GB2355197A - A dry powder/solid formulation for dissolving in water and subsequent use as a chlorine releasing sterilant - Google Patents
A dry powder/solid formulation for dissolving in water and subsequent use as a chlorine releasing sterilant Download PDFInfo
- Publication number
- GB2355197A GB2355197A GB9909719A GB9909719A GB2355197A GB 2355197 A GB2355197 A GB 2355197A GB 9909719 A GB9909719 A GB 9909719A GB 9909719 A GB9909719 A GB 9909719A GB 2355197 A GB2355197 A GB 2355197A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formulation
- water
- chlorine
- chlorite
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 238000009472 formulation Methods 0.000 title claims abstract description 26
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 title claims abstract description 12
- 239000000460 chlorine Substances 0.000 title claims abstract description 12
- 229910052801 chlorine Inorganic materials 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 239000000843 powder Substances 0.000 title claims abstract description 6
- 239000007787 solid Substances 0.000 title claims abstract description 4
- 229910001919 chlorite Inorganic materials 0.000 claims abstract description 6
- 229910052619 chlorite group Inorganic materials 0.000 claims abstract description 6
- 239000000645 desinfectant Substances 0.000 claims abstract description 5
- 239000000872 buffer Substances 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 230000001954 sterilising effect Effects 0.000 claims abstract description 4
- 239000004094 surface-active agent Substances 0.000 claims abstract description 4
- 239000012895 dilution Substances 0.000 claims abstract description 3
- 238000010790 dilution Methods 0.000 claims abstract description 3
- 239000000945 filler Substances 0.000 claims abstract description 3
- 239000007800 oxidant agent Substances 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims abstract description 3
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000003513 alkali Substances 0.000 claims abstract 2
- 239000002274 desiccant Substances 0.000 claims abstract 2
- 229910052751 metal Inorganic materials 0.000 claims abstract 2
- 239000002184 metal Substances 0.000 claims abstract 2
- 239000003352 sequestering agent Substances 0.000 claims abstract 2
- 238000007906 compression Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 abstract description 14
- 239000004155 Chlorine dioxide Substances 0.000 abstract description 7
- 235000019398 chlorine dioxide Nutrition 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 abstract description 4
- 230000007935 neutral effect Effects 0.000 abstract description 4
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 abstract description 4
- 229960002218 sodium chlorite Drugs 0.000 abstract description 4
- CEJLBZWIKQJOAT-UHFFFAOYSA-N dichloroisocyanuric acid Chemical compound ClN1C(=O)NC(=O)N(Cl)C1=O CEJLBZWIKQJOAT-UHFFFAOYSA-N 0.000 abstract description 3
- 239000003112 inhibitor Substances 0.000 abstract description 3
- 230000002378 acidificating effect Effects 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 239000003899 bactericide agent Substances 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 abstract description 2
- 230000007797 corrosion Effects 0.000 abstract description 2
- 230000001960 triggered effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- -1 alkaline earth metal chlorite Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A disinfectant/sterilising formulation is provided as a dry powder/solid which comprises a chlorine releasing compound (which will release chlorine on contact with water) so that the formulation, when dissolved in water, produces a near neutral biocidally active solution. The chlorine releasing compound is preferably sodium dichloroisocyanurate and the formulation preferably further comprises an alkali or alkaline metal chlorite (eg sodium chlorite). Release of chlorine dioxide from the chlorite is triggered by the release of chlorine when the formulation is dissolved in water. Chlorine dioxide is a very powerful oxidising agent and an excellent bactericide, which is normally produced by a highly acidic reaction with sodium chlorite. The formulation may also incorporate a buffer, a desiccant (to provide storage stability), a surfactant, a filler (to maintain and bulk the composition), a tableting aid, a sequestrant (to aid effectiveness of formulation if used with hard dilution water) and a corrosion inhibitor. The formulation is primarily intended for use in sterilising medical and dental instuments and as a high level disinfectant in hospital, veterinary and food establishments. It is also intended for areas where the utmost hygiene is required.
