FR2676072B1 - Vecteur de delivrance d'arn. - Google Patents

Vecteur de delivrance d'arn.

Info

Publication number
FR2676072B1
FR2676072B1 FR919105465A FR9105465A FR2676072B1 FR 2676072 B1 FR2676072 B1 FR 2676072B1 FR 919105465 A FR919105465 A FR 919105465A FR 9105465 A FR9105465 A FR 9105465A FR 2676072 B1 FR2676072 B1 FR 2676072B1
Authority
FR
France
Prior art keywords
delivery vector
rna delivery
rna
vector
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR919105465A
Other languages
English (en)
Other versions
FR2676072A1 (fr
Inventor
Pierre Meulien
Shivadasan Krishnan
Frederic Martinon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Priority to FR919105465A priority Critical patent/FR2676072B1/fr
Priority to EP92910885A priority patent/EP0537326A1/fr
Priority to AU17681/92A priority patent/AU652831B2/en
Priority to CA002086510A priority patent/CA2086510A1/fr
Priority to JP4509832A priority patent/JPH06502998A/ja
Priority to PCT/FR1992/000393 priority patent/WO1992019752A1/fr
Publication of FR2676072A1 publication Critical patent/FR2676072A1/fr
Application granted granted Critical
Publication of FR2676072B1 publication Critical patent/FR2676072B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR919105465A 1991-05-03 1991-05-03 Vecteur de delivrance d'arn. Expired - Fee Related FR2676072B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR919105465A FR2676072B1 (fr) 1991-05-03 1991-05-03 Vecteur de delivrance d'arn.
EP92910885A EP0537326A1 (fr) 1991-05-03 1992-04-30 Vecteur de delivrance d'arn
AU17681/92A AU652831B2 (en) 1991-05-03 1992-04-30 RNA delivery vector
CA002086510A CA2086510A1 (fr) 1991-05-03 1992-04-30 Vecteur de delivrance d'arn
JP4509832A JPH06502998A (ja) 1991-05-03 1992-04-30 Ｒｎａデリバリーベクター
PCT/FR1992/000393 WO1992019752A1 (fr) 1991-05-03 1992-04-30 Vecteur de delivrance d'arn

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR919105465A FR2676072B1 (fr) 1991-05-03 1991-05-03 Vecteur de delivrance d'arn.

Publications (2)

Publication Number Publication Date
FR2676072A1 FR2676072A1 (fr) 1992-11-06
FR2676072B1 true FR2676072B1 (fr) 1994-11-18

Family

ID=9412502

Family Applications (1)

Application Number Title Priority Date Filing Date
FR919105465A Expired - Fee Related FR2676072B1 (fr) 1991-05-03 1991-05-03 Vecteur de delivrance d'arn.

Country Status (6)

