FR2643272A1 - Ultrasound radiator for use in cavities - Google Patents

Ultrasound radiator for use in cavities Download PDF

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Publication number
FR2643272A1
FR2643272A1 FR9002203A FR9002203A FR2643272A1 FR 2643272 A1 FR2643272 A1 FR 2643272A1 FR 9002203 A FR9002203 A FR 9002203A FR 9002203 A FR9002203 A FR 9002203A FR 2643272 A1 FR2643272 A1 FR 2643272A1
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Prior art keywords
ultrasonic
cannula
radiator
biological tissue
action
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Pending
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FR9002203A
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French (fr)
Inventor
Nikolai Ivanovich Nesterov
Alexandr Vladimirovic Razuvaev
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TSENIR MED REABILITATSI
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TSENIR MED REABILITATSI
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N7/02Localised ultrasound hyperthermia
    • A61N7/022Localised ultrasound hyperthermia intracavitary
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • A61B2017/22021Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter electric leads passing through the catheter

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

According to the invention, the radiator comprises a body 1 equipped with a cannula 2 in which is mounted a means 5 having an ultrasound action on a biological tissue; the means 5 in this case comprises three pairs of piezoceramic plates 6 arranged symmetrically in each pair relative to the longitudinal axis of the cannula 2. The invention applies in particular to urology.

Description

La présente invention concerne la médecine et a notamment pour objet des radiateurs ultra-sonores intracavitaires. The present invention relates to medicine and in particular relates to intra-cavity ultrasonic radiators.

L'invention peut être utilisée en urologie pour le traitement des prostatites, des cystites, de l'adénome de la prostate, en gynécologie pour le traitement de la vaginite, de l'érosion cervicale, de l'endométriose, en oto-rhino-laryngologie pour le traitement de la tonsillite, en stomatologie pour le#traitement de la gingivite, de la stomatite. The invention can be used in urology for the treatment of prostatitis, cystitis, prostate adenoma, in gynecology for the treatment of vaginitis, cervical erosion, endometriosis, oto-rhino- laryngology for the treatment of tonsillitis, in stomatology for the # treatment of gingivitis, stomatitis.

On connaît un radiateur ultra-sonore comprenant un corps-doté d'une canule dans laquelle est monté un moyen exerçant une action ultra-sonore sur un tissu biologique (Medexport, URSS, appareil LO#-lA, Moscou, 1976). An ultrasonic radiator is known comprising a body endowed with a cannula in which is mounted a means exerting an ultrasonic action on a biological tissue (Medexport, USSR, apparatus LO # -lA, Moscow, 1976).

Dans ce radiateur, le moyen ayant une action ultra-sonore sur un tissu biologique a la forme d'un seul élément piézocéramique, dont le diamètre de l'élément est de 1 cm2 , et dont la surface de radiation est plane. Le fait de prévoir un seul élément piézocéramique ne permet pas d'agir en même temps sur la totalité de la surface des tissus biologiques affectés, de sorte qui on est obligé de recourir à une méthode-labile. Or les méthodes labiles ncessitent la présence permanente du médecin, provoquent le traumatisme des tissus environnants, ce qui risque de provoquer une complication du processus principal et du processus concomitant. In this radiator, the means having an ultrasonic action on a biological tissue has the form of a single piezoceramic element, whose diameter of the element is 1 cm 2, and whose radiation surface is flat. The fact of providing a single piezoceramic element does not make it possible to act at the same time on the entire surface of the affected biological tissues, so that one is obliged to resort to a labile method. However, labile methods require the permanent presence of the doctor, causing trauma to the surrounding tissues, which risks causing a complication of the main process and the concomitant process.

On connaît un autre radiateur ultra-sonore comprenant un corps doté d'une canule dans laquelle est monté un moyen ayant une action ultra-sonore sur un tissu biologique (SU, A, 5808655.  Another ultrasonic radiator is known comprising a body provided with a cannula in which is mounted a means having an ultrasonic action on a biological tissue (SU, A, 5808655.

