EP2024369A4 - Novel process for the preparation of sildenafil citrate - Google Patents

Novel process for the preparation of sildenafil citrate

Info

Publication number
EP2024369A4
EP2024369A4 EP07805617A EP07805617A EP2024369A4 EP 2024369 A4 EP2024369 A4 EP 2024369A4 EP 07805617 A EP07805617 A EP 07805617A EP 07805617 A EP07805617 A EP 07805617A EP 2024369 A4 EP2024369 A4 EP 2024369A4
Authority
EP
European Patent Office
Prior art keywords
preparation
novel process
sildenafil citrate
sildenafil
citrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07805617A
Other languages
German (de)
French (fr)
Other versions
EP2024369A2 (en
Inventor
Seeta Ramanjaneyulu Gorantla
Mohan Bhandari
Venkata Sunil Kumar Indukuri
Srinivas Simhadri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of EP2024369A2 publication Critical patent/EP2024369A2/en
Publication of EP2024369A4 publication Critical patent/EP2024369A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP07805617A 2006-06-05 2007-06-01 Novel process for the preparation of sildenafil citrate Withdrawn EP2024369A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN960CH2006 2006-06-05
PCT/IN2007/000219 WO2007141805A2 (en) 2006-06-05 2007-06-01 Novel process for the preparation of sildenafil citrate

Publications (2)

Publication Number Publication Date
EP2024369A2 EP2024369A2 (en) 2009-02-18
EP2024369A4 true EP2024369A4 (en) 2010-10-27

Family

ID=38801906

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07805617A Withdrawn EP2024369A4 (en) 2006-06-05 2007-06-01 Novel process for the preparation of sildenafil citrate

Country Status (2)

Country Link
EP (1) EP2024369A4 (en)
WO (1) WO2007141805A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI462739B (en) 2010-11-02 2014-12-01 Univ Kaohsiung Medical Processes for preparing piperazinium salts of sildenafil-analogues and use thereof
AT512084A1 (en) 2011-10-20 2013-05-15 Univ Wien Tech DIAZABICYCLO AND DIAZASPIRO ALKAN DERIVATIVES AS PHOSPHODIESTERASE-5 INHIBITORS
CN102690273B (en) * 2012-06-07 2014-11-05 杭州奥默医药技术有限公司 Preparation method of sildenafil
CN103664961B (en) * 2013-12-18 2015-12-09 成都医路康医学技术服务有限公司 A kind of synthesis technique of Virga
CN103772394A (en) * 2014-03-04 2014-05-07 南京友杰医药科技有限公司 Synthesis method of ethyl-removed sildenafil
CN105777669B (en) * 2016-04-21 2018-03-20 锦州医科大学 The method that 2 ethyoxyl 5 (the base sulfonyl of 4 methyl piperazine 1) benzoic acid are prepared with gaultherolin
CN111116591A (en) * 2018-10-30 2020-05-08 天津科伦药物研究有限公司 Method for preparing sildenafil citrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
KR100353014B1 (en) * 1998-11-11 2002-09-18 동아제약 주식회사 Pyrazolopyrimidinone derivatives for the treatment of impotence
CN1127506C (en) * 2001-06-29 2003-11-12 刘宝顺 Compound for treating impotence

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BAXENDALE I R ET AL: "Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/S0960-894X(00)00383-8, vol. 10, no. 17, 1 September 2000 (2000-09-01), pages 1983 - 1986, XP004214152, ISSN: 0960-894X *

Also Published As

Publication number Publication date
EP2024369A2 (en) 2009-02-18
WO2007141805A2 (en) 2007-12-13
WO2007141805A3 (en) 2008-02-21

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Legal Events

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