GB2433319A - In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound - Google Patents

In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound

Info

Publication number
GB2433319A
GB2433319A GB0510478A GB0510478A GB2433319A GB 2433319 A GB2433319 A GB 2433319A GB 0510478 A GB0510478 A GB 0510478A GB 0510478 A GB0510478 A GB 0510478A GB 2433319 A GB2433319 A GB 2433319A
Authority
GB
United Kingdom
Prior art keywords
compound
pharmacologic
predicting
pharmacokinetic
test material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0510478A
Other versions
GB0510478D0 (en
Inventor
Elka Touitou
Biana Godin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of GB0510478D0 publication Critical patent/GB0510478D0/en
Publication of GB2433319A publication Critical patent/GB2433319A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a method and an assay for predicting the pharmacologic and/or pharmacokinetic and/or pharmacodynamic activity and/or effective concentration of a test material using cell and/or protozoa and/or micro-organism by assessing the effect of the test material on the and/or protozoa and/or micro-organism. Further, the invention provides an apparatus or a system, which comprises a donor and a receiver compartments, separated by membrane, wherein cell and/or protozoa and/or micro-organism are present in the receiver compartments, for predicting the pharmacologic of pharmacokinetic effects such as effective concentration of a test material, by assessing the effect of the test material, on the cell and/or protozoa and/or micro-organism. In addition, the invention provides use of an artificial human skin for measuring the diffusion or the penetration of a test material through the skin.
GB0510478A 2002-10-23 2003-10-23 In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound Withdrawn GB2433319A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42023402P 2002-10-23 2002-10-23
PCT/IL2003/000876 WO2004037160A2 (en) 2002-10-23 2003-10-23 In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound

Publications (2)

Publication Number Publication Date
GB0510478D0 GB0510478D0 (en) 2005-06-29
GB2433319A true GB2433319A (en) 2007-06-20

Family

ID=32176539

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0510478A Withdrawn GB2433319A (en) 2002-10-23 2003-10-23 In vitro test for studying compound predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound

Country Status (4)

Country Link
US (1) US20060127967A1 (en)
AU (1) AU2003278564A1 (en)
GB (1) GB2433319A (en)
WO (1) WO2004037160A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611630B2 (en) 2004-03-30 2009-11-03 Bend Research, Inc. Method and device for evaluation of pharmaceutical compositions
JP5491377B2 (en) * 2007-03-30 2014-05-14 ９８９８リミテッド Drug platform technology for natural product development
JP5218153B2 (en) 2009-02-26 2013-06-26 株式会社日立プラントテクノロジー Microorganism detection apparatus, detection method, and sample container used therefor
US8729941B2 (en) * 2010-10-06 2014-05-20 Micron Technology, Inc. Differential amplifiers, clock generator circuits, delay lines and methods
JP6596001B2 (en) 2013-12-24 2019-10-23 ティシュヴィジョン、インコーポレーテッド Multifocal multiphoton imaging system and method
CN107942018A (en) * 2017-10-20 2018-04-20 上海交通大学 A kind of in-vitro evaluation model evaluated or quality inspection is microneedle cutaneous
CN110441302B (en) * 2018-05-03 2021-12-07 中国医学科学院药物研究所 Nondestructive quality control method for tulobuterol transdermal patch
US11668723B2 (en) 2019-07-09 2023-06-06 Logan Instruments Corporation Automated dissolution/permeation testing system
CN115684514B (en) * 2022-11-24 2024-04-26 则正(济南)生物科技有限公司 Method for evaluating bioavailability of simulated medicine and original ground medicine and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734372A (en) * 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
US4559299A (en) * 1983-02-04 1985-12-17 Brown University Research Foundation Inc. Cytotoxicity assays in cell culturing devices
US5489304A (en) * 1994-04-19 1996-02-06 Brigham & Women's Hospital Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARTLETT et al, Parasitology, 2000, 121, 49-54 *
FRANZ et al, J. Invest. Dermatol., 1975, 64, 190-195 *

Also Published As

Publication number Publication date
WO2004037160A3 (en) 2006-08-17
AU2003278564A1 (en) 2004-05-13
WO2004037160A2 (en) 2004-05-06
GB0510478D0 (en) 2005-06-29
AU2003278564A8 (en) 2004-05-13
US20060127967A1 (en) 2006-06-15

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)