GB1297991A - - Google Patents

Info

Publication number
GB1297991A
GB1297991A GB1297991DA GB1297991A GB 1297991 A GB1297991 A GB 1297991A GB 1297991D A GB1297991D A GB 1297991DA GB 1297991 A GB1297991 A GB 1297991A
Authority
GB
United Kingdom
Prior art keywords
output
generator
blood pressure
signal
pulse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1297991A publication Critical patent/GB1297991A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A61N1/36564—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension

Abstract

1297991 Apparatus for influencing blood pressure LKB MEDICAL AB 17 Feb 1970 [24 Feb 1969] 7643/70 Heading ASR [Also in Division G3] Apparatus for influencing the blood-pressure regulatory system of a patient comprises an electrode 5 or 6 for application on or close to an afferent nerve from a baroreceptor, a transducer 8 operative to give an output signal substantially representing the instantaneous arterial blood pressure, signal-transforming means, 10 to 14, receiving said output signal and providing an output signal including a component proportional to the mean value of the transducer output and permissably but not necessarily including a component proportional to the time-derivative of the transducer output, and a frequency-controlled pulse generator 7 receiving the output of the signal-transforming means as a frequency-control signal for generating output pulses with a pulse-repetition rate proportional to the magnitude of the output of the signal-transforming means, the generator output being applied to said electrode. The outputs from circuits 10 and 11 of the signaltransforming means are fed via variable circuit elements, for example potentiometers, 12, 14 respectively, to a summing circuit 13 supplying the control signal for a pulse generator 7. Generator 7 has two outputs feeding pulse series to electrodes 5, 6, one output of generator 7 being delayed relative to the other by a time less than the shortest interval between two successive pulses in a pulse series. The pulse series have a mean p.r.f. determined by the mean blood pressure and a modulation of the p.r.f. determined by the time derivative of the blood pressure. Generator 7 has a threshold level for the control signal, below which no pulses are generated, corresponding to a constant blood pressure of about 40-50 mm. Hg. The p.r.f. range of the pulse series is 0-300 Hz, generator 7 becoming "saturated" at the upper p.r.f. when a control signal corresponding to a constant blood pressure in excess of about 250-300 mm. Hg. is received. The device is preferably used to reduce blood pressure in hypertensive patients, the p.r.f. of the pulse series increasing to a maximum value during an initial relatively short portion of the duration of each pulse series and thereafter decreasing continuously. The two electrodes 5, 6 and the transducer 8 may be implanted, being coupled to external circuitry by wires, or inductively. Alternatively, the whole device, including inductively-rechargeable batteries, may be implanted.
GB1297991D 1969-02-24 1970-02-17 Expired GB1297991A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE02528/69A SE346468B (en) 1969-02-24 1969-02-24

Publications (1)

Publication Number Publication Date
GB1297991A true GB1297991A (en) 1972-11-29

Family

ID=20260112

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1297991D Expired GB1297991A (en) 1969-02-24 1970-02-17

Country Status (7)

Country Link
US (1) US3650277A (en)
JP (1) JPS4915438B1 (en)
DE (1) DE2008316A1 (en)
FR (1) FR2032996A5 (en)
GB (1) GB1297991A (en)
NO (1) NO126300B (en)
SE (1) SE346468B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
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EP0277314A1 (en) * 1986-12-04 1988-08-10 Robert Tapper Electrical dosimetry control system
US7869881B2 (en) 2003-12-24 2011-01-11 Cardiac Pacemakers, Inc. Baroreflex stimulator with integrated pressure sensor
US8024050B2 (en) 2003-12-24 2011-09-20 Cardiac Pacemakers, Inc. Lead for stimulating the baroreceptors in the pulmonary artery
US8126560B2 (en) 2003-12-24 2012-02-28 Cardiac Pacemakers, Inc. Stimulation lead for stimulating the baroreceptors in the pulmonary artery
US8660648B2 (en) 2005-10-24 2014-02-25 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator

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DE2008316A1 (en) 1971-02-11
NO126300B (en) 1973-01-22
US3650277A (en) 1972-03-21
FR2032996A5 (en) 1970-11-27
SE346468B (en) 1972-07-10
JPS4915438B1 (en) 1974-04-15

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