GB2225948A - Respiratory condition diagnosis and apparatus therefor. - Google Patents
Respiratory condition diagnosis and apparatus therefor. Download PDFInfo
- Publication number
- GB2225948A GB2225948A GB8924637A GB8924637A GB2225948A GB 2225948 A GB2225948 A GB 2225948A GB 8924637 A GB8924637 A GB 8924637A GB 8924637 A GB8924637 A GB 8924637A GB 2225948 A GB2225948 A GB 2225948A
- Authority
- GB
- United Kingdom
- Prior art keywords
- signals
- components
- expiration
- patient
- analysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B7/00—Instruments for auscultation
- A61B7/003—Detecting lung or respiration noise
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Diagnosis of respiratory dysfunctions including asthma and bronchitis is facilitated by generating electrical signals representative of breath sounds from a patient in effectively continuous manner during respiration extending through at least one phase of an expiration/inspiration cycle, and subjecting the resultant signals to spectral analysis to indicate frequency components in a range up to at least 5 kHz and the relative intensities of such components. The signals preferably result from an expiration phase, and especially a forced expiration, with generation effected from a microphone (11, 11a) housed in a hand-held tubular instrument with a separable mouthpiece (10). The components resulting from analysis are preferably visually displayed by way of a two-dimensional array (17) with frequency/time ordinates and component intensity indicated as variations in colour, contrast or another parameter.
Description
RESPIRATORY CONDITION DIAGNOSIS
AND APPARATUS THEREFOR
This invention concerns respiratory condition diagnosis and apparatus therefor.
The invention has been conceived and developed to date primarily for the diagnosis of asthma, particularly in distinction from an alternative diagnosis of bronchitis, and especially in relation to children. An earlier study (British
Medical Journal, 29 July 1978, pp.331-332) showed that asthma in children can be undetected and subject to delay in diagnosis, with the most common cause of delay, particularly in the pre-school age group under 4-years old, being an alternative diagnosis of bronchitis. This can result in a lack of treatment or an unnecessary use of antibiotics, the latter being rarely appropriate in asthma, and consequent further bronchial damage leading to hyper-responsive airways.
The traditional use of the stethoscope and use of the more recent instruments for measuring peak expiratory flow rate, PFR, do not allow a satisfactory resolution of this situation. For example in the case of school children simple bronchitis can lead to a drop in PFR without necessarily exhibiting any degree of bronchial muscle spasm to signal the relevant dysfunction, and in the case of pre-school children there is an inability to monitor
PFR accurately due to a lack of compliance.
Various proposals have been made suggesting that an improved respiratory condition diagnosis may be facilitated by a procedure involving use of a transducer to provide olortniral signals representative of breath sounds Anfl in-t,-umDntztiell to analyze such signals for features characteristic of dysfunction of interest. However. these rrr.osAls have not given results indicative of routine clinical utility.
An object of the present invention is to improve this overall situation and to this end follows a procedure of this last form, but with signal provision being effectively continuous during respiration extending through at least one phase of an inspiration/expiration cycle and signal analysis being of a spectral form to indicate frequency components in a range up to at least about 5 kHz and the relative intensities of such components.
This combination of signal provision and analysis has, during development of the invention, been found to be necessary to the provision of results which are consistent to a degree appropriate to routine clinical utility. At the same time this finding indicates why prior proposals having a similar objective have in fact not proved satisfactory. The prior proposals have, for example, variously entailed application of a transducer to the chest wall with consequent attenuation of breath sounds down to about 2 kHz, the provision of signals from a transducer in response to sound pressure level and so not representative of the sound frequency spectrum, and the analysis of signals representing breath sounds at only one instant in time.
Preferably, according to the present invention signal provision is effective during an expiration phase as breath sounds are generally more pronounced then than during inspiration. More preferably, the sounds in question are those arising from forced expiration as this will tend to enhance signal characteristics of interest.
Also the transducer is preferably applied in the. near vicinity of the mouth for effectively direct response to breath sounds to the extent that no significant attenuation occurs by way of sound transmission through body tissue.
For the purposes of these preferred facets of the invention the transducer is suitably sited in a mouthpiece nf predetermined form. Clearly this will serve to locAte the transducer appropriately. Also, the use of a mouthpiece will assist in normalising the procedural conditions from patient to patient and from one occasion to another for the same patient, and particularly so in the case of forced expiration.
The signal analysis preferably provides a visual display and this is conveniently of a form in which time and frequency serve as respective coordinates in a 2-dimensional plot with frequency component intensity being depicted by way of density, colour or like variation effectively serving as a further coordinate in the display. It may be appropriate, such as in the case where intensity is represented by a visual density variation, to display components only when above a predetermined threshold representing significance relative to noise.
While the invention has been discussed this far largely in terms of a diagnostic procedure, equally well it contemplates apparatus for carrying of the procedure.
In any event, a fuller understanding of the invention may be assisted by the following further description, given by way of example, with reference to the accompanying drawings, in which:
Figure 1 schematically illustrates an apparatus embodiment according to the invention and employed during initial development thereof, and
Figures 2-9 respectively show different display plots obtained with use of the apparatus of Figure 1.
The apparatus of Figure 1 includes a mouthpiece 10, and a microphone 11 connectable to the input of a tape recorder 12.
The tape recorder output is applicable by way of an analogueto-digital converter 13 to the store of a computer 14 under the control of a record program denoted at 15. The stored data in the computer is applicable, in turn, under the control of an analysis program denoted at 16, to an X-Y plotter 17 of pen recorder form.
The mouthpiece is of disposable form such as used in peak expiratory flow meters and the microphone is of hand-held form for location near, but not in line with. the expired breath from the mouthpiece. Further develormont i elv to involve incorporation of a miniature microphone or other suitable electroacoustic transducer in tho side wall of a tubular instrument for use with a separable disposable mouthpiece, the instrument being adapted for appropriate cleaning. Such a development is indicated in Figure 1 by way of transducer 11.
Development may well also involve the use of a dedicated microprocessor or, more economically, a suitable commerciallyavailable personal computer with dedicated software for direct handling of the microphone output.
In any event, the microphone output is converted to digital form for the purposes of computer handling, including analysis, and the analysis entails fast Fourier transformation to convert the data from the time domain to the frequency domain. More particularly the transformation provides signals indicating, at each of a plurality of closely spaced successive instants of time, the microphone output intensity at each of a plurality of similarly spaced successive frequencies in the range 0-5 kHz.
The last signals are applied, in the extent to which they exceed a predetermined threshold representative of noise, to the pen recorder to produce a so-called Z-plot. This plot involves a plurality of traces extending in registered manner along the paper to represent time t in seconds as the X-ordinate, with the traces being successively spaced across the paper to represent frequency f in kHz as the Y-ordinate, and each trace including transverse oscillations of amplitude proportionate to frequency component intensity whereby to effect a visually perceived density variation as a Z-ordinate. In initial development such analysis and plots have been produced with 72 traces for respiration periods of 1.95 records including a forced expiration.
Figure 2 shows one such plot for a normal adult male (40-years old). A characteristic of significance is seen to be the presence of bands of relatively high spectral energy well distributed over the whole frequency range of the plot. These bands are identified by the addition of horizontal bounding lines after generation of the plot and z f tg wed 1 ine below the time axis indicates the period of about 0.5 s during which the bands occurred. this period in fact indicating the period of peak expiration. The bands have in fact been calculated to correspond with the natural acoustic frequencies of the bronchial tree in simple organ pipe modes of oscillation and the bands have been found to be consistently repeated on successive expirations.
Figures 3-5 show similar plots for an asthmatic female adult (38-years old). These plots individually relate to expiration in circumstances involving no medication, 20 minutes following selfadministration of a bronchodilatory drug ("Salbutamol") via an aerosol spray, and 2-months following routine use of such therapy.
The characteristics of significance in these plots indicate a marked reduction of spectral energy bands in Figure 3 compared to
Figure 2, with only two bands occurring in the vicinity of 1 kHz and 2.5 kHz, but with these bands being of high intensity. In
Figure 4 these two bands recur, but at reduced intensity, and a further band appears just below 4 kHz. In Figure 5 the plot is yet more comparable with that of Figure 2.
A point of interest arising from these plot comparisons so far is that improvement in an asthmatic's condition is associated with a shift of spectral energy upwards in terms of frequency.
This contrasts with the commonly perceived view that asthma produces a high frequency wheeze, whereas in fact the frequency shift is down. This perception is now seen to arise from increased intensity of breath sounds at lower frequency.
Again, the plots of Figures 3-5 are found to be repeatable.
Figures 6 and 7 show plots for an asthmatic female child (9-years old) in circumstances corresponding to those for
Figures 3 and 4, and similarity is seen with a shift in spectral energy from lower to high frequencies. These plots are, again, repeatable. It is to be noted that it was found appropriate to increase the gain in the recorder to allow for weak expiration, but this does not affect the relative nature of the bands.
The remaining Figures 8 and 9 show plots for an adult male (58-years old) with a mixture of asthma and bronchitis in circumstances also corresponding tr those of Figuies es3and 4. It can be seen that there are similarities with and differences from the earlier plots which is ronsistent with bronchodilation influencing the asthmatic component of the patient's condition but being unable to reverse the airways obstruction related to bronchitic component. Thus, bronchodilation reduces the spectral
Intensity in Figure 9 compared to Figure 8, but in neither case can one readily perceive discrete bands of higher energy through the frequency range.
