EP1210583A4 - In situ methods for measuring the release of a substance from a dosage form - Google Patents

In situ methods for measuring the release of a substance from a dosage form

Info

Publication number
EP1210583A4
EP1210583A4 EP00961420A EP00961420A EP1210583A4 EP 1210583 A4 EP1210583 A4 EP 1210583A4 EP 00961420 A EP00961420 A EP 00961420A EP 00961420 A EP00961420 A EP 00961420A EP 1210583 A4 EP1210583 A4 EP 1210583A4
Authority
EP
European Patent Office
Prior art keywords
substance
release
measuring
dosage form
situ methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00961420A
Other languages
German (de)
French (fr)
Other versions
EP1210583A1 (en
Inventor
Philip Palermo
Kevin C Bynum
John Pocreva
Bud Pine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delphian Technology Inc
Original Assignee
Delphian Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delphian Technology Inc filed Critical Delphian Technology Inc
Publication of EP1210583A1 publication Critical patent/EP1210583A1/en
Publication of EP1210583A4 publication Critical patent/EP1210583A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G01J3/433—Modulation spectrometry; Derivative spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8514—Probe photometers, i.e. with optical measuring part dipped into fluid sample with immersed mirror
    • G01N2021/8521—Probe photometers, i.e. with optical measuring part dipped into fluid sample with immersed mirror with a combination mirror cell-cuvette
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8528—Immerged light conductor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP00961420A 1999-08-30 2000-08-30 In situ methods for measuring the release of a substance from a dosage form Withdrawn EP1210583A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15144399P 1999-08-30 1999-08-30
US151443P 1999-08-30
PCT/US2000/023800 WO2001016582A1 (en) 1999-08-30 2000-08-30 In situ methods for measuring the release of a substance from a dosage form

Publications (2)

Publication Number Publication Date
EP1210583A1 EP1210583A1 (en) 2002-06-05
EP1210583A4 true EP1210583A4 (en) 2004-08-11

Family

ID=22538787

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00961420A Withdrawn EP1210583A4 (en) 1999-08-30 2000-08-30 In situ methods for measuring the release of a substance from a dosage form

Country Status (5)

Country Link
EP (1) EP1210583A4 (en)
JP (1) JP2003508748A (en)
AU (1) AU7337500A (en)
CA (1) CA2383906A1 (en)
WO (1) WO2001016582A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077616A1 (en) 2001-03-27 2002-10-03 Euro-Celtique, S.A. Atr crystal device
US7620576B1 (en) 2003-01-21 2009-11-17 Trading Technologies International, Inc. Method and apparatus for providing order queue information
US7024955B2 (en) 2003-03-01 2006-04-11 Symyx Technologies, Inc. Methods and systems for dissolution testing
US7809628B1 (en) 2003-05-30 2010-10-05 Trading Technologies International Inc. System and method for estimating order position
JP2005172779A (en) * 2003-12-10 2005-06-30 Semiconductor Res Found Method and apparatus for measuring bacteria, virus and toxic substance by irradiation with electromagnetic wave
GB0524225D0 (en) * 2005-11-29 2006-01-04 Amersham Biosciences Ab Methods and apparatus for detecting and measuring the concentration of a substance in a solution
JP2009063335A (en) * 2007-09-05 2009-03-26 Fujifilm Corp Measuring method for interaction of physiologically active substance with substance to be examined
US8803095B2 (en) 2008-04-04 2014-08-12 Colgate-Palmolive Company Analysis of substrates having agents deposited thereon
JP2009075134A (en) * 2009-01-05 2009-04-09 Junichi Nishizawa Identification device for bacterium or toxic substance
JP5773914B2 (en) * 2011-03-11 2015-09-02 ディステック，インコーポレーテッド Centrally controlled modular motorized testing
CN102721796A (en) * 2012-06-27 2012-10-10 浙江省中医药研究院 Experimental device for simulating local drug release behavior of medicine and application thereof
JP6635363B2 (en) * 2014-10-24 2020-01-22 京都府公立大学法人 Method for discriminating tumor site, device for discriminating tumor site
WO2016079797A1 (en) * 2014-11-18 2016-05-26 日本メクトロン株式会社 Inline concentration measurement probe and concentration measurement system
CN109975274B (en) * 2019-04-16 2024-01-23 北京科技大学 Online rapid detection device for silicon content of molten iron of blast furnace
CN116322304A (en) * 2020-10-26 2023-06-23 索尼集团公司 Information processing device, information processing method, and program
CN112816446B (en) * 2020-12-24 2022-02-01 四川长虹电器股份有限公司 Method for detecting powder decay of fluorescent wheel based on fluorescence spectrum
CA3223357A1 (en) * 2021-07-12 2023-01-19 Brigitte Elisa Anna Burm Improved substance quantification in complex mixtures
CN117783459B (en) * 2024-02-28 2024-05-07 沈阳科惠生物医药科技有限公司 Drug dissolution curve determination method and system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070874A (en) * 1990-01-30 1991-12-10 Biocontrol Technology, Inc. Non-invasive determination of glucose concentration in body of patients
WO1997046860A2 (en) * 1996-06-04 1997-12-11 Euro-Celtique, S.A. Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335438A (en) * 1980-04-17 1982-06-15 Smolen Victor F Method and apparatus for automatic dissolution testing of products
US4740709A (en) * 1986-04-10 1988-04-26 The United States Of America As Represented By The Department Of Health And Human Services Method of sensing fluid properties independent of bubble concentrations
JP2955365B2 (en) * 1994-02-25 1999-10-04 デイステク インコーポレイテツド Dissolution test equipment
US5679954A (en) * 1994-11-14 1997-10-21 Soloman; Sabrie Non-destructive identification of tablet and tablet dissolution by means of infared spectroscopy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070874A (en) * 1990-01-30 1991-12-10 Biocontrol Technology, Inc. Non-invasive determination of glucose concentration in body of patients
WO1997046860A2 (en) * 1996-06-04 1997-12-11 Euro-Celtique, S.A. Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANETE F ET AL: "LIQUID-LIQUID EXTRACTION IN CONTINUOUS FLOW SYSTEMS WITHOUT PHASE SEPARATION", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 60, no. 21, 1 November 1988 (1988-11-01), pages 2354 - 2355, XP000024604, ISSN: 0003-2700 *
See also references of WO0116582A1 *

Also Published As

Publication number Publication date
CA2383906A1 (en) 2001-03-08
AU7337500A (en) 2001-03-26
WO2001016582A9 (en) 2002-09-12
JP2003508748A (en) 2003-03-04
WO2001016582A1 (en) 2001-03-08
EP1210583A1 (en) 2002-06-05

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Owner name: DELPHIAN TECHNOLOGY INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20040624

RIC1 Information provided on ipc code assigned before grant

Ipc: 7G 01J 3/433 B

Ipc: 7G 01N 13/00 B

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Ipc: 7G 01N 21/63 A

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Effective date: 20081213