EP2066381A1

EP2066381A1 - Inhaler

Info

Publication number: EP2066381A1
Application number: EP07801719A
Authority: EP
Inventors: Heinrich Kladders
Original assignee: Boehringer Ingelheim International GmbH
Current assignee: Boehringer Ingelheim International GmbH
Priority date: 2006-09-20
Filing date: 2007-08-17
Publication date: 2009-06-10
Also published as: DE102006044755A1; US20100059051A1; WO2008034505A1

Abstract

The invention relates to an inhaler (1) for inhaling a formulation (2), said inhaler comprising a filiform support (4) for metering and/or conveying the formulation.

Description

inhaler

The present invention relates to an inhaler according to the preamble of claim 1.

In particular, the present invention relates to an inhaler for dispensing or inhaling a preferably pulverulent formulation, that is to say a powder inhaler. However, the formulation may in principle also be in the liquid phase, as a dispersion or in any other fluidizable form.

In particular, the formulation is a therapeutic agent or drug. In particular, the formulation accordingly contains or consists of at least one active substance. The formulation thus serves in particular for medical treatment or other therapeutic purposes.

In the present invention, the formulation is taken up by a carrier and in particular dosed into individual cans.

The present invention has for its object to provide a new inhaler, so that in a simple manner, a promotion, accurate metering and / or effective application of a particular powdered formulation is possible.

The above object is achieved by an inhaler according to claim 1. Advantageous developments are the subject of the dependent claims.

According to the proposal, the carrier is thread-shaped. This allows in a very simple way a recording or promotion of the formulation by the carrier is conveyed or pulled, for example, by a formulation containing the reservoir. Here, the preferably rough surface absorbs the preferably powdery formulation.

The dosage of the formulation can be carried out particularly simply and accurately by appropriately advancing or conveying the carrier. The dispensing or dispensing takes place in particular in that the carrier is moved in an area or section or with a section, preferably to vibrations, in particular like a string.

The discharge of the formulation is preferably carried out by an air flow, which flows against the carrier in particular transversely to its longitudinal extent.

In the present invention, the terms "air" and "air flow" are preferably to be understood in a broader sense also to the effect that also another gas or a flow of another gas is included. In the following, however, the term "air" is always used, since air is usually used as the gas for agitation and / or as the conveying medium for conveying the formulation after dissolution of or from the carrier or for dispersing the formulation.

Further aspects, features, characteristics and advantages of the present invention will become apparent from the claims and the following description of preferred embodiments with reference to the drawing. It shows:

Fig. 1 is a schematic section of an inhaler according to a first

embodiment; and

2 shows a schematic section of an inhaler according to a second embodiment.

In the figures, the same reference numerals are used for the same or similar parts, even though a repeated description is omitted. In particular, the same or corresponding advantages and properties then result. The individual figures are not for representation or simplification reasons to scale and reduced to essential components relevant to the invention.

Fig. 1 shows schematically the structure of a proposed inhaler 1 according to one embodiment. The inhaler 1 is preferably designed to be portable and / or works in particular only mechanically. The inhaler 1 is used for dispensing or inhaling a preferably powdered formulation 2 in the sense mentioned above.

In the illustrated embodiment, the formulation 2 is present in particular as a bed or loose. In particular, formulation 2 is contained in a reservoir 3 or the like.

The formulation 2 is metered or conveyed by means of a thread-shaped support 4. The carrier 4 is preferably passed through this or the reservoir 3 with the formulation 2 for receiving the formulation 2 or can be moved or pulled through the reservoir 3. For this purpose, the carrier 4 has, in particular, a correspondingly rough or open or otherwise suitable surface, in order to receive a particularly defined quantity of the formulation 2 in this case. Optionally, the recording by electrostatic forces o. The like. Can be supported.

In the notification of presentation, the formulation 2 is preferably first taken up in the inhaler 1 or in sections or sequentially by the carrier 3. However, other solutions are possible here as well. For example, the entire carrier 3 can also be provided with formulation 2 in advance or before insertion into the inhaler 1.

The carrier 4 can be moved or conveyed further into a metering chamber 5 after or during the reception of the formulation 2, in particular in sections or stepwise. Here, the carrier 4 releases the formulation 2 during or for inhalation. This is achieved or supported in particular by an air flow 6 and / or a movement, in particular oscillation, of at least one section of the carrier 4. The carrier 4 is preferably assigned a manipulation device in order to move or vibrate the carrier 4 at least in sections. On the manipulation device will be discussed later in more detail.

In the illustrated example, the air flow 6 is preferably generated during inhalation or inhalation by a user, not shown, of the inhaler 1. However, the air flow 6, for example, by a pump, - A -

be generated. The air flow 6 is used in particular for a discharge of the formulation 4 dispensed or metered by the carrier 4.

The formulation 2 dispersed in the air or in another conveying medium is preferably output via a mouthpiece 7 of the inhaler 1 or inhaled by a user (not shown).

For receiving or providing the carrier 4, a first coil 8 is preferably provided. In the illustrated example, the carrier 4 is guided by the coil 8 through the reservoir 3 and the metering chamber 5. Finally, the carrier 4 is rewound in the inhaler 1, in particular of a second coil 9 in the illustrated example. To guide the carrier 4 of this guide elements, such as guide rollers 10 o. The like., To be assigned.

For the desired further movement or further conveying of the carrier 4, the inhaler 1 preferably has a suitable drive device (not shown). The drive means acts for example on the second coil 9, so that a gradual winding and thus further movement of the carrier 4 is made possible.

The drive device is preferably manually operable, for example by opening the inhaler 1, the mouthpiece 7 o. The like. However, the drive device can work in any desired manner. For example, can be achieved by a spring, a spring memory o. The like., That the carrier 4 is moved on quasi automatically. In this case, in particular, only a triggering is required to move the carrier 4 a step or section, if desired, for example, immediately before the next inhalation o. The like. Such a drive device, for example, by an integrated into the second coil 9 or this associated spring, in particular a watch spring o. The like., To be realized. The drive device, for example, but also work electrically.

Preferably, the carrier 4 or the first and / or second coil 8, 9 and / or the drive device o. The like. An unillustrated ratchet or locking mechanism assigned to allow in particular exclusively the preferred stepwise further movement of the carrier 4. In the first embodiment, the manipulation device is preferably designed such that the carrier 4 is moved or plucked and / or caused to vibrate by plucking. For this purpose, the manipulation device preferably has a plucking element 1 1, which in particular can be operated manually, in the illustrated embodiment by means of a handle 12. For example, the plucking element 11 can engage behind the carrier 4 in a freely tensioned region within the metering chamber 5 and deflect the carrier 4 by means of the handle 12, so that after release of the handle 12 - and in particular return by a return spring 13 - the carrier 4 in particular can oscillate freely in the manner of a string, as indicated by dashed lines in Fig. 1.

However, other constructive solutions for the manipulation device or the plucking or stimulation of the carrier 4 are possible.

In order to deliver or at least support the delivery, the carrier 4 is thus moved in particular transversely to its longitudinal extension, particularly preferably set into oscillation. Preferably, the discharge of the formulation 2 then takes place simultaneously or subsequently, in particular by means of the air flow 6 or by means of another suitable conveying medium.

As an alternative or in addition to the manipulation device, the air flow 6 can also act and / or move the carrier 4 directly and / or indirectly.

A second embodiment of the proposed inhaler 1 will be explained below with reference to FIG. Only essential differences from the first embodiment will be explained below, so that in particular the previous remarks and explanations apply correspondingly or additionally to the second embodiment.

In the second embodiment, the inhaler 1 or the manipulation device has a vibrating body 14, which in particular can be moved or set into oscillation by the air flow 6. In the illustrated example, the vibrating body 14 is preferably formed substantially spherical. However, it may also have any other suitable shape, for example an elongated, egg-shaped, cylindrical or rotationally symmetrical shape.

Preferably, the oscillating body 14 is received in a region of the metering chamber 5 or a separate space 15 to which the air flow 6 can be supplied via a channel 16. The channel 16 opens to the area or space 15, in particular with a cross-section which is reduced in comparison with and against the oscillating body 14. However, other arrangements are possible here.

With appropriate dimensioning or tuning, the vibrating body 14 is reciprocated by the air flow 6 and, in particular, set in oscillation, more preferably along the main flow direction. Particularly preferably, the geometric conditions correspond to the information in EP 0 147 755 A2, which is referred to in this regard as supplementary disclosure.

In particular, the reciprocating movement of the vibrating body 14 is effected by the so-called Bernoulli effect.

The vibrating body 14 strikes the carrier 4 in particular transversely to the longitudinal extent. The carrier 4 is correspondingly displaced by the movement or oscillation of the vibrating body 14 in a preferably flutter-like or wave-like movement or oscillation. This leads to the desired movement of the carrier 4 in a very effective manner in order to assist or to achieve a release of the formulation 2 from the carrier 4 or a dispersion of the formulation 2.

Particularly preferably, the oscillating body 14 acts on the carrier 4 in a striking manner. However, other mechanisms of action may also be effective.

Preferably, the air flow 6 also forms the conveying medium in order to disperse and / or convey the formulation 2 dissolved by the carrier 4, in particular by its movement, and preferably via the mouthpiece 7 of FIG Dispensing inhaler 1 and output to a user, not shown. The air flow 6 can also be generated or provided by a pump, compressed air or the like.

However, as a delivery medium for the formulation 2, a different or separate air flow or other air in the aforementioned sense - including other gas - are used.

According to a variant, not shown, the carrier 4 may already be provided with the formulation 2 in advance - ie before insertion or installation in the inhaler 1 - or be. In this case, in particular, the reservoir 3 for the formulation 2 can be omitted. Instead, the carrier 4 preferably received or wound in the first coil 8 may already be provided with the formulation 2.

The formulation 2 may, for example, also be applied as a coating to the surface of the carrier 4 or cover it partially or completely.

The carrier 4 is formed according to the proposal thread-shaped. This allows in particular a simple unwinding and winding and a simple guide.

The term "filamentary" is to be understood in particular as meaning that the cross section is at least substantially circular. In a broader sense, however, the term "thread-like" preferably also includes other cross-sectional shapes. In the limiting case, the carrier 4 may also have an at least substantially rectangular cross-section and / or optionally be band-shaped.

The support 4 is particularly preferably constructed from a plurality of fiber elements, fibers, filaments or the like and / or provided with an open or non-closed surface. However, the carrier 4 may in principle also be a monofilament, a single fiber or the like, in particular if the surface is appropriately or suitably treated. is to allow for adhering and / or receiving the formulation 2 in the desired or required manner.

In the illustrated embodiment, the inhaler particularly preferably works only mechanically. In principle, however, the inhaler 1 can also operate electrically or electronically and / or contain such components or components. This applies in particular to a trigger device for triggering a discharge of formulation 2 or the duration of inhalation, a drive, a pump, a counter, a lock, a control device or the like.

Individual features and aspects of the various embodiments can also be arbitrarily combined with each other or used in other designs of inhalers.

The present invention is not limited to inhalers, but can be used accordingly in other atomizers. Accordingly, the term "inhaler" is preferably also to be understood in a broader sense as including other dispensers or nebulizers, in particular for medical or other therapeutic purposes.

Preferred ingredients and / or compositions of preferably medicinal formulation 2 are listed below. As already mentioned, these are in particular powders or liquids in the widest sense. Particularly preferred in formulation 2 are:

The compounds mentioned below can be used alone or in combination for use in the device according to the invention. In the compounds listed below, W is a pharmacologically active agent and (for example) selected from the group consisting of betamimetics, anticholinergics, corticosteroids, PDE4 inhibitors, LTD4 antagonists, EGFR inhibitors, dopamine agonists, HIV antihistamines, PAF- Antagonists and PI3 kinase inhibitors. Furthermore, two or three combinations of W can be combined and used for application in the device according to the invention. Exemplary combinations of W would be: W represents a betamimetics combined with anticholinergics, corticosteroids, PDE4 inhibitors, EGFR inhibitors or LTD4 antagonists, W represents an anticholinergic agent combined with a betamimetics, corticosteroids, PDE4 inhibitors, EGFR inhibitors or LTD4- antagonists,

W represents a corticosteroid combined with a PDE4 inhibitor, EGFR inhibitor or LTD4 antagonist - W represents a PDE4 inhibitor combined with an EGFR inhibitor or LTD4 antagonist

W represents an EGFR inhibitor combined with a LTD4 antagonist.

Preferred betamimetics here are compounds selected from the group consisting of albuterol, arformoterol, bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, isoetharines, isoprenaline, levosalbutamol, mabuterol , Meluadrine, Metaproterenol, Orciprenaline, Pirbuterol, Procaterol, Reproterol, Rimiterol, Ritodrine, Salmefamol, Salmeterol, Soterenol, Sulphone terol, Terbutaline, Tiaramide, Tolubuterol, Zinterol, CHF-1035, HO-KU-81, KUL-1248 and

- 3- (4- {6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) ethylamino] hexyloxy} -butyl) -benzylsulfonamide

- 5- [2- (5,6-diethyl-indan-2-ylamino) -l-hydroxy-ethyl] -8-hydroxy-1H-quinolin-2-one

4-hydroxy-7- [2 - {[2 - {[3- (2-phenylethoxy) propyl] sulphonyl} ethyl] -amino} ethyl] -2 (3H) -benzothiazolone - 1- (2-fluoro-4 -hydroxyphenyl) -2- [4- (1-benzimidazolyl) -2-methyl-2-butylamino] ethanol - 1 - [3- (4-Methoxybenzylamino) -4-hydroxyphenyl] -2- [4- (1-benzimidazolyl) -2-methyl-2-butylamino] ethanol

- 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- [3- (4-N, N-dimethylaminophenyl) -2-methyl-2-propylamino] ethanol - 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- [3- (4-methoxyphenyl) -2-methyl-2-propylamino] ethanol

- 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- [3- (4-n-butyloxyphenyl) -2-methyl-2-propylamino] ethanol

- 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- {4- [3- (4-methoxyphenyl) -l, 2,4-triazole-3 -yl] -2-methyl-2-butylamino} ethanol

5-hydroxy-8- (1-hydroxy-2-isopropylaminobutyl-1) -2H-1,4-benzoxazin-3 (4H) -one

- 1- (4-amino-3-chloro-5-trifluoromethylphenyl) -2-tert-butylamino) ethanol

6-Hydroxy-8- {1-hydroxy-2- [2- (4-methoxy-phenyl) -l, 1-dimethyl-ethylamino] -ethyl} -4 H -benzo [1,4] oxazin-3-one

6-Hydroxy-8- {1-hydroxy-2- [2- (4-phenoxy-acetic acid ethyl ester) -l, 1-dimethyl-ethylamino] -ethyl} -4H-benzo [1,4] oxazin-3-one

6-Hydroxy-8- {1-hydroxy-2- [2- (4-phenoxy-acetic acid) -l, 1-dimethyl-ethylamino] -ethyl} -4H-benzo [1,4] oxazin-3-one - 8- {2- [l, l-dimethyl-2- (2,4,6-trimethylphenyl) -ethylamino] -l-hydroxy-ethyl} -6-hydroxy-4H-benzo [l, 4] oxazine-3 -one

- 6-hydroxy-8- {1-hydroxy-2- [2- (4-hydroxy-phenyl) -l, 1-dimethyl-ethylamino] -ethyl} -4H-benzo [1,4] oxazin-3-one

- 6-hydroxy-8- {1-hydroxy-2- [2- (4-isopropyl-phenyl) -l, ldimethyl-ethylamino] -ethyl} -4H-benzo [1,4] oxazin-3-one

- 8- {2- [2- (4-ethylphenyl) -1,1-dimethyl-ethylamino] -l-hydroxy-ethyl} -6-hydroxy-4H-benzo [1,4-oxazin-3-one

- 8- {2- [2- (4-Ethoxy-phenyl) -l, l-dimethyl-ethylamino] -l-hydroxy-ethyl} -6-hydroxy-4H-benzo [1,4] oxazin-3-one - 4- (4- {2- [2-hydroxy-2- (6-hydroxy-3-oxo-3,4-dihydro-2H-benzo [l, 4] oxazin-8-yl) -ethylamino] -2 -methyl-propyl} -phenoxy) -butyric acid

- 8- {2- [2- (3,4-Difluoro-phenyl) -l, l-dimethyl-ethylamino] -l-hydroxy-ethyl} - 6-hydroxy-4H-benzo [1,4] oxazine-3 -one

- 1- (4-ethoxycarbonylamino-3-cyano-5-fluorophenyl) -2- (tert-butylamino) ethanol