Country Link
EP (1) EP0537326A1 (fr)
JP (1) JPH06502998A (fr)
AU (1) AU652831B2 (fr)
CA (1) CA2086510A1 (fr)
FR (1) FR2676072B1 (fr)
WO (1) WO1992019752A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320548D0 (en) * 1993-10-06 1993-11-24 Sandoz Ltd Improvements in or relating to organic compounds
US6472375B1 (en) 1998-04-16 2002-10-29 John Wayne Cancer Institute DNA vaccine and methods for its use
US6432925B1 (en) * 1998-04-16 2002-08-13 John Wayne Cancer Institute RNA cancer vaccine and methods for its use
DE69943068D1 (de) * 1999-09-09 2011-02-03 Curevac Gmbh Transfer von mRNA unter Verwendung von polykationischen Verbindungen
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
WO2012006369A2 (fr) 2010-07-06 2012-01-12 Novartis Ag Immunisation de grands mammifères à l'aide de faibles doses d'arn
CN103153284B (zh) 2010-07-06 2015-11-25 诺华股份有限公司 含有其pKa值有利于RNA递送的脂质的脂质体
HUE058667T2 (hu) 2010-08-31 2022-09-28 Glaxosmithkline Biologicals Sa Pegilált liposzómák immunogént kódoló RNS szállítására
EP2627351B1 (fr) * 2010-10-11 2018-12-26 GlaxoSmithKline Biologicals SA Plateformes de délivrance d'antigènes
US11896636B2 (en) 2011-07-06 2024-02-13 Glaxosmithkline Biologicals Sa Immunogenic combination compositions and uses thereof
EP3052106A4 (fr) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
EP3052521A1 (fr) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucléotides codant pour un récepteur de lipoprotéines de faible densité
HRP20220070T1 (hr) 2014-04-23 2022-04-01 Modernatx, Inc. Cjepiva nukleinske kiseline
EP3324979B1 (fr) 2015-07-21 2022-10-12 ModernaTX, Inc. Vaccins contre une maladie infectieuse
US11364292B2 (en) 2015-07-21 2022-06-21 Modernatx, Inc. CHIKV RNA vaccines
ES2910425T3 (es) 2015-09-17 2022-05-12 Modernatx Inc Compuestos y composiciones para la administración intracelular de agentes terapéuticos
WO2017070624A1 (fr) 2015-10-22 2017-04-27 Modernatx, Inc. Vaccins contre des maladies tropicales
JP6925688B2 (ja) 2015-10-22 2021-08-25 モデルナティーエックス， インコーポレイテッド 水痘帯状疱疹ウイルス（ｖｚｖ）のための核酸ワクチン
JP2018531290A (ja) 2015-10-22 2018-10-25 モデルナティーエックス， インコーポレイテッド 性感染症ワクチン
MX2018004916A (es) * 2015-10-22 2019-07-04 Modernatx Inc Vacuna contra el virus de la influenza de amplio espectro.
RS63051B1 (sr) 2015-12-22 2022-04-29 Modernatx Inc Jedinjenja i kompozicije za intracelularnu isporuku agenasa
US11583504B2 (en) 2016-11-08 2023-02-21 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
US10925958B2 (en) 2016-11-11 2021-02-23 Modernatx, Inc. Influenza vaccine
US11103578B2 (en) 2016-12-08 2021-08-31 Modernatx, Inc. Respiratory virus nucleic acid vaccines
WO2018170260A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus respiratoire syncytial
EP3609534A4 (fr) 2017-03-15 2021-01-13 ModernaTX, Inc. Vaccin à large spectre contre le virus de la grippe
WO2018170336A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Formulation de nanoparticules lipidiques
WO2018170256A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus de l'herpès simplex
AU2018234814B2 (en) 2017-03-15 2022-06-30 Modernatx, Inc. Crystal forms of amino lipids
WO2018170270A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Vaccin contre le virus varicelle-zona
KR20190132405A (ko) 2017-03-15 2019-11-27 모더나티엑스, 인크. 치료제의 세포내 전달을 위한 화합물 및 조성물
EP3638215A4 (fr) 2017-06-15 2021-03-24 Modernatx, Inc. Formulations d'arn
AU2018326799A1 (en) 2017-08-31 2020-02-27 Modernatx, Inc. Methods of making lipid nanoparticles
EP3681514A4 (fr) 2017-09-14 2021-07-14 ModernaTX, Inc. Vaccins à arn contre le virus zika
MA54676A (fr) 2018-01-29 2021-11-17 Modernatx Inc Vaccins à base d'arn contre le vrs
US11351242B1 (en) 2019-02-12 2022-06-07 Modernatx, Inc. HMPV/hPIV3 mRNA vaccine composition
CN112237628A (zh) * 2019-07-17 2021-01-19 四川大学华西医院 靶向EBV的LMP2-mRNA纳米疫苗
CA3154618A1 (fr) 2019-09-19 2021-03-25 Modernatx, Inc. Composes lipidiques de queue ramifies et compositions pour l'administration intracellulaire d'agents therapeutiques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
FR2598619A1 (fr) * 1986-05-16 1987-11-20 Mafitra Management Services In Medicament antiviral a base d'acide nucleique modifie, et son procede de preparation
GB8827592D0 (en) * 1988-11-25 1988-12-29 Taniguchi T Improvements in & relating to regulation of expression
AU5344190A (en) * 1989-03-21 1990-10-22 Vical, Inc. Expression of exogenous polynucleotide sequences in a vertebrate

Also Published As

Publication number Publication date
AU1768192A (en) 1992-12-21
AU652831B2 (en) 1994-09-08
EP0537326A1 (fr) 1993-04-21
FR2676072A1 (fr) 1992-11-06
CA2086510A1 (fr) 1992-11-04
JPH06502998A (ja) 1994-04-07
WO1992019752A1 (fr) 1992-11-12

Similar Documents

Publication Publication Date Title
FR2676072B1 (fr) Vecteur de delivrance d'arn.
EP0633022A3 (fr) Agents chondroprotectives.
ITRM940324A0 (it) "formulazioni galenione contenenti macrolidi".
FR2696039B1 (fr) Structure de support d'aimant.
MX9205172A (es) Genes de pinosilvinsintasa.
NO911138D0 (no) Bakterielle vektorer.
MX9204547A (es) Neristatina 1.
FR2693693B1 (fr) Bras d'essuie-glace.
FR2676925B1 (fr) Liposomes.
HK58595A (en) Shampoo composition.
OA09815A (en) "Insecticidally effective peptides".
FR2674234B1 (fr) Bobine porteuse d'elements filiformes ou similaires.
FR2699716B1 (fr) Manchon d'étiquetage.
ITRM930146A0 (it) Composti fosfonito-hals dotati di proprieta' stabilizzati alla luce.
FR2672482B3 (fr) Vitrine d'exposition.
IT1272346B (it) "accessorio di raccordo".
FI920158A (fi) Foerfarande foer framstaellning av 3'-fluorpyrimidinnukleosider.
FR2710901B1 (fr) Elément de support d'empilage.
FR2680293B1 (fr) Annuleur d'echo lointain.
FR2678305B3 (fr) Raccordement d'armature.
FI921756A0 (fi) Foerfarande foer framstaellning av 4'-demetyliepipodofyllotoxin glukosid 4'-fosfater.
FR2677788B1 (fr) Panneau d'affichage.
FI923201A0 (fi) 3,4-dehydropiperidinderivat.
Lingdell et al. Smådjur i gotländska vatten
Muminović Praktična astronomija

Legal Events

Date Code Title Description
ST Notification of lapse