GB1393654A - Cell vaccine production - Google Patents

Cell vaccine production

Info

Publication number
GB1393654A
GB1393654A GB2763673A GB2763673A GB1393654A GB 1393654 A GB1393654 A GB 1393654A GB 2763673 A GB2763673 A GB 2763673A GB 2763673 A GB2763673 A GB 2763673A GB 1393654 A GB1393654 A GB 1393654A
Authority
GB
United Kingdom
Prior art keywords
plates
cells
tank
inches
june
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2763673A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1393654A publication Critical patent/GB1393654A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06—Plates; Walls; Drawers; Multilayer plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/14—Rotation or movement of the cells support, e.g. rotated hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18461—Methods of inactivation or attenuation
    • C12N2760/18464—Methods of inactivation or attenuation by serial passage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

1393654 Making viral vaccines MERCK & CO INC 11 June 1973 [14 June 1972] 27636/73 Heading A5B [Also in Divisions Bl and C6] In a process for the production of cells and/ or vaccines cells are grown and/or infected with virus in a rotary multiplate propagator which comprises a cylindrical tank 2 and a plurality of plates 19 mounted normally to the axis of the cylindrical tank and rotatable thereabout, the plate and tank diameters being in the ratio 0.8:1 to 0.9:1. Preferably the surface area to volume ratio of the apparatus lies between 5.5:1 and 6.0:1. The tank may be of stainless steel, and the plates of titanium, and typical diameters are 7“ inches and 6 inches or 6 inches and 5.4 inches respectively. Drive to the shaft 20 on which the plates are mounted includes a magnetic coupling 25, 26 and the tank is provided with inlet and outlet connections for supply and egress of air or air/CO 2 mixture, culture medium and product or spent liquor. Coating of the plates with cells is effected with the apparatus placed with its axis vertical and the apparatus may be inverted to ensure coating of both sides of the plates. Cell growth or infection of cells grown on the plates is carried out with the apparatus horizontal, about half full of liquid medium and with the plates rotating e.g. at about 1/5 r.p.m. Reference is made and examples given relating to production of viral vaccines such as mumps, measles, rubella, Marek's, influenza, parainfluenza, varicella, trachoma, and respiratory syncytia and cells such as WI-38, chick embryo and duck embryo cells.
GB2763673A 1972-06-14 1973-06-11 Cell vaccine production Expired GB1393654A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26282572A 1972-06-14 1972-06-14

Publications (1)

Publication Number Publication Date
GB1393654A true GB1393654A (en) 1975-05-07

Family

ID=22999223

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2763673A Expired GB1393654A (en) 1972-06-14 1973-06-11 Cell vaccine production

Country Status (6)

Country Link
JP (1) JPS4955524A (en)
BR (1) BR7304428D0 (en)
ES (1) ES415570A1 (en)
GB (1) GB1393654A (en)
IE (1) IE37741B1 (en)
NL (1) NL7307143A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2352883A1 (en) * 1976-05-28 1977-12-23 Rentschler Arzneimittel PROCESS FOR CELL MASS CULTURE AND DEVICE OF CHAMBERS FOR ITS EXECUTION
FR2463806A1 (en) * 1979-08-24 1981-02-27 Searle & Co PROCESS FOR CULTURING CELLS ON MULTIPLE STACKED PLATES
GB2405641A (en) * 2003-09-04 2005-03-09 Hygiene Technik Inc Automated biological growth and dispensing system
DE102010005415A1 (en) * 2010-01-22 2011-07-28 Zellwerk GmbH, 16727 Dynamic breeding, proliferation and/or differentiation of suspended primary or stem cells of human and animal origins, comprises adhering cells on cell carrier in rotating bed-bioreactor and breading by alternating movement of cell carrier
US8206973B2 (en) 2003-09-04 2012-06-26 Gotohti.Com Inc Automated biological growth and dispensing system
WO2017158611A1 (en) 2016-03-14 2017-09-21 Patel Ravindrakumar Dhirubhai A bioreactor system and method thereof

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2352883A1 (en) * 1976-05-28 1977-12-23 Rentschler Arzneimittel PROCESS FOR CELL MASS CULTURE AND DEVICE OF CHAMBERS FOR ITS EXECUTION
FR2463806A1 (en) * 1979-08-24 1981-02-27 Searle & Co PROCESS FOR CULTURING CELLS ON MULTIPLE STACKED PLATES
GB2405641A (en) * 2003-09-04 2005-03-09 Hygiene Technik Inc Automated biological growth and dispensing system
GB2405641B (en) * 2003-09-04 2008-03-26 Hygiene Technik Inc Automated biological growth and dispensing system
US8206973B2 (en) 2003-09-04 2012-06-26 Gotohti.Com Inc Automated biological growth and dispensing system
US9816067B2 (en) 2003-09-04 2017-11-14 Op-Hygiene Ip Gmbh Automated biological growth and dispensing apparatus
DE102010005415A1 (en) * 2010-01-22 2011-07-28 Zellwerk GmbH, 16727 Dynamic breeding, proliferation and/or differentiation of suspended primary or stem cells of human and animal origins, comprises adhering cells on cell carrier in rotating bed-bioreactor and breading by alternating movement of cell carrier
DE102010005415B4 (en) * 2010-01-22 2015-07-16 Zellwerk Gmbh Method and device for the dynamic expansion and / or differentiation of suspended primary cells or stem cells of human and animal origin
WO2017158611A1 (en) 2016-03-14 2017-09-21 Patel Ravindrakumar Dhirubhai A bioreactor system and method thereof
US11365382B2 (en) 2016-03-14 2022-06-21 Omnibrx Biotechnologies Private Limited Bioreactor system and method thereof

Also Published As

Publication number Publication date
IE37741L (en) 1973-12-14
ES415570A1 (en) 1976-06-16
JPS4955524A (en) 1974-05-29
NL7307143A (en) 1973-12-18
IE37741B1 (en) 1977-09-28
BR7304428D0 (en) 1974-08-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee