2014-01-28 Senorx, Inc. Marker or filler forming fluid
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8447386B2 (en) 2003-05-23 2013-05-21 Senorx, Inc. Marker or filler forming fluid
US8634899B2 (en) 2003-11-17 2014-01-21 Bard Peripheral Vascular, Inc. Multi mode imaging marker
US11278370B2 (en) 2005-04-20 2022-03-22 Bard Peripheral Vascular, Inc. Marking device with retractable cannula
US10342635B2 (en) 2005-04-20 2019-07-09 Bard Peripheral Vascular, Inc. Marking device with retractable cannula
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US8486028B2 (en) 2005-10-07 2013-07-16 Bard Peripheral Vascular, Inc. Tissue marking apparatus having drug-eluting tissue marker
WO2008019001A2 (en) * 2006-08-04 2008-02-14 Senorx, Inc. Marker formed of starch or other suitable polysaccharide
WO2008019001A3 (en) * 2006-08-04 2009-04-02 Senorx Inc Marker formed of starch or other suitable polysaccharide
US8437834B2 (en) 2006-10-23 2013-05-07 C. R. Bard, Inc. Breast marker
US11471244B2 (en) 2006-12-12 2022-10-18 C.R. Bard, Inc. Multiple imaging mode tissue marker
US9901415B2 (en) 2006-12-12 2018-02-27 C. R. Bard, Inc. Multiple imaging mode tissue marker
US9579077B2 (en) 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US9042965B2 (en) 2006-12-18 2015-05-26 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
US11833275B2 (en) 2008-09-23 2023-12-05 Senorx, Inc. Porous bioabsorbable implant
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US10786604B2 (en) 2008-09-23 2020-09-29 Senorx, Inc. Porous bioabsorbable implant
US8670818B2 (en) 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US11779431B2 (en) 2008-12-30 2023-10-10 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US10258428B2 (en) 2008-12-30 2019-04-16 C. R. Bard, Inc. Marker delivery device for tissue marker placement
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
WO2015079433A1 (en) 2013-11-26 2015-06-04 Omrix Biopharmaceuticals Ltd. Dry pad comprising thrombin and pectin
CN105764537A (en) * 2013-11-26 2016-07-13 奥姆里克斯生物药品有限公司 Dry pad comprising thrombin and pectin
US11484623B2 (en) 2013-11-26 2022-11-01 Omrix Biopharmaceuticals Ltd. Dry pad comprising thrombin and pectin
JP2016539694A (en) * 2013-11-26 2016-12-22 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． Dry pad containing thrombin and pectin
AU2014356002B2 (en) * 2013-11-26 2017-07-13 Omrix Biopharmaceuticals Ltd. Dry pad comprising thrombin and pectin
CN116212008A (en) * 2023-03-15 2023-06-06 武汉康宁美生物科技有限公司 Wound surface disinfection gel and preparation method thereof

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