ES2159488B1 - Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica. - Google Patents
Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.Info
- Publication number
- ES2159488B1 ES2159488B1 ES200000625A ES200000625A ES2159488B1 ES 2159488 B1 ES2159488 B1 ES 2159488B1 ES 200000625 A ES200000625 A ES 200000625A ES 200000625 A ES200000625 A ES 200000625A ES 2159488 B1 ES2159488 B1 ES 2159488B1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- procedure
- derivatives
- pirimidone
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Procedimiento para la preparación de derivados de pirimidona con actividad antifúngica. Procedimiento para la preparación de derivados de pirimidona de fórmula I, caracterizado porque comprende hacer reaccionar un compuesto de fórmula II con un compuesto de fórmula III en presencia de una base. Los derivados de pirimidona de fórmula I son útiles como agentes antifúngicos.
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000625A ES2159488B1 (es) | 2000-03-07 | 2000-03-07 | Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica. |
ARP010101022A AR027607A1 (es) | 2000-03-07 | 2001-03-02 | Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica |
US10/221,099 US6653475B2 (en) | 2000-03-07 | 2001-03-05 | Method for preparing pyrimidone derivatives with antifungal activity |
PCT/ES2001/000081 WO2001066519A2 (es) | 2000-03-07 | 2001-03-05 | Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica |
EP01909840A EP1282084B9 (en) | 2000-03-07 | 2001-03-05 | Method for preparing pyrimidone derivatives with antifungal activity |
BRPI0108990A BRPI0108990B8 (pt) | 2000-03-07 | 2001-03-05 | processo para preparação de derivados de pirimidona com atividade antifungos |
KR1020027011732A KR100735583B1 (ko) | 2000-03-07 | 2001-03-05 | 항진균 활성을 갖는 피리미돈 유도체의 제조 방법 |
DE60100810T DE60100810T2 (de) | 2000-03-07 | 2001-03-05 | Verfahren zur präparation von pyrimidonderivaten mit fungizidder aktivität |
PT01909840T PT1282084E (pt) | 2000-03-07 | 2001-03-05 | Processo para a preparacao de derivados de pirimidona com actividade antifungica |
JP2001565337A JP4772248B2 (ja) | 2000-03-07 | 2001-03-05 | 抗真菌活性を有するピリミドン誘導体の製造方法 |
AU2001237447A AU2001237447A1 (en) | 2000-03-07 | 2001-03-05 | Method for preparing pyrimidone derivatives with antifungal activity |
ES01909840T ES2207605T3 (es) | 2000-03-07 | 2001-03-05 | Procedimiento para la preparacion de derivados de pirimidona con actividad angifungica. |
AT01909840T ATE250256T1 (de) | 2000-03-07 | 2001-03-05 | Verfahren zur präparation von pyrimidonderivaten mit fungizidder aktivität |
MXPA02008556A MXPA02008556A (es) | 2000-03-07 | 2001-03-05 | Procedimiento para la preparacion de derivados de pirimidona con actividad anifungica. |
DK01909840T DK1282084T3 (da) | 2000-03-07 | 2001-03-05 | Fremgangsmåde til fremstilling af pyrimidonderivater med antifungal aktivitet |
CA002402390A CA2402390C (en) | 2000-03-07 | 2001-03-05 | Process for the preparation of pyrimidone derivatives with antifungal activity |
NO20024256A NO323314B1 (no) | 2000-03-07 | 2002-09-06 | Fremgangsmate for fremstilling av pyrimidonderivater med antifungal aktivitet |
HK03104472.6A HK1052244B (zh) | 2000-03-07 | 2003-06-21 | 用於製備具有抗真菌活性的嘧啶酮衍生物的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200000625A ES2159488B1 (es) | 2000-03-07 | 2000-03-07 | Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2159488A1 ES2159488A1 (es) | 2001-10-01 |
ES2159488B1 true ES2159488B1 (es) | 2002-04-16 |
Family
ID=8492714
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200000625A Expired - Fee Related ES2159488B1 (es) | 2000-03-07 | 2000-03-07 | Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica. |
ES01909840T Expired - Lifetime ES2207605T3 (es) | 2000-03-07 | 2001-03-05 | Procedimiento para la preparacion de derivados de pirimidona con actividad angifungica. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01909840T Expired - Lifetime ES2207605T3 (es) | 2000-03-07 | 2001-03-05 | Procedimiento para la preparacion de derivados de pirimidona con actividad angifungica. |
Country Status (17)
Country | Link |
---|---|
US (1) | US6653475B2 (es) |
EP (1) | EP1282084B9 (es) |
JP (1) | JP4772248B2 (es) |
KR (1) | KR100735583B1 (es) |
AR (1) | AR027607A1 (es) |
AT (1) | ATE250256T1 (es) |
AU (1) | AU2001237447A1 (es) |
BR (1) | BRPI0108990B8 (es) |
CA (1) | CA2402390C (es) |
DE (1) | DE60100810T2 (es) |
DK (1) | DK1282084T3 (es) |
ES (2) | ES2159488B1 (es) |
HK (1) | HK1052244B (es) |
MX (1) | MXPA02008556A (es) |
NO (1) | NO323314B1 (es) |
PT (1) | PT1282084E (es) |
WO (1) | WO2001066519A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
US8367824B2 (en) * | 2002-01-28 | 2013-02-05 | Ube Industries Ltd. | Process for producing quinazolin-4-one derivative |
JP5055263B2 (ja) | 2005-03-30 | 2012-10-24 | ダエウン ファーマシューティカル カンパニー リミテッド | 抗真菌性トリアゾール誘導体 |
EP2009009A1 (en) * | 2007-06-26 | 2008-12-31 | Palau Pharma, S.A. | Crystalline antifungal compounds |
EP1887004A1 (en) * | 2006-08-07 | 2008-02-13 | Palau Pharma, S.A. | Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one |
BRPI0716026A2 (pt) * | 2006-08-07 | 2013-08-06 | Stiefel Laboratories | compostos antiféngicos cristalinos |
TWI395728B (zh) | 2006-12-06 | 2013-05-11 | Du Pont | 製備2-胺基-5-氰基苯甲酸衍生物之方法 |
TWI415827B (zh) | 2006-12-21 | 2013-11-21 | Du Pont | 製備2-胺基-5-氰基苯甲酸衍生物之方法 |
EP2257555B1 (en) | 2008-03-03 | 2012-07-04 | National Chemical Laboratory | Thieno[2,3-d]-pyrimidine-4(3h)-one compounds with antifungal properties and process thereof |
SE532624C2 (sv) * | 2008-06-19 | 2010-03-09 | Andritz Technology And Asset Management Gmbh | Kylning av en cellulosamassabana |
CA2829785C (en) * | 2011-03-15 | 2019-02-26 | Fdc Limited | Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4(3h)-one moiety as antifungal agents |
CN106588889B (zh) * | 2016-11-25 | 2019-01-22 | 江苏恒盛药业有限公司 | 一种伏立康唑的制备方法 |
CN111018839B (zh) * | 2019-12-02 | 2022-12-23 | 中国人民解放军第二军医大学 | 三氮唑醇类衍生物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8819308D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Triazole antifungal agents |
TW218017B (es) | 1992-04-28 | 1993-12-21 | Takeda Pharm Industry Co Ltd | |
BR9606547A (pt) * | 1995-08-02 | 1997-10-14 | Uriach & Cia Sa J | Novos derivados de pirimidona com atividade fungicida |
-
2000
- 2000-03-07 ES ES200000625A patent/ES2159488B1/es not_active Expired - Fee Related
-
2001
- 2001-03-02 AR ARP010101022A patent/AR027607A1/es active IP Right Grant
- 2001-03-05 US US10/221,099 patent/US6653475B2/en not_active Expired - Lifetime
- 2001-03-05 AU AU2001237447A patent/AU2001237447A1/en not_active Abandoned
- 2001-03-05 JP JP2001565337A patent/JP4772248B2/ja not_active Expired - Lifetime
- 2001-03-05 WO PCT/ES2001/000081 patent/WO2001066519A2/es active IP Right Grant
- 2001-03-05 MX MXPA02008556A patent/MXPA02008556A/es active IP Right Grant
- 2001-03-05 DK DK01909840T patent/DK1282084T3/da active
- 2001-03-05 AT AT01909840T patent/ATE250256T1/de active
- 2001-03-05 KR KR1020027011732A patent/KR100735583B1/ko active IP Right Grant
- 2001-03-05 PT PT01909840T patent/PT1282084E/pt unknown
- 2001-03-05 CA CA002402390A patent/CA2402390C/en not_active Expired - Lifetime
- 2001-03-05 DE DE60100810T patent/DE60100810T2/de not_active Expired - Lifetime
- 2001-03-05 ES ES01909840T patent/ES2207605T3/es not_active Expired - Lifetime
- 2001-03-05 EP EP01909840A patent/EP1282084B9/en not_active Expired - Lifetime
- 2001-03-05 BR BRPI0108990A patent/BRPI0108990B8/pt not_active IP Right Cessation
-
2002
- 2002-09-06 NO NO20024256A patent/NO323314B1/no not_active IP Right Cessation
-
2003
- 2003-06-21 HK HK03104472.6A patent/HK1052244B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT1282084E (pt) | 2004-02-27 |
WO2001066519A3 (es) | 2002-01-31 |
EP1282084A2 (en) | 2003-02-05 |
CA2402390A1 (en) | 2001-09-13 |
ATE250256T1 (de) | 2003-10-15 |
KR20020075809A (ko) | 2002-10-05 |
NO20024256L (no) | 2002-09-06 |
ES2207605T3 (es) | 2004-06-01 |
KR100735583B1 (ko) | 2007-07-04 |
ES2159488A1 (es) | 2001-10-01 |
BR0108990A (pt) | 2003-12-30 |
EP1282084B9 (en) | 2005-03-02 |
NO20024256D0 (no) | 2002-09-06 |
WO2001066519A2 (es) | 2001-09-13 |
AU2001237447A1 (en) | 2001-09-17 |
EP1282084B1 (en) | 2003-09-17 |
BRPI0108990B8 (pt) | 2021-05-25 |
NO323314B1 (no) | 2007-03-12 |
DK1282084T3 (da) | 2004-02-02 |
JP2004500391A (ja) | 2004-01-08 |
DE60100810D1 (de) | 2003-10-23 |
DE60100810T2 (de) | 2004-07-01 |
HK1052244B (zh) | 2003-12-19 |
BR0108990B1 (pt) | 2014-03-25 |
CA2402390C (en) | 2009-09-15 |
AR027607A1 (es) | 2003-04-02 |
MXPA02008556A (es) | 2003-02-24 |
US6653475B2 (en) | 2003-11-25 |
US20030064986A1 (en) | 2003-04-03 |
JP4772248B2 (ja) | 2011-09-14 |
HK1052244A1 (en) | 2003-09-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010120 Kind code of ref document: A1 Effective date: 20010120 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20200626 |