2-hydroxy-5- (1-hydroxy-2- {2- [4- (2-hydroxy-2-phenyl-ethylamino) -phenyl] -ethylamino} -ethyl) -benzaldehyde - N- [2-hydroxy- 5- (1-Hydroxy-2- {2- [4- (2-hydroxy-2-phenyl-ethylamino) -phenyl] -ethylamino} -ethyl) -phenyl] -formamide 8-hydroxy-5- (1-hydroxy -2- {2- [4- (6-methoxy-biphenyl-3-ylamino) -phenyl] -ethylamino} -ethyl) -LH-quinolin-2-one

8-hydroxy-5- [1-hydroxy-2- (6-phenethylaminohexy-lino) ethyl] -1-quinolin-2-one

- 5- [2- (2- {4- [4- (2-amino-2-methyl-propoxy) -phenyl-amino] -phenyl} -ethyl-amino) -1-hydroxy-ethyl] -8-hydroxy-1H quinolin-2-one [3- (4- {6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) ethylamino] -hexyloxy} -butyl) -5-methylphenyl] - urea - 4- (2- {6- [2- (2,6-dichloro-benzyloxy) -ethoxy] -hexylamino} -l-hydroxy-ethyl) -2-hydroxymethyl-phenol

- 3- (4- {6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethyl-phenyl) -ethyl-amino] -hexy-loxy} -butyl (l) -benzylsulfonamide

- 3- (3- {7- [2-Hydroxy-2- (4-hydroxy-3-hydroxymethyl-phenyl) -ethyl-amino] -heptyloxy} -propyl) -benzylsulfonamide

- 4- (2- {6- [4- (3-Cyclopentanesulfonyl-phenyl) -butoxy] -hexylamino} -l-hydroxy-ethyl) -2-hydroxymethyl-phenol

N-adamantan-2-yl-2- (3- {2- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) -ethylamino] -propyl} -phenyl) -acetamide optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydro fumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.

Preferred anticholinergic compounds here are compounds which are selected from the group consisting of tiotropium salts, preferably the bromide salt, oxitropium salts, preferably the bromide salt, flutropium salts, preferably the bromide salt, ipratropium salts, preferably the bromide salt, glycopyrronium salts, preferably the bromide salt, trospi - salt, preferably the chloride salt, tolterodine. In the above-mentioned salts, the cations are the pharmacologically active ingredients. As anions, the aforementioned salts may preferably contain chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate , Succinate, benzoate or p-toluenesulfonate, with chloride, bromide, iodide, sulfate, methanesulfonate or p-toluenesulfonate being preferred as counterions. Of all the salts, the chlorides, bromides, iodides and methanesulfonates are particularly preferred.

Likewise preferred anticholinergics are selected from the salts of the formula AC-I

AC-I wherein X "is a single negatively charged anion, preferably an anion selected from the group consisting of fluoride, chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate and p-Toluenesulfonate, preferably a singly negatively charged anion, more preferably an anion selected from the group consisting of fluoride, chloride, bromide, methanesulfonate and p-toluenesulfonate, most preferably bromide, optionally in the form of their racemates, enantiomers or hydrates Significance are those drug combinations that contain the enantiomers of the formula AC-1-en

in which X "can have the abovementioned meanings Further preferred anticholinergics are selected from the salts of the formula AC-2

in which R is either methyl or ethyl and in which X "can have the abovementioned meanings In an alternative embodiment, the compound of the formula AC-2 can also be present in the form of the free base AC-2-base.

Further mentioned compounds are: 2,2-Diphenylpropionsäuretropenolester methobromide

2,2-diphenylpropionic acid copoprene methobromide

2-fluoro-2,2-diphenylacetic acid copoprene methobromide

2-fluoro-2,2-diphenylacetic acid tropol ester methobromide

- 3,3 \ 4,4'-Tetrafluorbenzilsäuretropenolester-methobromide - 3,3 ', _{4,4'-5-methobromide} Tetrafluorbenzilsäurescopinester

4,4'-Difluorobenzylic acid tropol ester methobromide

4,4'-Difluorobenzic acid copoprene methobromide

3,3'-Difluorobenzylic acid tropol ester methobromide

3,3'-Difluorobenzic acid copoprene-methobromide - 9-hydroxy-fluorene-9-carboxylic acid-tropol ester-methobromide

9-fluoro-fluoren-9-carboxylic acid-tropol ester-methobromide

9-Hydroxy-fluorene-9-carboxylic acid copo-ester methobromide

9-fluoro-fluorene-9-carboxylic acid copo-ester methobromide

9-Methyl-fluorene-9-carboxylic acid-tropol ester-methobromide - 9-methyl-fluorene-9-carboxylic acid-co-ester methobromide

Benzylic acid cyclopropyltropine ester methobromide

2,2-diphenylpropionic acid cyclopropyltropine ester methobromide

9-hydroxy-xanthene-9-carboxylic acid cyclopropyltropine ester methobromide

9-Methyl-fluorene-9-carboxylic acid cyclopropyltropine ester methobromide 9-methyl-xanthene-9-carboxylic acid cyclopropyltropine ester methobromide

9-Hydroxy-fluorene-9-carboxylic acid cyclopropyltropine ester methobromide

- 4,4'-Difluorbenzilsäuremethylestercyclopropyltropinester methobromide

9-Hydroxy-xanthene-9-carboxylic acid-tropol ester-methobromide 5-9-hydroxy-xanthene-9-carboxylic acid-co-ester methobromide

9-methyl-xanthene-9-carboxylic acid-tropol ester-methobromide

9-methyl-xanthene-9-carboxylic acid-co-ester methobromide

9-ethyl-xanthene-9-carboxylic acid-tropol ester-methobromide

9-Difluoromethyl-xanthene-9-carboxylic acid-tropol ester-methobromide 10 -9-hydroxymethyl-xanthene-9-carboxylic acid-co-ester methobromide

The abovementioned compounds can also be used in the context of the present invention as salts in which, instead of the methobromide, the salts Metho-X are used, where X may have the meanings given above for X ^" .

15

Preferred corticosteroids here are compounds selected from the group consisting of beclomethasone, betamethasone, budesonide, butixocort, ciclesonide, deflazacort, dexamethasone, etiprednol, flunisolide, fluticasone, loteprednol, mometasone, prednisolone, prednisone, rofleponide, Triamcinolone, RPR-106541, NS-126, ST-26 and

- 6,9-Difluoro-17- [(2-furanicarbonyloxy)] - 11-hydroxy-16-methyl-1,3-oxo-androsta-1,4-diene-17-carbothionic acid (S) -fluoromethyl lester

6,9-difluoro-11-hydroxy-16-methyl-1-oxo-17-propionyl-loxy-androsta- 1, 4-5-diene-17-carbothionic acid (S) - (2-oxo-tetrahydro-) furan-3 Sy 1) ester,

- 6α, 9α-difluoro-1-hydroxy-16α-methyl-3-oxo-17α- (2,2,3,3-tertamethylcyclopropylcarbonylo) oxy-androsta-1,4-diene-17β-carboxylic acid cyanomethyl ester optionally in the form of their racemates, enantiomers or diastereomers and optionally in the form of their salts and derivatives, their solvates and / or hydrates. Any reference to steroids includes reference to their optional salts or derivatives, hydrates or solvates. Examples of possible salts and derivatives of steroids may be: alkali metal salts, such as, for example, sodium or potassium salts, sulfobenzoates, phosphates, isonicotinates, acetates, dichloroacetates, propionates, dihydrogen phosphates, palmitates, pivalates or even furoates.

Preferred PDE4 inhibitors are compounds selected from the group consisting of enprofylline, theophylline, roflumilast, ariflo (cilomilast), tofimilast, pumafentrin, lirilmast, arofylline, atizoram, D-4418, bay 198004, BY343, CP-325,366, D-4396 (Sch-351591), AWD-12-281 (GW-842470), NCS-613, CDP-840, D-4418, PD-168787, T-440, T-2585, V-11294A, Cl-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370 and

- N- (3,5-dichloro-1-oxo-pyridin-4-yl) -4-difluoromethoxy-3-cyclopropylmethoxybenzamide

- (-) p - [(4 "R *, 10bS *) - 9-ethoxy-1,2,3,4,4a, 10b-hexahydro-8-methoxy-2-methylbenzo [s] [1, 6] naphthyridin-6-yl] -N, N-diisopropylbenzamide

- (R) - (+) - 1- (4-bromobenzyl) -4 - [(3-cyclopentyloxy) -4-methoxyphenyl] -2-pyrrolidone-3- (cyclopentyloxy-4-methoxyphenyl) -l- (4- N '- [N-2-cyano-S-methylisothioureido] benzyl) -2-pyrrolidone

cis [4-cyano-4- (3-cyclopenty-loxy-4-methoxyphenyl) cyclohexane-1-carboxylic acid]

2-carbomethoxy-4-cyano-4- (3-cyclopropylmethoxy-4-difluoromethoxyphenyl) cyclohexan-1-one

cis [4-cyano-4- (3-cyclopropylmethoxy-4-difluoromethoxyphenyl) cyclohexane-1-ol]

- (R) - (+) - Ethyl [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidin-2-ylidene acetate - (S) - (-) - ethyl [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidine -2-ylidene] acetate 9-cyclopentyl-5,6-dihydro-7-ethyl-3- (2-thienyl) -9H-pyrazolo [3,4-c] -1,4,4-triazolo [4,3-a] pyridine

9-cyclopentyl-5,6-dihydro-7-ethyl-3- (tert -butyl) -9H-pyrazolo [3,4-c] -1,4,4-triazolo [4,3-a] pyridine optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydro fumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro p-toluenesulfonate.

Preferred LTD4 antagonists here are compounds which are selected from the group consisting of monoglucast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF- 5078, VUF-K-8707, L-733321 and

- 1 - (((R) - (3- (2- (6,7-Difluoro-2-quinolinyl) ethenyl) phenyl) -3- (2- (2-hydroxy-2-propyl) phenyl) thio) methyl cyclopropane-acetic acid,

- 1 - (((1 (R) -3 (3- (2- (2,3-dichlorothieno [3,2-b] pyridin-5-yl) - (E) - ethenyl) phenyl) -3- ( 2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) cyclopropaneacetic acid [2 - [[2- (4-tert-butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl] phenyl] - acetic acid optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydro fumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro p-toluenesulfonate. Salts or derivatives which the LTD4 antagonists may be able to form, for example, are understood to mean alkali metal salts such as, for example, sodium or potassium salts, alkaline earth metal salts, sulfobenzoates, phosphates, isonicotinates, acetates, propionates, dihydrogen phosphates, palmitates, pivalates or even furoates.

