GB2333295A - Modified protein G and fragments thereof - Google Patents

Modified protein G and fragments thereof

Info

Publication number
GB2333295A
GB2333295A GB9828306A GB9828306A GB2333295A GB 2333295 A GB2333295 A GB 2333295A GB 9828306 A GB9828306 A GB 9828306A GB 9828306 A GB9828306 A GB 9828306A GB 2333295 A GB2333295 A GB 2333295A
Authority
GB
United Kingdom
Prior art keywords
fragments
modified protein
protein
fab
fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9828306A
Other versions
GB9828306D0 (en
Inventor
Jeremy Derrick
Gordon Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manchester Institute of Science and Technology (UMIST)
University of Leicester
University of Manchester
Original Assignee
University of Manchester Institute of Science and Technology (UMIST)
University of Leicester
University of Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9614033.0A external-priority patent/GB9614033D0/en
Application filed by University of Manchester Institute of Science and Technology (UMIST), University of Leicester, University of Manchester filed Critical University of Manchester Institute of Science and Technology (UMIST)
Priority to GB9828306A priority Critical patent/GB2333295A/en
Publication of GB9828306D0 publication Critical patent/GB9828306D0/en
Publication of GB2333295A publication Critical patent/GB2333295A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A polypeptide sequence which is a modified form of protein G or fragment thereof which selectively binds to one of the Fab or Fc fragments of an antibody relative to the other as compared to the corresponding selectivity of binding of unmodified protein G.
GB9828306A 1996-07-04 1997-07-04 Modified protein G and fragments thereof Withdrawn GB2333295A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9828306A GB2333295A (en) 1996-07-04 1997-07-04 Modified protein G and fragments thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9614033.0A GB9614033D0 (en) 1996-07-04 1996-07-04 Modified protein G and fragments thereof
PCT/GB1997/001818 WO1998001560A1 (en) 1996-07-04 1997-07-04 Modified protein g and fragments thereof
GB9828306A GB2333295A (en) 1996-07-04 1997-07-04 Modified protein G and fragments thereof

Publications (2)

Publication Number Publication Date
GB9828306D0 GB9828306D0 (en) 1999-02-17
GB2333295A true GB2333295A (en) 1999-07-21

Family

ID=26309634

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9828306A Withdrawn GB2333295A (en) 1996-07-04 1997-07-04 Modified protein G and fragments thereof

Country Status (1)

Country Link
GB (1) GB2333295A (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Immunomethods 1993 2(1) pp9-15 Derrick et al. *
J. Molecular Biology 1992 228(4) pp1219-1234 Lian et al. *
J. Molecular Biology 1994 243 pp906-918 Derrick et al. *
Molecular Immunology 1988 25(2) pp121-126 Erntell et al. *
Structure 1995 3(3) pp265-278 Sauer-Eriksson et al. *
The Biochemical Journal 1990 267(1) pp171-177 Goward et al. *

Also Published As

Publication number Publication date
GB9828306D0 (en) 1999-02-17

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)