GB2454615A - Antidiabetic azabicyclo (3.1.0) hexan compounds - Google Patents
Antidiabetic azabicyclo (3.1.0) hexan compounds Download PDFInfo
- Publication number
- GB2454615A GB2454615A GB0902845A GB0902845A GB2454615A GB 2454615 A GB2454615 A GB 2454615A GB 0902845 A GB0902845 A GB 0902845A GB 0902845 A GB0902845 A GB 0902845A GB 2454615 A GB2454615 A GB 2454615A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- hexan
- antidiabetic
- azabicyclo
- stereoisomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides novel compounds of the general formula (I), wherein the symbols are same as described in specification, their pharmaceutically acceptable salts, their tautomeric forms, their stereoisomers, pharmaceutical compositions containing them, to process and intermediates for the preparation of the above said compounds, having the utility of these compounds in medicine and to methods for their therapeutic use, and their use in the treatment of diabetes and related diseases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN730KO2006 | 2006-07-21 | ||
PCT/IN2007/000298 WO2008010238A2 (en) | 2006-07-21 | 2007-07-20 | Antidiabetic azabicyclo [3. 1. 0] hexan compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
GB0902845D0 GB0902845D0 (en) | 2009-04-08 |
GB2454615A true GB2454615A (en) | 2009-05-13 |
Family
ID=38812084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB0902845A Withdrawn GB2454615A (en) | 2006-07-21 | 2007-07-20 | Antidiabetic azabicyclo (3.1.0) hexan compounds |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2007274598A1 (en) |
GB (1) | GB2454615A (en) |
WO (1) | WO2008010238A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
FR2932479A1 (en) * | 2008-06-13 | 2009-12-18 | Servier Lab | NOVEL AZABICYCLIC DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
WO2011107494A1 (en) | 2010-03-03 | 2011-09-09 | Sanofi | Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof |
DE102010015123A1 (en) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | New benzylamidic diphenylazetidinone compounds, useful for treating lipid disorders, hyperlipidemia, atherosclerotic manifestations or insulin resistance, and for reducing serum cholesterol levels |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2758041B1 (en) | 2011-09-20 | 2021-01-13 | Basf Se | Low-molecular modulators of the cold-menthol receptor trpm8 and use of same |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013068486A1 (en) | 2011-11-08 | 2013-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of male infertility |
TW202108559A (en) | 2019-05-31 | 2021-03-01 | 美商醫肯納腫瘤學公司 | Tead inhibitors and uses thereof |
US11274082B2 (en) | 2019-05-31 | 2022-03-15 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
CN110237045A (en) * | 2019-07-11 | 2019-09-17 | 广西大学 | A kind of capsule |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999062872A1 (en) * | 1998-06-04 | 1999-12-09 | Astrazeneca Ab | New 3-aryl-2-hydroxypropionic acid derivative (i) |
WO2004089898A1 (en) * | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
-
2007
- 2007-07-20 AU AU2007274598A patent/AU2007274598A1/en not_active Abandoned
- 2007-07-20 WO PCT/IN2007/000298 patent/WO2008010238A2/en active Application Filing
- 2007-07-20 GB GB0902845A patent/GB2454615A/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999062872A1 (en) * | 1998-06-04 | 1999-12-09 | Astrazeneca Ab | New 3-aryl-2-hydroxypropionic acid derivative (i) |
WO2004089898A1 (en) * | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
Non-Patent Citations (2)
Title |
---|
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 16, No. 15, 2006, (Kuhn; Hilpert B et al), pages 4016 - 4020, ISSN 0960-894X * |
JOURNAL OF MEDICINAL CHEMISTRY, Vol. 45, No. 4, 2002, (SAUERBERG PER; ET AL), pages 789 - 804, ISSN 0022-2623 * |
Also Published As
Publication number | Publication date |
---|---|
AU2007274598A1 (en) | 2008-01-24 |
WO2008010238A3 (en) | 2008-04-17 |
GB0902845D0 (en) | 2009-04-08 |
WO2008010238A2 (en) | 2008-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |