GB1486832A - Prostanoic acid derivatives - Google Patents

Prostanoic acid derivatives

Info

Publication number
GB1486832A
GB1486832A GB34334/74A GB3433474A GB1486832A GB 1486832 A GB1486832 A GB 1486832A GB 34334/74 A GB34334/74 A GB 34334/74A GB 3433474 A GB3433474 A GB 3433474A GB 1486832 A GB1486832 A GB 1486832A
Authority
GB
United Kingdom
Prior art keywords
alkoxy
vinylene
alkylidene
pharmaceutically
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34334/74A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB34334/74A priority Critical patent/GB1486832A/en
Priority to IE1550/75A priority patent/IE43198B1/en
Priority to ZA00754491A priority patent/ZA754491B/en
Priority to CA231,547A priority patent/CA1067490A/en
Priority to AU83102/75A priority patent/AU502146B2/en
Priority to IN1391/CAL/75A priority patent/IN141386B/en
Priority to NL7509078A priority patent/NL7509078A/en
Priority to FI752196A priority patent/FI752196A/fi
Priority to BE158923A priority patent/BE832098A/en
Priority to SE7508779A priority patent/SE7508779L/en
Priority to NO752734A priority patent/NO752734L/no
Priority to FR7524249A priority patent/FR2281101A1/en
Priority to DK354575A priority patent/DK354575A/en
Priority to DD187691A priority patent/DD124595A5/xx
Priority to DE19752534989 priority patent/DE2534989A1/en
Priority to JP50095328A priority patent/JPS51125042A/en
Priority to AT606175A priority patent/ATA606175A/en
Publication of GB1486832A publication Critical patent/GB1486832A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1486832 Compositions containing prostaglandins IMPERIAL CHEMICAL INDUSTRIES Ltd 7 July 1975 [5 Aug 1974] 34334/74 Heading A5B [Also in Divisions C2 and C3] Pharmaceutically and veterinary compositions in a form suitable for oral, parenteral, rectal, vaginal administration or for inhalation, contain prostaglandins of the formula I wherein either R' is carboxy hydroxymethyl or (C 1-10 alkoxy) carbonyl, R<SP>4</SP> is OH and R<SP>5</SP> is H 1 or R<SP>1</SP> is carboxy or (C 1-10 alkoxy) carbonyl and R<SP>4</SP> and R<SP>5</SP> together form an oxo radical; R<SP>2</SP> is OH or C 1-4 alkoxy; Y is ethylene or trans-vinylene, either A is ethylene or vinylene and X is C 1-6 alkylidene-oxy wherein the alkylidene is bonded to CHR and the oxygen is bonded to R<SP>3</SP>, or C 1-6 alkylidene, or A is vinylene and X is a direct bond; and R<SP>3</SP> is phenyl or naphthyl optionally substituted by one or two halogen atoms, NO2, OH, CF 3 , phenyl, C 1-5 alkyl, di(C 1-5 alkyl) amino, C 2-5 alkenyl or C 1-5 alkoxy radicals, or for these compounds wherein R' is carboxy the pharmaceutically or veterinary acceptable salts thereof together with pharmaceutically or veterinarily acceptable diluents or carriers. The compounds may be used in combination, or concurrently with uterine stimulants, for example, oxytosin, or gonadotrophins, for example pregnant mare serum gonadotrophin or human chorionic gonadotrophin. The compounds are used in the induction of labour, the control of the oestrus cycle, as contraceptives, as hypotensives, for the relief of bronchospasm, or as inhibitors of gastric secretion or blood platelet aggregation.
GB34334/74A 1974-08-05 1974-08-05 Prostanoic acid derivatives Expired GB1486832A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB34334/74A GB1486832A (en) 1974-08-05 1974-08-05 Prostanoic acid derivatives
IE1550/75A IE43198B1 (en) 1974-08-05 1975-07-11 Prostanoic acid derivatives
ZA00754491A ZA754491B (en) 1974-08-05 1975-07-14 Prostanoic acid derivatives
CA231,547A CA1067490A (en) 1974-08-05 1975-07-15 Prostanoic acid derivatives
AU83102/75A AU502146B2 (en) 1974-08-05 1975-07-16 11-epi-prostanoic acid derivatives
IN1391/CAL/75A IN141386B (en) 1974-08-05 1975-07-16
NL7509078A NL7509078A (en) 1974-08-05 1975-07-30 PROCESS FOR THE PREPARATION OF PROSTANIC ACID DERIVATIVES.
FI752196A FI752196A (en) 1974-08-05 1975-07-31
BE158923A BE832098A (en) 1974-08-05 1975-08-04 PROSTANOIC ACID DERIVATIVES
SE7508779A SE7508779L (en) 1974-08-05 1975-08-04 WAY TO PRODUCE PROSTANIC ACID DERIVATIVES
NO752734A NO752734L (en) 1974-08-05 1975-08-04
FR7524249A FR2281101A1 (en) 1974-08-05 1975-08-04 PROSTANOIC ACID DERIVATIVES
DK354575A DK354575A (en) 1974-08-05 1975-08-05 PROSTANIC ACID DERIVATIVES
DD187691A DD124595A5 (en) 1974-08-05 1975-08-05
DE19752534989 DE2534989A1 (en) 1974-08-05 1975-08-05 PROSTANIC ACID DERIVATIVES
JP50095328A JPS51125042A (en) 1974-08-05 1975-08-05 Process for manufacture of 111epiiprostanic acid derivatives
AT606175A ATA606175A (en) 1974-08-05 1975-08-05 METHOD FOR PRODUCING NEW PROSTANIC ACID DERIVATIVES AND THEIR SALTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB34334/74A GB1486832A (en) 1974-08-05 1974-08-05 Prostanoic acid derivatives

