GB201112718D0 - Methods - Google Patents

Methods

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Publication number
GB201112718D0
GB201112718D0 GB201112718A GB201112718A GB201112718D0 GB 201112718 D0 GB201112718 D0 GB 201112718D0 GB 201112718 A GB201112718 A GB 201112718A GB 201112718 A GB201112718 A GB 201112718A GB 201112718 D0 GB201112718 D0 GB 201112718D0
Authority
GB
United Kingdom
Prior art keywords
inhibiting
reducing
methods
inflammation
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201112718A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Priority to GB201112718A priority Critical patent/GB201112718D0/en
Publication of GB201112718D0 publication Critical patent/GB201112718D0/en
Priority to PCT/GB2012/000605 priority patent/WO2013014405A2/en
Ceased legal-status Critical Current

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)

Abstract

The invention relates to methods of inhibiting inflammation in a system comprising reducing or inhibiting CD63 in said system, wherein said inflammation is IgE-negative. The invention also relates to methods for inhibiting leukocyte recruitment in a system, inhibiting leukocyte rolling in a system, or inhibiting leukocyte extravasation in a system comprising reducing or inhibiting CD63 in said system. The invention also provides a method of reducing P-selectin levels comprising reducing or inhibiting CD63, and a method of reducing P-selectin clustering comprising reducing or inhibiting CD63.
GB201112718A 2011-07-22 2011-07-22 Methods Ceased GB201112718D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB201112718A GB201112718D0 (en) 2011-07-22 2011-07-22 Methods
PCT/GB2012/000605 WO2013014405A2 (en) 2011-07-22 2012-07-20 Methods

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201112718A GB201112718D0 (en) 2011-07-22 2011-07-22 Methods

Publications (1)

Publication Number Publication Date
GB201112718D0 true GB201112718D0 (en) 2011-09-07

Family

ID=44652232

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201112718A Ceased GB201112718D0 (en) 2011-07-22 2011-07-22 Methods

Country Status (2)

Country Link
GB (1) GB201112718D0 (en)
WO (1) WO2013014405A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3454943A4 (en) * 2016-05-11 2020-01-15 Leuvas Therapeutics Blockade of tim-1 pathways and p-selectin pathways in treatment of neuroinflammatory degenerative disease
US20190388548A1 (en) * 2018-06-26 2019-12-26 Tzu Chi University Method for providing ocular neuroprotection or for preventing, treating or alleviating the effects of, an ocular disease associated with retinal ganglion cell death
JP2023547026A (en) 2020-09-10 2023-11-09 バスキュラー バイオジェニックス リミテッド Motile sperm domain-containing protein 2 antibody and its use
EP4313146A1 (en) * 2021-03-29 2024-02-07 ImmuneWalk Therapeutics, Inc. Motile sperm domain containing protein 2, integrin beta2 and cd63

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
WO2005007695A2 (en) 2003-07-14 2005-01-27 Beth Israel Deaconess Medical Center, Inc. Anti-cd63 antibodies and methods of use thereof
WO2007117432A2 (en) * 2006-03-30 2007-10-18 The Regents Of The University Of Michigan Methods and compositions for modulating angiogenesis and tumor growth
WO2011029823A1 (en) * 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells

Also Published As

Publication number Publication date
WO2013014405A3 (en) 2013-05-30
WO2013014405A2 (en) 2013-01-31

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)