GB2284760B - A method of preparing pharmaceutical compositions by melt pelletisation - Google Patents
A method of preparing pharmaceutical compositions by melt pelletisationInfo
- Publication number
- GB2284760B GB2284760B GB9324045A GB9324045A GB2284760B GB 2284760 B GB2284760 B GB 2284760B GB 9324045 A GB9324045 A GB 9324045A GB 9324045 A GB9324045 A GB 9324045A GB 2284760 B GB2284760 B GB 2284760B
- Authority
- GB
- United Kingdom
- Prior art keywords
- pharmaceutical compositions
- preparing pharmaceutical
- pelletisation
- melt
- melt pelletisation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (119)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9324045A GB2284760B (en) | 1993-11-23 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
IL11966094A IL119660A (en) | 1993-05-10 | 1994-04-27 | Controlled release formulation comprising tramadol |
IL109460A IL109460A (en) | 1993-05-10 | 1994-04-27 | Controlled release formulation comprising tramadol |
NZ260408A NZ260408A (en) | 1993-05-10 | 1994-04-27 | Controlled release preparation comprising tramadol |
DK94303128.6T DK0624366T3 (en) | 1993-05-10 | 1994-04-29 | Composition containing controlled release tramadol |
EP95114527A EP0699436B2 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation |
DK04030658.1T DK1527775T3 (en) | 1993-05-10 | 1994-04-29 | Controlled release tramadol-containing composition |
DE69434479T DE69434479T2 (en) | 1993-05-10 | 1994-04-29 | Tramadol-containing drug with controlled release of active ingredient |
AT95114527T ATE201989T1 (en) | 1993-05-10 | 1994-04-29 | MEDICINAL PRODUCTS WITH CONTROLLED DELIVERY OF ACTIVE INGREDIENTS |
DK04014719T DK1468679T3 (en) | 1993-05-10 | 1994-04-29 | Controlled release tramadol-containing formulation |
EP94303128A EP0624366B1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation containing tramadol |
DK95114527.5T DK0699436T4 (en) | 1993-05-10 | 1994-04-29 | Controlled release preparation |
PT95114527T PT699436E (en) | 1993-05-10 | 1994-04-29 | CONTROLLED LIBERATION FORMULA |
DE9422335U DE9422335U1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation |
AT04014719T ATE303140T1 (en) | 1993-05-10 | 1994-04-29 | MEDICINAL PRODUCT CONTAINING TRAMADOL WITH CONTROLLED RELEASE OF ACTIVE INGREDIENTS |
ES04014719T ES2247574T3 (en) | 1993-05-10 | 1994-04-29 | FORMULATION OF CONTROLLED RELEASE THAT INCLUDES TRAMADOL. |
DE69400215T DE69400215T2 (en) | 1993-05-10 | 1994-04-29 | Tramadol-containing medicine with delayed release of active ingredient |
AT04030658T ATE468850T1 (en) | 1993-05-10 | 1994-04-29 | MEDICINAL PRODUCT CONTAINING TRAMADOL WITH CONTROLLED RELEASE OF ACTIVE INGREDIENTS |
ES09004973T ES2331046T1 (en) | 1993-05-10 | 1994-04-29 | CONTROLLED RELEASE FORMULATION. |
EP96101147A EP0729751A1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation containing tramadol |
ES94303128T ES2088312T3 (en) | 1993-05-10 | 1994-04-29 | CONTROLLED RELEASE FORMULATION CONTAINING TRAMADOL. |
DE69427472T DE69427472T3 (en) | 1993-05-10 | 1994-04-29 | Drugs with controlled release of active ingredient |
DE0699436T DE699436T1 (en) | 1993-05-10 | 1994-04-29 | Controlled drug delivery drugs |
AT94303128T ATE138566T1 (en) | 1993-05-10 | 1994-04-29 | DELAYED RELEASE MEDICINAL PRODUCT CONTAINING TRAMADOL |
EP04014719A EP1468679B1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation containing tramadol |
DE69435295T DE69435295D1 (en) | 1993-05-10 | 1994-04-29 | Tramadol-containing drug with controlled release of active ingredient |
DE0729751T DE729751T1 (en) | 1993-05-10 | 1994-04-29 | Tramadol-containing drug with delayed drug delivery |
PT04014719T PT1468679E (en) | 1993-05-10 | 1994-04-29 | CONTROLLED FREQUENCY FORMULA CONTAINING TRAMADOL |
PT04030658T PT1527775E (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation containing tramadol |
