GB1354939A - Process for the manufacture of 1,1,2-triphenylalk-1-enes - Google Patents

Process for the manufacture of 1,1,2-triphenylalk-1-enes

Info

Publication number
GB1354939A
GB1354939A GB1354939DA GB1354939A GB 1354939 A GB1354939 A GB 1354939A GB 1354939D A GB1354939D A GB 1354939DA GB 1354939 A GB1354939 A GB 1354939A
Authority
GB
United Kingdom
Prior art keywords
formula
prepared
triphenylalk
enes
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of GB1354939A publication Critical patent/GB1354939A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • C07C39/215—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring containing, e.g. diethylstilbestrol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1354939 Tertiaryamino-alkoxy-phenylacetonitriles and 1,1,2 - triphenylalk - 1 - enes IMPERIAL CHEMICAL INDUSTRIES Ltd 23 Aug 1972 [28 Oct 1971] 50132/71 Heading C2C Novel compounds of Formula II wherein R<SP>1</SP>, R<SP>2</SP> and R<SP>5</SP> are methyl or ethyl, R<SP>3</SP> and R<SP>4</SP> are phenyl and A is C 2-4 alkylene, are prepared by reaction of a 1-halo-1-phenylalkane with a novel compound of formula which is prepared by reacting the amine R<SP>1</SP>.R<SP>2</SP>.N.A-Halogen with (4 - hydroxyphenyl) phenylacetonitrile obtained as in Specification 1,354,940. Compounds of Formula I are prepared from the above compounds of Formula II by treatment with an alkali metal amide.
GB1354939D 1971-10-28 1971-10-28 Process for the manufacture of 1,1,2-triphenylalk-1-enes Expired GB1354939A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5013271 1971-10-28

Publications (1)

Publication Number Publication Date
GB1354939A true GB1354939A (en) 1974-06-05

Family

ID=10454788

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1354939D Expired GB1354939A (en) 1971-10-28 1971-10-28 Process for the manufacture of 1,1,2-triphenylalk-1-enes

Country Status (2)

Country Link
DE (1) DE2252879A1 (en)
GB (1) GB1354939A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077428A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8293767B2 (en) 2005-01-21 2012-10-23 Astex Therapeutics Limited 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
US8779147B2 (en) 2003-07-22 2014-07-15 Astex Therapeutics, Ltd. 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8779147B2 (en) 2003-07-22 2014-07-15 Astex Therapeutics, Ltd. 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators
US9051278B2 (en) 2003-07-22 2015-06-09 Astex Therapeutics, Ltd. 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinase and glycogen synthase kinase-3 modulators
WO2006077428A1 (en) 2005-01-21 2006-07-27 Astex Therapeutics Limited Pharmaceutical compounds
US8293767B2 (en) 2005-01-21 2012-10-23 Astex Therapeutics Limited 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations

Also Published As

Publication number Publication date
DE2252879A1 (en) 1973-05-03

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Legal Events

Date Code Title Description
PS Patent sealed