Dans ce radiateur ultra-sonore, le moyen ayant une action ultra-sonore a la forme d'un seul élément piézocéramique. In this ultrasonic radiator, the means having an ultrasonic action has the form of a single piezoceramic element.

Le fait de prévoir un seul élément piézocéramique ne permet pas d'agir en même temps sur toute la zone affectée du tissu biologique à cause de la trop faible surface de radiation de cet élément. De ce fait. on est obligé d'avoir recours à des méthodes labiles d'action ultra-sonore sur la zone affectée du tissu. The fact of providing a single piezoceramic element does not make it possible to act at the same time on the entire affected area of the biological tissue because of the too small radiation surface of this element. Thereby. we are forced to use labile methods of ultrasonic action on the affected area of the tissue.

Les méthodes stables d'action ultra-sonore sur les tissus biologiques moue, mètre Si l'intensité de cette action est minimale, provoquent une inflammation ré"-tionnelle des tissus. D'autre part, les méthodes labiles risquent de provoquer le traumatisme mécanique des tissus voisins et nécessitent la participation permanente du médecin à la séance de traitement. Stable methods of ultrasonic action on biological tissues pout, meter If the intensity of this action is minimal, cause tissue inflammation. On the other hand, labile methods risk causing mechanical trauma neighboring tissues and require the permanent participation of the doctor in the treatment session.

tans le cadre de l'invention, on s'est proposé de créer un radiateur ultra-sonore intracavitaire dont le moyen ayant une action ultra-sonore sur le tissu biologique serait relise de manière à pouvoir augmenter nettement la surface de la zone affectée du tissu bi# otique soumise à 'action ultra-sonore, à pouvoir appicuer des méthodes Labiles d'action ultra-sonore avec le radiateur en position stable, à pouvoir éviter les effets traumatisants des ultra-sons sur le tissu biologique avec le radiateur en position stable et les lésions mécaniques des tissus environnants provoquées par le radiateur, ainsi qu'exclure la participation physique du médecin aux séaroes de traitement par ultra-sons. In the context of the invention, it has been proposed to create an intra-cavity ultrasonic radiator whose means having an ultrasonic action on the biological tissue would be re-read so as to be able to significantly increase the surface of the affected area of the tissue bi # otic subject to ultrasonic action, to be able to apply Labile methods of ultrasonic action with the radiator in stable position, to be able to avoid the traumatic effects of ultrasound on biological tissue with the radiator in stable position and mechanical damage to surrounding tissue caused by the radiator, as well as excluding the physician's physical involvement in the treatment of ultrasound.

Ce problème est résolu grâce à un radiateur ultra-sonore intracavitaire comprenant un corps doté d'une canule dans laquelle est monte un moyen ayant une action ultra-sonore sur un tissu biologique, ce moyen cotrprenant, selon l'invention, au moins une paire de plaques piézocéramiques. This problem is solved by means of an intra-cavity ultrasonic radiator comprising a body provided with a cannula in which is mounted a means having an ultrasonic action on a biological tissue, this means comprising, according to the invention, at least one pair piezoceramic plates.

il est préférable que les plaques piéz#céramiques de chque paire soient symétriquement disposées par rapport à l'axe longitudinal de la canule dudit corps. it is preferable that the piezo # ceramic plates of each pair are symmetrically arranged with respect to the longitudinal axis of the cannula of said body.

Un tel mode de réalisation du radiateur ultra-sonore intracatitaire selon l'invention permet d'obtenir une irradiation ultra-sonore uniforme des foyers pathologiques, en particulier de ceux situés dans la prostate qui est d'une structure bilobulée symétrique. Such an embodiment of the intracatitary ultrasonic radiator according to the invention makes it possible to obtain uniform ultrasonic irradiation of the pathological foci, in particular of those located in the prostate which is of a symmetrical bilobulated structure.

En outre, le radiateur selon l'invention permet d'avoir une action ultra-sonore dirigée# sur des portions de tissus biologiques lésionnés. In addition, the radiator according to the invention makes it possible to have a directed ultrasonic action # on portions of damaged biological tissue.

