FR2258171A1 - Oral male contraceptives - comprising steroidal progestogens potentiated with hydroxybenzoic acids - Google Patents

Oral male contraceptives - comprising steroidal progestogens potentiated with hydroxybenzoic acids

Info

Publication number
FR2258171A1
FR2258171A1 FR7401943A FR7401943A FR2258171A1 FR 2258171 A1 FR2258171 A1 FR 2258171A1 FR 7401943 A FR7401943 A FR 7401943A FR 7401943 A FR7401943 A FR 7401943A FR 2258171 A1 FR2258171 A1 FR 2258171A1
Authority
FR
France
Prior art keywords
hydroxybenzoic acids
potentiated
progestogens
acid
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7401943A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7401943A priority Critical patent/FR2258171A1/en
Publication of FR2258171A1 publication Critical patent/FR2258171A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof

Abstract

Male contraceptive compsn. comprises (a) 17alpha-acetoxy-6alpha-methylpregn-4-ene-3,20-dione (A') and/or 19alpha-ethynylnortestosterone enol cyclopentylacetate (A2) and (b) one or more of salicylic acid, aspirin, gentisic acid, O,O-diacetylgentisic acid and their salts with organic and inorganic bases and (c) an orally acceptable carrier. Oral contraceptive agent for inhibiting the fertilizing ability of human spermatozoa. The dose of the progestogens A' and A2 is reduced by the potentiating action of the hydroxybenzoic acids (b). Pref. compsns. contain 0.1-0.5 mg of (a) and 3-6 g of (b). The ratio of (b) to (a) is 5000-100,000:1, pref. between 10,000-50,000:1.
FR7401943A 1974-01-21 1974-01-21 Oral male contraceptives - comprising steroidal progestogens potentiated with hydroxybenzoic acids Withdrawn FR2258171A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7401943A FR2258171A1 (en) 1974-01-21 1974-01-21 Oral male contraceptives - comprising steroidal progestogens potentiated with hydroxybenzoic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7401943A FR2258171A1 (en) 1974-01-21 1974-01-21 Oral male contraceptives - comprising steroidal progestogens potentiated with hydroxybenzoic acids

Publications (1)

Publication Number Publication Date
FR2258171A1 true FR2258171A1 (en) 1975-08-18

Family

ID=9133741

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7401943A Withdrawn FR2258171A1 (en) 1974-01-21 1974-01-21 Oral male contraceptives - comprising steroidal progestogens potentiated with hydroxybenzoic acids

Country Status (1)

Country Link
FR (1) FR2258171A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036145A1 (en) * 1980-03-07 1981-09-23 INTERx RESEARCH CORPORATION An orally administered drug form comprising a polar bioactive agent and an adjuvant
US4459295A (en) * 1980-03-07 1984-07-10 Interx Research Corporation Method of increasing oral absorption of glycosidic and related antibiotics
JPS62198699A (en) * 1986-02-24 1987-09-02 ルセル−ユクラフ Novel steroid wherein 9(11) is saturated and 10-position is substituted by group containing triple bond, its production,its use as drug and pharmaceutical composition

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036145A1 (en) * 1980-03-07 1981-09-23 INTERx RESEARCH CORPORATION An orally administered drug form comprising a polar bioactive agent and an adjuvant
US4459295A (en) * 1980-03-07 1984-07-10 Interx Research Corporation Method of increasing oral absorption of glycosidic and related antibiotics
US4462991A (en) * 1980-03-07 1984-07-31 Interx Research Corp. Method of increasing oral absorption of polar bioactive agents
JPS62198699A (en) * 1986-02-24 1987-09-02 ルセル−ユクラフ Novel steroid wherein 9(11) is saturated and 10-position is substituted by group containing triple bond, its production,its use as drug and pharmaceutical composition
JPH0791312B2 (en) 1986-02-24 1995-10-04 ルセル−ユクラフ Novel steroid in which position 9 (11) is saturated and position 10 is substituted with a group containing a triple bond, process for producing the same and drug

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Legal Events

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ST Notification of lapse