Description
2355197 A Powder Formulation for Water Dilution and Subsequent use as a
Sterilant Medical, dental and other instruments are often made of high quality stainless steel and can be cleaned and sterilised between uses by high temperature steam under pressure. In contrast to this many instruments are made of heat-sensitive plastics, rubber, glass and electronic components. For this reason, heat sensitive instruments can only be sterilised by cold chemical germicides. Chemical sterilants presently available have many ethical and toxicological difficulties. The disclosed formula does not.
The formulation provides a method of generating chlorine dioxide in an aqueous liquid in which first of all chlorine is released and that in turn triggers the release of chlorine dioxide from an alkali metal or alkaline earth metal chlorite by adding to the aqueous liquid a water soluble solid composition containing a chlorine-releasing compound which in the dry state is stable. Upon addition to the aqueous media chlorine species are produced and subsequently generate chlorine dioxide by reaction with the alkali metal chlorite. The solution formed is very powerful disinfectant and sterilising liquid containing both chlorine dioxide and chlorine species which reduce the risk of formation of resistant bacteria.
The chlorine donor that provides the trigger for the conversion of the alkali metal chlorite at a near neutral pH is sodium dichloroisocyanurate. The powder composition may if necessary contain a substantial proportion of inert solid filler. The formulation may also contain one or more buffers to bring the pH of the aqueous liquid to near neutral and thereafter preserve it.
2 Typical Formulation Preferred Range Sodium Dichloroisocyanurate 5% 1-10% Sodium Chlorite 15% 5-25% Sodium Bicarbonate 5% 1-10% Sodium Phosphate 5% 1-10% Citric Acid 20% 5-50% Sodium Lauryl Sulphate 5% 1-10% Sodium Sulphate 45% 5-50% Thus, this invention provides a novel method of producing an aqueous solution containing chloride dioxide. Chloride dioxide is a very powerful oxidising agent and an excellent bactericide.
It is normally produced by a highly acidic reaction with sodium chlorite. The invention presents a method and a powder formulation which when added to water provides a high concentration of chlorine dioxide in a near neutral formulation. The formulation can also incorporate a surfactant or surfactants, and a corrosion inhibitor or inhibitors.
The formulation is primarily intended for use as.a medical sterilant and high level disinfectant in hospital, veterinary and food establishments, but is also intended for areas where the utmost hygiene is required.
3
Claims (8)
1. A disinfectant and or sterilising formulation that is a dry powder/solid which, when dissolved in water, produces a biocidally active solution and comprising of, but not limited to: a chlorine releasing compound which will release chlorine on contact with water.
2. A formulation as claimed in claim 1 and further comprising an alkali or alkaline metal chlorite.
3. A formulation as claimed in claim I or claim 2 and further comprising a buffer of buffers.
4. A formulation as claimed in any preceding claim and further comprising a desiccant to provide storage stability.
5. A formulation as claimed in any preceding claim and further comprising a surfactant which is stable in the presence of oxidising agents.
6. A formulation as claimed in any preceding claim and further comprising a filler to maintain and bulk the composition.
4
7. A formulation as claimed in any preceding claim and further comprising a tableting aid to help compression and binding in a tablet forming formulation.
8. A formulation as claimed in any preceding claim and ffirther comprising a sequestrant to aid effectiveness of formulation if used with hard dilution water (temporary or permanent).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9909719A GB2355197A (en) | 1999-04-27 | 1999-04-27 | A dry powder/solid formulation for dissolving in water and subsequent use as a chlorine releasing sterilant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9909719A GB2355197A (en) | 1999-04-27 | 1999-04-27 | A dry powder/solid formulation for dissolving in water and subsequent use as a chlorine releasing sterilant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9909719D0 GB9909719D0 (en) | 1999-06-23 |
| GB2355197A true GB2355197A (en) | 2001-04-18 |
Family
ID=10852371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9909719A Withdrawn GB2355197A (en) | 1999-04-27 | 1999-04-27 | A dry powder/solid formulation for dissolving in water and subsequent use as a chlorine releasing sterilant |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2355197A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2426708A (en) * | 2005-05-05 | 2006-12-06 | Animax Ltd | Multi-part disinfectant |
| WO2008057067A2 (en) * | 2005-08-15 | 2008-05-15 | Drexel University | Biocidal materials |
| JP2009528351A (en) * | 2006-02-28 | 2009-08-06 | ビーエーエスエフ、カタリスツ、エルエルシー | Chlorine dioxide based cleaner / cleaning agent |
| JP2009541197A (en) * | 2006-06-21 | 2009-11-26 | ビーエーエスエフ、カタリスツ、エルエルシー | Stabilized composition for chlorine dioxide production |
| CN105668730A (en) * | 2016-03-22 | 2016-06-15 | 江苏祥豪实业有限公司 | Novel chlorine dioxide material for treating water and method for preparing novel chlorine dioxide material |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104190A (en) * | 1976-03-23 | 1978-08-01 | Minnesota Mining And Manufacturing Company | Generation of chlorine dioxide for disinfection and sterilization |
| EP0081962A2 (en) * | 1981-12-08 | 1983-06-22 | Warner-Lambert Company | Denture cleansing composition |
| GB2263108A (en) * | 1992-01-11 | 1993-07-14 | Albright & Wilson | Halogen oxides in aqueous solution |
| JPH06157222A (en) * | 1992-11-16 | 1994-06-03 | Mikasa Kagaku Kogyo Kk | Agent for controlling staining alga and mos organism and control of staining alga and mos with the agent |
| US5738840A (en) * | 1994-04-07 | 1998-04-14 | Profresh Properties, Inc. | Oral rinse and method of treating halitosis |
-
1999
- 1999-04-27 GB GB9909719A patent/GB2355197A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4104190A (en) * | 1976-03-23 | 1978-08-01 | Minnesota Mining And Manufacturing Company | Generation of chlorine dioxide for disinfection and sterilization |
| EP0081962A2 (en) * | 1981-12-08 | 1983-06-22 | Warner-Lambert Company | Denture cleansing composition |
| GB2263108A (en) * | 1992-01-11 | 1993-07-14 | Albright & Wilson | Halogen oxides in aqueous solution |
| JPH06157222A (en) * | 1992-11-16 | 1994-06-03 | Mikasa Kagaku Kogyo Kk | Agent for controlling staining alga and mos organism and control of staining alga and mos with the agent |
| US5738840A (en) * | 1994-04-07 | 1998-04-14 | Profresh Properties, Inc. | Oral rinse and method of treating halitosis |
Non-Patent Citations (2)
| Title |
|---|
| WPI Abstract Accession No 1990-103958/14 & PAJ abstract of JP 020055201 A 23.02.1990 * |
| WPI Abstract Accession No 1994-221718/27 & JP 060157222 A 03.06.1994 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2426708A (en) * | 2005-05-05 | 2006-12-06 | Animax Ltd | Multi-part disinfectant |
| GB2426708B (en) * | 2005-05-05 | 2009-12-16 | Animax Ltd | Two-Part Disinfectant |
| WO2008057067A2 (en) * | 2005-08-15 | 2008-05-15 | Drexel University | Biocidal materials |
| WO2008057067A3 (en) * | 2005-08-15 | 2009-04-09 | Univ Drexel | Biocidal materials |
| JP2009528351A (en) * | 2006-02-28 | 2009-08-06 | ビーエーエスエフ、カタリスツ、エルエルシー | Chlorine dioxide based cleaner / cleaning agent |
| US8673297B2 (en) | 2006-02-28 | 2014-03-18 | Basf Corporation | Chlorine dioxide based cleaner/sanitizer |
| US9340756B2 (en) | 2006-02-28 | 2016-05-17 | Basf Corporation | Chlorine dioxide based cleanser/sanitizer |
| JP2009541197A (en) * | 2006-06-21 | 2009-11-26 | ビーエーエスエフ、カタリスツ、エルエルシー | Stabilized composition for chlorine dioxide production |
| KR101409142B1 (en) * | 2006-06-21 | 2014-06-17 | 바스프 카탈리스트 엘엘씨 | Stabilized composition for producing chlorine dioxide |
| CN105668730A (en) * | 2016-03-22 | 2016-06-15 | 江苏祥豪实业有限公司 | Novel chlorine dioxide material for treating water and method for preparing novel chlorine dioxide material |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9909719D0 (en) | 1999-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |