EP3577221A4 - Polynukleotid-sekundärstruktur - Google Patents
Polynukleotid-sekundärstruktur Download PDFInfo
- Publication number
- EP3577221A4 EP3577221A4 EP18748592.5A EP18748592A EP3577221A4 EP 3577221 A4 EP3577221 A4 EP 3577221A4 EP 18748592 A EP18748592 A EP 18748592A EP 3577221 A4 EP3577221 A4 EP 3577221A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- secondary structure
- polynucleotide secondary
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762453482P | 2017-02-01 | 2017-02-01 | |
PCT/US2018/016514 WO2018144778A1 (en) | 2017-02-01 | 2018-02-01 | Polynucleotide secondary structure |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3577221A1 EP3577221A1 (de) | 2019-12-11 |
EP3577221A4 true EP3577221A4 (de) | 2020-12-23 |
Family
ID=63041198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18748592.5A Pending EP3577221A4 (de) | 2017-02-01 | 2018-02-01 | Polynukleotid-sekundärstruktur |
Country Status (4)
Country | Link |
---|---|
US (2) | US20200032274A1 (de) |
EP (1) | EP3577221A4 (de) |
MA (1) | MA47438A (de) |
WO (1) | WO2018144778A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
BR112016024644A2 (pt) | 2014-04-23 | 2017-10-10 | Modernatx Inc | vacinas de ácido nucleico |
US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
EP3324979B1 (de) | 2015-07-21 | 2022-10-12 | ModernaTX, Inc. | Impfstoffe gegen infektionserkrankungen |
WO2017031232A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Methods for preparing particles and related compositions |
EP3364981A4 (de) | 2015-10-22 | 2019-08-07 | ModernaTX, Inc. | Impfstoff gegen das humane cytomegalovirus |
CA3002819A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Sexually transmitted disease vaccines |
CA3002912A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Nucleic acid vaccines for varicella zoster virus (vzv) |
EP3364950A4 (de) | 2015-10-22 | 2019-10-23 | ModernaTX, Inc. | Impfstoffe gegen tropenkrankheiten |
EP4011451A1 (de) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Impfstoffe gegen atemwegsvirus |
EP3964200A1 (de) | 2015-12-10 | 2022-03-09 | ModernaTX, Inc. | Zusammensetzungen und verfahren zur abgabe von therapeutischen wirkstoffen |
US10465190B1 (en) | 2015-12-23 | 2019-11-05 | Modernatx, Inc. | In vitro transcription methods and constructs |
KR102533456B1 (ko) | 2016-05-18 | 2023-05-17 | 모더나티엑스, 인크. | 릴랙신을 인코딩하는 폴리뉴클레오타이드 |
CN116837052A (zh) | 2016-09-14 | 2023-10-03 | 摩登纳特斯有限公司 | 高纯度rna组合物及其制备方法 |
JP6980780B2 (ja) | 2016-10-21 | 2021-12-15 | モデルナティーエックス, インコーポレイテッド | ヒトサイトメガロウイルスワクチン |
US10925958B2 (en) | 2016-11-11 | 2021-02-23 | Modernatx, Inc. | Influenza vaccine |
US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
WO2018151816A1 (en) | 2017-02-16 | 2018-08-23 | Modernatx, Inc. | High potency immunogenic compositions |
MA52262A (fr) | 2017-03-15 | 2020-02-19 | Modernatx Inc | Vaccin à large spectre contre le virus de la grippe |
US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
US11045540B2 (en) | 2017-03-15 | 2021-06-29 | Modernatx, Inc. | Varicella zoster virus (VZV) vaccine |
MA47787A (fr) | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
MA47790A (fr) | 2017-03-17 | 2021-05-05 | Modernatx Inc | Vaccins à base d'arn contre des maladies zoonotiques |
US11905525B2 (en) | 2017-04-05 | 2024-02-20 | Modernatx, Inc. | Reduction of elimination of immune responses to non-intravenous, e.g., subcutaneously administered therapeutic proteins |
US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
EP3668979A4 (de) | 2017-08-18 | 2021-06-02 | Modernatx, Inc. | Verfahren zur hplc-analyse |
WO2019036682A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | RNA VARIANTS POLYMERASE |
EP3668977A4 (de) | 2017-08-18 | 2021-04-21 | Modernatx, Inc. | Analytische hplc-verfahren |
WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
US10653767B2 (en) | 2017-09-14 | 2020-05-19 | Modernatx, Inc. | Zika virus MRNA vaccines |
MA54676A (fr) | 2018-01-29 | 2021-11-17 | Modernatx Inc | Vaccins à base d'arn contre le vrs |
US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
MA55037A (fr) | 2019-02-20 | 2021-12-29 | Modernatx Inc | Variants d'arn polymérase pour le coiffage co-transcriptionnel |
GB2594365B (en) | 2020-04-22 | 2023-07-05 | BioNTech SE | Coronavirus vaccine |
EP4179112A2 (de) | 2020-07-13 | 2023-05-17 | The Board of Trustees of the Leland Stanford Junior University | Systeme und verfahren zur beurteilung der rna-stabilität |
US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
