EP3933027A4 - Self-driven microfluidic chip and method for using same - Google Patents

Self-driven microfluidic chip and method for using same Download PDF

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Publication number
EP3933027A4
EP3933027A4 EP20779964.4A EP20779964A EP3933027A4 EP 3933027 A4 EP3933027 A4 EP 3933027A4 EP 20779964 A EP20779964 A EP 20779964A EP 3933027 A4 EP3933027 A4 EP 3933027A4
Authority
EP
European Patent Office
Prior art keywords
self
same
microfluidic chip
driven microfluidic
driven
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20779964.4A
Other languages
German (de)
French (fr)
Other versions
EP3933027A1 (en
Inventor
Yibo Gao
Qi Song
Weijia Wen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Shineway Tech Corp
Shenzhen Shineway Technology Corp
Original Assignee
Shenzhen Shineway Tech Corp
Shenzhen Shineway Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Shineway Tech Corp, Shenzhen Shineway Technology Corp filed Critical Shenzhen Shineway Tech Corp
Publication of EP3933027A1 publication Critical patent/EP3933027A1/en
Publication of EP3933027A4 publication Critical patent/EP3933027A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP20779964.4A 2019-03-27 2020-03-26 Self-driven microfluidic chip and method for using same Pending EP3933027A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910235034.1A CN109929749B (en) 2019-03-27 2019-03-27 Self-driven micro-fluidic chip and application method thereof
PCT/CN2020/081497 WO2020192742A1 (en) 2019-03-27 2020-03-26 Self-driven microfluidic chip and method for using same

Publications (2)

Publication Number Publication Date
EP3933027A1 EP3933027A1 (en) 2022-01-05
EP3933027A4 true EP3933027A4 (en) 2022-04-27

Family

ID=66988370

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20779964.4A Pending EP3933027A4 (en) 2019-03-27 2020-03-26 Self-driven microfluidic chip and method for using same

Country Status (3)

Country Link
EP (1) EP3933027A4 (en)
CN (1) CN109929749B (en)
WO (1) WO2020192742A1 (en)

Families Citing this family (24)

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CN109929749B (en) * 2019-03-27 2021-07-27 深圳市尚维高科有限公司 Self-driven micro-fluidic chip and application method thereof
CN110295107A (en) * 2019-07-01 2019-10-01 贵州金玖生物技术有限公司 A kind of multi-pass amount micro-fluidic chip for detection of nucleic acids
CN110616138A (en) * 2019-10-09 2019-12-27 山东百骏生物科技有限公司 Chambered multi-index nucleic acid amplification micro-fluidic chip
CN110628611A (en) * 2019-10-16 2019-12-31 中国水产科学研究院黄海水产研究所 Self-driven micro-fluidic chip with integrated processing and amplification color development functions
CN111013676A (en) * 2019-12-17 2020-04-17 江苏圣极基因科技有限公司 Liquid drop preparation method and micro-fluidic chip
CN111394234B (en) * 2019-12-24 2022-11-01 南通大学 Digital chip and method for nucleic acid amplification
CN111363664B (en) * 2020-04-24 2023-06-30 吉林医药学院 LAMP detection chip based on three-layer microchip detection and control method thereof
CN111721818B (en) * 2020-06-04 2022-07-05 南京市食品药品监督检验院 Self-driven electrochemical detection chip and preparation method thereof
CN111812085A (en) * 2020-07-27 2020-10-23 重庆大学 Fermented yellow water detection device
CN112816477B (en) * 2021-01-21 2023-01-17 北京航空航天大学 Method for researching interaction between solid powder and biological sample by using microfluid chip
CN112945637A (en) * 2021-01-28 2021-06-11 上海浚真生命科学有限公司 Sampling device
CN113030452B (en) * 2021-03-02 2022-11-08 南京信息工程大学 Evaporation effect compensation device for trace liquid analysis and working method thereof
CN113278510A (en) * 2021-04-06 2021-08-20 中国人民解放军东部战区总医院 But multiple detection micro-fluidic chip of nucleic acid of autoinjection
CN113512490B (en) * 2021-04-19 2022-06-17 杭州优思达生物技术有限公司 Self-driven micro-fluidic detection device and application thereof
CN113289701A (en) * 2021-05-21 2021-08-24 合肥工业大学 Pump-free micro-fluidic chip for electrochemical detection and preparation method thereof
CN113969232A (en) * 2021-11-12 2022-01-25 南通大学 Digital micro-fluidic chip device for nucleic acid detection and use method
CN113881560A (en) * 2021-11-15 2022-01-04 深圳市研元生物科技有限公司 Nucleic acid detecting plate embedded in gene chip
CN114231408B (en) * 2021-12-31 2024-04-30 圣湘生物科技股份有限公司 Nucleic acid detection chip and nucleic acid detection method
CN114345431B (en) * 2022-01-27 2023-07-25 郭景桓 Microfluidic device and application thereof
CN115541514B (en) * 2022-12-05 2023-03-28 常州先趋医疗科技有限公司 Detection device and detection method based on absorption spectroscopy
CN115975804B (en) * 2022-12-23 2023-11-07 成都诺医德医学检验实验室有限公司 Chip device and method for cell culture and automatic drug addition
CN116948806B (en) * 2023-09-19 2024-01-09 国科温州研究院(温州生物材料与工程研究所) Digital PCR chip with wide measurement range, use method and manufacturing method
CN117070346B (en) * 2023-10-16 2024-02-06 鲲鹏基因（北京）科技有限责任公司 PCR kit, reaction mechanism and reaction equipment
CN117244600B (en) * 2023-11-15 2024-02-13 至美时代生物智能科技(北京)有限公司 Reaction chamber, reaction chamber group and micro-fluidic chip

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WO2003035229A2 (en) * 2001-10-26 2003-05-01 Ntu Ventures Pte Ltd Integrated fluidic device for sample preparation and assay
WO2016118949A1 (en) * 2015-01-23 2016-07-28 Neofluidics Llc A microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors

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JP4556194B2 (en) * 2008-02-01 2010-10-06 セイコーエプソン株式会社 Biological sample reaction method
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CN102277294B (en) * 2011-08-03 2013-04-17 浙江大学 High-density array chip device used for digital nucleic acid amplification
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CN107475074B (en) * 2017-09-12 2024-04-05 深圳市尚维高科有限公司 Microfluidic PCR chip
CN108424845B (en) * 2018-01-24 2021-07-13 北京博奥晶典生物技术有限公司 Easily-detected SNP/InDel typing detection system and use method
CN109929749B (en) * 2019-03-27 2021-07-27 深圳市尚维高科有限公司 Self-driven micro-fluidic chip and application method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035229A2 (en) * 2001-10-26 2003-05-01 Ntu Ventures Pte Ltd Integrated fluidic device for sample preparation and assay
WO2016118949A1 (en) * 2015-01-23 2016-07-28 Neofluidics Llc A microfluidic serial dilution platform based well-plate using an oil-free immiscible phase driven by manual or electronic pipettors

Non-Patent Citations (2)

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Title
See also references of WO2020192742A1 *
XIAOWEN HUANG ET AL: "On-Site Formation of Emulsions by Controlled Air Plugs", SMALL, vol. 10, no. 4, 1 February 2014 (2014-02-01), pages 758 - 765, XP055479243, ISSN: 1613-6810, DOI: 10.1002/smll.201202659 *

Also Published As

Publication number Publication date
WO2020192742A1 (en) 2020-10-01
EP3933027A1 (en) 2022-01-05
CN109929749A (en) 2019-06-25
CN109929749B (en) 2021-07-27

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