The overall results as shown by the plots of Figures 2-9 show a clear basis on which diagnosis can be aided in detecting asthma relative to its absence and, moreover, in distinguishing from bronchitis.
It has been made clear in the above description that the invention is open to practical implementation in a varied manner, particularly in respect of apparatus. The apparatus of Figure 1 was chosen to allow flexibility whereby the underlying concept of correlation between breath sound characteristics and respiratory condition could be more thoroughly examined than in the past. In the result such a correlation has now been established and apparatus suited to routine usage can be developed on the basis of the present findings, which apparatus is likely to be of a dedicated form with consequent simplication and increased convenience in use. Some facets of such development have been indicated and other possibilities include, for example, the provision of an averaging facility whereby display results take account of plural operations by the patient, and extension of the frequency range for the purposes of analysis.
Claims (9)
1. A method of providing data useful in diagnosis of respiratory dysfunctions including asthma and bronchitis, which method comprises generating electrical signals representative of breath sounds from a patient in effectively continuous manner during respiration extending through at least one phase of an expiration/inspiration cycle, and subjecting said signals to spectral analysis to indicate frequency components thereof in a range up to at least 5 kHz and the relative intensities of such components.
2. A method according to Claim 1 wherein said signals are generated during the expiration phase of a respiration cycle.
3. A method according to Claim 2 wherein said expiration phase is a forced expiration.
4. A method according to Claim 1,2 or 3 wherein said signals are generated by detection of said sounds in the near vicinity of the mouth.
5. A method according to Claim 4 wherein said signals are generated by a microphone or other electroacoustic transducer housed in a tubular instrument through which the patient breathes.
6. A method according to Claim 5 wherein said instrument is hand-held by the patient and includes a separable mouthpiece for the patient.
7. A method according to any preceding claim wherein frequency components indicated by said analysis are presented in a two-dimensional visual display of which the ordinates respectively represent the frequencies and times of occurrence of the components, with the relative intensities of such components being represented by variation of colour. contrast or other parameter in said display.
8. A method according to an preceding claim wherein said signals are repetitively generated for successive respiration cycles of the patient, and said signals or components thereof are averaged for such cycles respectively prior to or following analysis.
9. Apparatus for carrying out the method according to any preceding claim.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888825611A GB8825611D0 (en) | 1988-11-02 | 1988-11-02 | Respiratory condition diagnosis & apparatus therefor |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8924637D0 GB8924637D0 (en) | 1989-12-20 |
GB2225948A true GB2225948A (en) | 1990-06-20 |
GB2225948B GB2225948B (en) | 1992-12-02 |
Family
ID=10646164
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB888825611A Pending GB8825611D0 (en) | 1988-11-02 | 1988-11-02 | Respiratory condition diagnosis & apparatus therefor |
GB8924637A Expired - Lifetime GB2225948B (en) | 1988-11-02 | 1989-11-01 | Respiratory condition diagnosis and apparatus therefor |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB888825611A Pending GB8825611D0 (en) | 1988-11-02 | 1988-11-02 | Respiratory condition diagnosis & apparatus therefor |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0396712A1 (en) |
JP (1) | JPH03503498A (en) |
GB (2) | GB8825611D0 (en) |
WO (1) | WO1990004945A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887208B2 (en) | 2002-01-10 | 2005-05-03 | Deepbreeze Ltd. | Method and system for analyzing respiratory tract sounds |
US7517319B2 (en) | 2003-06-02 | 2009-04-14 | Deepbreeze Ltd. | Method and system for analyzing cardiovascular sounds |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4338466A1 (en) * | 1993-11-11 | 1995-05-18 | Fraunhofer Ges Forschung | Method and device for the automatic detection of conspicuous breathing noises |
IL117146A0 (en) * | 1996-02-15 | 1996-06-18 | Gull Medical Software Systems | Diagnosis of lung condition |
FR2791248B1 (en) * | 1999-03-24 | 2001-08-24 | Georges Kehyayan | DEVICE FOR ANALYZING AUSCULTATORY NOISE, IN PARTICULAR RESPIRATORY NOISE |
IL130818A (en) | 1999-07-06 | 2005-07-25 | Intercure Ltd | Interventive-diagnostic device |
US6733464B2 (en) | 2002-08-23 | 2004-05-11 | Hewlett-Packard Development Company, L.P. | Multi-function sensor device and methods for its use |
US8672852B2 (en) | 2002-12-13 | 2014-03-18 | Intercure Ltd. | Apparatus and method for beneficial modification of biorhythmic activity |
CA2574642A1 (en) * | 2004-07-23 | 2006-01-26 | Intercure Ltd. | Apparatus and method for breathing pattern determination using a non-contact microphone |
CA2872785C (en) * | 2012-05-10 | 2021-06-29 | University Of Washington Through Its Center For Commercialization | Sound-based spirometric devices, systems, and methods |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3611801A (en) * | 1968-10-28 | 1971-10-12 | Nasa | Respiration monitor |
DE2948863A1 (en) * | 1979-12-05 | 1981-06-11 | Ulrich H. Priv.-Doz. Dr.med. 7542 Schömberg Cegla | Diagnostic appts. measuring lung and bronchial noise - simultaneously records respiration level for correlation with recorded noise pulses |
DE3044639C2 (en) * | 1980-11-27 | 1983-05-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Respirophonometer |
US4586514A (en) * | 1983-08-10 | 1986-05-06 | Biotronics Instruments | Phonoangiographic spectral analysing apparatus |
-
1988
- 1988-11-02 GB GB888825611A patent/GB8825611D0/en active Pending
-
1989
- 1989-11-01 JP JP51169189A patent/JPH03503498A/en active Pending
- 1989-11-01 GB GB8924637A patent/GB2225948B/en not_active Expired - Lifetime
- 1989-11-01 WO PCT/GB1989/001306 patent/WO1990004945A1/en not_active Application Discontinuation
- 1989-11-01 EP EP19890912642 patent/EP0396712A1/en not_active Withdrawn
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6887208B2 (en) | 2002-01-10 | 2005-05-03 | Deepbreeze Ltd. | Method and system for analyzing respiratory tract sounds |
US7517319B2 (en) | 2003-06-02 | 2009-04-14 | Deepbreeze Ltd. | Method and system for analyzing cardiovascular sounds |
Also Published As
Publication number | Publication date |
---|---|
GB2225948B (en) | 1992-12-02 |
GB8924637D0 (en) | 1989-12-20 |
WO1990004945A1 (en) | 1990-05-17 |
JPH03503498A (en) | 1991-08-08 |
GB8825611D0 (en) | 1988-12-07 |
EP0396712A1 (en) | 1990-11-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1740095B1 (en) | Non-invasive monitoring of respiratory rate | |
US5301679A (en) | Method and system for analysis of body sounds | |
Pasterkamp et al. | Digital respirosonography: new images of lung sounds | |
Fenton et al. | Automated spectral characterization of wheezing in asthmatic children | |
US6342039B1 (en) | Microprocessor system for the simplified diagnosis of sleep apnea | |
Charbonneau et al. | An accurate recording system and its use in breath sounds spectral analysis | |
IL93587A (en) | Analysis of swallowing dysfunction | |
WO2003055395A1 (en) | Analysis of acoustic medical signals | |
JPH06501865A (en) | Monitoring depth of anesthesia | |
GB2225948A (en) | Respiratory condition diagnosis and apparatus therefor. | |
CN109788933A (en) | Utilize the system and method for ultrasonic monitoring tracheae interior air-flow | |
Sovijärvi et al. | A new versatile PC-based lung sound analyzer with automatic crackle analysis (HeLSA); repeatability of spectral parameters and sound amplitude in healthy subjects | |
Jabloun et al. | A generating model of realistic synthetic heart sounds for performance assessment of phonocardiogram processing algorithms | |
Akay et al. | Investigating the effects of vasodilator drugs on the turbulent sound caused by femoral artery stenosis using short-term Fourier and wavelet transform methods | |
Kaniusas et al. | Acoustical signal properties for cardiac/respiratory activity and apneas | |
Beck et al. | The Reproducibility of Forced Expiratory Wheezes1-3 | |
MXPA01011471A (en) | Noninvasive monitoring of intracranial pressure. | |
Dupuis et al. | Combined detection of respiratory and cardiac rhythm disorders by high-resolution differential cuff pressure measurement | |
Solomon et al. | Fundamental frequency and tracheal pressure during three types of vocalizations elicited from anesthetized dogs | |
Oud et al. | Spirometry and forced oscillometry assisted optimal frequency band determination for the computerized analysis of tracheal lung sounds in asthma | |
Gan et al. | Contactless respiration rate measurement using optical method and empirical mode decomposition | |
Naufal et al. | Advancement on automatic blood pressure measurement using auscultatory method: A literature review | |
Muthusamy et al. | An overview of respiratory airflow estimation techniques: Acoustic vs non-acoustic | |
Johnson et al. | Airflow perturbation device for measuring airways resistance of humans and animals | |
Oliynik | Time-domain fragment-similarity processing of the auscultation records for detection of their periodic components |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19931101 |