EP2126044A4 - Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof - Google Patents

Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof

Info

Publication number
EP2126044A4
EP2126044A4 EP07796720A EP07796720A EP2126044A4 EP 2126044 A4 EP2126044 A4 EP 2126044A4 EP 07796720 A EP07796720 A EP 07796720A EP 07796720 A EP07796720 A EP 07796720A EP 2126044 A4 EP2126044 A4 EP 2126044A4
Authority
EP
European Patent Office
Prior art keywords
stem
preparation
bone marrow
cord blood
progenitor cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07796720A
Other languages
German (de)
French (fr)
Other versions
EP2126044A1 (en
Inventor
Philip H Coelho
Bruce A Baker
John R Chapman
Junzhi Li
Robert S Childers
Prince Emmanuel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermogenesis Corp
Original Assignee
Thermogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermogenesis Corp filed Critical Thermogenesis Corp
Publication of EP2126044A1 publication Critical patent/EP2126044A1/en
Publication of EP2126044A4 publication Critical patent/EP2126044A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A61M1/0236—Multiple bag systems for separating or storing blood components with sampling means, e.g. sample bag or sampling port
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0437—Blood stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/331—Optical measuring means used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • External Artificial Organs (AREA)
EP07796720A 2007-03-28 2007-07-06 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof Withdrawn EP2126044A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66421207A 2007-03-28 2007-03-28
PCT/US2007/015560 WO2008121120A1 (en) 2007-03-28 2007-07-06 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof

Publications (2)

Publication Number Publication Date
EP2126044A1 EP2126044A1 (en) 2009-12-02
EP2126044A4 true EP2126044A4 (en) 2010-04-07

Family

ID=39808561

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07796720A Withdrawn EP2126044A4 (en) 2007-03-28 2007-07-06 Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof

Country Status (5)

Country Link
EP (1) EP2126044A4 (en)
JP (2) JP2010537624A (en)
CN (2) CN103555559B (en)
HK (1) HK1193428A1 (en)
WO (1) WO2008121120A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095964A1 (en) * 2010-02-03 2011-08-11 Fuil Technologies Limited A method and apparatus for separating a liquid component from a liquid medium
KR101946441B1 (en) * 2010-03-18 2019-04-22 세스카 쎄라퓨틱스 인코포레이티드 System for purifying certain cell populations in blood or bone marrow by depleting others
CN102618438A (en) * 2012-04-11 2012-08-01 章毅 System for detecting and screening umbilical cord blood stem cells
WO2015149098A1 (en) * 2014-03-31 2015-10-08 Liporegena Gmbh Device for the withdrawal and portioning of fatty tissue
EP2987515A1 (en) * 2014-08-19 2016-02-24 Reapplix APS Centrifuge and method of centrifuging a blood sample
JP6976864B2 (en) * 2015-12-29 2021-12-08 サーモゲネシス コーポレーション Cell separators, systems, and methods
WO2018129467A1 (en) * 2017-01-08 2018-07-12 Cesca Therapeutics, Inc. Devices and methods for bio-processing cellular samples
US20190336541A1 (en) * 2017-01-11 2019-11-07 Sungkwang Medical Foundation Pcnt as a target protein for treatment or diagnosis of brain-nervous system diseases
JP7261791B2 (en) 2017-09-28 2023-04-20 テルモ株式会社 Biological Component Collection Device, Biological Component Collection System, and Method of Operating the Biological Component Collection System
EP3687593B1 (en) 2017-09-28 2023-04-05 Terumo Kabushiki Kaisha Biological component collection system and circuit internal pressure acquisition method
EP3873558B1 (en) 2018-11-01 2023-03-08 TERUMO Kabushiki Kaisha Biological component collection system and circuit internal pressure acquisition method
US11697799B2 (en) * 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
CN110093253A (en) * 2019-06-04 2019-08-06 河南省人民医院 It is disposable to go red blood cell bone marrow collection bag and method
CN113980894B (en) * 2021-12-27 2022-03-15 深圳博雅感知医疗科技有限公司 Method for preparing bone marrow condensed cells and application thereof in treating premature ovarian failure

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103522A (en) * 1994-07-20 2000-08-15 Fred Hutchinson Cancer Research Center Human marrow stromal cell lines which sustain hematopoiesis
JPH1084950A (en) * 1996-09-13 1998-04-07 Asahi Medical Co Ltd Collecting method of hematopoietic stem cell, collecting apparatus and collecting device
JP4412621B2 (en) * 1997-01-24 2010-02-10 旭化成クラレメディカル株式会社 Cell separation method
CA2278208C (en) * 1997-01-24 2011-09-20 Asahi Medical Co., Ltd. Cell separation method
JPH119270A (en) * 1997-06-26 1999-01-19 Asahi Medical Co Ltd Separation and recovery of nucleated cell and separating and recovering device for nucleated cell
US20020051762A1 (en) * 1998-01-23 2002-05-02 Shahin Rafii Purified populations of endothelial progenitor cells
US7241281B2 (en) * 2002-04-08 2007-07-10 Thermogenesis Corporation Blood component separation method and apparatus
ITMI20030897A1 (en) * 2003-04-30 2004-11-01 Crb Nederland B V PROCEDURE AND EQUIPMENT FOR FRACTIONING BLOOD.
EP1906729B1 (en) * 2005-06-02 2012-03-28 Stemcyte, Inc. Plasma-depleted, non-red blood cell-depleted cord blood compositions and methods of use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOIRET NATHALIE ET AL: "CD34+CDw90(Thy-1)+ subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and long-term culture-initiating cells.", EXPERIMENTAL HEMATOLOGY (NEW YORK), vol. 31, no. 12, December 2003 (2003-12-01), pages 1275 - 1283, XP002569567, ISSN: 0301-472X *
DENG J -P ET AL: "Isolation and culture of bone marrow mesenchymal stem cells by red blood cell lysis method", JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 20070121 CN, vol. 11, no. 3, 21 January 2007 (2007-01-21), pages 579 - 582, XP001539971, ISSN: 1673-8225 *
GASTENS M H ET AL: "Good manufacturing practice-compliant expansion of marrow-derived stem and progenitor cells for cell therapy", CELL TRANSPLANTATION, ELSEVIER SCIENCE, US, vol. 16, no. 7, 1 January 2007 (2007-01-01), pages 685 - 696, XP008093571, ISSN: 0963-6897 *
See also references of WO2008121120A1 *
TSUBAKI K ET AL: "Concentration of progenitor cells collected from bone marrow fluid using a continuous flow cell separator.", THERAPEUTIC APHERESIS : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR APHERESIS AND THE JAPANESE SOCIETY FOR APHERESIS FEB 2001, vol. 5, no. 1, February 2001 (2001-02-01), pages 46 - 48, XP002569566, ISSN: 1091-6660 *

Also Published As

Publication number Publication date
CN103555559B (en) 2015-04-22
HK1193428A1 (en) 2014-09-19
JP2010537624A (en) 2010-12-09
CN103555559A (en) 2014-02-05
WO2008121120A1 (en) 2008-10-09
JP5832591B2 (en) 2015-12-16
CN101707891A (en) 2010-05-12
EP2126044A1 (en) 2009-12-02
JP2014176389A (en) 2014-09-25

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20090925

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LI, JUNZHI

Inventor name: CHILDERS, ROBERT, S.

Inventor name: CHAPMAN, JOHN, R.

Inventor name: EMMANUEL, PRINCE

Inventor name: BAKER, BRUCE, A.

Inventor name: COELHO, PHILIP, H.

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/0775 20100101ALI20100225BHEP

Ipc: C12N 5/0789 20100101ALI20100225BHEP

Ipc: C12N 5/00 20060101AFI20081023BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20100308

17Q First examination report despatched

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