EP04030658A EP1527775B1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation containing tramadol |
DE09004973T DE09004973T8 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation |
EP09004973.5A EP2103303B1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation containing tramadol |
ES04030658T ES2346651T3 (en) | 1993-05-10 | 1994-04-29 | FORMULATION OF CONTROLLED LIBERATION THAT TRAMADOL FORMULATION OF CONTROLLED LIBERATION CONTAINING TRAMADOL. |
SG1996008705A SG67347A1 (en) | 1993-05-10 | 1994-04-29 | Controlled release formulation |
ES95114527T ES2159591T5 (en) | 1993-05-10 | 1994-04-29 | Controlled Release Formulation |
CZ19941093A CZ288517B6 (en) | 1993-05-10 | 1994-05-04 | Pharmaceutical preparation in unit dosage form and process of its preparation |
FI942092A FI942092A (en) | 1993-05-10 | 1994-05-06 | Restrained released composition |
HU9401478A HU228177B1 (en) | 1993-05-10 | 1994-05-06 | Controlled release formulation containing tramadol |
EG26394A EG20577A (en) | 1993-05-10 | 1994-05-08 | Controlled release formulation contaning tramadol |
AU61963/94A AU6196394A (en) | 1993-05-10 | 1994-05-09 | Controlled release formulation |
NO941719A NO306446B1 (en) | 1993-05-10 | 1994-05-09 | Oral pharmaceutical preparation comprising tramadol with controlled release effect |
CA002123160A CA2123160C (en) | 1993-05-10 | 1994-05-09 | Controlled release formulation |
US08/241,129 US5591452A (en) | 1993-05-10 | 1994-05-10 | Controlled release formulation |
CN94105356A CN1094755C (en) | 1993-05-10 | 1994-05-10 | Controlled release formulation |
JP6096671A JP3045924B2 (en) | 1993-05-10 | 1994-05-10 | Controlled release oral drug formulations |
SK1437-98A SK283143B6 (en) | 1993-05-10 | 1994-05-10 | Pharmaceutical preparation for controlled release |
IDP991104D ID25988A (en) | 1993-05-10 | 1994-05-10 | DRUG FORMULATION WHICH SOLVED CAN BE ARRANGED (Fraction of P-940726) |
SK541-94A SK279971B6 (en) | 1993-05-10 | 1994-05-10 | Controlled release pharmaceutical composition and process for its preparation |
TW085103273A TW496736B (en) | 1993-05-10 | 1994-05-12 | Controlled release formulation |
IL10994494A IL109944A (en) | 1993-07-01 | 1994-06-08 | Sustained release dosage unit forms containing morphine and a method of preparing these sustained release dosage unit forms |
SG1996009186A SG50706A1 (en) | 1993-07-01 | 1994-06-09 | Sustained release compositions and a method of preparing pharmaceutical compositions |
ES94304144T ES2124372T5 (en) | 1993-07-01 | 1994-06-09 | SUSTAINED RELEASE COMPOSITIONS CONTAINING MORPHINE. |
EP94304144A EP0636370B2 (en) | 1993-07-01 | 1994-06-09 | Sustained release compositions containing morphine |
DE69414046T DE69414046T3 (en) | 1993-07-01 | 1994-06-09 | Morphine-containing medicinal compositions with delayed drug delivery |
DK94304144T DK0636370T4 (en) | 1993-07-01 | 1994-06-09 | Deposits containing morphine |
AT94304144T ATE172376T1 (en) | 1993-07-01 | 1994-06-09 | MORPHINE-CONTAINING MEDICINAL COMPOSITIONS WITH DELAYED RELEASE |
CZ19941550A CZ287918B6 (en) | 1993-07-01 | 1994-06-23 | Orally administered unit dosage form with controlled release and process for preparing thereof |
SK763-94A SK280534B6 (en) | 1993-07-01 | 1994-06-23 | Sustained release preparations of morphine and a method of preparing the same |
NZ260883A NZ260883A (en) | 1993-07-01 | 1994-06-29 | Oral sustained-release medicaments containing morphine |
AU66105/94A AU6610594A (en) | 1991-12-24 | 1994-06-30 | Sustained release compositions and a method of preparing pharmaceutical compositions |
CA002127166A CA2127166C (en) | 1993-07-01 | 1994-06-30 | Sustained release morphine compositions and a method of preparation |
FI943141A FI114285B (en) | 1993-07-01 | 1994-06-30 | Process for preparing sustained release pharmaceutical dosage unit form |
PL94304062A PL179282B1 (en) | 1993-07-01 | 1994-06-30 | Retarded release compositions and method of obtaining such compositions |