L'invention sera mieux comprise a la lecture de la description qui va suivre d'un exemple de réalisation et en se référant aux dessins annexés'dans lesquels
- la figure 1 représente le radiateur ultra-sonore intracavitaire selon l'invention, en vue de face
- la figure 2 est une coupe suivant la ligne -T-II de la figure 1, à échelle agrandie
- la figure 3 représente la canule du radiateur de la figure 1 à échelle agrandie
- la figure 4 représente, en coupe longitudinale, la canule de la figure o ; et
- la figure 5 représente l'organigramme du dispositif d'ultrasoncthérapie dont fait partie le radiateur selon la figure 1.
The invention will be better understood on reading the following description of an embodiment and with reference to the accompanying drawings in which
- Figure 1 shows the intra-cavity ultrasonic radiator according to the invention, in front view
- Figure 2 is a section along the line -T-II of Figure 1, on an enlarged scale
- Figure 3 shows the cannula of the radiator of Figure 1 on an enlarged scale
- Figure 4 shows, in longitudinal section, the cannula of Figure o; and
- Figure 5 shows the flowchart of the ultrasound therapy device which includes the radiator according to Figure 1.

Le radiateur ultra-sonore intracavitaire selon l'invention comprend un corps 1 (figure lr dont l'une des extrémités est reliée à une canule.2 et l'autre, à un élément porteur 3 dont l'extrémité libre porte une fiche de raccord 4 servant à brancher le radiateur selon l'invention sur un bloc de commande. (Le bloc de coz.z.ande n'est pas représenté sur le dessin, car il ne fait pas l'objet de la présente invention. Ce bloc de commande peut être tout bloc de commarde connu des spécialistes dans le domaine en question, par exemple celui décrit dans le livre de U. Titze e.a., "Circuiterie à se#i-conducteurs", 1983, édition Mir (Moscou). The intra-cavity ultrasonic radiator according to the invention comprises a body 1 (FIG. 1r, one of the ends of which is connected to a cannula. 2 and the other, to a carrier element 3, the free end of which carries a connector plug. 4 used to connect the radiator according to the invention to a control block. (The block of coz.z.ande is not shown in the drawing, because it is not the subject of the present invention. control can be any block of board known to specialists in the field in question, for example that described in the book by U. Titze and others, "Circuitry with # i-conductors", 1983, Mir edition (Moscow).

Dans la canule 2 est monté un moyen 5 ayant une action ultra-sonore sur un tissu biologique, comme le montre bien la figure 2. Le moyen 5 (figures 1 et 2) est doté de trois paires de plaques piézocéramiques 6. In the cannula 2 is mounted a means 5 having an ultrasonic action on a biological tissue, as well shown in FIG. 2. The means 5 (Figures 1 and 2) is provided with three pairs of piezoceramic plates 6.

Les plaques piézocéramiques 6 (figure 3) de chaque paire sont disposées symétriquement par rapport à l'axe longitudinal 7 de la canule 2 du corps 1. The piezoceramic plates 6 (FIG. 3) of each pair are arranged symmetrically with respect to the longitudinal axis 7 of the cannula 2 of the body 1.

Dans la version d'exécuticn considérée du radiateur selon l'invention, le moyen 5 ccmprend trois paires de plaques piézocérami#ues 6. Toutefois, le nombre de paires de plaques piézocéraramiques 6 peut varier entre une et plusieurs selcn la surface à irradier par ultra-sons et les dimensions de la zone affectée du tissu biologique. In the version of execution considered of the radiator according to the invention, the means 5 cm takes three pairs of piezoceramic plates # ues 6. However, the number of pairs of piezoceraramic plates 6 can vary between one and several depending on the surface to be irradiated by ultra - its and the dimensions of the affected area of the biological tissue.

