EP2341941A4 - Heparosan polymers and methods of making and using same for the enhancement of therapeutics - Google Patents
Heparosan polymers and methods of making and using same for the enhancement of therapeuticsInfo
- Publication number
- EP2341941A4 EP2341941A4 EP09813350.7A EP09813350A EP2341941A4 EP 2341941 A4 EP2341941 A4 EP 2341941A4 EP 09813350 A EP09813350 A EP 09813350A EP 2341941 A4 EP2341941 A4 EP 2341941A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- therapeutics
- enhancement
- making
- methods
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9557208P | 2008-09-09 | 2008-09-09 | |
US38304609A | 2009-03-19 | 2009-03-19 | |
US17927509P | 2009-05-18 | 2009-05-18 | |
PCT/US2009/005050 WO2010030342A2 (en) | 2008-09-09 | 2009-09-09 | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2341941A2 EP2341941A2 (en) | 2011-07-13 |
EP2341941A4 true EP2341941A4 (en) | 2014-12-10 |
Family
ID=44123336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09813350.7A Withdrawn EP2341941A4 (en) | 2008-09-09 | 2009-09-09 | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP2341941A4 (en) |
CA (1) | CA2773755C (en) |
WO (1) | WO2010030342A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8580290B2 (en) | 2001-05-08 | 2013-11-12 | The Board Of Regents Of The University Of Oklahoma | Heparosan-based biomaterials and coatings and methods of production and use thereof |
US9925209B2 (en) | 2008-03-19 | 2018-03-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same |
US9687559B2 (en) | 2008-03-19 | 2017-06-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
PL2831237T3 (en) | 2012-03-30 | 2018-06-29 | The Board Of Regents Of The University Of Oklahoma | High molecular weight heparosan polymers and methods of production and use thereof |
EP2895385A2 (en) | 2012-09-17 | 2015-07-22 | Technip France | Truss spar vortex induced vibration damping with vertical plates |
JP2015533152A (en) * | 2012-10-15 | 2015-11-19 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | Factor VII conjugate |
JP2015532307A (en) * | 2012-10-15 | 2015-11-09 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | Coagulation factor VII polypeptide |
KR20160065925A (en) | 2013-10-15 | 2016-06-09 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Coagulation factor vii polypeptides |
AR099340A1 (en) * | 2014-02-12 | 2016-07-13 | Novo Nordisk As | CONJUGATES OF THE COAGULATION FACTOR IX |
AR101060A1 (en) * | 2014-02-12 | 2016-11-23 | Novo Nordisk As | FVIII CONJUGATES |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992022331A1 (en) * | 1991-06-06 | 1992-12-23 | The School Of Pharmacy | Pharmaceutical compositions |
WO1997041897A1 (en) * | 1996-05-09 | 1997-11-13 | Virion Systems, Inc. | Preparation of protein/polysaccharide conjugate vaccines using homobifunctional and heterobifunctional vinylsulfones |
US20020192205A1 (en) * | 2001-05-11 | 2002-12-19 | Francis Michon | Immunogenic compositions of low molecular weight hyaluronic acid and methods to prevent, treat and diagnose infections and diseases caused by group A and group C streptococci |
US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US20040087488A1 (en) * | 2002-07-02 | 2004-05-06 | Genzyme Corporation | Hydrophilic biopolymer-drug conjugates, their preparation and use |
US20040197868A1 (en) * | 2001-05-08 | 2004-10-07 | Deangelis Paul L. | Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same |
US20060105431A1 (en) * | 1998-11-11 | 2006-05-18 | Deangelis Paul L | Polymer grafting by polysaccharide synthases using artificial sugar acceptors |
US20060116346A1 (en) * | 2002-10-18 | 2006-06-01 | Fidia Farmaceutici S.P.A. | Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
EP1870421A1 (en) * | 2005-03-31 | 2007-12-26 | Seikagaku Corporation | Novel anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate |
US20080109236A1 (en) * | 1998-04-02 | 2008-05-08 | Deangelis Paul L | Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases |
US20080112951A1 (en) * | 2003-07-04 | 2008-05-15 | Armelle Phalipon | Glycoconjugates and Their Use as Potential Vaccines Against Infection by Shigella Flexneri |
EP1923402A1 (en) * | 2005-06-28 | 2008-05-21 | Seikagaku Corporation | Method for determination of enzymatic activity |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US7291673B2 (en) * | 2000-06-02 | 2007-11-06 | Eidgenossiche Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
US6833488B2 (en) * | 2001-03-30 | 2004-12-21 | Exotech Bio Solution Ltd. | Biocompatible, biodegradable, water-absorbent material and methods for its preparation |
US8580290B2 (en) * | 2001-05-08 | 2013-11-12 | The Board Of Regents Of The University Of Oklahoma | Heparosan-based biomaterials and coatings and methods of production and use thereof |
US6623729B2 (en) * | 2001-07-09 | 2003-09-23 | Korea Advanced Institute Of Science And Technology | Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
US7655445B2 (en) * | 2003-11-12 | 2010-02-02 | Massachusetts Institute Of Technology | Methods for synthesis of sulfated saccharides |
-
2009
- 2009-09-09 WO PCT/US2009/005050 patent/WO2010030342A2/en active Application Filing
- 2009-09-09 EP EP09813350.7A patent/EP2341941A4/en not_active Withdrawn
- 2009-09-09 CA CA2773755A patent/CA2773755C/en active Active
