EP3307913A4 - Methods of diagnosing and treating autism - Google Patents

Methods of diagnosing and treating autism Download PDF

Info

Publication number
EP3307913A4
EP3307913A4 EP16812321.4A EP16812321A EP3307913A4 EP 3307913 A4 EP3307913 A4 EP 3307913A4 EP 16812321 A EP16812321 A EP 16812321A EP 3307913 A4 EP3307913 A4 EP 3307913A4
Authority
EP
European Patent Office
Prior art keywords
diagnosing
methods
treating autism
autism
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16812321.4A
Other languages
German (de)
French (fr)
Other versions
EP3307913A1 (en
Inventor
Hakon Hakonarson
Tara Wenger
Charlly Kao
Dexter HADLEY
Zhi-liang WU
Joseph Glessner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Hospital of Philadelphia CHOP
Original Assignee
Childrens Hospital of Philadelphia CHOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/740,230 external-priority patent/US11219617B2/en
Application filed by Childrens Hospital of Philadelphia CHOP filed Critical Childrens Hospital of Philadelphia CHOP
Publication of EP3307913A1 publication Critical patent/EP3307913A1/en
Publication of EP3307913A4 publication Critical patent/EP3307913A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP16812321.4A 2015-06-15 2016-06-15 Methods of diagnosing and treating autism Withdrawn EP3307913A4 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14/740,230 US11219617B2 (en) 2014-05-30 2015-06-15 Methods of diagnosing and treating autism
US201562215628P 2015-09-08 2015-09-08
US201562215633P 2015-09-08 2015-09-08
US201562215673P 2015-09-08 2015-09-08
US201562215636P 2015-09-08 2015-09-08
PCT/US2016/037596 WO2016205348A1 (en) 2015-06-15 2016-06-15 Methods of diagnosing and treating autism

Publications (2)

Publication Number Publication Date
EP3307913A1 EP3307913A1 (en) 2018-04-18
EP3307913A4 true EP3307913A4 (en) 2019-03-27

Family

ID=57546224

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16812321.4A Withdrawn EP3307913A4 (en) 2015-06-15 2016-06-15 Methods of diagnosing and treating autism

Country Status (5)

Country Link
EP (1) EP3307913A4 (en)
CN (1) CN108474036A (en)
AU (1) AU2016278053A1 (en)
CA (1) CA2989326A1 (en)
WO (1) WO2016205348A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011293363A1 (en) 2010-08-24 2013-02-28 The Children's Hospital Of Philadelphia Association of rare recurrent genetic variations to attention-deficit, hyperactivity disorder (ADHD) and methods of use thereof for the diagnosis and treatment of the same
JP7281280B2 (en) 2015-09-08 2023-05-25 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア Method for diagnosing and treating Tourette's syndrome
WO2018195184A1 (en) * 2017-04-19 2018-10-25 Aevi Genomics Medicine, Inc. Methods of diagnosing and treating adhd in biomarker positive subjects
CN109813912B (en) * 2019-01-04 2021-12-28 深圳大学 Application of group of serum differential protein combinations in preparation of reagent for detecting autism
CN113706458B (en) * 2021-07-15 2023-03-28 电子科技大学 Autism detection device based on Gossip model
CN114446476B (en) * 2022-01-28 2023-02-17 中南大学湘雅二医院 Construction method, prediction method and device of autism treatment effect prediction model

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20140315992A1 (en) * 2011-07-07 2014-10-23 The Children's Hospital Of Philadelphia Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1202962A (en) 1982-10-19 1986-04-08 David P. Clifford Substituted n-phenyl-n'-benzoyl ureas and their use as insecticides and acaricides
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
FR2597100A1 (en) 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd PYROGLUTAMIDE DERIVATIVES
US20140216734A1 (en) * 2013-02-05 2014-08-07 Schlumberger Technology Corporation Casing collar location using elecromagnetic wave phase shift measurement
WO2014152965A2 (en) * 2013-03-14 2014-09-25 The Children's Hospital Of Philadelphia Schizophrenia-associated genetic loci identified in genome wide association studies and use thereof as novel therapeutic targets

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20140315992A1 (en) * 2011-07-07 2014-10-23 The Children's Hospital Of Philadelphia Genetic Alterations Associated with Autism and the Autistic Phenotype and Methods of Use Thereof for the Diagnosis and Treatment of Autism

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GREGORY KAREN J ET AL: "Pharmacology of metabotropic glutamate receptor allosteric modulators: structural basis and therapeutic potential for CNS disorders", PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCI, ELSEVIER, NL, vol. 115, 1 January 2013 (2013-01-01), pages 61 - 121, XP009192627, ISSN: 1878-0814, DOI: 10.1016/B978-0-12-394587-7.00002-6 *
MALYKH ANDREI G ET AL: "Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders", DRUGS, SPRINGER INTERNATIONAL PUBLISHING, vol. 70, no. 3, 1 January 2010 (2010-01-01), pages 287 - 312, XP009162620, ISSN: 0012-6667, DOI: 10.2165/11319230-000000000-00000 *
See also references of WO2016205348A1 *

Also Published As

Publication number Publication date
WO2016205348A1 (en) 2016-12-22
EP3307913A1 (en) 2018-04-18
CN108474036A (en) 2018-08-31
AU2016278053A1 (en) 2018-01-04
CA2989326A1 (en) 2016-12-22

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