Preferred EGFR inhibitors are compounds selected from the group consisting of cetuximab, trastuzumab, ABX-EGF, Mab ICR-62 and

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6 - {[4- (morpholin-4-yl) -l-oxo-2-but-1-yl-yl-amino-T-cyclopropyl-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-diethylamino) -l-oxo-2-buten-1-yl-amino] -cyclopropyl-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-dimethylamino) -l-oxo-2-buten-1-yl-aminol-T-cyclopropylmethoxy-quinazoline-4- [(R) - (1-phenyl-1-ethyl) amino] -6- {[4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] aminol-T-cyclopentyloxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4 - ((R) -6-methyl-2-oxo-4-methyl-4-yl) -l-oxo-2-one buten-l-yl] amino} -7-cyclopropylmethoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4 - ((R) -6-methyl-2-oxo-4-methyl-4-yl) -l-oxo-2-one buten-1-yl] amino} -7 - [(S) - (tetrahydrofuran-3-yl) oxy] -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4 - ((R) -2-methoxymethyl-6-oxo-4-methyl-4-yl) -l-oxo-2-one buten-1-yl] amino} -7-cyclopropylmethoxyquinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [2 - ((S) -6-methyl-2-oxo] phosphoryl-4-yl) -ethoxy] -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - ({4- [N- (2-methoxy-ethyl) -N-methyl-amino] -l-oxo-2-buten-1-one yl} amino) -7-cyclopropylmethoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] -amino} -7-cyclopentyloxy-quinazoline - 4 - [(R) - (1-phenylethyl) amino] -6 - {[4- (N, N-bis (2-methoxyethyl) amino] -1-oxo-2-butene l-yl] amino} -7-cyclopropylmethoxy-quinazoline

- 4 - [(R) - (1-Phenyl-ethyl) -amino] -6 - ({4- [N- (2-methoxyethyl) -N-ethyl-amino] -l-oxo-2-butene l-yl} amino) -7-cyclopropylmethoxyquinazoline - 4 - [(R) - (1-phenylethyl) amino] -6 - ({4- [N- (2-methoxyethyl) -N-methyl - amino] -l-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxy-quinazoline

- 4 - [(R) - (1-phenylethyl) amino] -6 - ({4- [N- (tetrahydropyran-4-yl) -N-methylamino] -l-oxo-2-butene l-yl} amino) -7-cyclopropylmethoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-dimethylamino) -l-oxo-2-but-1-yl] -amino} -7 - ((R ) -tetrahydrofuran-3-yloxy) quinazoline

- 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7 - ((S. ) -tetrahydrofuran-3-yloxy) -quinazoline

- 4- [(3-chloro-4-fluorophenyl) amino] -6- ({4- [N- (2-methoxyethyl) -N-methyl-amino] -1-oxo-2-butene - 1 -y 1} -amino) -7-cyclopenty-loxy-quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N-cyclopropyl-N-methyl-amino) - 1 -oxo-2-buten-1-yl] amino} -7-cyclopenty-loxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-dimethylamino) -l-oxo-2-buten-1-yl] -amino} -7 - [(R ) - (tetrahydrofuran-2-yl) methoxy] -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-dimethylamino) -l-oxo-2-buten-1-yl] -amino} -7 - [(S. ) - (tetrahydrofuran-2-yl) methoxy] -quinazoline

- 4 - [(3-ethynylphenyl) amino] -6,7-bis (2-methoxy-ethoxy) -quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -7- [3- (4-methyl-4-yl) -propyloxy] -6- [(vinylcarbonyl) -amino] -quinazoline

- 4 - [(R) - (1-Phenylethyl) amino] -6- (4-hydroxy-phenyl) -7H-pyrrolo [2,3-d] pyrimidine

- 3-Cyano-4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - {[4- (N, N-dimethylamino) -l-oxo-2-but-1-yl] -amino} -7 ethoxy-quinoline

- 4 - {[3-Chloro-4- (3-fluoro-benzyloxy) -phenyl] -amino} -6- (5 - {[(2-methanesulfonyl-ethyl) -amino] -methyl} -furan-2-yl) -quinazoline - 4 - [(R) - (1-Phenyl-ethyl) -amino] -6 - {[4 - ((R) -6-methyl-2-oxo-morpholin-4-yl]-1-oxo-2-ol butene-1-yl] amino} -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6 - {[4- (4-methyl-4-yl) -l-oxo-2-but-1-yl] -amino} -7 - [(tetrahydrofuran -2-yl) methoxy] quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - ({4- [N, N-bis (2-methoxy-ethyl) -amino] -1 -oxo-2-butene-1-yl} amino) -7- [(tetrahydrofuran-2-yl) -methoxy] -quinazoline

- 4 - [(3-ethynylphenyl) amino] -6 - {[4- (5,5-dimethyl-2-oxomorpholin-4-yl) -1-oxo-2-butene-1-yl ] amino} quinazole in - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [2- (2,2-dimethyl-6-oxo-4-methyl-4-yl) -ethoxy] - 7-methoxy-quinazoline

4-[(3-chloro-4-fluoro-phenyl) -amino] -6- [2- (2,2-dimethyl-6-oxo-4-aminol-4-yl) -ethoxy] -7 - [(R) - (tetrahydrofuran-2-yl) methoxy] -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -7- [2- (2,2-dimethyl-6-oxo-4-aminol-4-yl) -ethoxy] -6 - [(S) - (tetrahydrofiiran-2-yl) methoxy] -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {2- [4- (2-oxo-4-methyl-4-yl) -piperidin-1-yl] -ethoxy} -7- methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [1- (tert-butyloxycarbonyl) -piperidin-4-yloxy] -7-methoxy-quinazoline-4 - [(3-chloro 4-fluoro-phenyl) -amino] -6- (trans-4-amino-cyclohexan-1-yloxy) -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (trans-4-methanesulfonylamino-cyclohexan-1-yloxy) -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (tetrahydropyran-3-yloxy) -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (1-methyl-piperidin-4-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {1 - [(4-morpholino-4-yl) carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline - 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- {1 - [(methoxymethyl) -carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline

4-[(3-chloro-4-fluoro-phenyl) -amino] -6- (piperidin-3-yloxy) -7-methoxy-quinazoline-4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [1- (2-acetylamino-ethyl) -piperidin-4-yloxy] -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (tetrahydropyran-4-yloxy) -7-ethoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6 - ((S) -tetrahydrofuran-3-yloxy) -7-hydroxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (tetrahydropyran-4-yloxy) -7- (2-methoxyethoxy) quinazole