NO942470A NO306449B1 (en) | 1993-07-01 | 1994-06-30 | Orally administered morphine preparation for sustained release as well as preparation of multiparticulates for use in the preparation |
KR1019940015740A KR100365572B1 (en) | 1993-07-01 | 1994-07-01 | Sustained-release and pharmaceutical compositions |
HU9402007A HU220075B (en) | 1993-07-01 | 1994-07-01 | Retarde pharmaceutical compositions containing morphine and process for producing them |
JP15121994A JP3647897B2 (en) | 1993-07-01 | 1994-07-01 | Sustained release unit dosage form |
BG99078A BG62473B1 (en) | 1993-11-23 | 1994-09-29 | Pharmaceutical preparation with monitored release |
BG99077A BG62316B1 (en) | 1993-10-07 | 1994-09-29 | Pharmaceutical forms with continuous release and method for their preparation |
EG61694A EG20600A (en) | 1993-10-07 | 1994-10-03 | Sustained release compositions and a method of preparing pharmaceutical compositions |
PT94308493T PT654263E (en) | 1993-11-23 | 1994-11-17 | METHOD FOR THE PREPARATION OF A PROLONGED LIBERTYACAO COMPOSITION |
ES94308493T ES2168290T3 (en) | 1993-11-23 | 1994-11-17 | METHOD FOR PREPARING A SUSTAINED RELEASE COMPOSITION. |
DE69429710T DE69429710T2 (en) | 1993-11-23 | 1994-11-17 | Process for the preparation of a drug composition with delayed drug delivery |
AT94308493T ATE212224T1 (en) | 1993-11-23 | 1994-11-17 | METHOD FOR PRODUCING A MEDICINAL COMPOSITION WITH DELAYED RELEASE |
EP94308493A EP0654263B1 (en) | 1993-11-23 | 1994-11-17 | Method for preparing a sustained release composition |
DK94308493T DK0654263T3 (en) | 1993-11-23 | 1994-11-17 | Process for the preparation of a sustained release preparation |
NZ264953A NZ264953A (en) | 1993-11-23 | 1994-11-18 | Manufacture of drug-containing particles from a mixture of particulate drug and a particulate hydrophobic and/or hydrophilic fusible carrier or diluent in a high speed mixer such that the carrier/diluent melts and breaking up the agglomerates thus formed; sustained release forms |
BG99198A BG62429B1 (en) | 1993-11-23 | 1994-11-21 | Method for the preparation of pharmaceutical compositions |
CZ19942866A CZ289650B6 (en) | 1993-11-23 | 1994-11-21 | Process for preparing a medicament controllably releasing active substance thereof |
IN1134MA1994 IN179010B (en) | 1993-11-23 | 1994-11-21 | |
IL11170994A IL111709A (en) | 1993-11-23 | 1994-11-21 | Process for the manufacture of sustained release particles and dosage forms comprising particles obtained by the process |
NO19944473A NO314124B1 (en) | 1993-11-23 | 1994-11-22 | Process for the preparation of particles |
FI945476A FI113335B (en) | 1993-11-23 | 1994-11-22 | Process for the preparation of particles useful in pharmaceutical compositions |
HU9403353A HU217205B (en) | 1993-11-23 | 1994-11-22 | Sustained release compositions and a method of preparing pharmaceutical compositions |
PL94305939A PL178883B1 (en) | 1993-11-23 | 1994-11-22 | Prolonged release compositions and method of obtaining them |
SK1406-94A SK280496B6 (en) | 1993-11-23 | 1994-11-22 | Process for preparing particles with permanent release of active substance |
EG74294A EG20910A (en) | 1993-11-23 | 1994-11-22 | Sustained release compositions and a method of preparing pharmaceutical compositions |
AU79015/94A AU682223C (en) | 1993-11-23 | 1994-11-23 | Sustained release compositions and a method of preparing pharmaceutical compositions |
KR1019940031398A KR100354702B1 (en) | 1993-11-23 | 1994-11-23 | Manufacturing method and sustained release composition of pharmaceutical composition |
CN94118503A CN1121213C (en) | 1993-11-23 | 1994-11-23 | Sustained release compositions and a method of preparing pharmaceutical compositions |
ZA949296A ZA949296B (en) | 1993-11-23 | 1994-11-23 | Sustained release compositions and a method of preparing pharmaceutical compositions. |
