EP1750701A1 - Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique - Google Patents

Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique

Info

Publication number
EP1750701A1
EP1750701A1 EP05756511A EP05756511A EP1750701A1 EP 1750701 A1 EP1750701 A1 EP 1750701A1 EP 05756511 A EP05756511 A EP 05756511A EP 05756511 A EP05756511 A EP 05756511A EP 1750701 A1 EP1750701 A1 EP 1750701A1
Authority
EP
European Patent Office
Prior art keywords
clopidogrel
clopidogrel hydrochloride
solution
hydrochloride
amorphous form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05756511A
Other languages
German (de)
English (en)
Inventor
Vladimir Kaznakov
Eva Veverkova
Miroslav Veverka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Pharmaceuticals sro
Original Assignee
Ivax Pharmaceuticals sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0412172A external-priority patent/GB0412172D0/en
Priority claimed from GB0418395A external-priority patent/GB0418395D0/en
Application filed by Ivax Pharmaceuticals sro filed Critical Ivax Pharmaceuticals sro
Publication of EP1750701A1 publication Critical patent/EP1750701A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

L'invention concerne un hydrochlorure de méthyl (+)-(S)-(2-chlorophényl)-6,7-dihydrothiéno[3,2-c]pyridine-5(4H)-acétate de forme amorphe, des procédés permettant de préparer cette forme amorphe, et une composition pharmaceutique contenant cette forme amorphe. Cette forme amorphe est utile en tant qu'inhibiteur de l'agrégation des plaquettes sanguines, et en tant qu'agent antithrombotique.
EP05756511A 2004-06-01 2005-06-01 Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique Withdrawn EP1750701A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0412172A GB0412172D0 (en) 2004-06-01 2004-06-01 Amorphous form of clopidogrel hydrochloride and its use as an antithrombotic compound
GB0418395A GB0418395D0 (en) 2004-08-18 2004-08-18 Amorphous form of clopidogrel hydrochloride and its use as an antithrombotic compound
PCT/US2005/019326 WO2005117866A1 (fr) 2004-06-01 2005-06-01 Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique

Publications (1)

Publication Number Publication Date
EP1750701A1 true EP1750701A1 (fr) 2007-02-14

Family

ID=34971760

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05756511A Withdrawn EP1750701A1 (fr) 2004-06-01 2005-06-01 Hydrochlorure de clopidogrel amorphe et son utilisation en tant qu'antithrombotique

Country Status (3)

Country Link
EP (1) EP1750701A1 (fr)
IL (1) IL179717A0 (fr)
WO (1) WO2005117866A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006074066A1 (fr) * 2004-12-30 2006-07-13 Nektar Therapeutics Formulation non cristalline comprenant du clopidogrel
WO2007029096A2 (fr) * 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Nouvelles formes polymorphes de chlorhydrate de clopidogrel
WO2007128476A1 (fr) * 2006-05-04 2007-11-15 Sandoz Ag Compositions pharmaceutiques contenant du chlorhydrate de clopidogrel
EP1970054A3 (fr) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Comprimés de clopidogrel
EP2107061A1 (fr) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation de clopidogrel enrichi optiquement

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
WO2002018357A1 (fr) * 2000-08-29 2002-03-07 Rpg Life Sciences Limited Procede en recipient unique pour preparer des sels d'addition acides pharmaceutiquement acceptables de derives de 4, 5, 6, 7 - tetrahydrothieno (3,2-c) pyridine ayant une activite antithrombotique
ES2316650T3 (es) * 2001-12-18 2009-04-16 Teva Pharmaceutical Industries Ltd. Polimorfos de hidrogenosulfato de clopidogrel.
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
GB2393181A (en) * 2002-09-19 2004-03-24 Cipla Ltd Amorphous clopidogrel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005117866A1 *

Also Published As

Publication number Publication date
IL179717A0 (en) 2007-05-15
WO2005117866A1 (fr) 2005-12-15

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