EP2742154A4 - Compositions de biomarqueurs et procédés - Google Patents

Compositions de biomarqueurs et procédés

Info

Publication number
EP2742154A4
EP2742154A4 EP12821745.2A EP12821745A EP2742154A4 EP 2742154 A4 EP2742154 A4 EP 2742154A4 EP 12821745 A EP12821745 A EP 12821745A EP 2742154 A4 EP2742154 A4 EP 2742154A4
Authority
EP
European Patent Office
Prior art keywords
methods
biomarker compositions
biomarker
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12821745.2A
Other languages
German (de)
English (en)
Other versions
EP2742154A2 (fr
Inventor
Kirk Brown
Traci Pawlowski
David Spetzler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caris Life Sciences Switzerland Holdings GmbH
Original Assignee
Caris Life Sciences Switzerland Holdings GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caris Life Sciences Switzerland Holdings GmbH filed Critical Caris Life Sciences Switzerland Holdings GmbH
Publication of EP2742154A2 publication Critical patent/EP2742154A2/fr
Publication of EP2742154A4 publication Critical patent/EP2742154A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57434Specifically defined cancers of prostate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
EP12821745.2A 2011-08-08 2012-08-08 Compositions de biomarqueurs et procédés Withdrawn EP2742154A4 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US201161521333P 2011-08-08 2011-08-08
US201161523763P 2011-08-15 2011-08-15
US201161526623P 2011-08-23 2011-08-23
US201161529762P 2011-08-31 2011-08-31
US201161534352P 2011-09-13 2011-09-13
US201161537462P 2011-09-21 2011-09-21
US201161542639P 2011-10-03 2011-10-03
US201161551674P 2011-10-26 2011-10-26
US201161559676P 2011-11-14 2011-11-14
US201261612111P 2012-03-16 2012-03-16
US201261619803P 2012-04-03 2012-04-03
PCT/US2012/050030 WO2013022995A2 (fr) 2011-08-08 2012-08-08 Compositions de biomarqueurs et procédés

Publications (2)

Publication Number Publication Date
EP2742154A2 EP2742154A2 (fr) 2014-06-18
EP2742154A4 true EP2742154A4 (fr) 2015-08-12

Family

ID=47669214

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12821745.2A Withdrawn EP2742154A4 (fr) 2011-08-08 2012-08-08 Compositions de biomarqueurs et procédés

Country Status (8)

Country Link
EP (1) EP2742154A4 (fr)
JP (1) JP2014522993A (fr)
KR (1) KR20140067001A (fr)
CN (1) CN103874770A (fr)
AU (1) AU2012294458A1 (fr)
BR (1) BR112014002975A2 (fr)
CA (1) CA2844671A1 (fr)
WO (1) WO2013022995A2 (fr)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102089444A (zh) 2008-05-14 2011-06-08 德玛泰克国际公司 利用核酸分析方法来诊断黑素瘤和太阳能雀斑
CA2791905A1 (fr) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarqueurs pour theranostique
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
BR112014032728A2 (pt) 2012-06-27 2017-11-28 Berg Llc uso de marcadores no diagnóstico e tratamento de câncer de próstata
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
CN103160509B (zh) * 2013-03-07 2015-02-18 新乡医学院第一附属医院 一种与食管癌术后早期复发和预后相关的miRNA标志物及其应用
MX2015013141A (es) * 2013-03-15 2016-06-21 Univ Texas Biogénesis de miarn en exosomas para diagnóstico y terapia.
CN104076151B (zh) * 2013-03-29 2017-04-12 复旦大学附属华山医院 一种用于胶质瘤早期诊断的试剂盒
JP6556121B2 (ja) * 2013-04-29 2019-08-07 アポジェニックス アーゲー 癌を診断する方法
WO2014183093A1 (fr) * 2013-05-10 2014-11-13 University Of Southern California Biomarqueurs de méthylation de l'adn pour le cancer de la vessie
CN106029900B (zh) * 2013-08-06 2020-02-28 外来体诊断公司 尿生物标志物群、基因表达特征及其使用方法
JP2016533752A (ja) * 2013-08-28 2016-11-04 カリス ライフ サイエンシズ スウィッツァーランド ホー オリゴヌクレオチドプローブおよびその使用
ES2813877T3 (es) 2013-08-28 2021-03-25 Crown Bioscience Inc Taicang Distintivos de expresión génica predictivos de la respuesta de un sujeto a un inhibidor multicinasa y métodos de uso de los mismos
CN105723221B (zh) * 2013-11-06 2018-07-06 Jsr株式会社 分离方法、检测方法、信号测定方法、疾病的判定方法、疾病治疗药的药效评价方法、试剂盒以及液态组合物
FR3014198B1 (fr) * 2013-12-03 2017-03-03 Biomerieux Sa Procede d'isolement d'exosomes
WO2015083829A1 (fr) * 2013-12-06 2015-06-11 国立大学法人東京大学 Clapet, structure de régulation de fluide, dispositif à fluide et procédé de fabrication de clapet
CA2934828A1 (fr) * 2013-12-30 2015-07-09 The Henry M. Jackson Foundation For The Advancement Of Military Medici, Inc. Profils de genes du cancer de la prostate et procedes de leur utilisation
EP3090064B1 (fr) 2013-12-31 2019-11-13 Yeda Research and Development Co. Ltd. Diagnostic du lupus érythémateux systémique à l'aide d'oligonucléotides antigènes
WO2015117164A1 (fr) * 2014-02-03 2015-08-06 Memorial Sloan-Kettering Cancer Center Macrophages associés à une tumeur et procédés et compositions pour cibler une thérapie anticancéreuse et identifier des répondeurs potentiels
WO2015165973A1 (fr) 2014-04-29 2015-11-05 Apogenix Gmbh Anticorps anti-cd95l de diagnostic
WO2015165779A2 (fr) * 2014-05-01 2015-11-05 Stichting Vu-Vumc Petits arnnc servant de biomarqueurs
CN111996254A (zh) 2014-06-12 2020-11-27 东丽株式会社 前列腺癌的检测试剂盒或装置以及检测方法
ES2481819B1 (es) * 2014-06-12 2015-04-01 Sistemas Genómicos, S.L. Método de evaluación para evaluar una posibilidad de cáncer de mama
US20160038608A1 (en) * 2014-08-07 2016-02-11 National Taiwan University Silica-based mesoporous carrier and delivery method of using the same
BR112017005730B1 (pt) * 2014-09-26 2023-12-12 Somalogic Operating Co., Inc Método para triagem de um indivíduo quanto ao risco de um evento cardiovascular ou para predizer a probabilidade que um indivíduo tenha tal evento
KR101596166B1 (ko) 2014-10-07 2016-02-19 가톨릭대학교 산학협력단 유방암 진단 및 치료를 위한 마이크로 rna의 용도
CN104313171A (zh) * 2014-11-06 2015-01-28 南京大学 一种诊断神经胶质瘤的microRNA分子标记物及其应用
SG11201704660YA (en) 2014-12-08 2017-07-28 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
CN105807063B (zh) * 2014-12-29 2018-02-06 中国人民解放军第二军医大学 Cd63在制备肝脏疾病诊断试剂盒或制备预防或治疗肝脏疾病药物中的应用
CN104548134A (zh) * 2015-01-04 2015-04-29 中国人民解放军第二军医大学 miR-144及其抑制剂的应用
US20180148783A1 (en) * 2015-01-05 2018-05-31 The Johns Hopkins University Method of epigenetic analysis for determining clinical genetic risk
WO2016121821A1 (fr) * 2015-01-27 2016-08-04 Jsr株式会社 Procédé de séparation, procédé de détection, procédé de mesure de signaux, procédé de détermination de maladie, procédé d'évaluation de l'efficacité d'un médicament, kit, composition liquide, et diluent d'analyte
US11318163B2 (en) 2015-02-18 2022-05-03 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
IL284985B2 (en) 2015-02-18 2023-03-01 Enlivex Therapeutics R& D Ltd Combined immunotherapy and cytokine control therapy for cancer treatment
US11497767B2 (en) 2015-02-18 2022-11-15 Enlivex Therapeutics R&D Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11304976B2 (en) 2015-02-18 2022-04-19 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11000548B2 (en) 2015-02-18 2021-05-11 Enlivex Therapeutics Ltd Combination immune therapy and cytokine control therapy for cancer treatment
US11596652B2 (en) 2015-02-18 2023-03-07 Enlivex Therapeutics R&D Ltd Early apoptotic cells for use in treating sepsis
EP3265814B1 (fr) 2015-03-01 2020-11-18 Immunarray Ltd. Diagnostic du lupus érythémateux systémique à l'aide d'antigènes protéiques, peptidiques et oligonucléotidiques
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN104714032B (zh) * 2015-04-02 2015-09-16 闫星宇 用于产后子痫诊断的标志物及其检测试剂
CN107708811B (zh) 2015-04-21 2021-04-30 恩立夫克治疗有限责任公司 治疗性汇集的血液凋亡细胞制剂与其用途
CN108271413A (zh) * 2015-05-20 2018-07-10 Jsr株式会社 分离方法、检测方法、信号测定方法、疾病的判定方法、药效评价方法、试剂盒、液态组合物以及检体稀释液
JP2018520125A (ja) 2015-06-10 2018-07-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 疾患の処置のためのエキソソームの使用
CN104992058B (zh) * 2015-06-25 2017-08-01 成都厚立信息技术有限公司 疾病风险调整模型建立方法
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
CN105177117A (zh) * 2015-07-03 2015-12-23 张理义 重症抑郁障碍生物标记物、筛选方法及试剂盒
CN106350578A (zh) * 2015-07-13 2017-01-25 中国人民解放军第二军医大学 Ny-eso-1在微卫星不稳定性肠癌的诊断和治疗中的应用
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
CN105039342B (zh) * 2015-08-06 2017-12-01 李家平 能抑制MAT2A基因表达的siRNA及其应用
WO2017025954A1 (fr) * 2015-08-09 2017-02-16 Immunarray Ltd Méthodes de détermination du risque qu'un patient atteint d'un lupus érythémateux systémique (sle) développe des syndromes neuropsychiatriques
CN105067822B (zh) * 2015-08-12 2017-05-24 中山大学附属肿瘤医院 用于食管癌诊断的标志物
JP6583817B2 (ja) * 2015-09-04 2019-10-02 国立大学法人山口大学 子宮平滑筋における腫瘍の診断マーカー
KR102078310B1 (ko) * 2015-09-11 2020-02-19 주식회사 압타머사이언스 비소세포성 폐암 진단용 단백질 바이오마커 패널 및 이를 이용한 비소세포성 폐암 진단 방법
KR20180063127A (ko) 2015-09-17 2018-06-11 암젠 인크 Il23 경로 바이오마커를 사용한, il23-길항제에 대한 임상 반응의 예측
