ES475050A1 - Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dione - Google Patents
Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dioneInfo
- Publication number
- ES475050A1 ES475050A1 ES475050A ES475050A ES475050A1 ES 475050 A1 ES475050 A1 ES 475050A1 ES 475050 A ES475050 A ES 475050A ES 475050 A ES475050 A ES 475050A ES 475050 A1 ES475050 A1 ES 475050A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- dioxabicyclo
- octane
- dione
- dipnenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- NUAAAPRSVYXHHB-UHFFFAOYSA-N 1,4-diphenyl-1,3a,4,6a-tetrahydrofuro[3,4-c]furan-3,6-dione Chemical group O=C1OC(C=2C=CC=CC=2)C(C(O2)=O)C1C2C1=CC=CC=C1 NUAAAPRSVYXHHB-UHFFFAOYSA-N 0.000 abstract 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 abstract 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
- IVOMOUWHDPKRLL-UHFFFAOYSA-N UNPD107823 Natural products O1C2COP(O)(=O)OC2C(O)C1N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001851 cinnamic acid derivatives Chemical class 0.000 abstract 1
- 229940095074 cyclic amp Drugs 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 238000005691 oxidative coupling reaction Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
New derivatives of 2,6-diphenyl- 3,7-dioxabicyclo-[3,3,0]-octane-4,8- dione substituted on the phenyl rings have been found to have an anti-tumor, catechol-0-methyltransferase inhibitory and cyclic AMP phosphodiesterase inhibitory activity. The derivatives are prepared by subjecting cinnamic acid derivatives to an oxidative coupling reaction in the presence of an oxidizing agent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13742077A JPS5473789A (en) | 1977-11-15 | 1977-11-15 | 2,6-diphenyl-3,7-dioxabicyclo-3.3.0-octane 4,8-dione derivative and anticarcinogens, catechol-o-methyl transferase inhibitors and adenosine 3',5'-cyclic phosphoric acid phosphodiesterase inhibitors containing the derivative as active component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475050A1 true ES475050A1 (en) | 1979-04-16 |
Family
ID=15198205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475050A Expired ES475050A1 (en) | 1977-11-15 | 1978-11-14 | Derivatives of 2,6-dipnenyl-3,7- dioxabicyclo-[3,3,0]-octane-4,8-dione |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5473789A (en) |
| AR (1) | AR217335A1 (en) |
| BE (1) | BE871994A (en) |
| DE (1) | DE2849107A1 (en) |
| ES (1) | ES475050A1 (en) |
| FR (1) | FR2408610A1 (en) |
| GB (1) | GB2010273A (en) |
| IT (1) | IT1109272B (en) |
| NL (1) | NL7811308A (en) |
| SE (1) | SE7811759L (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62581A (en) * | 1985-06-26 | 1987-01-06 | Takemoto Oil & Fat Co Ltd | Production of natural phenolic oxidation-resistant substance |
| JPS6330416A (en) * | 1986-07-24 | 1988-02-09 | Wakunaga Pharmaceut Co Ltd | Agent for improving cerebral circulation and metabolism |
| US6588625B2 (en) | 2001-04-24 | 2003-07-08 | Abbott Laboratories | Sample handling system |
| KR100479405B1 (en) * | 2002-05-24 | 2005-03-30 | 주식회사 싸이제닉 | Cinnamic acid dimers, their preparation and the use thereof for treating neurodegenerative disease |
| JP2011195465A (en) * | 2010-03-17 | 2011-10-06 | Wakayama Prefecture | Process for manufacturing cinnamic acid derivative, and cinnamic acid derivative |
| JP5914897B2 (en) * | 2012-03-08 | 2016-05-11 | 和歌山県 | Method for producing furofuran derivative |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52102433A (en) * | 1976-02-19 | 1977-08-27 | Microbial Chem Res Found | Hypotensive agents containing 1,4-dihydroxy-1,4-di-(3,5-dimethoxy-4-hy droxyphenyl)butane-2,3-dicarboxylic acid dilactone as main component |
| JPS52136193A (en) * | 1976-05-10 | 1977-11-14 | Microbial Chem Res Found | Novel dehydrodicaffeic acid dilactone |
-
1977
- 1977-11-15 JP JP13742077A patent/JPS5473789A/en active Pending
-
1978
- 1978-11-02 GB GB7842884A patent/GB2010273A/en not_active Withdrawn
- 1978-11-10 AR AR274419A patent/AR217335A1/en active
- 1978-11-11 DE DE19782849107 patent/DE2849107A1/en not_active Withdrawn
- 1978-11-14 SE SE7811759A patent/SE7811759L/en unknown
- 1978-11-14 BE BE191714A patent/BE871994A/en unknown
- 1978-11-14 ES ES475050A patent/ES475050A1/en not_active Expired
- 1978-11-15 FR FR7832242A patent/FR2408610A1/en not_active Withdrawn
- 1978-11-15 NL NL7811308A patent/NL7811308A/en not_active Application Discontinuation
- 1978-11-15 IT IT51906/78A patent/IT1109272B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DE2849107A1 (en) | 1979-05-17 |
| AR217335A1 (en) | 1980-03-14 |
| GB2010273A (en) | 1979-06-27 |
| IT1109272B (en) | 1985-12-16 |
| NL7811308A (en) | 1979-05-17 |
| IT7851906A0 (en) | 1978-11-15 |
| JPS5473789A (en) | 1979-06-13 |
| FR2408610A1 (en) | 1979-06-08 |
| SE7811759L (en) | 1979-05-16 |
| BE871994A (en) | 1979-05-14 |
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