JP28993694A JP3411114B2 (en) | 1993-11-23 | 1994-11-24 | Method for producing long-acting composition and pharmaceutical composition |
US08/449,772 US6326027B1 (en) | 1993-05-10 | 1995-05-24 | Controlled release formulation |
US08/607,852 US5849240A (en) | 1993-11-23 | 1996-02-27 | Method of preparing sustained release pharmaceutical compositions |
US08/607,851 US5891471A (en) | 1993-11-23 | 1996-02-27 | Pharmaceutical multiparticulates |
IN747MA1996 IN182557B (en) | 1993-11-23 | 1996-05-06 | |
GR960401422T GR3020084T3 (en) | 1993-05-10 | 1996-05-30 | Controlled release formulation containing tramadol. |
US08/677,798 US6254887B1 (en) | 1993-05-10 | 1996-07-10 | Controlled release tramadol |
IL11966096A IL119660A0 (en) | 1993-05-10 | 1996-11-20 | Controlled release formulation |
US08/843,571 US5879705A (en) | 1993-07-27 | 1997-04-18 | Sustained release compositions of morphine and a method of preparing pharmaceutical compositions |
US08/944,106 US5965163A (en) | 1993-11-23 | 1997-09-30 | Substained release compositions and a method of preparing pharmaceutical compositions |
AU39957/97A AU3995797A (en) | 1993-05-10 | 1997-10-07 | Controlled release formulation |
AU52995/98A AU722358B2 (en) | 1991-12-24 | 1998-02-06 | Sustained release compositions and a method of preparing pharmaceutical compositions |
JP22971898A JP3267561B2 (en) | 1993-05-10 | 1998-08-14 | Use of tramadol or a pharmaceutically acceptable salt thereof and analgesic |
US09/264,399 US6143328A (en) | 1993-07-27 | 1999-03-08 | Sustained release compositions and a method of preparing pharmaceutical compositions |
CNB991066421A CN1146410C (en) | 1993-05-10 | 1999-05-17 | Controlled release formulation |
NO19993484A NO313124B1 (en) | 1993-05-10 | 1999-07-15 | Use of tramadol in the manufacture of a medicament for the treatment of pain |
US09/370,270 US6162467A (en) | 1993-11-23 | 1999-08-09 | Sustained release compositions and a method of preparing pharmaceutical compositions |
AT0081699U AT3413U3 (en) | 1993-05-10 | 1999-11-25 | MEDICINAL PRODUCT WITH CONTROLLED RELEASE OF TRAMADOL |
US09/740,732 US20010019725A1 (en) | 1993-11-23 | 2000-12-19 | Sustained release compositions and a method of preparing pharmaceutical compositions |
US09/800,204 US7074430B2 (en) | 1993-05-10 | 2001-03-06 | Controlled release tramadol tramadol formulation |
NO20013566A NO331650B1 (en) | 1993-05-10 | 2001-07-19 | Oral preparation of tramadol or a pharmaceutically acceptable salt thereof with controlled release effect |
GR20010401419T GR3036565T3 (en) | 1993-05-10 | 2001-09-06 | Controlled release formulation |
JP2001297270A JP3443574B2 (en) | 1993-05-10 | 2001-09-27 | Analgesic containing tramadol or a salt thereof |
JP2002271157A JP2003113075A (en) | 1993-11-23 | 2002-09-18 | Sustained release composition |
FI20030560A FI121565B (en) | 1993-05-10 | 2003-04-14 | A process for the preparation of a controlled release formulation of tramadol |
US11/435,015 US20060269603A1 (en) | 1993-05-10 | 2006-05-16 | Controlled release tramadol formulations |
US12/152,474 US20090117191A1 (en) | 1993-05-10 | 2008-05-14 | Controlled release tramadol formulations |
FI20105856A FI122717B (en) | 1993-05-10 | 2010-08-17 | The method produces a controlled release preparation of tramadol hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9324045A GB2284760B (en) | 1993-11-23 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
Publications (3)
Publication Number | Publication Date |
---|---|
GB9324045D0 GB9324045D0 (en) | 1994-01-12 |
GB2284760A GB2284760A (en) | 1995-06-21 |
GB2284760B true GB2284760B (en) | 1998-06-24 |
Family
ID=10745553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9324045A Expired - Lifetime GB2284760B (en) | 1991-12-24 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
Country Status (3)
Country | Link |
---|---|
GB (1) | GB2284760B (en) |
IN (1) | IN179010B (en) |
