GB1270841A - Benzothiazoline derivatives - Google Patents

Benzothiazoline derivatives

Info

Publication number
GB1270841A
GB1270841A GB1654869A GB1654869A GB1270841A GB 1270841 A GB1270841 A GB 1270841A GB 1654869 A GB1654869 A GB 1654869A GB 1654869 A GB1654869 A GB 1654869A GB 1270841 A GB1270841 A GB 1270841A
Authority
GB
United Kingdom
Prior art keywords
piperazinyl
substituted
compound
dialkyl
appropriate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1654869A
Inventor
Suminori Umio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to GB1654869A priority Critical patent/GB1270841A/en
Publication of GB1270841A publication Critical patent/GB1270841A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,270,841. Benzothiazolinone derivatives. FUJISAWA PHARMACEUTICAL CO. Ltd. 28 March, 1969, No. 16548/69. Heading C2C. Novel compounds I in which A is alkylene; R<SP>1</SP> is halo, CF 3 or alkoxy and R<SP>2</SP> is H while R<SP>3</SP> is 2-[N-methyl-N-(2- hydroxyethyl)amino]ethyl or NR<SP>2</SP>R<SP>3</SP> is 4- hydroxypiperidino; 4 - alkanoyloxy - alkyl - 1- piperazinyl; dialkyl - substituted - 4 - alkoxycarbonylalkyl - 1 - piperazinyl; trialkyl - substituted - 1 - piperazinyl; 4 - alkanoylalkyl - 1- piperazinyl; dialkyl - substituted - 4 - (alkynyl, alkenyl or hydroxyalkyl )- 1 -piperazinyl; 4- benzoyl - 1 - piperazinyl; 4 - phenylalkyl - 1- piperazinyl optionally having two alkoxy groups on the benzene ring; or 4-alkyl-1-homopiperazinyl (dialkyl substituted and trialkyl substituted having the substituent alkyl groups at 2 of the 4 or 3 of the 5 available positions of the piperazine ring are prepared by: (1) reacting an appropriate 3-unsubstituted compound or its metal salt with a compound X-A-CONR<SP>2</SP>R<SP>3</SP> (X = halo); (2) reacting an appropriate 3- carboxyalkyl compound or a salt, acid halide, acid anhydride, amide, ester or azide thereof with an amine HNR<SP>2</SP>R<SP>3</SP>; and (3) by acylation of an appropriate 4-hydroxypiperazino derivative. Pharmaceutical compositions comprise a compound I together with a suitable carrier and have anti-inflammatory and antiarrhythmic activity.
GB1654869A 1969-03-28 1969-03-28 Benzothiazoline derivatives Expired GB1270841A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1654869A GB1270841A (en) 1969-03-28 1969-03-28 Benzothiazoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1654869A GB1270841A (en) 1969-03-28 1969-03-28 Benzothiazoline derivatives

Publications (1)

Publication Number Publication Date
GB1270841A true GB1270841A (en) 1972-04-19

Family

ID=10079303

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1654869A Expired GB1270841A (en) 1969-03-28 1969-03-28 Benzothiazoline derivatives

Country Status (1)

Country Link
GB (1) GB1270841A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022317A1 (en) * 1979-06-12 1981-01-14 Fujisawa Pharmaceutical Co., Ltd. 2-Oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives
EP0232740A1 (en) * 1986-01-17 1987-08-19 Fujisawa Pharmaceutical Co., Ltd. N-containing fused heterocyclic compounds, processes for the preparation thereof and pharmaceutical compositions comprising the same
DE19618970A1 (en) * 1996-05-10 1997-11-13 Klinge Co Chem Pharm Fab New thiazolopyridines

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0022317A1 (en) * 1979-06-12 1981-01-14 Fujisawa Pharmaceutical Co., Ltd. 2-Oxo-benzothiazoline, benzoxazoline or indoline derivatives, their preparation, and pharmaceutical compositions comprising such derivatives
EP0232740A1 (en) * 1986-01-17 1987-08-19 Fujisawa Pharmaceutical Co., Ltd. N-containing fused heterocyclic compounds, processes for the preparation thereof and pharmaceutical compositions comprising the same
US4797399A (en) * 1986-01-17 1989-01-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine compounds and antithrombotic pharmaceutical composition comprising the same
DE19618970A1 (en) * 1996-05-10 1997-11-13 Klinge Co Chem Pharm Fab New thiazolopyridines

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