ES476566A3 - Procedure for the manufacture of biologically active components protected or encapsulated for feeding ruminants. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

According to this discovery, it has been found that biologically active substances, such as amino acids, vitamins, antibiotics, etec, can be transported through the belly in such a way that they develop their biological effects after the book or omasum, if the materials administered they were in the form of particles, for example, capsules, dragees, granules or the like, in which the active substances are totally enclosed in a film of protective material that is substantially immune to degradation in the rumen, but which releases the active substance after the omaso. Thus the particles can pass through the rumen, without changing substantially, to be located later to the omasum, where the biologically active substance becomes capable of being used by the animal. We refer to these particles, hereinafter, as capsules. Some active substances, such as amino acids, can be absorbed from the gastrointestinal tract and used within the host animal's own body, while other active materials can manifest their activity within the digestive tract lumen. The capsules can be prepared by a wide variety of known encapsulation techniques, for example, fluid bed techniques, dragee, centrifugal extrusion method, etc., and any protective material that does not release the active substance in the ruminal fluid can be used, but that it releases this substance after the omado and is tolerated by the animal. Thus, the capsules can be formed by a continuous outer shell of protective material, or without a continuous outer shell of protective material, or without a different outer shell if the active substance is encapsulated in deposits in a matrix of protective material. However, it is important that the active material is completely enclosed in protective material, since the capsules must be able to withstand long periods of time in the rumen without large quantities of active substance being released from the capsules by the ruminal fluid. (Machine-translation by Google Translate, not legally binding)