EP3165926A1 (fr) * 2015-11-06 2017-05-10 Humanitas Mirasole S.p.A. Procédé de caractérisation des microvésicules spécifiques de cellule
US11230735B2 (en) 2015-12-24 2022-01-25 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing sepsis
WO2017113565A1 (fr) * 2015-12-29 2017-07-06 中国医学科学院肿瘤医院 Kit pour le diagnostic auxiliaire d'un patient atteint d'un cancer du foie ou d'un cancer du tractus digestif basé sur un marqueur protéinique psg3
JP6884155B2 (ja) 2016-02-18 2021-06-09 エンリヴェックス セラピューティクス リミテッド 癌治療のための併用免疫療法及びサイトカイン制御療法
WO2017161357A1 (fr) 2016-03-18 2017-09-21 Caris Science, Inc. Sondes oligonucléotidiques et utilisations de celles-ci
CN105842461A (zh) * 2016-04-30 2016-08-10 广州恒泰生物科技有限公司 子宫肉瘤早中期快速诊断试剂盒及其制备方法
CA3025486A1 (fr) 2016-05-25 2017-11-30 Caris Science, Inc. Sondes oligonucleotidiques et utilisations de celles-ci
CN107475356A (zh) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 骨肉瘤循环肿瘤细胞鉴定试剂盒
CN105907875A (zh) * 2016-06-13 2016-08-31 武汉泰安康生物科技有限公司 一种筛选肾癌外周血miRNA标志物的方法及肾癌标志物miR-378
JP6980219B2 (ja) * 2016-08-22 2021-12-15 いであ株式会社 がんを検出、又はがんの進行期を判定する方法
EP3541958A1 (fr) * 2016-11-15 2019-09-25 Ventana Medical Systems, Inc. Compositions et procédés de prognostic et de traitement du cancer colorectal
CN108165635B (zh) * 2016-12-07 2021-07-13 南京农业大学 Kiaa1462基因启动子区变异位点及其在提高鹅产蛋性能上的应用
US20210072255A1 (en) 2016-12-16 2021-03-11 The Brigham And Women's Hospital, Inc. System and method for protein corona sensor array for early detection of diseases
DE202017007364U1 (de) * 2016-12-16 2021-02-11 The Brigham And Women's Hospital Inc. Anordnung markierter Sensorelemente zum Erfassen unterschiedlicher Proteine, die unterschiedliche Sensorelemente binden
CN106636296A (zh) * 2016-12-22 2017-05-10 广州医科大学附属肿瘤医院 Hsp27在舌癌化疗耐受诊治中的应用
CN106501517B (zh) * 2016-12-27 2018-05-08 北京蛋白质组研究中心 检测血清中sparc蛋白的物质在制备筛查肝细胞癌试剂盒中的应用
CN106939340A (zh) * 2017-03-31 2017-07-11 哈尔滨医科大学 一种与肺腺癌转移及预后相关的分子标记物及其应用
CN106947820B (zh) * 2017-04-11 2020-09-29 成都望路医药技术有限公司 Vcan在结肠腺癌诊治中的用途
JP7390711B2 (ja) 2017-05-12 2023-12-04 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン 個体およびコホートの薬理学的表現型予測プラットフォーム
CN106987649A (zh) * 2017-05-31 2017-07-28 上海博慷生物科技有限公司 一种用于检测脑胶质瘤的引物组及检测方法
CN109085355A (zh) * 2017-06-13 2018-12-25 中国医学科学院肿瘤医院 血清蛋白标志物组合在肺癌筛查和诊治中的应用
CN107273718A (zh) * 2017-06-27 2017-10-20 电子科技大学 一种融合dna甲基化特征的生存时间分析方法
JP7029719B2 (ja) * 2017-08-31 2022-03-04 静岡県 バイオマーカー
CN107630092B (zh) * 2017-10-23 2020-03-31 广州医科大学附属第二医院 miR-505-3p应用于前列腺癌骨转移的诊断、预后和治疗
WO2019126267A1 (fr) * 2017-12-22 2019-06-27 Wisconsin Alumni Research Foundation Surfaces formées par nano-ingénierie pour la capture de biomarqueurs du cancer
CN107868829B (zh) * 2017-12-26 2021-05-18 浙江自贸区锐赛生物医药科技有限公司 评估脊索瘤术后复发风险的组合试剂、试剂盒及其应用
CN107937621A (zh) * 2018-01-12 2018-04-20 南方医科大学皮肤病医院(广东省皮肤病医院、广东省皮肤性病防治中心、中国麻风防治研究中心) miRNA的应用、应用其的产品及检测方法
CN108192970A (zh) * 2018-01-24 2018-06-22 苏州大学 一种肝癌诊断标志物及其应用
CN108048460B (zh) * 2018-02-01 2021-04-09 浙江大学 一种新型分子标记及其在制备用于头颈癌诊断和预后的试剂盒中的应用
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