US11492611B2 (en) | 2020-08-31 | 2022-11-08 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for producing RNA constructs with increased translation and stability |
US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
CN117730157A (zh) * | 2022-04-15 | 2024-03-19 | 萨默费尼根有限公司 | 用于定量监测mRNA加帽效率的方法 |
WO2023235820A1 (en) * | 2022-06-03 | 2023-12-07 | Eclipse Bioinnovations, Inc. | Methods for obtaining rna secondary structure of lnp-encapsulated rna |
US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011156539A2 (en) * | 2010-06-11 | 2011-12-15 | Syngenta Participations Ag | Compositions and methods for protein production |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2305699B1 (de) | 2001-06-05 | 2014-08-13 | CureVac GmbH | Stabilisierte mRNA mit erhöhtem G/C-Gehalt und optimierter Codon Usage für die Impfung gegen Schlafkrankheit, Leishmaniose und Toxoplasmose |
US8768630B2 (en) * | 2010-02-19 | 2014-07-01 | The Regents Of The University Of Michigan | miRNA target prediction |
EP3682905B1 (de) * | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
EP2931319B1 (de) * | 2012-12-13 | 2019-08-21 | ModernaTX, Inc. | Modifizierte nukleinsäuremoleküle und deren verwendungen |
EP2983804A4 (de) | 2013-03-15 | 2017-03-01 | Moderna Therapeutics, Inc. | Ionenaustauschreinigung von mrna |
US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
WO2014144039A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Characterization of mrna molecules |
US10138507B2 (en) | 2013-03-15 | 2018-11-27 | Modernatx, Inc. | Manufacturing methods for production of RNA transcripts |
WO2014152031A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Ribonucleic acid purification |
WO2014144711A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Analysis of mrna heterogeneity and stability |
PL3146924T3 (pl) | 2015-09-24 | 2023-03-20 | Medinice S.A. | Krioaplikator do mało-inwazyjnej ablacji kardiochirurgicznej |
-
2018
- 2018-02-01 EP EP18748592.5A patent/EP3577221A4/de active Pending
- 2018-02-01 US US16/483,012 patent/US20200032274A1/en not_active Abandoned
- 2018-02-01 WO PCT/US2018/016514 patent/WO2018144778A1/en unknown
- 2018-02-01 MA MA047438A patent/MA47438A/fr unknown
-
2023
- 2023-01-04 US US18/093,119 patent/US20230250439A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011156539A2 (en) * | 2010-06-11 | 2011-12-15 | Syngenta Participations Ag | Compositions and methods for protein production |
Non-Patent Citations (2)
Title |
---|
KARIKÓ KATALIN ET AL: "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 16, no. 11, 1 November 2008 (2008-11-01), pages 1833 - 1840, XP002598556, ISSN: 1525-0024, [retrieved on 20080916], DOI: 10.1038/MT.2008.200 * |
See also references of WO2018144778A1 * |
Also Published As
Publication number | Publication date |
---|---|
MA47438A (fr) | 2019-12-11 |
US20230250439A1 (en) | 2023-08-10 |
WO2018144778A1 (en) | 2018-08-09 |
US20200032274A1 (en) | 2020-01-30 |
EP3577221A1 (de) | 2019-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3577221A4 (de) | Polynukleotid-sekundärstruktur | |
EP3692489A4 (de) | Quantenfeste blockchain | |
EP3645618A4 (de) | Polyolefinzusammensetzung | |
EP3612568B8 (de) | Zelle | |
EP3589248A4 (de) | Kryotherapien | |
EP3732715A4 (de) | Zweidurchgangsstrukturen mit nullversatz | |
EP3459756A4 (de) | Struktur zur verhinderung von fälschungen | |
EP3684343A4 (de) | Verbesserte suprapartikel | |
EP3688700A4 (de) | Durch nachrichten ausgewiesene blockchains | |
EP3665343A4 (de) | Bauelement | |
EP3320931A4 (de) | Wählschalter | |
EP3665276A4 (de) | Verbesserte endoinulinasen | |
EP3674407A4 (de) | Modifiziertes polynukleotid | |
EP3596929A4 (de) | Shoutcasting | |
EP3652319C0 (de) | Herstellung von methionin mittels hefe | |
EP3486982A4 (de) | Struktur | |
EP3585947A4 (de) | Dammanordnung | |
EP3367398A4 (de) | Transformator zur verwendung in einem fahrzeug | |
EP3685644B8 (de) | Rfid-arbeitskabine | |
EP3730143A4 (de) | Omidenepag-kombination | |
EP3712265A4 (de) | Variantenziel | |
EP3665480A4 (de) | Strukturen zur apoptosenachahmung | |
AU2017904707A0 (en) | Humelove | |
AU2017904592A0 (en) | Picaccia | |
AU2017904507A0 (en) | foncph |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 20190829 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20201119 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07H 21/02 20060101ALI20201113BHEP Ipc: A61K 48/00 20060101ALI20201113BHEP Ipc: C12Q 1/68 20180101ALI20201113BHEP Ipc: C12N 15/11 20060101AFI20201113BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20230127 |