GB201021979D0 - New compound - Google Patents
New compoundInfo
- Publication number
- GB201021979D0 GB201021979D0 GB201021979A GB201021979A GB201021979D0 GB 201021979 D0 GB201021979 D0 GB 201021979D0 GB 201021979 A GB201021979 A GB 201021979A GB 201021979 A GB201021979 A GB 201021979A GB 201021979 D0 GB201021979 D0 GB 201021979D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- inhibitor
- antagonist
- agonist
- receptor
- ccr1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Butyl-N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)-3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-5 oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCR1 antagonist; a chemokine antagonist (not CCR1); a corticosteroid; a CRTh2 antagonist; a DP1 antagonist; an Histone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a PDE4 inhibitor; a PPAR? agonist; a protease inhibitor; a p38 inhibitor, a selective glucocorticoid receptor agonist (SEGRA), a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201021979A GB201021979D0 (en) | 2010-12-23 | 2010-12-23 | New compound |
PCT/GB2011/052560 WO2012085583A1 (en) | 2010-12-23 | 2011-12-22 | New compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201021979A GB201021979D0 (en) | 2010-12-23 | 2010-12-23 | New compound |
Publications (1)
Publication Number | Publication Date |
---|---|
GB201021979D0 true GB201021979D0 (en) | 2011-02-02 |
Family
ID=43599002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB201021979A Ceased GB201021979D0 (en) | 2010-12-23 | 2010-12-23 | New compound |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB201021979D0 (en) |
WO (1) | WO2012085583A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20110083U1 (en) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | PLATE FOR THE CONSTRUCTION OF TRUCKS FOR AIRPLANES |
EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
BR112015013628A2 (en) | 2012-12-18 | 2017-07-11 | Almirall Sa | cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
TWI643853B (en) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES |
TWI641373B (en) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES |
TW201517906A (en) | 2013-07-25 | 2015-05-16 | Almirall Sa | Combinations comprising MABA compounds and corticosteroids |
TW201617343A (en) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | New bicyclic derivatives having [beta]2 adrenergic agonist and M3 muscarinic antagonist activities |
CN109195975B (en) * | 2016-09-30 | 2022-01-04 | 四川海思科制药有限公司 | Diazaspiro [5.5] undecane derivative and application thereof |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB432097A (en) | 1935-03-28 | 1935-07-19 | John Rea Chance | Improvements in brackets for the handles of perambulators |
CN1390255A (en) | 1999-11-24 | 2003-01-08 | 武田药品工业株式会社 | Use of disease-associated gene |
DE60030768T2 (en) | 1999-12-24 | 2007-11-08 | F. Hoffmann-La Roche Ag | NITRIL DERIVATIVES AS CATHEPSIN K HEMMER |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
CO5300399A1 (en) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | HETEROCICLIOCS CONTAINING NITROGEN, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
AR028948A1 (en) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | NEW COMPOUNDS |
AU2001281255B2 (en) | 2000-08-14 | 2006-07-20 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
SE0100902D0 (en) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0102617D0 (en) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102616D0 (en) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0104251D0 (en) | 2001-12-14 | 2001-12-14 | Astrazeneca Ab | Novel compounds |
SE0104331D0 (en) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Novel compounds |
AR038703A1 (en) | 2002-02-28 | 2005-01-26 | Novartis Ag | DERIVATIVES OF 5-PHENYLTIAZOL AND USE AS AN INHIBITOR OF QUINASA P I 3 |
AR039385A1 (en) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | THIOXANTINE DERIVATIVES AS INHIBITORS OF MIELOPEROXIDASA |
SE0300091D0 (en) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (en) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0301010D0 (en) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
SE0301569D0 (en) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
CN1835942A (en) | 2003-06-19 | 2006-09-20 | 金纳莱公司 | Mucin synthesis inhibitors |
EP1644326B1 (en) | 2003-06-30 | 2016-11-02 | Merck Canada Inc. | Cathepsin cysteine protease inhibitors |
SE0301963D0 (en) | 2003-07-02 | 2003-07-02 | Astrazeneca Ab | New compounds |
SA04250253B1 (en) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | Substiuted phenoxacetic as pharmaceutced compunds for treating respiratory diseases such as asthma and copd |
SE0302486D0 (en) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
DE602004031037D1 (en) | 2003-11-19 | 2011-02-24 | Array Biopharma Inc | HETEROCYCLIC INHIBITORS OF MEK |
MXPA06012829A (en) | 2004-05-04 | 2007-01-26 | Warner Lambert Co | Pyrrolyl substituted pyrido[2,3-d]pyrimidin-7-ones and derivatives thereof as therapeutic agents. |
SE0401762D0 (en) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
PL1831149T3 (en) | 2004-12-23 | 2012-06-29 | Galderma Res & Dev | Novel ligands that modulate rar receptors and use thereof in human medicine and in cosmetics |
WO2006091112A1 (en) | 2005-02-22 | 2006-08-31 | Genesis Reasearch And Development Corporation Limited | Compositions for the delivery of rna interference molecules and methods for their use |
US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
CA2635830A1 (en) | 2006-01-23 | 2007-07-26 | Laboratoires Serono S.A. | Thiazole derivatives and use thereof |
UY30267A1 (en) | 2006-04-13 | 2007-11-30 | Astrazeneca Ab | NEW DERIVATIVES OF THIOXANTINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PREPARATION PROCEDURES AND APPLICATIONS |
WO2007123939A2 (en) | 2006-04-19 | 2007-11-01 | Laboratoires Serono S.A. | Novel arylamino n-heteraryls as mek inhibitors |
TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
EP2032597A2 (en) | 2006-06-16 | 2009-03-11 | UMC Utrecht Holding B.V. | Fplr-1 inhibitors for use in diseases involving amyloid-induced inflammatory events (flipr and flipr-like) and immunecomplex-mediated diseases |
WO2008010765A1 (en) | 2006-07-19 | 2008-01-24 | Astrazeneca Ab | Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity |
JP2010502739A (en) | 2006-09-07 | 2010-01-28 | パリオン・サイエンシィズ・インコーポレーテッド | Improvement of mucosal hydration and mucus clearance by treatment with sodium channel inhibitors and osmotic regulators |
WO2008064136A2 (en) | 2006-11-17 | 2008-05-29 | Acadia Pharmaceuticals Inc. | Compounds with activity at retinoic acid receptors |
SE0602739L (en) | 2006-12-18 | 2008-03-25 | Nilar Int Ab | A system for reducing power in a battery stack arrangement, and a vehicle equipped with such a system |
JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Indazolyl amide derivatives for the treatment of glucocorticoid receptor mediated disorders |
SA08280783B1 (en) | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | Pyridopyrimidine Derivatives as PDE4 Inhibitors |
CN101842361B (en) | 2007-06-27 | 2013-06-05 | 阿斯利康(瑞典)有限公司 | Pyrazinone derivatives and their use in the treatment of lung diseases |
NZ584160A (en) | 2007-10-04 | 2011-05-27 | Astrazeneca Ab | Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity |
TWI445705B (en) | 2008-05-20 | 2014-07-21 | Astrazeneca Ab | Phenyl and benzodioxinyl substituted indazoles derivatives |
GB0913342D0 (en) * | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
-
2010
- 2010-12-23 GB GB201021979A patent/GB201021979D0/en not_active Ceased
-
2011
- 2011-12-22 WO PCT/GB2011/052560 patent/WO2012085583A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2012085583A1 (en) | 2012-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AT | Applications terminated before publication under section 16(1) |