CA3095056A1 (fr) 2018-04-13 2019-10-17 Freenome Holdings, Inc. Mise en ƒuvre de l'apprentissage automatique pour un dosage multi-analytes d'echantillons biologiques
FR3080185A1 (fr) * 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
CN108570501B (zh) * 2018-04-28 2020-06-12 北京师范大学 多发性骨髓瘤分子分型及应用
CN108559778B (zh) * 2018-04-28 2020-06-12 北京师范大学 多发性骨髓瘤分子分型及其在用药指导上的应用
CN108586579B (zh) * 2018-05-11 2021-11-30 京东方科技集团股份有限公司 一种类肽及其衍生物、盐、制备方法和用途
CN108931633B (zh) * 2018-05-22 2021-08-27 郑州大学第一附属医院 胆囊癌诊断和预后判断标志物pim1
CN108841962B (zh) * 2018-08-01 2021-11-19 博奥生物集团有限公司 一种非小细胞肺癌检测试剂盒及其应用
KR102094608B1 (ko) * 2018-08-08 2020-04-23 고려대학교 산학협력단 혈액암의 분류 및 예후 판단에 필요한 정보를 제공하는 방법
US11535899B2 (en) 2018-08-10 2022-12-27 Toray Industries, Inc. Kit, device and method for detecting prostate cancer
CN109321656B (zh) * 2018-10-22 2021-10-01 上海交通大学医学院附属仁济医院 蛋白depdc1作为诊断三阴乳腺癌的标记物的用途
JP2020074769A (ja) * 2018-11-01 2020-05-21 花王株式会社 被験体の皮膚細胞に由来する核酸の調製方法
CN109507425A (zh) * 2018-11-07 2019-03-22 国家纳米科学中心 基于热泳细胞外囊泡的前列腺癌症复发监控系统及方法
EP3877400A4 (fr) 2018-11-07 2022-09-07 Seer, Inc. Compositions, procédés et systèmes d'analyse de couronne protéique et leurs utilisations
WO2020104588A1 (fr) * 2018-11-22 2020-05-28 Institut D'investigació Sanitària Pere Virgili Biomarqueurs de l'agressivité du cancer de la prostate
CN109609630B (zh) * 2018-12-03 2023-01-13 哈尔滨医科大学 用于早期胃癌诊断的分子标志物及其应用
CN109439757A (zh) * 2018-12-18 2019-03-08 首都医科大学附属北京佑安医院 血浆外泌体miR-455-3p作为早期肝癌诊断标志物的应用
CN109652504B (zh) * 2018-12-27 2021-03-16 杭州迪相实业有限公司 一种同时检测外泌体膜蛋白和mRNA的方法
JP2022517563A (ja) * 2019-01-02 2022-03-09 チョーチアン クラウンマブ バイオテック カンパニー リミテッド タンパク質キナーゼバイオマーカーと組み合わせた、多標的キナーゼ阻害剤を使用したがんの処置
CN109609653B (zh) * 2019-02-12 2019-07-19 山东大学齐鲁医院 诊断或治疗胶质瘤的分子标记物及其应用
EP3699300A1 (fr) * 2019-02-22 2020-08-26 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Arnmi séminaux en tant que biomarqueurs non invasifs pour le diagnostic et/ou le pronostic du cancer de la prostate
EP3948290A4 (fr) 2019-03-26 2023-08-09 Dermtech, Inc. Nouveaux classificateurs de gènes et leurs utilisations pour des cancers de la peau
CN110196329A (zh) * 2019-05-31 2019-09-03 郑州大学第一附属医院 一种食管癌早期联合检测试剂盒
JPWO2020262374A1 (fr) * 2019-06-27 2020-12-30
CN110279707A (zh) * 2019-07-05 2019-09-27 深圳市康宁医院(深圳市精神卫生研究所深圳市精神卫生中心) miR-212在制备用于治疗成瘾的药物中的应用
US20220291233A1 (en) * 2019-07-19 2022-09-15 Universiteit Antwerpen Mucin isoforms in diseases characterized by barrier dysfunction
KR102346864B1 (ko) * 2019-07-24 2022-01-04 한국전자기술연구원 방광암 진단 또는 예후 분석용 바이오마커 조성물, 키트 및 이를 이용한 진단 방법
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
CN110295228A (zh) * 2019-08-05 2019-10-01 中国人民解放军总医院第八医学中心 检测gata2的物质在制备诊断活动性结核病的试剂盒中的应用
CN110551809A (zh) * 2019-08-21 2019-12-10 昆明医科大学第一附属医院 miR-124在脊髓损伤修复中的用途
CN110564867B (zh) * 2019-10-10 2022-06-24 扬州大学 一种秦川牛cfl1基因的snp分子标记及其检测方法
CN110643672A (zh) * 2019-10-15 2020-01-03 西安交通大学 高表达TrkB作为新型靶点在抑制胰腺癌转移方面的医药用途
WO2021132654A1 (fr) * 2019-12-27 2021-07-01 関西ペイント株式会社 Procédé de production de matière à peindre, procédé de prédiction de données de teinte et système informatique de combinaison de couleurs
CN111647658B (zh) * 2020-06-05 2022-09-27 上海市第一人民医院 Linc00963相关致癌轴在前列腺癌远处转移的早期诊断和治疗中的应用