- 4- [(3-Chloro-4-fluoro-phenyl) amino] -6- {trans-4- [(dimethylamino) sulfonylamino] -cyclohexane-1-yloxy} -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- {trans-4 - [(4-chloro-4-yl) carbonylamino] -cyclohexan-1-yloxy} -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {trans-4 - [(morpholin-4-yl) sulfonylamino] -cyclohexane-1-yloxy} -7-methoxy-quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (tetrahydropyran-4-yloxy) -7- (2-acetylamino-ethoxy) -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (tetrahydropyran-4-yloxy) -7- (2-methanesulfonylamino-ethoxy) -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {1- (piperidin-1-yl) -carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (1-aminocarbonylmethyl-piperidin-4-yloxy) -7-methoxy-quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (cis-4- {N - [(tetrahydropyran-4-yl) -carbonyl] -N-methyl-amino} -cyclohexane-1-one yloxy) -7-methoxyquinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (cis-4- {N - [(morpholine-4-)

5 yl) carbonyl] -N-methyl-amino} -cyclohexan-1-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (cis-4- {N - [(4-methyl-4-yl) -sulfonyl] -N-methyl-amino} -cyclohexane-1 - yloxy) -7-methoxy-quinazo-Hn lo - 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (trans-4-ethanesulfonylamino-cyclohexan-1-yloxy) -7-methoxy -quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-ethoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (1-methanesulfonyl-1-piperidin-4-yloxy) -7- (2-methoxy-ethoxy) -quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [1- (2-methoxy-acetyl) -piperidin-4-yloxy] -7- (2-methoxyethoxy) -quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (cis-4-acetylamino-cyclohexan-1-yloxy) -7-methoxy-quinazoline O-4 - [(3-ethynyl-phenyl ) amino] -6- [1- (tert-butyloxycarbonyl) -piperidin-4-yloxy] -7-methoxy-quinazoline

- 4 - [(3-ethynyl-phenyl) -amino] -6- (tetrahydropyran-4-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (cis-4- {N - [(piperidin-1-yl) -carbonyl] -5N-methyl-amino} -cyclohexane 1 yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (cis-4- {N - [(4-methyl-1-piperazine-1-ylcarbonyl) -N-methyl-amino-1-cyclohexane] yloxy) -7-methoxyquinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {cis-4 - [(monoolholin-4-yl) carbonylamino] -cyclohexan-1-yloxy} -7-methoxy-quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- {1- [2- (2-oxopyrrolidin-1-yl) -ethyl] -piperidin-4-yloxy} -7-methoxy-quinazoline 4-[(3-chloro-4-fluoro-phenyl) -amino] -6- {1 - [(morpholin-4-yl) -carbonyl] -piperidin-4-yloxy} -7- (2-methoxy-ethoxy) -quinazoline

- 4 - [(3-ethynyl-phenyl) -amino] -6- (1-acetyl-piperidin-4-yloxy) -7-methoxy-quinazoline

- 4 - [(3-Ethynylphenyl) amino] -6- (1-methylpiperidin-4-yloxy) -7-methoxyquinazoline

- 4 - [(3-Ethynylphenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (1-methyl-1-piperidin-4-yloxy) -7 (2-methoxy-ethoxy) -quinazoline-4 - [(3 Chloro-4-fluoro-phenyl l) amino] -6- (1-isopropyloxycarbonyl-1-piperidin-4-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (cis-4-methylaminocyclohexan-1-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {cis-4- [N- (2-methoxy-acetyl) -N-methyl-amino] -cyclohexan-1-yloxy} - 7-methoxy-quinazoline

- 4 - [(3-ethynyl-phenyl) -amino] -6- (piperidin-4-yloxy) -7-methoxy-quinazoline

- 4 - [(3-ethynyl-phenyl) -amino] -6- [1- (2-methoxy-acetyl) -piperidin-4-yloxy] -7-methoxy-quinazoline

- 4 - [(3-ethynyl-phenyl) -amino] -6- {1- (4-chloro-4-yl) carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {1 - [(cis-2,6-dimethyl-4-chloro-4-yl) carbonyl] -piperidin-4-yloxy} -7 methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {1 - [(2-methyl-4-aminomethyl) carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline - 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- {1 - [(S, S) - (2-oxa-5-azabicyclo [2.2.1] hept-5-yl ) carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- {1 - [(N-methyl-N-2-methoxyethyl-amino) -carbonyl] -piperidin-4-yloxy} -7-methoxy -quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (1-ethyl-piperidin-4-yloxy) -7-methoxy-quinazoline

4-[(3-chloro-4-fluoro-phenyl) -amino] -6- {1 - [(2-methoxyethyl) -carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline-4 - [(3 -Chloro-4-fluoro-phenyl) -amino] -6- {1 - [(3-methoxy-propyl-amino) -carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [cis-4- (N-methanesulfonyl-N-methyl-amino) -cylohexan-1-yloxy] -7-methoxy quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [cis-4- (N-acetyl-N-methylamino) -cylohexan-1-yloxy] -7-methoxy quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (trans-4-methylamino-cyclohexan-1-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [trans-4- (N-methanesulfonyl-N-methyl-amino) -cyclohexan-1-yloxy] -7-methoxy quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (trans-4-dimethylamino-cyclohexan-1-yloxy) -7-methoxy-quinazoline

- 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (trans-4- {N - [(morpholin-4-yl) -carbonyl] -N-methyl-amino} -cyclohexane-1-one yloxy) -7-methoxy-quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- [2- (2,2-dimethyl-6-oxomorpholin-4-yl) -ethoxy ] -7 - [(S) - (tetrahydrofuran-2-yl) methoxy] -quinazoline

- 4 - [(3-Chloro-4-fluoro-phenyl) amino] -6- (1-methanesulfonyl-1-piperidin-4-yloxy) -7-methoxy-quinazoline - 4 - [(3-chloro-4-fluoro-phenyl) -amino] -6- (1-cyano-piperidin-4-yloxy) -7-methoxy-quinazoline, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydro fumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro p-toluenesulfonate.