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992022331A1 (en) * | 1991-06-06 | 1992-12-23 | The School Of Pharmacy | Pharmaceutical compositions |
US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
WO1997041897A1 (en) * | 1996-05-09 | 1997-11-13 | Virion Systems, Inc. | Preparation of protein/polysaccharide conjugate vaccines using homobifunctional and heterobifunctional vinylsulfones |
US20080109236A1 (en) * | 1998-04-02 | 2008-05-08 | Deangelis Paul L | Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases |
US20060105431A1 (en) * | 1998-11-11 | 2006-05-18 | Deangelis Paul L | Polymer grafting by polysaccharide synthases using artificial sugar acceptors |
US20040197868A1 (en) * | 2001-05-08 | 2004-10-07 | Deangelis Paul L. | Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same |
US20020192205A1 (en) * | 2001-05-11 | 2002-12-19 | Francis Michon | Immunogenic compositions of low molecular weight hyaluronic acid and methods to prevent, treat and diagnose infections and diseases caused by group A and group C streptococci |
US20040087488A1 (en) * | 2002-07-02 | 2004-05-06 | Genzyme Corporation | Hydrophilic biopolymer-drug conjugates, their preparation and use |
US20060116346A1 (en) * | 2002-10-18 | 2006-06-01 | Fidia Farmaceutici S.P.A. | Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
US20080112951A1 (en) * | 2003-07-04 | 2008-05-15 | Armelle Phalipon | Glycoconjugates and Their Use as Potential Vaccines Against Infection by Shigella Flexneri |
EP1870421A1 (en) * | 2005-03-31 | 2007-12-26 | Seikagaku Corporation | Novel anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate |
EP1923402A1 (en) * | 2005-06-28 | 2008-05-21 | Seikagaku Corporation | Method for determination of enzymatic activity |
Non-Patent Citations (2)
Title |
---|
A. E. SISMEY-RAGATZ ET AL: "Chemoenzymatic Synthesis with Distinct Pasteurella Heparosan Synthases: MONODISPERSE POLYMERS AND UNNATURAL STRUCTURES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 39, 11 July 2007 (2007-07-11), pages 28321 - 28327, XP055116675, ISSN: 0021-9258, DOI: 10.1074/jbc.M701599200 * |
KIYOSHI SUZUKI ET AL: "Generation and characterization of a series of monoclonal antibodies that specifically recognize [HexA(Ã Â+-2S)-GlcNAc]n epitopes in heparan sulfate", GLYCOCONJUGATE JOURNAL, KLUWER ACADEMIC PUBLISHERS, BO, vol. 25, no. 8, 7 May 2008 (2008-05-07), pages 703 - 712, XP019642419, ISSN: 1573-4986, DOI: 10.1007/S10719-008-9130-Z * |
Also Published As
Publication number | Publication date |
---|---|
CA2773755A1 (en) | 2010-03-18 |
EP2341941A2 (en) | 2011-07-13 |
CA2773755C (en) | 2017-04-25 |
WO2010030342A2 (en) | 2010-03-18 |
WO2010030342A3 (en) | 2010-06-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL267138A (en) | Improved cell composition and methods of making the same | |
EP2341941A4 (en) | Heparosan polymers and methods of making and using same for the enhancement of therapeutics | |
EG27167A (en) | Microemulsifiers and methods of making and using same | |
AU2009234373A8 (en) | Coferons and methods of making and using them | |
PL2290051T3 (en) | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism | |
EP2296879A4 (en) | Polymeric blends and methods of using same | |
IL208205A (en) | Bcr-complex-specific antibodies and methods of using same | |
PT3660073T (en) | Low-burst polymers and methods to produce polymers | |
IL218310A0 (en) | Actinic-ray or radiation-sensitive resin composition and method of forming pattern using the composition | |
EP2264079A4 (en) | Copolymer and method for producing the same | |
HK1149933A1 (en) | Diazacarbazoles and methods of use | |
EP2288365A4 (en) | Targeted coagulation factors and method of using the same | |
PL3269819T3 (en) | Microorganism producing o-acetyl-homoserine and the method of producing o-acetyl-homoserine using the microorganism | |
EP2207823A4 (en) | Copolymer composition and method of producing the composition | |
EP2309938A4 (en) | Cryo-surgical systems and methods of using the same | |
IL209548A0 (en) | Diazacarbazoles and methods of use | |
EP2242854A4 (en) | Sirna compounds and methods of use thereof | |
EP2282648A4 (en) | Prebiotic composition and methods of making and using the same | |
EP2414321A4 (en) | Hydrophobic monomers, hydrophobically-derivatized supports, and methods of making and using the same | |
EP2176066A4 (en) | Structural member and method of producing the structural member | |
IL197655A0 (en) | Emulsions and methods of their production | |
IL212388A0 (en) | Solubilizer for metal ions and methods of producing the same | |
EP2267075A4 (en) | Polyacetal resin composition and method for producing the same | |
EP2318508A4 (en) | Determination of the integrity of rna | |
GB0800324D0 (en) | Polymer and preparation process |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20110408 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA RS |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20141110 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 9/10 20060101ALI20141104BHEP Ipc: A61K 47/36 20060101ALI20141104BHEP Ipc: A61K 47/48 20060101AFI20141104BHEP Ipc: A61K 9/00 20060101ALI20141104BHEP |
|
17Q | First examination report despatched |
Effective date: 20160901 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20190221 |