CN111690746A (zh) * 2020-06-30 2020-09-22 镇江维思生物科技有限责任公司 与肺癌相关的血小板rna标志物及其应用
CN113940999B (zh) * 2020-07-15 2022-11-29 中国农业大学 一种治疗非酒精性脂肪肝性肝病治疗靶点的应用
CN112180100A (zh) * 2020-09-27 2021-01-05 西安交通大学 Tweak作为鉴别不同类型银屑病的分子标志物的应用
CN112255408B (zh) * 2020-10-16 2023-04-14 牡丹江医学院 一种肿瘤生物标志物及肿瘤检测试剂盒
CN112285195B (zh) * 2020-10-27 2021-08-10 江南大学 一种牛奶外泌体的特征性糖蛋白标志物和牛奶外泌体的特征性标志物分离方法
CN112433053A (zh) * 2020-11-20 2021-03-02 四川大学华西医院 Tetraspanin-14蛋白检测试剂在制备肺癌筛查试剂盒中的用途
CN112301133B (zh) * 2020-12-01 2021-07-27 江门市中心医院 胆固醇生成基因标签在年轻乳腺癌患者预后预测中的应用
KR102427057B1 (ko) * 2020-12-04 2022-07-29 전남대학교산학협력단 단일섬유종양/혈관주위세포종 전이 진단 또는 예후 분석용 바이오 마커 및 이를 이용한 진단방법
US20240052422A1 (en) 2020-12-24 2024-02-15 Pontificia Universidad Catolica De Chile In-vitro method for diagnosing and predicting the aggressiveness of thyroid cancer, and the precision surgery options and type to be used to remove a tumour from a patient; kit; reagents forming the kit; and use of the reagents and use of molecular markers as part of the method
CN113151460B (zh) * 2021-01-29 2022-10-18 复旦大学附属中山医院 一种识别肺腺癌肿瘤细胞的基因标志物及其应用
CN115166245A (zh) * 2021-04-04 2022-10-11 兰州大学第一医院 Clu及其组合物在诊断胆管癌中的应用及胆管癌诊断试剂盒
KR102540416B1 (ko) * 2021-04-09 2023-06-12 주식회사 애티스랩 암 진단용 조성물, 키트, 및 이를 이용한 암 진단 방법
CN113125757B (zh) * 2021-04-22 2022-10-28 石河子大学 一种用于母猪早期妊娠诊断的蛋白生物标志物及其用于母猪早期妊娠检测的方法
CN113122544A (zh) * 2021-04-25 2021-07-16 杭州广科安德生物科技有限公司 一种特异性结合timp1蛋白的核酸适配体及其应用
CN113311166B (zh) * 2021-04-28 2022-10-28 新疆农垦科学院 一种用于绵羊早期妊娠诊断的蛋白生物标志物及其用于绵羊早期妊娠检测的方法
CN113186267A (zh) * 2021-06-07 2021-07-30 上海康黎诊断技术有限公司 一种人cyp2d6拷贝数变异和基因分型检测的引物探针组合、试剂盒以及方法
CN113687076B (zh) * 2021-07-14 2024-03-01 郑州大学 一种可用于肺腺癌早期诊断的联合检测血清标志物及其应用
GB202111635D0 (en) * 2021-08-13 2021-09-29 Randox Laboratories Risk prediction model for prostate cancer
TWI829369B (zh) * 2021-09-29 2024-01-11 日商西尾股份有限公司 美容方法
WO2023064883A1 (fr) * 2021-10-14 2023-04-20 The University Of Chicago Méthodes immunothérapeutiques pour le traitement du cancer
WO2023140658A1 (fr) * 2022-01-24 2023-07-27 고려대학교 산학협력단 Composition pharmaceutique pour le diagnostic, la prévention ou le traitement du sepsis à l'aide d'un facteur neurotrophique dérivé du cerveau
WO2023169686A1 (fr) * 2022-03-10 2023-09-14 Buzzard Pharmaceuticals AB Inhibiteur du récepteur de l'interleukine-1 de type 1 destiné à être utilisé dans le traitement du cancer
WO2024050856A1 (fr) * 2022-09-06 2024-03-14 南京市第一医院 Méthode et système pour aider un analyseur de cellules sanguines à déterminer une agrégation plaquettaire anormale
KR20240058548A (ko) * 2022-10-26 2024-05-07 연세대학교 산학협력단 유방암 진단 또는 재발 예측을 위한 세포외 소포체 유래 miRNA 유전자 바이오마커 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008092153A2 (fr) * 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Modification de composants à base d' exosome utilisés comme vaccin
WO2009015357A1 (fr) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Micro arn associé à l'exosome en tant que marqueur de diagnostic
WO2010056337A2 (fr) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Procédés et systèmes d'utilisation d'exosomes pour déterminer des phénotypes