Preferred dopamine agonists are compounds which are selected from the group consisting of bromocriptine, cabergoline, alpha-dihydroergocryptine, lisuride, pergolide, pramipexole, rooxinol, ropinirole, talipexol, terguride and viozan, optionally in the form of their racemates , Enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the betamimetics are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate ,

As Hl -Antihistaminika here are preferably compounds used, which are selected from the group consisting of epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, ketotifen, emedastine, dimetindene, clemastine, bamipine, Cexchlorpheniramin, phenamine, doxylamine , Chlorphenoxamine, dimenhydrinate, diphenhydramine, promethazine, ebastine, desloratidine and meclocine, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the betamimetics are preferably selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydrogen maleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.

In addition, inhalable macromolecules can be used as disclosed in EP 1 003 478 A1 or CA 2297174 A1.

Furthermore, the compound may be derived from the group of derivatives of ergot alkaloids, triptans, CGRP inhibitors, phosphodiesterase V inhibitors, optionally in the form of their racemates, enantiomers or diastereomers, optionally in the form of their pharmacologically acceptable acid addition salts, their solvates and / or hydrates.

As derivatives of ergot alkaloids: dihydroergotamine, ergotamine.

LIST OF REFERENCE NUMBERS

1 inhaler 9 second coil

2 Formulation 15 10 Leadership

3 reservoir 11 picking element

4 carrier 12 handle

5 dosing chamber 13 return spring 6 air flow 14 oscillating body

7 mouthpiece 20 15 room

8 first coil 16 channel

Claims

claims:

1. inhaler (1) for inhalation of a formulation (2), with a thread-like carrier (4) for metering and / or promotion of the formulation (2).

2. Inhaler according to claim 1, characterized in that the inhaler (1) has a reservoir (3) for the formulation (2).

3. Inhaler according to claim 2, characterized in that the carrier (4) in particular in sections or stepwise through the reservoir (3) for

Recording, promotion and / or dosage of the formulation (2) is movable or conveyable.

4. Inhaler according to one of the preceding claims, characterized in that the carrier (4) carrying the formulation (2) is in particular sectionwise or stepwise in a metering chamber (5) and / or in a Luftanströmbereich for delivery, promotion and / or dosage the formulation (2) is movable or conveyable.

5. Inhaler according to one of the preceding claims, characterized in that the inhaler (1) at least one coil (8, 9), preferably two coils (8, 9), for moving or conveying the carrier (4), in particular Ab- and winding the carrier (4).

6. Inhaler according to one of the preceding claims, characterized in that the carrier (4) is tensioned in particular by means of spring force.

7. Inhaler according to one of the preceding claims, characterized in that the carrier (4) metered or dispensed formulation (2) by means of an air stream (6) is dispersible and / or austragbar.

8. Inhaler according to one of the preceding claims, characterized in that the carrier (4) for dispensing or dispensing the formulation (2) transversely to its longitudinal extent at least partially movable, in particular is vibratable, is preferably by means of an air flow (6) or a manipulation device.

9. Inhaler according to claim 8, characterized in that the manipulation device on a Zupfelement (1 1) for moving, plucking or stimulating the

Support (4), in particular in a free-tensioned area having.

10. Inhaler according to claim 8 or 9, characterized in that the manipulation device manually, in particular by means of a handle (12), can be actuated.

11. Inhaler according to one of claims 8 to 10, characterized in that the manipulation device has a vibrating body (14) for moving, plucking or exciting the carrier (4), in particular in a freely tensioned area.

12. An inhaler according to claim 11, characterized in that the oscillating body (14) by means of a preferably also the discharge or the dispersion of the formulation (2) serving air stream (6) is vibratable bar.

13. Inhaler according to claim 12, characterized in that the air flow (6) flows against the oscillating body (14) in the direction of movement.

14. An inhaler according to any one of claims 11 to 13, characterized in that the oscillating body (14) acting on the carrier (4) for discharging and / or dispersing the formulation (2) acts.

15. Inhaler according to one of claims 11 to 14, characterized in that the oscillating body (14) is spherical or cylindrical.

16. Inhaler according to one of claims 11 to 15, characterized in that the oscillating body (14) transversely to the longitudinal extent of the carrier (4).

17. Inhaler according to one of claims 11 to 16, characterized in that the oscillating body (14) is loosely received in a particular of the carrier (4) limited area or space (15), which is preferably flowed through by the air flow (6) ,

18. Inhaler according to one of claims 7 to 17, characterized in that the air flow (6) extends transversely to the longitudinal extent of the carrier (4).

19. Inhaler according to one of claims 7 to 18, characterized in that the air flow (6) by inhalation or inhalation is generated or triggered.

20. An inhaler according to any one of claims 7 to 19, characterized in that the inhaler (1) is designed such that the air flow (6) serves as a delivery medium for discharging the formulation (2).

21. An inhaler according to any one of claims 7 to 19, characterized in that the inhaler (1) is designed such that independently of the air flow (6), another pumped medium for discharging the formulation (2) is used.

22. An inhaler according to one of the preceding claims, characterized in that the formulation (2) is pulverfbrmig.

23. Inhaler according to one of the preceding claims, characterized in that the inhaler (1) is designed to be portable.

24. Inhaler according to one of the preceding claims, characterized in that the inhaler (1) only works mechanically.