FR2884820B1 - Nouveaux inhibiteurs specifiques de la caspase-10 - Google Patents

Nouveaux inhibiteurs specifiques de la caspase-10

Info

Publication number
FR2884820B1
FR2884820B1 FR0504134A FR0504134A FR2884820B1 FR 2884820 B1 FR2884820 B1 FR 2884820B1 FR 0504134 A FR0504134 A FR 0504134A FR 0504134 A FR0504134 A FR 0504134A FR 2884820 B1 FR2884820 B1 FR 2884820B1
Authority
FR
France
Prior art keywords
caspase
specific inhibitors
new specific
new
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0504134A
Other languages
English (en)
Other versions
FR2884820A1 (fr
Inventor
Claude Lardy
Marc Lecomte
Thierry Convard
Catherine Vidal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0504134A priority Critical patent/FR2884820B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to ES06724094T priority patent/ES2362111T3/es
Priority to JP2008508105A priority patent/JP5210153B2/ja
Priority to AT06724094T priority patent/ATE502916T1/de
Priority to CA2605748A priority patent/CA2605748C/fr
Priority to DE602006020855T priority patent/DE602006020855D1/de
Priority to US11/912,461 priority patent/US8357721B2/en
Priority to AU2006239557A priority patent/AU2006239557B2/en
Priority to PCT/EP2006/003149 priority patent/WO2006114190A1/fr
Priority to EP06724094A priority patent/EP1881960B1/fr
Priority to ARP060101575A priority patent/AR053366A1/es
Publication of FR2884820A1 publication Critical patent/FR2884820A1/fr
Application granted granted Critical
Publication of FR2884820B1 publication Critical patent/FR2884820B1/fr
Priority to US13/687,693 priority patent/US20130090385A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/49—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR0504134A 2005-04-25 2005-04-25 Nouveaux inhibiteurs specifiques de la caspase-10 Expired - Fee Related FR2884820B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR0504134A FR2884820B1 (fr) 2005-04-25 2005-04-25 Nouveaux inhibiteurs specifiques de la caspase-10
PCT/EP2006/003149 WO2006114190A1 (fr) 2005-04-25 2006-04-06 Nouveaux inhibiteurs specifiques de la caspase-10
AT06724094T ATE502916T1 (de) 2005-04-25 2006-04-06 Neue spezifische caspase-10-inhibitoren
CA2605748A CA2605748C (fr) 2005-04-25 2006-04-06 Nouveaux inhibiteurs specifiques de la caspase-10
DE602006020855T DE602006020855D1 (de) 2005-04-25 2006-04-06 Neue spezifische caspase-10-inhibitoren
US11/912,461 US8357721B2 (en) 2005-04-25 2006-04-06 Specific caspase-10 inhibitors
ES06724094T ES2362111T3 (es) 2005-04-25 2006-04-06 Nuevos inhibidores específicos de la caspasa-10.
JP2008508105A JP5210153B2 (ja) 2005-04-25 2006-04-06 新規特異的カスパーゼ−１０阻害剤
EP06724094A EP1881960B1 (fr) 2005-04-25 2006-04-06 Nouveaux inhibiteurs specifiques de la caspase-10
AU2006239557A AU2006239557B2 (en) 2005-04-25 2006-04-06 Novel specific caspase-10 inhibitors
ARP060101575A AR053366A1 (es) 2005-04-25 2006-04-21 Derivados de aril - sulfonamidas como inhibidores especificos de caspasa-10, un metodo para su preparacion, composiciones farmaceuticas que los contienen y su uso en la elaboracion de un medicamento para el tratamiento de la retinopatia diabetica.
US13/687,693 US20130090385A1 (en) 2005-04-25 2012-11-28 Novel specific caspase-10 inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0504134A FR2884820B1 (fr) 2005-04-25 2005-04-25 Nouveaux inhibiteurs specifiques de la caspase-10

Publications (2)

Publication Number Publication Date
FR2884820A1 FR2884820A1 (fr) 2006-10-27
FR2884820B1 true FR2884820B1 (fr) 2007-07-27

Family

ID=35431604

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0504134A Expired - Fee Related FR2884820B1 (fr) 2005-04-25 2005-04-25 Nouveaux inhibiteurs specifiques de la caspase-10

Country Status (11)

Country Link
US (2) US8357721B2 (fr)
EP (1) EP1881960B1 (fr)
JP (1) JP5210153B2 (fr)
AR (1) AR053366A1 (fr)
AT (1) ATE502916T1 (fr)
AU (1) AU2006239557B2 (fr)
CA (1) CA2605748C (fr)
DE (1) DE602006020855D1 (fr)
ES (1) ES2362111T3 (fr)
FR (1) FR2884820B1 (fr)
WO (1) WO2006114190A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003209297A1 (en) * 2002-01-18 2003-09-02 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
US9223209B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing photoresist compositions and methods of use
US9223217B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
WO2018234483A1 (fr) * 2017-06-22 2018-12-27 Aaa Chemistry Aps Sondes accordables pour marquage sélectif de protéines et inhibition enzymatique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665440B1 (fr) * 1990-07-31 1994-02-04 Lipha Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant.
NZ331941A (en) * 1996-02-22 2000-04-28 Tularik Inc Pentafluorobenzenesulfonamides and analogs and use in regulation of LDL receptor synthesis
FR2757509B1 (fr) * 1996-12-23 1999-03-26 Lipha Nouveaux derives de sulfonamides et sulfonylurees, leurs preparations et medicaments les contenant
US6379950B1 (en) * 1998-01-09 2002-04-30 Thomas Jefferson University Recombinant, active caspases and uses thereof
US20010006965A1 (en) * 1998-04-17 2001-07-05 Rifat Pamukcu Method for treating patients with diabetic retinopathy by administering substituted sulfonyl indenyl acetic acids and alcohols
FR2815541B1 (fr) * 2000-10-24 2008-02-29 Lipha Utilisation d'inhibiteurs de l'apoptose des pericytes pour le traitement et/ou la prevention de la retinopathie diabetique

Also Published As

Publication number Publication date
US20080182906A1 (en) 2008-07-31
FR2884820A1 (fr) 2006-10-27
EP1881960B1 (fr) 2011-03-23
US20130090385A1 (en) 2013-04-11
DE602006020855D1 (de) 2011-05-05
AU2006239557B2 (en) 2011-11-03
AU2006239557A1 (en) 2006-11-02
CA2605748C (fr) 2014-03-18
JP5210153B2 (ja) 2013-06-12
CA2605748A1 (fr) 2006-11-02
ATE502916T1 (de) 2011-04-15
JP2008538774A (ja) 2008-11-06
EP1881960A1 (fr) 2008-01-30
US8357721B2 (en) 2013-01-22
WO2006114190A1 (fr) 2006-11-02
ES2362111T3 (es) 2011-06-28
AR053366A1 (es) 2007-05-02

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Effective date: 20141231