EP3316883A4 - Inhibitors of the fkbp51 protein from a high-throughput drug screen and methods of use - Google Patents
Inhibitors of the fkbp51 protein from a high-throughput drug screen and methods of use Download PDFInfo
- Publication number
- EP3316883A4 EP3316883A4 EP15897348.7A EP15897348A EP3316883A4 EP 3316883 A4 EP3316883 A4 EP 3316883A4 EP 15897348 A EP15897348 A EP 15897348A EP 3316883 A4 EP3316883 A4 EP 3316883A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- methods
- drug screen
- throughput drug
- fkbp51 protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2015/038664 WO2017003469A1 (en) | 2015-06-30 | 2015-06-30 | Inhibitors of the fkbp51 protein from a high-throughput drug screen and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3316883A1 EP3316883A1 (en) | 2018-05-09 |
EP3316883A4 true EP3316883A4 (en) | 2019-06-12 |
Family
ID=57608833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15897348.7A Withdrawn EP3316883A4 (en) | 2015-06-30 | 2015-06-30 | Inhibitors of the fkbp51 protein from a high-throughput drug screen and methods of use |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP3316883A4 (en) |
WO (1) | WO2017003469A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102051624B1 (en) * | 2018-11-30 | 2019-12-02 | 아밀로이드솔루션 주식회사 | Pharmaceutical composition for treatment of neurodegenerative brain disease comprising triflupromazine or pharmacurically acceptable salt thereof as an active ingredient |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013091900A1 (en) * | 2011-12-22 | 2013-06-27 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Pipecolate-diketoamides for treatment of psychiatric disorders |
WO2015039758A1 (en) * | 2013-09-19 | 2015-03-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Selective fkbp51 ligands for treatment of psychiatric disorders |
WO2015110271A1 (en) * | 2014-01-24 | 2015-07-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1392262A1 (en) * | 2001-05-24 | 2004-03-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
WO2011054399A1 (en) * | 2009-11-06 | 2011-05-12 | Avail Gmbh | Improvement of the glucocorticoid receptor function in asthma |
-
2015
- 2015-06-30 WO PCT/US2015/038664 patent/WO2017003469A1/en active Application Filing
- 2015-06-30 EP EP15897348.7A patent/EP3316883A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013091900A1 (en) * | 2011-12-22 | 2013-06-27 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Pipecolate-diketoamides for treatment of psychiatric disorders |
WO2015039758A1 (en) * | 2013-09-19 | 2015-03-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Selective fkbp51 ligands for treatment of psychiatric disorders |
WO2015110271A1 (en) * | 2014-01-24 | 2015-07-30 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Diazabicyclo[4.3.1]decane derivatives for treatment of psychiatric disorders |
Non-Patent Citations (4)
Title |
---|
O'LEARY J ET AL: "FKBP5 gene deletion prevents susceptibility to depression", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 41, 2011, & 41ST ANNUAL MEETING OF THE SOCIETY-FOR-NEUROSCIENCE; WASHINGTON, DC, USA; NOVEMBER 12 -16, 2011, XP002787677 * |
See also references of WO2017003469A1 * |
STRANG R R: "Experiences with cogentin in the treatment of Parkinsonism. A one-year controlled study of 94 patients.", ACTA NEUROLOGICA SCANDINAVICA 1966, vol. 41, no. 4, 1966, pages 413 - 418, XP002787676, ISSN: 0001-6314 * |
TISLOW R F: "USEFULNESS OF ANTI CHOLINERGIC DRUGS IN SUPPRESSING SYMPTOMS OF DEPRESSION IN MAN ABSTRACT BENZTROPINE CENT STIM TRIHEXYPHENIDYL CENT STIM BIPERIDEN CENT STIM", FEDERATION PROCEEDINGS, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, US, vol. 28, no. 2, 1 January 1969 (1969-01-01), pages 728, XP009510075, ISSN: 0014-9446 * |
Also Published As
Publication number | Publication date |
---|---|
WO2017003469A1 (en) | 2017-01-05 |
EP3316883A1 (en) | 2018-05-09 |
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Legal Events
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
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17P | Request for examination filed |
Effective date: 20180129 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: DICKEY, CHAD Inventor name: SABBAGH, JONATHAN JACOB |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/445 20060101ALI20190114BHEP Ipc: A61K 31/498 20060101ALI20190114BHEP Ipc: A61P 25/28 20060101ALI20190114BHEP Ipc: A61K 31/415 20060101ALI20190114BHEP Ipc: A61K 31/439 20060101AFI20190114BHEP Ipc: A61P 25/00 20060101ALI20190114BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20190514 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/498 20060101ALI20190508BHEP Ipc: A61K 31/415 20060101ALI20190508BHEP Ipc: A61K 31/439 20060101AFI20190508BHEP Ipc: A61P 25/00 20060101ALI20190508BHEP Ipc: A61K 31/445 20060101ALI20190508BHEP Ipc: A61P 25/28 20060101ALI20190508BHEP |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
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17Q | First examination report despatched |
Effective date: 20200812 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20201223 |