EP1668133A4 - Coiled-coil fusion proteins comprising cell receptor domains - Google Patents

Coiled-coil fusion proteins comprising cell receptor domains

Info

Publication number
EP1668133A4
EP1668133A4 EP04761779A EP04761779A EP1668133A4 EP 1668133 A4 EP1668133 A4 EP 1668133A4 EP 04761779 A EP04761779 A EP 04761779A EP 04761779 A EP04761779 A EP 04761779A EP 1668133 A4 EP1668133 A4 EP 1668133A4
Authority
EP
European Patent Office
Prior art keywords
coiled
fusion proteins
cell receptor
receptor domains
coil fusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04761779A
Other languages
German (de)
French (fr)
Other versions
EP1668133A1 (en
Inventor
Crescenzo Gregory De
Maureen D O'connor
Beatrice Paul-Roc
John Zwaagstra
Myriam Banville
Maria Jaramillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of EP1668133A1 publication Critical patent/EP1668133A1/en
Publication of EP1668133A4 publication Critical patent/EP1668133A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP04761779A 2003-09-05 2004-09-02 Coiled-coil fusion proteins comprising cell receptor domains Withdrawn EP1668133A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50085503P 2003-09-05 2003-09-05
PCT/CA2004/001616 WO2005024035A1 (en) 2003-09-05 2004-09-02 Coiled-coil fusion proteins comprising cell receptor domains

Publications (2)

Publication Number Publication Date
EP1668133A1 EP1668133A1 (en) 2006-06-14
EP1668133A4 true EP1668133A4 (en) 2007-08-29

Family

ID=34273005

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04761779A Withdrawn EP1668133A4 (en) 2003-09-05 2004-09-02 Coiled-coil fusion proteins comprising cell receptor domains

Country Status (5)

Country Link
EP (1) EP1668133A4 (en)
JP (1) JP2007503820A (en)
AU (1) AU2004270774A1 (en)
CA (1) CA2536936A1 (en)
WO (1) WO2005024035A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070184052A1 (en) * 2003-05-09 2007-08-09 Lin Herbert Y Soluble tgf-b type III receptor fusion proteins
WO2005086598A2 (en) 2004-03-18 2005-09-22 Lg Electronics Inc. Apparatus and method for recording and/or reproducing data to/from recording medium
US7710853B2 (en) 2004-03-18 2010-05-04 Lg Electronics, Inc. Recording medium with segment information thereon and apparatus and methods for forming, recording, and reproducing the recording medium
TWI381374B (en) 2004-03-18 2013-01-01 Lg Electronics Inc Recording medium with overlapping segment information thereon and apparatus and methods for forming, recording, and reproducing the recording medium
EP2491391B1 (en) * 2009-10-23 2018-02-28 GE Healthcare Bio-Sciences AB Method for determination of macromolecular multimers
WO2012071649A1 (en) * 2010-11-29 2012-06-07 National Research Council Of Canada Covalently dimerized bivalent binding agents
CA3041727A1 (en) * 2016-11-18 2018-05-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Engineered tgf-beta monomers and their use for inhibiting tgf-beta signaling

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012988A1 (en) * 1995-10-06 1997-04-10 Pence Coiled-coil heterodimer methods and compositions for the detection and purification of expressed proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6472179B2 (en) * 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
WO2000047612A2 (en) * 1999-02-11 2000-08-17 Xencor, Inc. Structure-based screening techniques for drug discovery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012988A1 (en) * 1995-10-06 1997-04-10 Pence Coiled-coil heterodimer methods and compositions for the detection and purification of expressed proteins

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANDERS ROBERT A ET AL: "Chimeric granulocyte/macrophage colony-stimulating factor/transforming growth factor-beta (TGF-beta) receptors define a model system for investigating the role of homomeric and heteromeric receptors in TGF-beta signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 36, 1996, pages 21758 - 21766, XP002432036, ISSN: 0021-9258 *
BEHNCKEN STUART N ET AL: "Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 22, 2 June 2000 (2000-06-02), pages 17000 - 17007, XP002432034, ISSN: 0021-9258 *
COCHRAN ANDREA G ET AL: "Imitation of Escherichia coli aspartate receptor signaling in engineered dimers of the cytoplasmic domain", SCIENCE (WASHINGTON D C), vol. 271, no. 5252, 1996, pages 1113 - 1116, XP002432035, ISSN: 0036-8075 *
DE CRESCENZO G ET AL: "Transforming Growth Factor-beta (TGF-beta) Binding to the Extracellular Domain of the Type II TGF-beta Receptor: Receptor Capture on a Biosensor Surface Using a New Coiled-coil Capture System Demonstrates that Avidity Contributes Significantly to High Affinity Binding", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 328, no. 5, 16 May 2003 (2003-05-16), pages 1173 - 1183, XP004454244, ISSN: 0022-2836 *
DE CRESCENZO GREGORY ET AL: "Real-time monitoring of the interactions of two-stranded de novo designed coiled-coils: Effect of chain length on the kinetic and thermodynamic constants of binding.", BIOCHEMISTRY, vol. 42, no. 6, 18 February 2003 (2003-02-18), pages 1754 - 1763, XP008075446, ISSN: 0006-2960 *
HAYS JOHN L ET AL: "Oligomerization-induced modulation of TPR-MET tyrosine kinase activity.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 30, 25 July 2003 (2003-07-25), pages 27456 - 27463, XP002432037, ISSN: 0021-9258 *
See also references of WO2005024035A1 *

Also Published As

Publication number Publication date
AU2004270774A1 (en) 2005-03-17
WO2005024035A1 (en) 2005-03-17
CA2536936A1 (en) 2005-03-17
JP2007503820A (en) 2007-03-01
EP1668133A1 (en) 2006-06-14

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Ipc: A61K 38/00 20060101ALN20070511BHEP

Ipc: G01N 33/53 20060101ALN20070511BHEP

Ipc: C07K 14/71 20060101ALI20070511BHEP

Ipc: C12N 15/62 20060101AFI20050331BHEP

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