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3316600A (en) * 1999-02-22 2000-09-21 Torben F. Orntoft Gene expression in bladder tumors
CA2544708A1 (fr) * 2003-11-03 2005-05-12 Genenews, Inc. Biomarqueurs du cancer du foie
DE602006015966D1 (de) * 2005-07-08 2010-09-16 Siemens Healthcare Diagnostics Verfahren zur vorhersage und überwachung einer unmittelbaren reaktion auf eine krebstherapie
US20080085524A1 (en) * 2006-08-15 2008-04-10 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
EP2092075A2 (fr) * 2006-11-06 2009-08-26 Source Precision Medicine, Inc. Profilage d'expression genique pour l'identification, la surveillance et le traitement d'un melanome
WO2009065230A1 (fr) * 2007-11-23 2009-05-28 British Columbia Cancer Agency Branch Procédés pour détecter un cancer du poumon et pour surveiller la réponse à un traitement
US8617806B2 (en) * 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
US20110177054A1 (en) * 2008-06-06 2011-07-21 Derrick Gibbings Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
CA2742324A1 (fr) * 2008-10-30 2010-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Procedes d'evaluation de motifs arn
GB0822836D0 (en) * 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method
US20130029339A1 (en) * 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
US20110166030A1 (en) * 2009-09-30 2011-07-07 Yixin Wang Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells
CA2782284A1 (fr) * 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Procedes et systemes pour isoler, stocker et analyser des vesicules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008092153A2 (fr) * 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Modification de composants à base d' exosome utilisés comme vaccin
WO2009015357A1 (fr) * 2007-07-25 2009-01-29 University Of Louisville Research Foundation, Inc. Micro arn associé à l'exosome en tant que marqueur de diagnostic
WO2010056337A2 (fr) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Procédés et systèmes d'utilisation d'exosomes pour déterminer des phénotypes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
T. DENG ET AL: "Abstract 444: Subpopulations of circulating microvesicles have different microRNA profiles", CANCER RESEARCH, vol. 71, no. 8 Supplement, 15 April 2011 (2011-04-15), pages 444 - 444, XP055168378, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2011-444 *
TA DENG ET AL: "Subpopulations of Circulating Microvesicles Have Different MicroRNA Profiles", 7 April 2011 (2011-04-07), XP055168385, Retrieved from the Internet <URL:http://www.carislifesciences.com/media/pdf/Spetzler-sorted-MiRs-AACR-poster-2011.pdf> [retrieved on 20150209] *
TRACI PAWLOWSKI ET AL: "Circulating exosomes may provide an alternate platform to monitor disease progression compared to circulating tumor cells CD-81 Labeled Exosome Level vs CTCs in Plasma Derived Exosomes miR-21 Copy Number vs CTCs in EpCAM+ Plasma Derived Exosomes", 5 July 2010 (2010-07-05), XP055168408, Retrieved from the Internet <URL:http://www.carislifesciences.com/media/pdf/ASCO_Pawlowski2010.pdf> [retrieved on 20150209] *