ZA (1) | ZA949296B (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US5849240A (en) | 1993-11-23 | 1998-12-15 | Euro-Celtique, S.A. | Method of preparing sustained release pharmaceutical compositions |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
US5958452A (en) | 1994-11-04 | 1999-09-28 | Euro-Celtique, S.A. | Extruded orally administrable opioid formulations |
US6068855A (en) | 1994-11-03 | 2000-05-30 | Euro-Celtique S. A. | Pharmaceutical composition containing a fusible carrier and method for producing the same |
US7829120B2 (en) | 2005-09-09 | 2010-11-09 | Labopharm Inc. | Trazodone composition for once a day administration |
US7988998B2 (en) | 2002-10-25 | 2011-08-02 | Labopharm Inc. | Sustained-release tramadol formulations with 24-hour efficacy |
US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998000143A1 (en) * | 1996-06-28 | 1998-01-08 | Knoll Pharmaceutical Company | Slow release pharmaceutical compositions and methods of making same |
DE19918325A1 (en) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives |
BR0213591A (en) | 2001-09-28 | 2004-08-31 | Mcneil Ppc Inc | Edible composition and dosage form comprising an edibly outside. |
US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
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US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
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Cited By (18)
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---|---|---|---|---|
US5849240A (en) | 1993-11-23 | 1998-12-15 | Euro-Celtique, S.A. | Method of preparing sustained release pharmaceutical compositions |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
US5965163A (en) | 1993-11-23 | 1999-10-12 | Euro-Celtique, S.A. | Substained release compositions and a method of preparing pharmaceutical compositions |
US6162467A (en) | 1993-11-23 | 2000-12-19 | Euro-Celtique, S.A. | Sustained release compositions and a method of preparing pharmaceutical compositions |
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
US6068855A (en) | 1994-11-03 | 2000-05-30 | Euro-Celtique S. A. | Pharmaceutical composition containing a fusible carrier and method for producing the same |
US6261599B1 (en) | 1994-11-04 | 2001-07-17 | Euro-Celtique, S.A. | Melt-extruded orally administrable opioid formulations |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US5958452A (en) | 1994-11-04 | 1999-09-28 | Euro-Celtique, S.A. | Extruded orally administrable opioid formulations |
US6335033B2 (en) | 1994-11-04 | 2002-01-01 | Euro-Celtique, S.A. | Melt-extrusion multiparticulates |
US6706281B2 (en) | 1994-11-04 | 2004-03-16 | Euro-Celtique, S.A. | Melt-extrusion multiparticulates |
US7988998B2 (en) | 2002-10-25 | 2011-08-02 | Labopharm Inc. | Sustained-release tramadol formulations with 24-hour efficacy |
US8487002B2 (en) | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
US7829120B2 (en) | 2005-09-09 | 2010-11-09 | Labopharm Inc. | Trazodone composition for once a day administration |
US8414919B2 (en) | 2005-09-09 | 2013-04-09 | Angelini Labopharm, Llc | Sustained drug release composition |
US8795723B2 (en) | 2005-09-09 | 2014-08-05 | Angelini Pharma Inc. | Sustained drug release compositions |
US8962019B2 (en) | 2005-09-09 | 2015-02-24 | Angelini Pharma, Inc. | Sustained drug release composition |
US9439866B2 (en) | 2005-09-09 | 2016-09-13 | Angelini Pharma, Inc. | Trazodone composition for once a day administration |
Also Published As
Publication number | Publication date |
---|---|
GB2284760A (en) | 1995-06-21 |
ZA949296B (en) | 1995-08-08 |
IN179010B (en) | 1997-08-09 |
GB9324045D0 (en) | 1994-01-12 |
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Legal Events
Date | Code | Title | Description |
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PE20 | Patent expired after termination of 20 years |
Expiry date: 20131122 |