Publications (1)

Publication Number Publication Date
GB1486832A true GB1486832A (en) 1977-09-28

Family

ID=10364354

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34334/74A Expired GB1486832A (en) 1974-08-05 1974-08-05 Prostanoic acid derivatives

Country Status (17)

Country Link
JP (1) JPS51125042A (en)
AT (1) ATA606175A (en)
AU (1) AU502146B2 (en)
BE (1) BE832098A (en)
CA (1) CA1067490A (en)
DD (1) DD124595A5 (en)
DE (1) DE2534989A1 (en)
DK (1) DK354575A (en)
FI (1) FI752196A (en)
FR (1) FR2281101A1 (en)
GB (1) GB1486832A (en)
IE (1) IE43198B1 (en)
IN (1) IN141386B (en)
NL (1) NL7509078A (en)
NO (1) NO752734L (en)
SE (1) SE7508779L (en)
ZA (1) ZA754491B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2197787A (en) * 1986-10-22 1988-06-02 Glaxo Group Ltd Anti-inflammatory compositions
US5889052A (en) * 1993-08-03 1999-03-30 Alcon Laboraties, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US6184250B1 (en) 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554030A (en) * 1976-05-10 1979-10-17 Upjohn Co Prostaglandins
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5688819A (en) * 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2197787A (en) * 1986-10-22 1988-06-02 Glaxo Group Ltd Anti-inflammatory compositions
US4855293A (en) * 1986-10-22 1989-08-08 Glaxo Group Limited Anti-inflammatory compositions comprising a systemic non-steroidal anti-inflammatory drug and a cyclopentyl ether
GB2197787B (en) * 1986-10-22 1990-11-21 Glaxo Group Ltd Anti-inflammatory compositions
US5889052A (en) * 1993-08-03 1999-03-30 Alcon Laboraties, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US6184250B1 (en) 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US6344478B2 (en) 1993-08-03 2002-02-05 Alcon Manufacturing, Ltd. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US6723748B2 (en) 1993-08-03 2004-04-20 Alcon Manufacturing, Ltd. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension

Also Published As

Publication number Publication date
FI752196A (en) 1976-02-06
SE7508779L (en) 1976-02-06
NL7509078A (en) 1976-02-09
IE43198B1 (en) 1981-01-14
NO752734L (en) 1976-02-06
ZA754491B (en) 1976-06-30
FR2281101A1 (en) 1976-03-05
IE43198L (en) 1976-02-05
BE832098A (en) 1976-02-04
DD124595A5 (en) 1977-03-02
JPS51125042A (en) 1976-11-01
IN141386B (en) 1977-02-19
AU502146B2 (en) 1979-07-12
DK354575A (en) 1976-02-06
AU8310275A (en) 1977-01-20
ATA606175A (en) 1978-05-15
FR2281101B1 (en) 1978-11-10
CA1067490A (en) 1979-12-04
DE2534989A1 (en) 1976-02-26

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee