FR2073427A1 - 4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activity - Google Patents
4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activityInfo
- Publication number
- FR2073427A1 FR2073427A1 FR7041137A FR7041137A FR2073427A1 FR 2073427 A1 FR2073427 A1 FR 2073427A1 FR 7041137 A FR7041137 A FR 7041137A FR 7041137 A FR7041137 A FR 7041137A FR 2073427 A1 FR2073427 A1 FR 2073427A1
- Authority
- FR
- France
- Prior art keywords
- heterocyclic
- cpds
- thiazoles
- ethyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
4-Methyl-5- ethyl-N-heterocyclic thiazoles - with antianoxic activity. Cpds. of formula: (where R is H, Me, Et or C6H5; Z is a nitrogen heterocycle connected via the N-atom, esp. morpholine, 2,6dimethylmorpholine, N-(2-aminoethyl)morpholine, imidazole, pyridazole, piperidine, pyrrodlidine, phthalimide, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydro-6-methylquinoline or N-methylpiperazine). The cpds. and their salts are anti-anoxic agents useful in treating ischaemic, and also have antipyretic and central anticholinergic activity. Cpds. are used at a daily dosage of 200-600 mg. Prepd. by treating the alpha-chloroethylthiazoles with appropriate N-heterocyclic cpds.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5840769 | 1969-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2073427A1 true FR2073427A1 (en) | 1971-10-01 |
Family
ID=10481551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7041137A Withdrawn FR2073427A1 (en) | 1969-11-28 | 1970-11-17 | 4-methyl-5-ethyl-n-heterocyclic thiazoles - with antianoxic activity |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2073427A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172137A (en) * | 1976-08-11 | 1979-10-23 | Roussel Uclaf | 5-Thiazole-alkylamines used as antilipolytics |
EP0244803A2 (en) * | 1986-05-06 | 1987-11-11 | Merrell Dow Pharmaceuticals Inc. | Novel dopamine beta hydroxylase inhibitors |
EP0417474A1 (en) * | 1984-11-05 | 1991-03-20 | Omron Corporation | Data input device in a card lock system |
WO1991010656A1 (en) * | 1990-01-19 | 1991-07-25 | Cedona Pharmaceuticals B.V. | Thiazole derivatives |
-
1970
- 1970-11-17 FR FR7041137A patent/FR2073427A1/en not_active Withdrawn
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172137A (en) * | 1976-08-11 | 1979-10-23 | Roussel Uclaf | 5-Thiazole-alkylamines used as antilipolytics |
EP0417474A1 (en) * | 1984-11-05 | 1991-03-20 | Omron Corporation | Data input device in a card lock system |
EP0244803A2 (en) * | 1986-05-06 | 1987-11-11 | Merrell Dow Pharmaceuticals Inc. | Novel dopamine beta hydroxylase inhibitors |
EP0244803A3 (en) * | 1986-05-06 | 1991-01-16 | Merrell Dow Pharmaceuticals Inc. | Novel dopamine beta hydroxylase inhibitors |
WO1991010656A1 (en) * | 1990-01-19 | 1991-07-25 | Cedona Pharmaceuticals B.V. | Thiazole derivatives |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |