ES2103180B1 - PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. - Google Patents

PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.

Info

Publication number
ES2103180B1
ES2103180B1 ES9401695A ES9401695A ES2103180B1 ES 2103180 B1 ES2103180 B1 ES 2103180B1 ES 9401695 A ES9401695 A ES 9401695A ES 9401695 A ES9401695 A ES 9401695A ES 2103180 B1 ES2103180 B1 ES 2103180B1
Authority
ES
Spain
Prior art keywords
leucotrenees
phenylacetamides
hydrogen
antagonist action
chlorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9401695A
Other languages
Spanish (es)
Other versions
ES2103180A1 (en
Inventor
Casellas David Mauleon
Germano Carganico
Perez Maria Luisa Garcia
Torro M Desamoarados Fos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9401695A priority Critical patent/ES2103180B1/en
Priority to PCT/EP1995/002958 priority patent/WO1996004246A1/en
Priority to AU32219/95A priority patent/AU3221995A/en
Publication of ES2103180A1 publication Critical patent/ES2103180A1/en
Application granted granted Critical
Publication of ES2103180B1 publication Critical patent/ES2103180B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FENILACETAMIDAS CON ACCION ANTAGONISTA DE LOS LEUCOTRIENOS. LA PRESENTE INVENCION SE REFIERE A NUEVAS FENILACETAMIDAS DE FORMULA I, FORMULA DONDE EL SUSTITUYENTE QUE CONTIENE A -CONR3- ESTA UNIDO A LA POSICION 3 O 4 DEL SISTEMA FENOLICO; R1 ES HIDROGENO, FLUOR, CLORO O -OCH3; R2 ES HIDROGENO, FLUOR, CLORO O BROMO; R3 ES HIDROGENO O METILO; B ES 5-TETRAZOLILO O -COOR4, R4 ES HIDROGENO, (C1-C4)-ALQUILO O FENILALQUILO; M Y N SON ENTEROS COMPRENDIDOS ENTRE 0 Y 6, CON LA CONDICION DE QUE M+N SEA MENOR O IGUAL A 6. DICHOS COMPUESTOS PRESENTAN UNA ACCION ANTAGONISTA DE LOS LEUCOTRIENOS, PUDIENDO SER UTILIZADOS COMO ANTIINFLAMATORIOS, ANTIALERGICOS O EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA CARDIOVASCULAR.PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. THE PRESENT INVENTION REFERS TO NEW PHENYLACETAMIDES OF FORMULA I, FORMULA WHERE THE SUBSTITUTE CONTAINING -CONR3- IS ATTACHED TO POSITION 3 OR 4 OF THE PHENOLIC SYSTEM; R1 IS HYDROGEN, FLUORINE, CHLORINE OR -OCH3; R2 IS HYDROGEN, FLUORINE, CHLORINE OR BROMINE; R3 IS HYDROGEN OR METHYL; B IS 5-TETRAZOLYL OR -COOR4, R4 IS HYDROGEN, (C1-C4) -ALKYL OR PHENYLALKYL; MYN ARE WHOLE COMPRISED BETWEEN 0 AND 6, WITH THE CONDITION THAT M + N IS LESS THAN OR EQUAL TO 6. SUCH COMPOUNDS PRESENT AN ANTAGONISTIC ACTION OF THE LEUCOTRENEES, MAY BE USED AS ANTI-INFLAMMATORY, ANTI-ALLERGIC, AND TREATMENT TREATMENTS IN .

ES9401695A 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES. Expired - Fee Related ES2103180B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9401695A ES2103180B1 (en) 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.
PCT/EP1995/002958 WO1996004246A1 (en) 1994-08-01 1995-07-26 Phenylacetamides having leukotriene-antagonistic action
AU32219/95A AU3221995A (en) 1994-08-01 1995-07-26 Phenylacetamides having leukotriene-antagonistic action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9401695A ES2103180B1 (en) 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.

Publications (2)

Publication Number Publication Date
ES2103180A1 ES2103180A1 (en) 1997-08-16
ES2103180B1 true ES2103180B1 (en) 1998-04-01

Family

ID=8287120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9401695A Expired - Fee Related ES2103180B1 (en) 1994-08-01 1994-08-01 PHENYLACETAMIDES WITH ANTAGONIST ACTION OF THE LEUCOTRENEES.

Country Status (3)

Country Link
AU (1) AU3221995A (en)
ES (1) ES2103180B1 (en)
WO (1) WO1996004246A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117551B1 (en) * 1995-12-29 1999-04-01 Menarini Lab NAPHTHALENIC QUINOLINS WITH ANTAGONIST ACTION OF THE LEUKOTRENEES, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME.
FR2761687B1 (en) * 1997-04-08 2000-09-15 Centre Nat Rech Scient QUINOLEIN DERIVATIVES, ESPECIALLY HAVING ANTIVIRAL PROPERTIES, THEIR PREPARATIONS AND THEIR BIOLOGICAL APPLICATIONS
IT1320162B1 (en) * 2000-02-09 2003-11-18 Rotta Research Lab DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4579866A (en) * 1984-05-29 1986-04-01 Usv Pharmaceutical Corp. Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
GB8728051D0 (en) * 1987-12-01 1988-01-06 Leo Pharm Prod Ltd Chemical compounds
DE3900261A1 (en) * 1988-05-31 1989-12-07 Bayer Ag SUBSTITUTED 4- (CHINOLIN-2-YL-METHOXY) PHENYL-ACETIC ACID DERIVATIVES
DE4129742A1 (en) * 1991-09-06 1993-03-11 Bayer Ag HETEROCYCLICALLY SUBSTITUTED CHINOLYLMETHOXY-PHENYLACETAMIDE

Also Published As

Publication number Publication date
ES2103180A1 (en) 1997-08-16
AU3221995A (en) 1996-03-04
WO1996004246A1 (en) 1996-02-15

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