EP2771002A4 - Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof - Google Patents
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereofInfo
- Publication number
- EP2771002A4 EP2771002A4 EP12843820.7A EP12843820A EP2771002A4 EP 2771002 A4 EP2771002 A4 EP 2771002A4 EP 12843820 A EP12843820 A EP 12843820A EP 2771002 A4 EP2771002 A4 EP 2771002A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- benzoic acid
- hydromorphone
- prodrugs
- making
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161551600P | 2011-10-26 | 2011-10-26 | |
US201261657201P | 2012-06-08 | 2012-06-08 | |
PCT/US2012/061813 WO2013063204A1 (en) | 2011-10-26 | 2012-10-25 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2771002A1 EP2771002A1 (en) | 2014-09-03 |
EP2771002A4 true EP2771002A4 (en) | 2015-08-12 |
Family
ID=48168468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12843820.7A Withdrawn EP2771002A4 (en) | 2011-10-26 | 2012-10-25 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
Country Status (19)
Country | Link |
---|---|
US (6) | US8816083B2 (en) |
EP (1) | EP2771002A4 (en) |
JP (1) | JP5769889B2 (en) |
KR (1) | KR101589846B1 (en) |
CN (2) | CN104136031B (en) |
AR (1) | AR088551A1 (en) |
AU (1) | AU2012328837B2 (en) |
BR (1) | BR112014010099A8 (en) |
CA (1) | CA2856608C (en) |
CL (1) | CL2014000995A1 (en) |
CO (1) | CO7010825A2 (en) |
HK (2) | HK1197191A1 (en) |
IL (1) | IL231822A0 (en) |
IN (1) | IN2014DN03009A (en) |
MX (1) | MX362857B (en) |
RU (1) | RU2573388C2 (en) |
SG (1) | SG11201401856VA (en) |
WO (1) | WO2013063204A1 (en) |
ZA (1) | ZA201402339B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
UA102916C2 (en) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Composition based on conjugates of hydrocodone with benzoic acid, benzoic acid or heteroaryl carboxylic acid derivatives, prodrugs and method for treatment of abuses |
RU2573388C2 (en) * | 2011-10-26 | 2016-01-20 | Кемфарм Инк. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods for producing and using them |
CA2932477C (en) | 2013-12-06 | 2023-10-10 | Baikang (Suzhou) Co., Ltd | Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs |
GB201417529D0 (en) | 2014-10-03 | 2014-11-19 | Isis Innovation | Beta lactamase inhibitors |
NZ731591A (en) | 2014-11-25 | 2018-06-29 | Kempharm Inc | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone |
MX2017006935A (en) * | 2014-12-02 | 2017-08-10 | Kempharm Inc * | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereof. |
US10449190B2 (en) | 2015-04-27 | 2019-10-22 | John K. Thottathil | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of opioids and uses thereof |
US10017519B2 (en) | 2015-04-27 | 2018-07-10 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof |
US9987269B2 (en) | 2015-04-27 | 2018-06-05 | 3St Research Llc | Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of oxymorphone and uses thereof |
US10226456B2 (en) | 2015-04-27 | 2019-03-12 | 3St Research Llc | Methods and compositions for preventing opioid abuse |
EP3210596A1 (en) | 2016-02-29 | 2017-08-30 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical composition |
EP3231420A1 (en) | 2016-02-29 | 2017-10-18 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical compositions |
EP3210630A1 (en) | 2016-02-29 | 2017-08-30 | G.L. Pharma GmbH | Abuse-deterrent pharmaceutical compositions |
WO2018071879A1 (en) * | 2016-10-14 | 2018-04-19 | Kempharm, Inc. | Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders |
IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
WO2021097532A1 (en) * | 2019-11-22 | 2021-05-27 | Deakin University | Organic corrosion inhibitors |
WO2021097531A1 (en) * | 2019-11-22 | 2021-05-27 | Deakin University | Polyionic corrosion inhibitors |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150524A (en) * | 1995-12-20 | 2000-11-21 | Cenes Ltd. | Morphine derivatives with analgesic activity |
WO2003011881A2 (en) * | 2001-07-27 | 2003-02-13 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain |
WO2008101202A1 (en) * | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | N-17-alkylated prodrugs of opioids |
WO2011008636A1 (en) * | 2009-07-15 | 2011-01-20 | Mallinckrodt Inc. | 3-oxy-hydromorphone derivatives |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
NZ298712A (en) * | 1995-01-16 | 1998-12-23 | Commw Scient Ind Res Org | Fatty acid acyl group conjugates as therapeutic compounds |
KR101476574B1 (en) | 1999-10-29 | 2014-12-24 | 유로-셀티크 소시에떼 아노뉨 | Controlled release hydrocodone formulations |
BR0210179A (en) | 2001-06-05 | 2004-04-27 | Control Delivery Sys Inc | Sustained-release analgesic compounds |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
WO2004082620A2 (en) | 2003-03-13 | 2004-09-30 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower the abuse potential and extended duration of action |
CA2540678C (en) | 2003-09-30 | 2011-02-22 | New River Pharmaceuticals Inc. | Pharmaceutical compositions for prevention of overdose or abuse |
US7661226B2 (en) * | 2005-01-11 | 2010-02-16 | Larson Manufacturing Company | Installation method for a storm door |
EP2007389A2 (en) * | 2006-04-14 | 2008-12-31 | Shire LLC | Compositions and methods for enhancing analgesic potency of covalently bound compounds, attenuating its adverse side effects, and preventing their abuse |
MX2008014794A (en) | 2006-05-26 | 2009-04-08 | Pharmacofore Inc | Controlled release of phenolic opioids. |
WO2008055230A2 (en) | 2006-10-31 | 2008-05-08 | Rebit, Inc. | Automatically shadowing data for a plurality of network-connected computers using a network-attached memory |
US20090186832A1 (en) | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid peptide pro-drugs of phenolic analgesics and uses thereof |
JP2013523599A (en) | 2009-04-02 | 2013-06-17 | シャイア エルエルシー | Novel opioid dicarboxylic acid linked amino acid and peptide prodrugs and uses thereof |
AU2010266209B2 (en) * | 2009-07-02 | 2013-09-26 | Kempharm, Inc. | Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, methods of making and use thereof |
UA102916C2 (en) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Composition based on conjugates of hydrocodone with benzoic acid, benzoic acid or heteroaryl carboxylic acid derivatives, prodrugs and method for treatment of abuses |
CA2768236C (en) | 2009-07-16 | 2018-05-22 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
WO2011031350A1 (en) | 2009-09-08 | 2011-03-17 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
CA2768199C (en) | 2010-07-16 | 2018-08-28 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
US8685916B2 (en) | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
RU2573388C2 (en) | 2011-10-26 | 2016-01-20 | Кемфарм Инк. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods for producing and using them |
-
2012
- 2012-10-25 RU RU2014121065/04A patent/RU2573388C2/en not_active IP Right Cessation
- 2012-10-25 JP JP2014538982A patent/JP5769889B2/en not_active Expired - Fee Related
- 2012-10-25 CA CA2856608A patent/CA2856608C/en not_active Expired - Fee Related
- 2012-10-25 CN CN201280064641.2A patent/CN104136031B/en not_active Expired - Fee Related
- 2012-10-25 AU AU2012328837A patent/AU2012328837B2/en not_active Ceased
- 2012-10-25 IN IN3009DEN2014 patent/IN2014DN03009A/en unknown
- 2012-10-25 SG SG11201401856VA patent/SG11201401856VA/en unknown
- 2012-10-25 WO PCT/US2012/061813 patent/WO2013063204A1/en active Application Filing
- 2012-10-25 KR KR1020147010696A patent/KR101589846B1/en active IP Right Grant
- 2012-10-25 MX MX2014004691A patent/MX362857B/en active IP Right Grant
- 2012-10-25 EP EP12843820.7A patent/EP2771002A4/en not_active Withdrawn
- 2012-10-25 BR BR112014010099A patent/BR112014010099A8/en not_active Application Discontinuation
- 2012-10-25 CN CN201610210323.2A patent/CN105749294A/en active Pending
- 2012-10-25 US US13/660,112 patent/US8816083B2/en active Active
- 2012-10-26 AR ARP120104022A patent/AR088551A1/en unknown
-
2014
- 2014-03-28 ZA ZA2014/02339A patent/ZA201402339B/en unknown
- 2014-03-31 IL IL231822A patent/IL231822A0/en unknown
- 2014-04-17 CL CL2014000995A patent/CL2014000995A1/en unknown
- 2014-04-28 CO CO14089601A patent/CO7010825A2/en unknown
- 2014-07-21 US US14/336,549 patent/US9566343B2/en active Active
- 2014-10-28 HK HK14110803A patent/HK1197191A1/en unknown
-
2016
- 2016-10-04 HK HK16111529.9A patent/HK1223279A1/en unknown
- 2016-12-30 US US15/395,475 patent/US9849185B2/en active Active
-
2017
- 2017-11-14 US US15/812,823 patent/US10064956B2/en active Active
-
2018
- 2018-08-03 US US16/054,575 patent/US10258696B2/en active Active
-
2019
- 2019-03-01 US US16/290,496 patent/US10441661B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150524A (en) * | 1995-12-20 | 2000-11-21 | Cenes Ltd. | Morphine derivatives with analgesic activity |
WO2003011881A2 (en) * | 2001-07-27 | 2003-02-13 | Euro-Celtique, S.A. | Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain |
WO2008101202A1 (en) * | 2007-02-16 | 2008-08-21 | Pharmacofore, Inc. | N-17-alkylated prodrugs of opioids |
WO2011008636A1 (en) * | 2009-07-15 | 2011-01-20 | Mallinckrodt Inc. | 3-oxy-hydromorphone derivatives |
Non-Patent Citations (1)
Title |
---|
See also references of WO2013063204A1 * |
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Ipc: A61K 31/485 20060101AFI20150706BHEP Ipc: A61K 31/185 20060101ALI20150706BHEP Ipc: A61K 31/616 20060101ALI20150706BHEP Ipc: C07D 489/00 20060101ALI20150706BHEP |
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Owner name: KEMPHARM, INC. |
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Ipc: A61P 25/04 20060101ALI20190521BHEP Ipc: A61K 31/485 20060101ALI20190521BHEP Ipc: A61K 31/185 20060101ALI20190521BHEP Ipc: A61K 47/55 20170101AFI20190521BHEP Ipc: A61K 31/616 20060101ALI20190521BHEP |
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