Selon les particularités anatomiques des tissus biologiques à traiter, la canule 2 peut avoir diverses configurations. Dans le mode de realisation considéré, le radiateur selon #invention est destiné au traitement de la prostate et, C fait, a la forme d'un cylindre dont la directrice est une ell#rse.  Depending on the anatomical particularities of the biological tissues to be treated, the cannula 2 can have various configurations. In the embodiment considered, the radiator according to #invention is intended for the treatment of the prostate and, in fact, has the shape of a cylinder whose director is an ell # rse.

La canule 2 (figure 4) est métallique et sa face en bout 8 est réalisée en ure matière isolante, pour éviter un contact direct avec les organes du malade et une tige conductrice ce courant 9 disposée à l'intérieur de la canule 2. La tige 5 est vissee dans la face en bcut 8 de la canule avec un isolateur 10 servant à isoler la canule 2 de la tige concuctrice de courant 9. The cannula 2 (FIG. 4) is metallic and its end face 8 is made of an insulating material, to avoid direct contact with the patient's organs and a conductive rod for this current 9 disposed inside the cannula 2. The rod 5 is screwed into the bcut face 8 of the cannula with an insulator 10 used to isolate the cannula 2 from the current-forming rod 9.

La tige 9 est fixée dans la canule 2 à l'aide d'une rondelle isolante 11 et d'un écr-cu 12. L'isolateur 10 est serré contre la face en bout 8 de la canule 2 à l'aide d'une rondelle 13 et d'un écrou 14. The rod 9 is fixed in the cannula 2 using an insulating washer 11 and a crimper 12. The insulator 10 is clamped against the end face 8 of the cannula 2 using a washer 13 and a nut 14.

L'isolateur 10 comporte des rondelles de contact 15 qui relient électriquement les plaques piézocéramiques 6 (figure 2) à un bloc de commande 16 (figure 5) par l'intermédiaire de la tige conductrice de courant 9 (figure 2). The insulator 10 comprises contact washers 15 which electrically connect the piezoceramic plates 6 (FIG. 2) to a control block 16 (FIG. 5) via the current conducting rod 9 (FIG. 2).

La figure 5 représente l'organigramme de l'un des modes de réalisation du dispositif d'ultrasoncthérapie dont fait partie le radiateur ultra-sonore intracavitaire, selon l'invention.  FIG. 5 represents the flow diagram of one of the embodiments of the ultrasound therapy device of which the intra-cavity ultrasonic radiator is part, according to the invention.

Ce dispositif comprend un générateur 17 d'oscillations électriques de fréquence ultra-sonore relié à un bloc 16 de -commande sur lequel sont branchées les plaques 6 du moyen 5 ayant une action ultra-sonore sur le tissu biologique, faisant partie du radiateur selon l'invention. This device comprises a generator 17 of electrical oscillations of ultrasonic frequency connected to a block 16 of -control on which are connected the plates 6 of the means 5 having an ultrasonic action on the biological tissue, forming part of the radiator according to the 'invention.

le générateur 17 peut être celui décrit dans TsBMTlMedprom, URSS, "Appareil d'ultrasonothérapie UST",
Moscou, 1980, et le bloc 16, celui mentionné plus haut.
the generator 17 can be that described in TsBMTlMedprom, USSR, "UST ultrasound therapy device",
Moscow, 1980, and block 16, the one mentioned above.

Le foncticnnementdu radiateur ultra-sonore intracavitaire selon l'invention est le suivant. The operation of the intra-cavity ultrasonic radiator according to the invention is as follows.

Les oscillations électriques de fréquence ultra-sonore engendrées par le générateur 17 (figure 5) sont canalisées par le bloc de coirsr:ande 16, la tige conductrice de ccurant 9 (figure 2) et les rondelles de contact 15, vers les plaques piézocéramiques 6 qui transfcrtnent leskoscillations électriques en oscillations ultra-sonores. The ultrasonic frequency electric oscillations generated by the generator 17 (figure 5) are channeled by the coir block: ande 16, the fuel conductor rod 9 (figure 2) and the contact washers 15, towards the piezoceramic plates 6 which convert electrical oscillations into ultrasonic oscillations.

Les branchements et débranchem.ents-des plaques piézocoramiques 6 (figure 5) effectués par le bloc 16 de commande dans une séquence déterminée permettent d'agir par ultra-sons sur la totalité du tissu biologique à traiter, par exemple sur toute la prostate. The connections and disconnection of the piezocoramic plates 6 (FIG. 5) carried out by the control block 16 in a determined sequence make it possible to act by ultrasound on all of the biological tissue to be treated, for example on the entire prostate.

Pendant le traitement à l'aide du radiateur ultra-sonore intracavitaire selon l'invention de 45 malades souffrant de prostatite chronique, on n'a constaté chez aucun d'entre eux d'exacerbation des hémorroldes chroniques, des indices d'hémorragie hémorroldale, des douleurs pendant la défécation. 8 malades seulement (17,8 ,6) ont constaté l'apparition d'une sensation d'inconfort dans la zone du rectum après les trois premières séances de traitement, qui disparaissait toutefois pendant les séances suivantes. During the treatment using the intracavitary ultrasonic radiator according to the invention of 45 patients suffering from chronic prostatitis, in none of them was there any exacerbation of chronic hemorrhoids, signs of hemorrhagic hemorrhage, pain during defecation. Only 8 patients (17.8, 6) noted the appearance of a feeling of discomfort in the rectum area after the first three treatment sessions, which however disappeared during the following sessions.

L'utilisation du radiateur intracavitaire selon l'invention pour l'ultrasonothérapie de malades souffrant de prostatite chronique a permis d'amélioration nettement l'efficacité de la cure. Une certaine arélicration ou une amélioration importante a été constatée chez 88% des - malades, l'état des 12% restants n'ayant pas changé. Dans aucun cas, on a constaté une exacerbat#cn de la prostatite ou des maladies concomitantes du rectum (hémorrcides chroniques, fissures du rectum, proctite, sphirinctérite). The use of the intracavitary radiator according to the invention for the ultrasound therapy of patients suffering from chronic prostatitis has significantly improved the effectiveness of the treatment. Some improvement or significant improvement was noted in 88% of the patients, the state of the remaining 12% having not changed. In no case was there an exacerbat # cn of prostatitis or concomitant diseases of the rectum (chronic hemorrcides, fissures of the rectum, proctitis, sphirincteritis).

Le radiateur ultra-sonore selon l'invention est facile à manier, il facilite la tâche du personnel médical, permet d'obtenir de manière sure une action ultra-sonore sur les tissus biologiques à traiter, d'éviter le traumatisme et les lésions de ces tissus et augmente la tolérance des malades rasades par rapport au traitement.  The ultrasonic radiator according to the invention is easy to handle, it facilitates the task of the medical personnel, makes it possible to obtain in an sure manner an ultrasonic action on the biological tissues to be treated, to avoid the trauma and the injuries of these tissues and increases the tolerance of shaving patients compared to treatment.

Claims (2)

REVENDICATIONS 1. Radiateur ultra-sonore intracavitaire, du type comprenant un corps doté d'une canule dans laquelle est monté un moyen ayant une action ultra-sonore sur un tissu biologique, caractérisé en ce que le moyen (5) ayant une action ultra-sonore sur un tissu biologique comprend au moins une paire de plaques piézo-céramiques (6). 1. Intracavitary ultrasonic radiator, of the type comprising a body provided with a cannula in which is mounted a means having an ultrasonic action on a biological tissue, characterized in that the means (5) having an ultrasonic action on a biological tissue comprises at least one pair of piezo-ceramic plates (6). 2. Radiateur ultra-sonore intracavitaire selon la revendication 1, caractérisé en ce que les plaques piézocéramiques (6) de chaque paire sont disposées symétriquement par rapport à l'axe longitudinal (7) de la canule (2) du corps (1).  2. Intracavitary ultrasonic radiator according to claim 1, characterized in that the piezoceramic plates (6) of each pair are arranged symmetrically with respect to the longitudinal axis (7) of the cannula (2) of the body (1).
FR9002203A 1989-02-23 1990-02-22 Ultrasound radiator for use in cavities Pending FR2643272A1 (en)

Applications Claiming Priority (1)

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SU4650476 1989-02-23

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JP (1) JPH02297354A (en)
CN (1) CN1045037A (en)
BG (1) BG49960A1 (en)
FR (1) FR2643272A1 (en)
IT (1) IT1238827B (en)

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US5380274A (en) * 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
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US5405318A (en) * 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
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US5997497A (en) * 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
EP1028660A1 (en) * 1997-10-31 2000-08-23 The University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
WO2001037735A3 (en) * 1999-11-25 2002-04-11 A Erich Theuer Device for carrying out the oscillation-induced selective treatment of malignant diseases
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US5957882A (en) * 1991-01-11 1999-09-28 Advanced Cardiovascular Systems, Inc. Ultrasound devices for ablating and removing obstructive matter from anatomical passageways and blood vessels
EP0835644A2 (en) * 1991-01-11 1998-04-15 Baxter International Inc. Ultrasonic angioplasty device incorporating transmission member and ablation probe
US5474530A (en) * 1991-01-11 1995-12-12 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm
US6929632B2 (en) 1991-01-11 2005-08-16 Advanced Cardiovascular Systems, Inc. Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels
US5324255A (en) * 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5368558A (en) * 1991-01-11 1994-11-29 Baxter International Inc. Ultrasonic ablation catheter device having endoscopic component and method of using same
US5380274A (en) * 1991-01-11 1995-01-10 Baxter International Inc. Ultrasound transmission member having improved longitudinal transmission properties
US5997497A (en) * 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US5267954A (en) * 1991-01-11 1993-12-07 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5397301A (en) * 1991-01-11 1995-03-14 Baxter International Inc. Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy
US5304115A (en) * 1991-01-11 1994-04-19 Baxter International Inc. Ultrasonic angioplasty device incorporating improved transmission member and ablation probe
EP0835644A3 (en) * 1991-01-11 1998-07-08 Baxter International Inc. Ultrasonic angioplasty device incorporating transmission member and ablation probe
US5342292A (en) * 1991-11-04 1994-08-30 Baxter International Inc. Ultrasonic ablation device adapted for guidewire passage
US5405318A (en) * 1992-05-05 1995-04-11 Baxter International Inc. Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels
US5382228A (en) * 1992-07-09 1995-01-17 Baxter International Inc. Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device
EP0582766A1 (en) * 1992-08-13 1994-02-16 Ministero Dell' Universita' E Della Ricerca Scientifica E Tecnologica Ultrasonic recanalization system and transducer therefor
US5417672A (en) * 1993-10-04 1995-05-23 Baxter International Inc. Connector for coupling an ultrasound transducer to an ultrasound catheter
US5427118A (en) * 1993-10-04 1995-06-27 Baxter International Inc. Ultrasonic guidewire
US5390678A (en) * 1993-10-12 1995-02-21 Baxter International Inc. Method and device for measuring ultrasonic activity in an ultrasound delivery system
US6689086B1 (en) 1994-10-27 2004-02-10 Advanced Cardiovascular Systems, Inc. Method of using a catheter for delivery of ultrasonic energy and medicament
EP0764004A4 (en) * 1995-03-31 1998-09-02 Boston Scient Corp Acoustic ablation
EP0764004A1 (en) * 1995-03-31 1997-03-26 Boston Scientific Corporation Acoustic ablation
US5971949A (en) * 1996-08-19 1999-10-26 Angiosonics Inc. Ultrasound transmission apparatus and method of using same
EP1028660A4 (en) * 1997-10-31 2006-03-29 Univ Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
EP1028660A1 (en) * 1997-10-31 2000-08-23 The University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
WO2001037735A3 (en) * 1999-11-25 2002-04-11 A Erich Theuer Device for carrying out the oscillation-induced selective treatment of malignant diseases

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BG49960A1 (en) 1992-04-15
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JPH02297354A (en) 1990-12-07
IT1238827B (en) 1993-09-03
IT9041533A1 (en) 1991-08-22

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