Also Published As

Publication number Publication date
CN103874770A (zh) 2014-06-18
CA2844671A1 (fr) 2013-02-14
JP2014522993A (ja) 2014-09-08
WO2013022995A3 (fr) 2013-04-04
WO2013022995A2 (fr) 2013-02-14
AU2012294458A1 (en) 2014-02-27
EP2742154A2 (fr) 2014-06-18
KR20140067001A (ko) 2014-06-03
BR112014002975A2 (pt) 2017-03-01

Similar Documents

Publication Publication Date Title
HRP20190135T1 (hr) 4-imidazopiridazin-1-yl-benzamidi i 4-imidazotriazin-1-yl-benzamidi kao inhibitori btk
EP2742154A4 (fr) Compositions de biomarqueurs et procédés
EP2721179A4 (fr) Compositions de biomarqueur et procédés associés
EP2922861A4 (fr) Compositions de biomarqueur et procédés
EP2823306A4 (fr) Compositions de biomarqueurs et procédés associés
SI2791160T1 (sl) Sestave modificirane MRNA
HK1202625A1 (en) Compositions and methods for assessing appendicitis
ZA201408594B (en) Xylitol-based anti-mucosal compositions and related methods and compositions
GB201408236D0 (en) Composition and method
GB201122195D0 (en) Composition and method
EP2672822A4 (fr) Procédés et composition pour améliorer la fonction cognitive
GB201411762D0 (en) Precoating methods and compositions
EP2734646A4 (fr) Compositions et procédés pour sélectionner des aptamères
EP2667710A4 (fr) Compositions insecticides et procédés connexes
ZA201308892B (en) Compositions and methods
EP2766357A4 (fr) Compositions méso-biliverdines et procédés associés
IL227384A0 (en) Metal steaming compounds and methods for chemical-mechanical polishing
GB201106433D0 (en) Composition and method
IL239426A0 (en) Methods and compositions of biomarkers
HK1203232A1 (en) Biomarker and use thereof
IL231798A0 (en) method and preparation
IL230868A0 (en) Biomarker preparations and methods
GB201116340D0 (en) Compositions and methods
GB201117620D0 (en) Method and composition
GB201116421D0 (en) Composition and method

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20140226

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/50 20060101ALI20150217BHEP

Ipc: G01N 33/68 20060101ALI20150217BHEP

Ipc: G01N 33/53 20060101ALI20150217BHEP

Ipc: G01N 33/566 20060101ALI20150217BHEP

Ipc: C12Q 1/68 20060101AFI20150217BHEP

Ipc: G01N 33/574 20060101ALI20150217BHEP

RIN1 Information on inventor provided before grant (corrected)

Inventor name: BROWN, KIRK

Inventor name: SPETZLER, DAVID

Inventor name: PAWLOWSKI, TRACI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PAWLOWSKI, TRACI

Inventor name: BROWN, KIRK

Inventor name: SPETZLER, DAVID

A4 Supplementary search report drawn up and despatched

Effective date: 20150713

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/50 20060101ALI20150707BHEP

Ipc: G01N 33/53 20060101ALI20150707BHEP

Ipc: G01N 33/574 20060101ALI20150707BHEP

Ipc: G01N 33/566 20060101ALI20150707BHEP

Ipc: C12Q 1/68 20060101AFI20150707BHEP

Ipc: G01N 33/68 20060101ALI20150707BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20170516

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20170927